journal
https://read.qxmd.com/read/37116065/implementation-of-calcium-and-vitamin-d-supplementation-in-glucocorticosteroid-induced-osteoporosis-prevention-guidelines-insights-from-rheumatologists
#21
REVIEW
Alexandra Balbir-Gurman, Tal Gazitt, Joy Feld, Devy Zisman
Glucocorticosteroid-induced osteoporosis (GIO) is the most common cause of secondary osteoporosis but is underdiagnosed and undertreated. Our aim in this communication is to review the literature on the implementation of current GIO prevention practices such as calcium and vitamin D supplementation with emphasis on the rheumatologists' perspective relating to the need for development of novel GIO educational prevention measures.
April 30, 2023: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/37116064/giant-cell-arteritis-state-of-the-art-in-diagnosis-monitoring-and-treatment
#22
REVIEW
Abid Awisat, Shiri Keret, Amal Silawy, Lisa Kaly, Itzhak Rosner, Michael Rozenbaum, Nina Boulman, Aniela Shouval, Doron Rimar, Gleb Slobodin
Giant cell arteritis (GCA) is the most prevalent subtype of vasculitis in adults. In recent years, there has been substantial improvement in the diagnosis and treatment of GCA, mainly attributed to the introduction of highly sensitive diagnostic tools, incorporation of modern imaging modalities for diagnosis and monitoring of large-vessel vasculitis, and introduction of highly effective novel biological therapies that have revolutionized the field of GCA. This article reviews state-of-the-art approaches for the diagnosis, monitoring, and treatment options of GCA...
April 30, 2023: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/37116063/idiopathic-eosinophilic-vasculitis-case-presentation-and-literature-review
#23
JOURNAL ARTICLE
Alexandra Balbir-Gurman, Adi Broyde, Ori Elkayam
OBJECTIVE: Idiopathic eosinophilic vasculitis has been described in previous case series as a possible manifestation of hypereosinophilic syndrome (HES) in asthma-free patients. A rare disease, it can be classified as an eosinophilic-rich, necrotizing, systemic form of vasculitis that affects vessels of various sizes in these patients. This report shares our experience with the treatment of a patient with eosinophilic vasculitis. CASE PRESENTATION: We present the case of a 45-year-old man who suffered from idiopathic HES manifesting as digital ulcers and peripheral ischemia of both the upper and lower limbs without the involvement of other systems...
April 30, 2023: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/37116062/basic-lessons-from-india-on-vaccination-letter-to-the-editor
#24
LETTER
Thorakkal Shamim
No abstract text is available yet for this article.
April 30, 2023: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/37116061/response-to-letter-from-dr-thorakkal-shamim
#25
LETTER
Peter J Hotez
No abstract text is available yet for this article.
April 30, 2023: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/37116060/biological-therapies-in-inflammatory-myopathies
#26
REVIEW
Abd El Haleem Natour, Shaye Kivity
Idiopathic inflammatory myopathies (IIM) are a rare group of disorders that feature progressive immune-mediated skeletal muscle destruction along with skin, lung, and joint involvement. Management of IIMs necessitates glucocorticoid therapy followed by conventional steroid-sparing agents to control disease activity. In the settings of refractory myositis or life-threatening manifestations, e.g. lung involvement or oropharyngeal dysphagia, second-line therapies are needed to minimize disease burden, avoid end-organ damage and steroid toxicity, and decrease mortality...
April 30, 2023: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/37116059/dual-biologic-therapy-in-patients-with-rheumatoid-arthritis-and-psoriatic-arthritis
#27
REVIEW
Victoria Furer, Ori Elkayam
Treatment with biological agents has become standard of care in treatment of immune-mediated diseases (IMD), including rheumatoid arthritis and psoriatic arthritis. Yet, a significant proportion of patients experience loss of response to biologics, need treatment escalation, or develop side effects. During the past decade, new biologic agents with different targeted molecular pathways have been approved for treatment of IMD, introducing the possibility of concomitant dual biologic therapy. The role of dual biologic therapy targeting different inflammatory pathways has become an area of great interest in the field of IMD, addressing the unmet clinical need of patients with refractory diseases and treatment of comorbidities, such as osteoporosis, asthma, atopic dermatitis, and urticaria...
April 30, 2023: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/36719670/a-25-hour-fast-among-quiescent-hereditary-coproporphyria-and-variegate-porphyria-patients-is-associated-with-a-low-risk-of-complications
#28
JOURNAL ARTICLE
Yonatan Edel, Rivka Mamet, Iftach Sagy, Igor Snast, Ran Kaftory, Tomer Mimouni, Assi Levi
OBJECTIVE: In patients with acute hepatic porphyria (AHP), prolonged fasting is a known trigger of AHP attacks. Despite this, some Jewish AHP patients-mainly hereditary coproporphyria (HCP) and variegate porphyria (VP) patients-fast for 25 consecutive hours during the traditional Jewish holy day known as Yom Kippur. In this study, we evaluated the effect of the fast on these patients. METHODS: A retrospective study and survey of AHP patients in Israel was carried out...
January 29, 2023: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/36719669/is-cirrhotic-cardiomyopathy-related-to-cirrhosis-severity
#29
JOURNAL ARTICLE
Subhash Chandra Dash, Beeravelli Rajesh, Suresh Kumar Behera, Naba Kishore Sundaray, Praveen Patil
OBJECTIVE: Cirrhotic cardiomyopathy (CCM) is associated with increased morbidity and mortality in patients with liver cirrhosis. Yet, it remains an under-diagnosed entity. Further, its relation to the severity of cirrhosis is contradictory. We conducted this study on an Indian population to determine the cardiac dysfunctions in cirrhosis of the liver and correlations with etiologies and cirrhosis severity. METHODS: This study enrolled patients with diagnosed liver cirrhosis without any cardiac disease or conditions affecting cardiac function...
January 29, 2023: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/36719668/the-joles-jewish-hospital-a-short-lived-dutch-small-city-hospital-with-an-unusual-resurrection
#30
JOURNAL ARTICLE
Jack Y Vanderhoek, Dick van de Kamp
The Joles Jewish Hospital in Haarlem (a small city in the Netherlands) was established in 1930 to provide a Jewish milieu for local patients. Mozes Joles, a wealthy Jewish businessman, bequeathed his fortune to the Haarlem Jewish community to accomplish this objective, and its spiritual leader, Rabbi Simon Philip de Vries, was the driving force in successfully achieving this goal. The Joles Hospital was forcibly closed by the Nazis in 1943, and the postwar leadership of the Haarlem Jewish community decided not to reopen it...
January 29, 2023: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/36719667/fresh-frozen-plasma-increases-hemorrhage-in-blunt-traumatic-brain-injury-and-uncontrolled-hemorrhagic-shock
#31
JOURNAL ARTICLE
Hilla Abergel, Miri Bidder, Itamar Ashkenazi, Leonid Reytman, Ricardo Alfici, Michael M Krausz
BACKGROUND: Blunt traumatic brain injury (bTBI) and uncontrolled hemorrhagic shock (UCHS) are common causes of mortality in polytrauma. We studied the influence of fresh frozen plasma (FFP) resuscitation in a rat model with both bTBI and UCHS before achieving hemorrhage control. METHODS: The bTBI was induced by an external weight drop (200 g) onto the bare skull of anesthetized male Lewis (Lew/SdNHsd) rats; UCHS was induced by resection of two-thirds of the rats' tails...
January 29, 2023: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/36719666/global-vaccinations-new-urgency-to-surmount-a-triple-threat-of-illness-antiscience-and-anti-semitism
#32
JOURNAL ARTICLE
Peter J Hotez
No abstract text is available yet for this article.
January 29, 2023: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/36394503/multimodal-imaging-in-rhinoorbitocerebral-mucormycosis-associated-with-type-2-diabetes-after-covid-19
#33
JOURNAL ARTICLE
Pavel Mikhailovich Zelter, Olesya Vladimirovna Zeleva, Egor Andreevich Sidorov, Dmitriy Vyacheslavovich Solovov, Evgeniy Nikolaevich Surovtsev
PURPOSE: This case series analyzed the appropriateness of computed tomography (CT) and magnetic resonance imaging (MRI) for visualization of rhinoorbitocerebral mucormycosis (ROCM) patterns associated with type 2 diabetes (T2D) post-recovery from coronavirus disease 2019 (COVID-19). METHODS: The study included 24 patients with invasive ROCM after having recovered from COVID-19. All patients underwent CT examinations and microbiological and histological verification; 5 patients underwent MRI...
October 27, 2022: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/36394502/outcomes-of-open-fronto-facial-resection-for-fungal-osteomyelitis-of-frontal-bone
#34
JOURNAL ARTICLE
Rupa Mehta, Karthik Nagaraga Rao, Nitin M Nagarkar, Anil Sharma, Badal Kumar, P Karthik
INTRODUCTION: The second wave of coronavirus disease 2019 (COVID-19) led to the resurgence of opportunistic infections due to the injudicious use of steroids. Sinonasal mucormycosis was declared an epidemic in India during the pandemic. Mucormycosis was managed effectively by surgical debridement along with systemic amphotericin B. Currently, a resurgence of mucormycosis following initial treatment, in the form of fungal osteomyelitis of the frontal bone, is being seen in India. METHODS: This prospective study included 10 patients with fungal osteomyelitis of the frontal bone due to mucormycosis...
October 27, 2022: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/36394501/crispr-technology-a-jewish-legal-perspective
#35
JOURNAL ARTICLE
John D Loike, Rabbi Tzvi Flaum
Clustered regularly interspaced short palindromic repeats (CRISPR) gene editing is an innovative and potentially game-changing biotechnology that can potentially reverse DNA mutations in a tissue-specific manner. In addition, CRISPR is being targeted for xenotransplantation, for increasing human longevity, in animal breeding, and in plant science. However, there are many ethical challenges that emerge from CRISPR technology. This article discusses several positions that relate to these ethical challenges from a Jewish legal perspective...
October 27, 2022: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/36394500/comparing-sublingual-and-inhaled-cannabis-therapies-for-low-back-pain-an-observational-open-label-study
#36
JOURNAL ARTICLE
Dror Robinson, Sivan Ritter, Mustafa Yassin
BACKGROUND AND OBJECTIVE: Medical cannabis is becoming an acceptable treatment modality in medicine, especially for pain relief. Concurrently, cannabis use is becoming more prevalent worldwide, a public demand-driven trend despite the lack of established scientific basis. This observational open-label study sought to investigate the effectiveness of cannabis therapy for alleviating low back pain symptoms. METHODS: Two types of cannabis treatment modalities were sequentially administered to chronic low back pain patients...
October 27, 2022: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/36394499/three-decades-of-cannabis-research-what-are-the-obstacles
#37
EDITORIAL
Michael Dor
No abstract text is available yet for this article.
October 27, 2022: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/36112165/biomarkers-in-external-apical-root-resorption-an-evidence-based-scoping-review-in-biofluids
#38
JOURNAL ARTICLE
Priyanka Kapoor, Aman Chowdhry, Dinesh Kumar Bagga, Deepak Bhargava
BACKGROUND: External apical root resorption (EARR), an unwanted sequela of orthodontic treatment, is difficult to diagnose radiographically. Hence, the current scoping review was planned to generate critical evidence related to biomarkers in oral fluids, i.e. gingival crevicular fluid (GCF), saliva, and blood, of patients showing root resorption, compared to no-resorption or physiologic resorption. METHODS: A literature search was conducted in major databases along with a manual search of relevant articles in the library, and further search from references of the related articles in March 2021...
September 14, 2022: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/36112164/a-unique-case-of-myositis
#39
JOURNAL ARTICLE
Noa Hurvitz, Ariel Kenig, Asa Kessler, Narmine Elkhateeb, Yossef Lerner, Michal Zamir, Fadi Kharouf
No abstract text is available yet for this article.
September 14, 2022: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/35921490/postoperative-pain-control-by-local-infiltration-analgesia-and-peripheral-nerve-block-in-primary-prosthetic-total-knee-arthroplasty
#40
JOURNAL ARTICLE
Alexey Vladimirovich Lychagin, Andrey Anatolyevich Gritsyuk, Nahum Rosenberg
BACKGROUND AND OBJECTIVE: Postoperative (post-op) pain control has an important impact on post-op rehabilitation. The logistics of its maintenance challenge the effect of peripheral nerve block on post-op pain control, with the risk for post-op complications. We hypothesized that perioperative use of local infiltration analgesia (LIA) is comparable to post-op pain control by peripheral nerve block. MATERIALS AND METHODS: We evaluated three groups of patients treated with primary total knee arthroplasty (TKA) due to symptomatic end-stage osteoarthritis with post-op pain control by LIA (LIA group, n=52), femoral plus sciatic nerve block (FSNB) (FSNB group, n=54), and without local or regional analgesia as controls (Control group, n=53)...
July 31, 2022: Rambam Maimonides Medical Journal
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