journal
Journals Contemporary Oncology Wspó�...

Contemporary Oncology Współczesna Onkologia

https://read.qxmd.com/read/38239868/virtual-docking-screening-and-quantitative-structure-activity-relationship-studies-to-explore-akt-and-pi3k-inhibitors-acting-on-mtor-in-cancers-by-theoretical-biology-and-medical-modeling
#21
JOURNAL ARTICLE
Ilham Kandoussi, Hanane Abbou, Ghyzlane El Haddoumi, Mariam Mansouri, Lahcen Belyamani, Azeddine Ibrahimi
INTRODUCTION: The mechanistic target of rapamycin (mTOR) coordinates the growth and metabolism of eukaryotic cells with a central role in the regulation of many fundamental cellular processes. It is strongly connected to phosphatidylinositol 3-kinase (PI3K) and AKT signaling. Activation of the PI3K/AKT/mTOR pathway leads to a profound disruption in the control of cell growth and survival, which ultimately leads to competitive growth advantage, metastatic competence, angiogenesis and therapeutic resistance...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38239867/namirna-mediated-high-expression-of-knstrn-correlates-with-poor-prognosis-and-immune-infiltration-in-hepatocellular-carcinoma
#22
JOURNAL ARTICLE
Liang Jin, Xiaojing Zhang, Ming Fan, Weimin Li, Xuan Zhang
INTRODUCTION: Mutations of kinetochore-localized astrin/sperm-associated antigen 5 (KNSTRN) can interfere with chromatid cohesion, increase aneuploidy in tumours, and enhance tumourigenesis. However, the role of the KNSTRN-binding protein in hepatocellular carcinoma (HCC) remains unclear. MATERIAL AND METHODS: Using The Cancer Genome Atlas databases, we investigated the potential oncogenic functions of KNSTRN in HCC along with R and various computational tools. RESULTS: Detailed results revealed that elevated expression of KNSTRN was considerably associated with poor overall survival (HR = 1...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38239866/the-role-of-cytoreductive-nephrectomy-in-the-treatment-of-patients-with-metastatic-kidney-cancer-review-article
#23
REVIEW
Maciej Michalak, Piotr Tomczak, Tomasz Milecki, Andrzej Antczak
The role of cytoreductive nephrectomy (CN), i.e. the removal of a kidney involved by cancer in patients with advanced kidney cancer with distant metastases, is the subject of intense debate among urologists and oncologists. For many years, CN has been considered the gold standard in the treatment of patients at this stage of the disease, especially in patients in good general health with no significant contraindications to surgical treatment. The starting point for questioning the validity of CN was the publication of the results of the cancer du rein metastatique nephrectomie et antiangiogéniques and SURTIME clinical trials (2018 and 2019, respectively), which questioned the validity of surgery in some patients with late-stage cancer...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38239865/quercetin-inhibits-the-activity-and-function-of-dendritic-cells-through-the-tlr4-irak4-nf-%C3%AE%C2%BAb-signalling-pathway
#24
JOURNAL ARTICLE
Chenglin Kang, Xiaomei Li, Peng Liu, Yue Liu, Yuan Niu, Xianhai Zeng, Jiangqi Liu, Hailiang Zhao, Shuqi Qiu
INTRODUCTION: To investigate the inhibitory effect of quercetin (QUE) on dendritic cells (DCs) through the toll-like receptor 4/interleukin-1 receptor-associated kinase 4/nuclear factor kappa-B (TLR4/IRAK4/NF-κB) signalling pathway. MATERIAL AND METHODS: CCK-8 and apoptosis assays were performed to determine the optimal concentration and action time of QUE to inhibit DCs. Protein extracts from treated DCs were used for Western blotting experiments to determine the relative expression levels of TLR4, IRAK4, and NF-κB p65 proteins...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38239864/fgfr2-point-mutation-in-2-cases-of-pleomorphic-adenoma-progressing-to-myoepithelial-carcinoma
#25
Julia Pikul, Anna Rzepakowska, Marcin Machnicki, Tomasz Stokłosa
INTRODUCTION: Salivary gland tumours are rare neoplasms. Pleomorphic adenoma (PA) is the most frequent benign lesion. Myoepithelial carcinoma (MECA) is rarely recognized malignancy, but the prognosis is unfavourable. The aim of this study was to identify genetic rearrangements that might be responsible for dynamic MECA progression in patients with primary radical PA excision. MATERIAL AND METHODS: Next-generation sequencing (NGS) of 1500 gene coding sequences was performed in primary and recurrent tumour tissue collected from 2 patients, in whom PA was initially diagnosed and within one year multifocal MECA was detected...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38239863/altered-immunoexpression-of-dna-polymerase-delta-1-catalytic-subunit-pold1-in-colorectal-cancer
#26
JOURNAL ARTICLE
Przemysław Stefaniak, Bartłomiej Emil Kraziński, Jacek Kieżun, Hanna Majewska, Janusz Godlewski
INTRODUCTION: The study aimed to determine the immunoexpression levels of polymerase delta 1 catalytic subunit (POLD1), a catalytic and proofreading subunit of DNA polymerase delta, in the sections of colorectal cancer (CRC), and to evaluate the significance of POLD1 as a potential prognostic factor in CRC. MATERIAL AND METHODS: Paired, tumour and non-cancerous tissue samples of the large intestine distant to the neoplasm were collected from the postoperative material of 78 patients who underwent surgical resection of CRC tumours...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38239862/an-elevated-systemic-inflammation-index-is-related-to-an-inferior-response-to-pomalidomide-and-dexamethasone-treatment-in-patients-with-relapsed-and-refractory-multiple-myeloma
#27
JOURNAL ARTICLE
Damian Mikulski, Paweł Robak, Grzegorz Mirocha, Wiktoria Ryżewska, Kamila Stańczak, Karol Okoński, Kacper Kościelny, Tadeusz Robak
INTRODUCTION: The systemic inflammation index (SII) might serve as an indicator of the equilibrium between the inflammatory and immune responses. The aim of the study was to determine the clinical value and prognostic significance of SII in the cohort of multiple myeloma (MM) patients treated with a regimen of pomalidomide and dexamethasone (Pd). MATERIAL AND METHODS: This retrospective, real-life study included patients who received a Pd regimen in our centre between November 2018 and July 2022...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38239861/potential-antitumour-effect-of-all-trans-retinoic-acid-on-regorafenib-treated-human-colon-cancer-cell-lines
#28
JOURNAL ARTICLE
Mariam Hamad, Radwa Ali Mehana, Mohammad M Abd-Al Haseeb, Maha Houssen
INTRODUCTION: Colorectal cancer (CRC) is a significant contributor to cancer-related mortality worldwide, ranking as the second leading cause of such deaths. Central to the progression of this malignancy is angiogenesis - a complex process orchestrated by vascular endothelial growth factor (VEGF). Regorafenib, a potent multikinase inhibitor, acts as a critical antagonist of multiple kinases involved in angiogenesis, proliferation, and metastasis. Conversely, all-trans retinoic acid (ATRA) has demonstrated compelling antitumour effects across various cancer types...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38239860/circulating-tumor-cells-in-colorectal-cancer-a-review-of-detection-methods-and-clinical-relevance
#29
REVIEW
Salma Saadi, Meryem Aarab, Imane Tabyaoui, Nadia Tahiri Jouti
Colorectal cancer (CRC) is the third most common cancer; it is one of the leading malignancies contributing to cancer mortality. Colorectal cancer is the third most diagnosed cancer in men and the second in women worldwide. Diagnosis of CRC depends on several clinical features such as age, primary site, tumor-node-metastasis stage, genetic parameters and the presence or absence of metastasis. The latter is a phenomenon that is induced by the shedding of tumor cells in the blood circulation by the primary tumor...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38239859/haemoglobin-and-c-reactive-protein-levels-are-efficient-at-identifying-neoplasms-as-the-most-common-early-mortality-of-chronic-diseases-in-emergency-department-patients
#30
JOURNAL ARTICLE
Wawrzyniec Mantorski, Piotr Feusette, Andrzej Tukiendorf, Edyta Idalia Wolny-Rokicka
INTRODUCTION: Extensive research has focused on emergency department (ED) and post-admission deaths, seeking to understand their frequency and causative factors. With the rising prevalence of advanced diseases, it is crucial to identify patients in need of end-of-life care and ensure its high quality. In this epidemiological study, we analyse routine ED blood tests to identify early warning signs of deteriorating patients with common non-traumatic and non-infectious (chronic) conditions...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38239858/activity-of-cabozantinib-in-further-line-treatment-of-metastatic-clear-cell-renal-cell-carcinoma-real-world-experience-in-a-single-center-retrospective-study
#31
JOURNAL ARTICLE
Piotr Domański, Jadwiga Jarosińska, Barbara Kruczyk, Mateusz Piętak, Anna Mydlak, Tomasz Demkow, Łukasz Kuncman, Marta Darewicz, Bożena Sikora-Kupis, Paulina Dumnicka, Jakub Kucharz
INTRODUCTION: Cabozantinib is an oral inhibitor of MET, AXL, and vascular endothelial growth factor receptors. It has an immunomodulatory effect and may influence the tumor's microenvironment and make mutated cells more sensitive to immune-mediated killing. These properties have made cabozantinib an effective drug for first-line or subsequent-line treatment after progression of metastatic renal cell carcinoma (mRCC), even after immunotherapy. MATERIAL AND METHODS: Seventy-one patients with mRCC were treated with second or further lines of cabozantinib at the Department of Genitourinary Oncology, Maria Sklodowska-Curie National Research Institute of Oncology...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794994/primary-pulmonary-hodgkin-s-lymphoma-mimicking-granulomatosis-with-polyangiitis-a-case-report-of-diagnostic-and-therapeutic-dilemmas
#32
Lucjan Sławiński, Julia Maria Sołek, Joanna Miłkowska-Dymanowska, Dorota Jesionek-Kupnicka, Joanna Góra-Tybor, Damian Mikulski, Marcin Braun
Primary pulmonary Hodgkin's lymphoma (PPHL) is a rare subtype of lymphoma that comprises a small percentage of primary pulmonary lymphomas. Due to its rarity and nonspecific symptoms, PPHL often presents diagnostic challenges. This case report presents a unique case of PPHL mimicking granulomatosis with polyangiitis, emphasizing the difficulties encountered during the diagnostic process. A 53-year-old female presented with vague symptoms including weakness, oedema, dry cough, and nasal cavity ulceration. Laboratory investigations revealed elevated C-reactive protein levels, a white blood cell count with neutrophilia, and lymphopaenia...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794993/attachment-styles-coping-with-stress-and-social-support-among-cancer-patients
#33
JOURNAL ARTICLE
Marta Karbowa-Płowens
INTRODUCTION: This paper presents the role of attachment style in determining an individual's way of coping with stress, which in turn helps to understand the differences in response and adjustment to cancer among cancer patients. Cancer is an illness that causes overwhelming distress, and dealing with it requires social support, among other coping strategies. MATERIAL AND METHODS: Studies show that social support is associated with a decrease in psychological symptoms and a better quality of life in cancer patients...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794992/subjective-health-and-its-predictors-in-leukaemia-patients-after-bone-marrow-transplantation
#34
JOURNAL ARTICLE
Helena Wrona-Polańska
INTRODUCTION: The aims of the study were to assess subjective health and its psychological predictors in leukaemia patients after bone marrow transplantation (BMT). The theoretical rationale of the study was the functional model of health (FMH). MATERIAL AND METHODS: Participants in the study comprised 141 patients after BMT (61 women, 80 men) in the age range between 20 and 40 years, most of whom had secondary education. A standardized interview and 10-point rating scales of sense of health and sense of calmness were used to assess the subjective health...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794991/great-mimicker-a-case-of-occult-melanoma-displaying-ganglioneuroblastic-differentiation
#35
Paulina Skrzypkowska, Michał Kunc, Wojciech Biernat
Melanomas are known for their diverse morphological features, presenting a diagnostic challenge for pathologists. Uncommon variations of melanoma can exhibit distinct cytological and histomorphological characteristics, including ganglioneuroblastic differentiation. However, this phenomenon is extremely rare, with only a few documented cases. Here, we present a unique case of an occult metastatic melanoma with ganglioneuroblastic differentiation developing in a 76-year-old male. The diagnosis was based on histopathology, immunophenotyping, and molecular testing, which revealed SOX10 positivity and an NRAS mutation...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794990/prognostic-value-of-geriatric-nutritional-risk-index-for-patients-with-biliary-tract-cancer-undergoing-surgical-resection-a-single-institution-retrospective-cohort-study
#36
JOURNAL ARTICLE
Shinichi Ikuta, Takayoshi Nakajima, Masataka Fujikawa, Tsukasa Aihara, Naoki Yamanaka
INTRODUCTION: The geriatric nutritional risk index (GNRI) is an index of nutritional status associated with clinical outcomes in various cancers; however, its prognostic value in biliary tract cancer (BTC) remains to be elucidated. This retrospective study aimed to investigate the association between preoperative GNRI and long-term prognosis of patients with BTC undergoing surgical resection. MATERIAL AND METHODS: A total of 213 patients were included. The relationships between GNRI and clinicopathological variables, including inflammatory markers such as C-reactive protein (CRP) and neutrophil-to-lympho-cyte ratio, were analysed...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794989/treatment-outcomes-of-egfr-tki-with-or-without-locoregional-brain-therapy-in-advanced-egfr-mutant-non-small-cell-lung-cancer-patients-with-brain-metastases
#37
JOURNAL ARTICLE
Do Mai Linh, Tran Huy Thinh, Nguyen-Van Hieu, Nguyen Minh Duc
INTRODUCTION: This study aimed to evaluate the treatment outcomes of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy alone or in combination with locoregional brain therapy for advanced EGFR-mutant non-small cell lung cancer (NSCLC) patients with brain metastases. MATERIAL AND METHODS: A retrospective study involving 72 advanced EGFR-mutant NSCLC patients with brain metastases at the Vietnam National Cancer Hospital were conducted. Patients were divided into 2 groups: EGFR-TKI (erlotinib) monotherapy and EGFR-TKI combined with locoregional therapy (γ knife surgery - GKS or whole-brain radiation therapy)...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794988/secretory-carcinoma-of-major-and-minor-salivary-glands-with-etv6-ntrk3-gene-fusion-overcoming-misdiagnosis-in-the-era-of-tumour-agnostic-therapy-with-trk-inhibitors
#38
JOURNAL ARTICLE
Monika Durzyńska, Karol Dominiak, Iwona Sosnowska, Irmina Maria Michalek
INTRODUCTION: Secretory carcinoma (SC) of the salivary gland is an extraordinarily rare tumour. Accurate diagnosis of SC is crucial for understanding the clinical course, prognosis, and selection of optimal therapy. The aim of this research was to analyse retrospectively the clinical and pathological characteristics of patients diagnosed with SC of the salivary gland from 2017 onwards, which aligns with its addition to the World Health Organization classification. MATERIAL AND METHODS: We conducted a retrospective, single-centre, clinicopathological analysis of patients diagnosed with SC of the salivary gland between 2017 and 2022...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794987/photon-based-high-dose-single-fraction-radiosurgery-an-effective-treatment-modality-for-recurrent-uveal-melanoma
#39
Concetta Laliscia, Federica Genovesi-Ebert, Franco Perrone, Taiusha Fuentes, Federica Cresti, Francesca Guido, Maria Tripodi, Fabiola Paiar
INTRODUCTION: To evaluate and report the outcome of a patient with locally recurrent uveal melanoma (UM) previously treated with brachytherapy (BT), using a second personalized globe-sparing radiotherapy approach. MATERIAL AND METHODS: In June 2020, a 78-year-old man arrived at our institution with diplopia and suspected uveal melanoma. At the ophthalmological evaluation (B-scan and A-scan ultrasonography) a lesion in the right eye at 6-7 hours of about 5 mm thickness, with internal lacunar areas, approximately 7 mm away from the limbus, was observed...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794986/quad-shot-an-effective-hypofractionated-palliative-radiotherapy-in-patients-with-non-melanoma-skin-cancer-a-single-institution-experience
#40
JOURNAL ARTICLE
Łukasz Graczyk, Robert Bibik, Antoni Woźniak, Emilia Jesień-Lewandowicz, Jacek Ciupis, Michał Szyburski, Jakub Bajer, Justyna Chałubińska-Fendler, Jacek Fijuth, Joanna Gabriela Jońska-Gmyrek
INTRODUCTION: The primary approach for managing skin cancer involves surgery, although radical radiotherapy (RT) may be considered as an alternative option in cases where patients decline the treatment themselves or are not eligible for surgical intervention. Herein we assess single-institution material in terms of the use of hypofractionated QUAD SHOT RT in patients disqualified from surgery. MATERIAL AND METHODS: Between December 2019 and December 2022, nine patients with locally advanced non-melanoma skin cancer were disqualified from surgery and as a result were treated at the Radom Oncology Centre, Poland...
2023: Contemporary Oncology Współczesna Onkologia
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