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Pediatric Gastroenterology, Hepatology & Nutrition

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https://read.qxmd.com/read/30671381/valproate-is-contraindicated-in-polg1-mutations
#1
COMMENT
Josef Finsterer
No abstract text is available yet for this article.
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30671380/meckel-s-diverticulum-diagnosed-in-a-child-with-suspected-small-bowel-crohn-s-disease
#2
Hyun Sik Kang, Jeong Sub Lee, Chang Rim Hyun, In-Ho Jung, Ki Soo Kang
We report a rare case of Meckel's diverticulum in a boy who initially presented with chronic iron deficiency anemia (IDA) without any history of gastrointestinal (GI) bleeding at 8 years-old. Isolated small bowel Crohn's disease was suspected based on findings of small bowel ulcers on capsule endoscopy. At four years from initial presentation, he developed massive GI bleeding. Abdominal computed tomographic angiography and small bowel series revealed findings suggestive of Meckel's diverticulum. Meckel's diverticulum should be suspected in children with unexplained chronic IDA even in the absence of prominent GI bleeding and negative findings on repetitive Meckel's scans...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30671379/enterourachal-fistula-as-an-initial-presentation-in-crohn-disease
#3
Senthilkumar Sankararaman, Ramy Sabe, Thomas J Sferra, Ali Salar Khalili
Crohn disease has a wide spectrum of clinical presentations and rarely can present with complications such as a bowel stricture or fistula. In this case report, we describe a 17-year-old male who presented with a history of recurrent anterior abdominal wall abscesses and dysuria. He was diagnosed with Crohn disease and also found to have a fistulous communication between the terminal ileum and a patent urachus. An ileocecectomy with primary anastomosis and complete resection of the abscess cavity was performed...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30671378/wire-guided-cannulation-facilitates-endoscopic-management-of-buried-bumper-syndrome-a-novel-technique
#4
Jacquelin Peck, Kaitlin Sapp, Alexander Wilsey, Michael Wilsey
Buried bumper syndrome is a rare but potentially severe complication of percutaneous endoscopic gastrostomy tube insertion. Though this complication is uncommon, it may lead to pressure necrosis, bleeding, perforation, peritonitis, sepsis, or death. Each case of buried bumper syndrome is unique in terms of patient comorbidities and anatomic positioning of the buried bumper. For this reason, many approaches have been described in the management of buried bumper syndrome. In this case report, we describe the case of an adolescent Caucasian female who developed buried bumper syndrome three years after undergoing percutaneous endoscopic gastrostomy insertion...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30671377/the-characteristics-and-outcomes-of-abernethy-syndrome-in-korean-children-a-single-center-study
#5
Eun Sil Kim, Ki Wuk Lee, Yon Ho Choe
Purpose: Abernethy malformation is a rare condition, which was first described in 1793 as a congenital extrahepatic porto-systemic shunt (CEPS) directing splanchnic blood flow into the inferior vena cava. Eighty cases have been published so far that reported CEPS, while in Korea, very few cases have been reported. Through this study, we present 6 cases of patients diagnosed with CEPS at Samsung Medical Center and compare these with other such cases published in France and China. Methods: We reviewed clinical, laboratory, and imaging data of 6 children with CEPS in our pediatric clinic between 2004 and 2017...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30671376/therapeutic-efficacy-of-exclusive-enteral-nutrition-with-specific-polymeric-diet-in-pediatric-crohn-s-disease
#6
Yunkoo Kang, Sowon Park, Seung Kim, Sang Yong Kim, Hong Koh
Purpose: The efficacy of exclusive enteral nutrition (EEN) with a polymeric diet has not been confirmed in Korean pediatric patients with Crohn's disease (CD). This study aimed to compare the effectiveness of EEN with a specific polymeric diet (Encover®) and corticosteroids (CSs) for the induction of remission in Korean pediatric CD patients. Methods: We retrospectively compared data from 51 pediatric CD patients who underwent induction therapy with EEN (n=19) or CSs (n=32) at Severance Children's Hospital or Incheon St...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30671375/dosage-related-prebiotic-effects-of-inulin-in-formula-fed-infants
#7
Hanifah Oswari, Ariani Dewi Widodo, Frieda Handayani, Mohammad Juffrie, Tonny Sundjaya, Jacques Bindels, Badriul Hegar
Purpose: The aim of this study was to identify the minimally meaningful dosage of inulin leading to a prebiotic effect in Indonesian infants. Methods: In a randomized controlled double-blinded, parallel, 3-arm intervention study, 164 healthy formula-fed infants aged 3 to 5 months first obtained formula-A (without inulin) during a 4-week adaptation period. Subsequently, 142 subjects were subjected to a 4-week feeding period by administering either formula-A (no inulin), formula-B (0...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30671374/usefulness-of-ultrasonography-in-the-diagnosis-of-peptic-ulcer-disease-in-children
#8
Eun Joo Lee, Yeoun Joo Lee, Jae Hong Park
Purpose: This study was performed to assess the clinical usefulness of transabdominal ultrasonography (TUS) in detecting peptic ulcer disease (PUD) in children. Methods: Twenty-four patients (19 boys, 5 girls; mean age, 10.6±4.5 years [range, 3.0-17.9 years]) who were admitted to the hospital for acute abdomen or gastrointestinal bleeding and diagnosed with PUD by endoscopy and who underwent TUS were included. Clinical data were retrospectively collected by reviewing patient medical records...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30671373/clinical-aspects-and-treatments-for-pediatric-inflammatory-bowel-diseases
#9
REVIEW
Jin Soo Moon
The incidence of pediatric inflammatory bowel disease (IBD) is increasing worldwide, especially in the developing countries. It differs from adult disease in clinical manifestations, especially with regard to genetic predisposition in monogenic IBD. Pediatric disease also have a tendency to show more aggressive inflammation and greater extent of lesion. Newer drugs such as anti-tumor necrosis factor α have been known to make a difference in treating pediatric IBD. Recent studies suggested that the patients with high risk factors might have some benefits from earlier use of biologics...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30671372/recent-advance-in-very-early-onset-inflammatory-bowel-disease
#10
REVIEW
Jung Ok Shim
Recent studies on pediatric inflammatory bowel disease (IBD) have revealed that early-onset IBD has distinct phenotypic differences compared with adult-onset IBD. In particular, very early-onset IBD (VEO-IBD) differs in many aspects, including the disease type, location of the lesions, disease behavior, and genetically attributable risks. Several genetic defects that disturb intestinal epithelial barrier function or affect immune function have been noted in these patients from the young age groups. In incidence of pediatric IBD in Korea has been increasing since the early 2000s...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30671371/successful-transition-from-pediatric-to-adult-care-in-inflammatory-bowel-disease-what-is-the-key
#11
REVIEW
Jeongseok Kim, Byong Duk Ye
The incidence of pediatric-onset inflammatory bowel disease (IBD) is on the rise, accounting for up to 25% of IBD cases. Pediatric IBD often has extensive bowel involvement with aggressive and rapidly progressing behavior compared to adult IBD. Because IBD has a high morbidity rate and can have a lifelong impact, successful transition from pediatric to adult care is important to maintain the continuity of care. Furthermore, successful transition facilitates appropriate development and psychosocial well-being among patients, as well as comprehensive and harmonious healthcare delivery amongst stakeholders...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30671370/clinical-practice-guideline-for-the-diagnosis-and-treatment-of-pediatric-obesity-recommendations-from-the-committee-on-pediatric-obesity-of-the-korean-society-of-pediatric-gastroenterology-hepatology-and-nutrition
#12
REVIEW
Dae Yong Yi, Soon Chul Kim, Ji Hyuk Lee, Eun Hye Lee, Jae Young Kim, Yong Joo Kim, Ki Soo Kang, Jeana Hong, Jung Ok Shim, Yoon Lee, Ben Kang, Yeoun Joo Lee, Mi Jin Kim, Jin Soo Moon, Hong Koh, JeongAe You, Young-Sook Kwak, Hyunjung Lim, Hye Ran Yang
The Committee on Pediatric Obesity of the Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition newly developed the first Korean Guideline on the Diagnosis and Treatment of Obesity in Children and Adolescents to deliver an evidence-based systematic approach to childhood obesity in South Korea. The following areas were systematically reviewed, especially on the basis of all available references published in South Korea and worldwide, and new guidelines were established in each area with the strength of recommendations based on the levels of evidence: 1) definition and diagnosis of overweight and obesity in children and adolescents; 2) principles of treatment of pediatric obesity; 3) behavioral interventions for children and adolescents with obesity, including diet, exercise, lifestyle, and mental health; 4) pharmacotherapy; and 5) bariatric surgery...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30345254/a-case-of-glycogen-storage-disease-iv-with-rare-homozygous-mutations-in-the-glycogen-branching-enzyme-gene
#13
So Yoon Choi, Ben Kang, Jae Young Choe, Yoon Lee, Hyo Jeong Jang, Hyung-Doo Park, Suk-Koo Lee, Yon Ho Choe
Glycogen storage disease (GSD) IV is a rare autosomal recessive inherited disorder caused by mutations in the gene coding for glycogen branching enzyme leading to progressive liver disease. GSD IV is associated with mutations in GBE1 , which encodes the glycogen branching enzyme. We report a case of GSD IV with rare homozygous mutations in the GBE1 gene (c.791G>A (p.Gly264Glu), which was successfully treated by liver transplantation.
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30345253/accessory-hepatic-lobe-a-rare-cause-of-prehepatic-portal-hypertension-in-a-child
#14
Elif Sağ, Ayşegül Cansu, Mustafa İmamoğlu, Murat Çakır
Accessory hepatic lobe is noted as and considered a rare disease in children. It can manifest with various symptoms and complications depending on the location, volume, type and position of the disease as presented on a child. The patient presented as a 14-month-old girl who was seen with a notable hepatosplenomegaly and portal hypertension. A diagnosis was made after taking an extensive medical history, observation and radiological examinations. The formal diagnosis was a prehepatic portal hypertension associated with accessory hepatic lobe...
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30345252/fecal-microbiota-transplantation-to-patients-with-refractory-very-early-onset-ulcerative-colitis
#15
Toshifumi Yodoshi, Thomas L Hurt
Recently, fecal microbiota transplantation (FMT) has been attracting attention as a possible medical treatment of ulcerative colitis (UC). A randomized controlled trial of FMT for children with UC is currently underway. Therapeutic effects of FMT for adults with UC remain controversial. We report two cases of early-onset UC in children. A patient was diagnosed with UC at age 1-year 9-month and underwent FMT at age 2-year 3-month. He attained clinical remission for three weeks after FMT, but then relapsed at four weeks, ultimately undergoing a total colectomy...
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30345251/endoscopic-balloon-dilation-for-treatment-of-congenital-antral-web
#16
Jacquelin Peck, Racha Khalaf, Ryan Marth, Claudia Phen, Roberto Sosa, Francisco Balsells Cordero, Michael Wilsey
Congenital antral webs are a rare but relevant cause of gastric outlet obstruction in infants and children. The condition may lead to feeding refusal, vomiting, and poor growth. Due to the relative rarity of the disease, cases of congenital antral web are frequently misdiagnosed or diagnosed with significant delay as physicians favorably pursue diagnoses of pyloric stenosis and gastric ulcer disease, which are more prevalent. We report a case of an eight-month-old female who presented with persistent non-bilious emesis, feeding difficulties, and failure to thrive and was discovered to have an antral web...
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30345250/minocycline-induced-autoimmune-hepatitis-a-rare-but-important-cause-of-drug-induced-autoimmune-hepatitis
#17
Elizabeth G Harmon, Randolph McConnie, Anil Kesavan
Drug-induced autoimmune hepatitis (DIAIH) is an increasingly recognized form of drug-induced liver injury that leads to a condition similar to idiopathic autoimmune hepatitis. A number of drugs have been associated with DIAIH, minocycline is one of the most well characterized. Minocycline is a semisynthetic tetracycline antibiotic used in the treatment of acne vulgaris. Minocycline-induced autoimmune hepatitis presents with serologic and histologic features similar to idiopathic autoimmune hepatitis. However, the natural history and outcomes of these two conditions differ significantly...
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30345249/a-newborn-with-gastric-hemangioma-treated-using-propranolol
#18
Huseyin Kaya, Ismail Kursad Gokce, Sukru Gungor, Hatice Turgut, Ramazan Ozdemir
Gastric hemangiomas are rare benign vascular tumors that can cause severe gastrointestinal system bleeding. We presented the case of a neonate with fresh bleeding and melena from the orogastric tube and detected gastric hemangioma in esophagogastroduodenoscopic examination. Propranolol is widely used in treatment of cutaneous hemangiomas and non-gastric gastrointestinal system hemangiomas. However, the surgical approach is preferred for treating gastric hemangiomas, and there are few reports of gastric hemangiomas associated with non-surgical treatment...
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30345248/non-surgical-management-of-gastroduodenal-fistula-caused-by-ingested-neodymium-magnets
#19
Claudia Phen, Alexander Wilsey, Emily Swan, Victoria Falconer, Lisa Summers, Michael Wilsey
Foreign body ingestions pose a significant health risk in children. Neodymium magnets are high-powered, rare-earth magnets that is a serious issue in the pediatric population due to their strong magnetic force and high rate of complications. When multiple magnets are ingested, there is potential for morbidity and mortality, including gastrointestinal fistula formation, obstruction, bleeding, perforation, and death. Many cases require surgical intervention for removal of the magnets and management of subsequent complications...
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30345247/reversal-of-immunogenicity-in-pediatric-inflammatory-bowel-disease-patients-receiving-anti-tumor-necrosis-factor-medications
#20
Elise Kang, Ali Khalili, Judy Splawski, Thomas J Sferra, Jonathan Moses
Loss of response to anti-tumor necrosis factor (anti-TNF) agents in the treatment of inflammatory bowel disease (IBD) is a major consideration to maintain sustained response. Reversal of immunogenicity can re-establish response and increase the durability of these agents. Strategies to reverse immunogenicity include dose-intensification and/or the addition of an immunomodulator. However, there is a relative paucity of data on the efficacy of such interventions in pediatric IBD patients. Available reports have not strictly utilized homogenous mobility shift assay, which reports on anti-drug antibodies even in the presence of detectable drug, whereas prior studies have been confounded by the use of drug sensitive assays...
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
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