journal
Journals Contemporary Oncology Wspó�...

Contemporary Oncology Współczesna Onkologia

https://read.qxmd.com/read/38239858/activity-of-cabozantinib-in-further-line-treatment-of-metastatic-clear-cell-renal-cell-carcinoma-real-world-experience-in-a-single-center-retrospective-study
#21
JOURNAL ARTICLE
Piotr Domański, Jadwiga Jarosińska, Barbara Kruczyk, Mateusz Piętak, Anna Mydlak, Tomasz Demkow, Łukasz Kuncman, Marta Darewicz, Bożena Sikora-Kupis, Paulina Dumnicka, Jakub Kucharz
INTRODUCTION: Cabozantinib is an oral inhibitor of MET, AXL, and vascular endothelial growth factor receptors. It has an immunomodulatory effect and may influence the tumor's microenvironment and make mutated cells more sensitive to immune-mediated killing. These properties have made cabozantinib an effective drug for first-line or subsequent-line treatment after progression of metastatic renal cell carcinoma (mRCC), even after immunotherapy. MATERIAL AND METHODS: Seventy-one patients with mRCC were treated with second or further lines of cabozantinib at the Department of Genitourinary Oncology, Maria Sklodowska-Curie National Research Institute of Oncology...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794994/primary-pulmonary-hodgkin-s-lymphoma-mimicking-granulomatosis-with-polyangiitis-a-case-report-of-diagnostic-and-therapeutic-dilemmas
#22
Lucjan Sławiński, Julia Maria Sołek, Joanna Miłkowska-Dymanowska, Dorota Jesionek-Kupnicka, Joanna Góra-Tybor, Damian Mikulski, Marcin Braun
Primary pulmonary Hodgkin's lymphoma (PPHL) is a rare subtype of lymphoma that comprises a small percentage of primary pulmonary lymphomas. Due to its rarity and nonspecific symptoms, PPHL often presents diagnostic challenges. This case report presents a unique case of PPHL mimicking granulomatosis with polyangiitis, emphasizing the difficulties encountered during the diagnostic process. A 53-year-old female presented with vague symptoms including weakness, oedema, dry cough, and nasal cavity ulceration. Laboratory investigations revealed elevated C-reactive protein levels, a white blood cell count with neutrophilia, and lymphopaenia...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794993/attachment-styles-coping-with-stress-and-social-support-among-cancer-patients
#23
JOURNAL ARTICLE
Marta Karbowa-Płowens
INTRODUCTION: This paper presents the role of attachment style in determining an individual's way of coping with stress, which in turn helps to understand the differences in response and adjustment to cancer among cancer patients. Cancer is an illness that causes overwhelming distress, and dealing with it requires social support, among other coping strategies. MATERIAL AND METHODS: Studies show that social support is associated with a decrease in psychological symptoms and a better quality of life in cancer patients...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794992/subjective-health-and-its-predictors-in-leukaemia-patients-after-bone-marrow-transplantation
#24
JOURNAL ARTICLE
Helena Wrona-Polańska
INTRODUCTION: The aims of the study were to assess subjective health and its psychological predictors in leukaemia patients after bone marrow transplantation (BMT). The theoretical rationale of the study was the functional model of health (FMH). MATERIAL AND METHODS: Participants in the study comprised 141 patients after BMT (61 women, 80 men) in the age range between 20 and 40 years, most of whom had secondary education. A standardized interview and 10-point rating scales of sense of health and sense of calmness were used to assess the subjective health...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794991/great-mimicker-a-case-of-occult-melanoma-displaying-ganglioneuroblastic-differentiation
#25
Paulina Skrzypkowska, Michał Kunc, Wojciech Biernat
Melanomas are known for their diverse morphological features, presenting a diagnostic challenge for pathologists. Uncommon variations of melanoma can exhibit distinct cytological and histomorphological characteristics, including ganglioneuroblastic differentiation. However, this phenomenon is extremely rare, with only a few documented cases. Here, we present a unique case of an occult metastatic melanoma with ganglioneuroblastic differentiation developing in a 76-year-old male. The diagnosis was based on histopathology, immunophenotyping, and molecular testing, which revealed SOX10 positivity and an NRAS mutation...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794990/prognostic-value-of-geriatric-nutritional-risk-index-for-patients-with-biliary-tract-cancer-undergoing-surgical-resection-a-single-institution-retrospective-cohort-study
#26
JOURNAL ARTICLE
Shinichi Ikuta, Takayoshi Nakajima, Masataka Fujikawa, Tsukasa Aihara, Naoki Yamanaka
INTRODUCTION: The geriatric nutritional risk index (GNRI) is an index of nutritional status associated with clinical outcomes in various cancers; however, its prognostic value in biliary tract cancer (BTC) remains to be elucidated. This retrospective study aimed to investigate the association between preoperative GNRI and long-term prognosis of patients with BTC undergoing surgical resection. MATERIAL AND METHODS: A total of 213 patients were included. The relationships between GNRI and clinicopathological variables, including inflammatory markers such as C-reactive protein (CRP) and neutrophil-to-lympho-cyte ratio, were analysed...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794989/treatment-outcomes-of-egfr-tki-with-or-without-locoregional-brain-therapy-in-advanced-egfr-mutant-non-small-cell-lung-cancer-patients-with-brain-metastases
#27
JOURNAL ARTICLE
Do Mai Linh, Tran Huy Thinh, Nguyen-Van Hieu, Nguyen Minh Duc
INTRODUCTION: This study aimed to evaluate the treatment outcomes of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy alone or in combination with locoregional brain therapy for advanced EGFR-mutant non-small cell lung cancer (NSCLC) patients with brain metastases. MATERIAL AND METHODS: A retrospective study involving 72 advanced EGFR-mutant NSCLC patients with brain metastases at the Vietnam National Cancer Hospital were conducted. Patients were divided into 2 groups: EGFR-TKI (erlotinib) monotherapy and EGFR-TKI combined with locoregional therapy (γ knife surgery - GKS or whole-brain radiation therapy)...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794988/secretory-carcinoma-of-major-and-minor-salivary-glands-with-etv6-ntrk3-gene-fusion-overcoming-misdiagnosis-in-the-era-of-tumour-agnostic-therapy-with-trk-inhibitors
#28
JOURNAL ARTICLE
Monika Durzyńska, Karol Dominiak, Iwona Sosnowska, Irmina Maria Michalek
INTRODUCTION: Secretory carcinoma (SC) of the salivary gland is an extraordinarily rare tumour. Accurate diagnosis of SC is crucial for understanding the clinical course, prognosis, and selection of optimal therapy. The aim of this research was to analyse retrospectively the clinical and pathological characteristics of patients diagnosed with SC of the salivary gland from 2017 onwards, which aligns with its addition to the World Health Organization classification. MATERIAL AND METHODS: We conducted a retrospective, single-centre, clinicopathological analysis of patients diagnosed with SC of the salivary gland between 2017 and 2022...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794987/photon-based-high-dose-single-fraction-radiosurgery-an-effective-treatment-modality-for-recurrent-uveal-melanoma
#29
Concetta Laliscia, Federica Genovesi-Ebert, Franco Perrone, Taiusha Fuentes, Federica Cresti, Francesca Guido, Maria Tripodi, Fabiola Paiar
INTRODUCTION: To evaluate and report the outcome of a patient with locally recurrent uveal melanoma (UM) previously treated with brachytherapy (BT), using a second personalized globe-sparing radiotherapy approach. MATERIAL AND METHODS: In June 2020, a 78-year-old man arrived at our institution with diplopia and suspected uveal melanoma. At the ophthalmological evaluation (B-scan and A-scan ultrasonography) a lesion in the right eye at 6-7 hours of about 5 mm thickness, with internal lacunar areas, approximately 7 mm away from the limbus, was observed...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37794986/quad-shot-an-effective-hypofractionated-palliative-radiotherapy-in-patients-with-non-melanoma-skin-cancer-a-single-institution-experience
#30
JOURNAL ARTICLE
Łukasz Graczyk, Robert Bibik, Antoni Woźniak, Emilia Jesień-Lewandowicz, Jacek Ciupis, Michał Szyburski, Jakub Bajer, Justyna Chałubińska-Fendler, Jacek Fijuth, Joanna Gabriela Jońska-Gmyrek
INTRODUCTION: The primary approach for managing skin cancer involves surgery, although radical radiotherapy (RT) may be considered as an alternative option in cases where patients decline the treatment themselves or are not eligible for surgical intervention. Herein we assess single-institution material in terms of the use of hypofractionated QUAD SHOT RT in patients disqualified from surgery. MATERIAL AND METHODS: Between December 2019 and December 2022, nine patients with locally advanced non-melanoma skin cancer were disqualified from surgery and as a result were treated at the Radom Oncology Centre, Poland...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37266343/analysis-of-the-efficacy-and-tolerability-of-folfirinox-chemotherapy-treatment-in-patients-over-65-years-of-age-with-diagnosis-of-advanced-adenocarcinoma-of-the-pancreas
#31
JOURNAL ARTICLE
Małgorzata Domagała-Haduch, Amanda Robek, Jakub Wnuk, Łukasz Michalecki, Iwona Gisterek
INTRODUCTION: Systemic treatment of pancreatic adenocarcinoma in the population of people over 65 years old is a challenge resulting from both the extremely unfavourable prognosis of this cancer and the particularly high sensitivity to the toxicity of chemotherapy in the elderly. This article presents the effectiveness and side effects of first-line chemotherapy according to the FOLFIRINOX regimen in patients over 65 years of age diagnosed with advanced pancreatic adenocarcinoma. MATERIAL AND METHODS: The analysis was conducted in a group of 43 patients diagnosed with locally advanced inoperable pancreatic cancer or metastatic pancreatic cancer...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37266342/days-at-home-in-the-last-three-months-of-life-patterns-of-care-analysis-in-patients-with-non-small-cell-lung-cancer
#32
JOURNAL ARTICLE
Carsten Nieder, Siv Gyda Aanes, Ellinor Christin Haukland
INTRODUCTION: To calculate the number of days patients with terminal non-small cell lung cancer (NSCLC) spent at home in the last 3 months of life, and to identify factors that predict a lower proportion of days at home. MATERIAL AND METHODS: Retrospective study of 434 deceased patients with NSCLC. The number of days spent in a hospital or nursing home was identified from electronic health records. RESULTS: Most patients received primary chemotherapy...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37266341/metastasis-to-the-ureter-as-the-first-manifestation-of-occult-pulmonary-adenocarcinoma-case-report-and-review-of-the-literature
#33
Aleksandra Ciarka, Filip Skowronek, Michał Kunc, Michał Bieńkowski, Pęksa Rafał
Lung cancer is a major epidemiological threat worldwide, which commonly metastasizes to distant sites. Often, the presence of metastasis is the first manifestation of lung cancer. Some of the most common sites for lung cancer metastasis are bones, adrenal glands, liver, brain, and lungs. However, metastases to unusual locations pose a diagnostic and therapeutic challenge. We present a case of a 74-year-old woman in whom the first manifestation of lung cancer was metastasis to the right ureter. We also analyse the available literature on lung cancer metastases to the ureter, taking into account the possible mechanisms of their spread in the ureter...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37266340/bladder-preservation-by-neoadjuvant-chemotherapy-followed-by-concurrent-chemoradiation-for-muscle-invasive-bladder-cancer
#34
JOURNAL ARTICLE
Dalia Hamouda Elsayed, Ola M Elfarargy, Mohamed Salah Elderey, Doaa Mandour, Nora Atef, Rehab Hemeda, Mostafa Kamel, Ahmed Azony, Heba F Taha
INTRODUCTION: In Egypt, bladder cancer (BC) represents about 8.7% of cancers in both sexes. In Egyptian men, it accounts for over 30% of all cancers, which makes it the second most frequent cancer. The standard curative treatment for patients with muscle-invasive bladder cancer (MIBC) has been radical cystectomy (RC) with urinary diversion and pelvic lymphadenectomy. Concomitant chemoradiation therapy (CCRT) in MIBC appears to produce results that are comparable to those of RC. MATERIAL AND METHODS: Between January 2018 and March 2021, 34 BC- diagnosed patients, who refused RC, were enrolled...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37266339/association-between-single-nucleotide-polymorphisms-in-dna-repair-genes-and-the-efficacy-of-radiotherapy-in-nasopharyngeal-carcinoma-patients
#35
JOURNAL ARTICLE
Rajaa Benzeid, Amin Gihbid, Nezha Tawfik, Nadia Benchakroun, Karima Bendahhou, Abdellatif Benider, Amal Guensi, Naima El Benna, Abdelkarim Filali Maltouf, Mohammed El Mzibri, Mohammed Attaleb, Meriem Khyatti, Imane Chaoui
INTRODUCTION: Single nucleotide polymorphisms (SNPs) in DNA repair genes are mainly correlated with the response to radiotherapy in nasopharyngeal cancer (NPC). In NPC patients, previous research has studied the association between X-ray repair cross-complementing group 1 and 3 (XRCC1 and XRCC3) polymorphisms and radio-therapeutic response. The objective of our study was to test the association between XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms and the response to radiotherapy in the NPC Moroccan population...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37266338/couples-sexual-health-after-gynaecological-cancer-diagnosis-an-unexplored-area-for-further-research
#36
JOURNAL ARTICLE
Krzysztof Nowosielski, Aleksandra Pałka
INTRODUCTION: The aim of the study was to assess the sexual inhibitory tone, body image, self-concept, and sexual performance in couples after gynaecological cancer treatment, and to identify areas for further prospective studies. MATERIAL AND METHODS: Thirty gynaecological cancer survivors with a heterosexual partner were assessed during a semi-structural sexual interview. Sexual excitation/sexual inhibition scales were used to evaluate proneness to sexual stimuli, whereas a body exposure during sexual activity questionnaire was used to assess body avoidance during sex...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37266337/an-improved-method-for-paraffin-embedded-cytological-preparations-application-to-the-detection-of-circulating-tumour-cells
#37
JOURNAL ARTICLE
Meryem Aarab, Salma Saadi, Imane Tabyaoui, Latifa Badre, Nadia Tahiri Jouti
INTRODUCTION: Conventional tissue biopsy is a key examination in cancer diagnosis. However, liquid biopsy is an alternative and less invasive solution that allows the detection of circulating tumour cells (CTCs). CTCs have emerged as a potential screening, diagnostic, and prognostic tool in cancer management. There are many technologies available for the detection and characterization of these cells, but most are either expensive or complicated to apply routinely. Cytological cell blocks (cytoblocks) may be a more practical and cost-effective method to enrich and characterize CTCs and even perform molecular studies...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37266336/galectin-9-expression-on-tumour-associated-immune-cells-is-associated-with-favourable-clinicopathological-features-and-better-outcomes-in-oral-squamous-cell-carcinoma
#38
JOURNAL ARTICLE
Rafał Pęksa, Michał Kunc, Michał Piątek, Barbara S Radecka, Barbara Alicja Jereczek-Fossa, Anna Starzyńska
INTRODUCTION: Galectin-9, a β-galactoside-binding protein, might be a potential target in cancer personalized therapy, but contradicting data exist regarding its prognostic significance in malignancy. Previous studies showed low or absent expression of galectin-9 on tumour cells of oral squamous cell carcinoma (OSCC); thus, we aimed to assess the prognostic impact of its expression on tumour-associated immune cells (TAICs). MATERIAL AND METHODS: A retrospective analysis was conducted on 62 patients with OSCC...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37266335/testicular-teratoma-with-nephroblastoma-in-an-adult-case-report-and-literature-review
#39
Caroline Landin, Fredrik M T Karlsson, Mari Lorier Småland, Anna Gabrych, Michał Kunc
Testicular germ cell tumours are the most common malignancies in young men. Germ cell tumours can be classified as seminomas or non-seminomas, each with different clinical features and treatment approaches. Germ cell tumours are occasionally associated with somatic-type malignancy, particularly in metastatic lymph nodes after adjuvant chemotherapy. Adenocarcinomas and rhabdomyosarcoma are the most common malignancies in this setting. In this report, we present a unique case of a 37-year-old patient who presented with a testicular teratoma containing a nephroblastoma component...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37266334/expression-profile-of-interleukin-6-4-hydroxy-2-nonenal-and-hypoxia-inducible-factor-1-%C3%AE-in-women-with-breast-cancer-and-their-association-with-clinicopathological-parameters
#40
JOURNAL ARTICLE
Saddek Yahia, Zineb Tahari, Asmahane Medjdoub, Fatima Zohra Tahari, Nadia Bessaih, Moussa Messatfa, Fatiha Deblaoui, Mourad Raiah, Houria Ouldcadi, Sonia Seddiki, Tewfik Sahraoui
INTRODUCTION: Breast cancer (BC) is the most common malignancy in women worldwide, representing a major public health burden. Therefore, there is a need to identify circulating biomarkers for the early detection of BC and to facilitate the diagnosis. Interleukin-6 (IL-6), 4-hydroxy-2-nonenal (4-HNE), and hypoxia-inducible factor 1-α (HIF-1α) are biomarkers involved in the initiation and progression of this disease. The aim of this study was to evaluate the concentrations of these molecules and to find a possible correlation with the clinicopathological parameters of patients with BC from western Algeria...
2023: Contemporary Oncology Współczesna Onkologia
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