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JOURNAL ARTICLE
Tomasz Milecki, Katarzyna Kluzek, Natalia Pstrąg, Andrzej Antczak, Wojciech A Cieślikowski, Mateusz Wichtowski, Łukasz Kuncman, Zbigniew Kwias, Joanna Wesoły
INTRODUCTION: Assessment of renal tumour masses is based on conventional imaging studies (computer tomography or magnetic resonance), which does not allow characterisation of the histopathological type. Moreover, the prediction of prognosis in localised and metastatic renal cell carcinoma requires improvement as well. Analysis of circulating free DNA (cfDNA) in blood is one of the variants of liquid biopsy that may improve diagnostics and prognosis issues of patients with renal tumour masses suspected to be renal cell carcinoma...
2023: Contemporary Oncology Współczesna Onkologia
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JOURNAL ARTICLE
Monika Adamska, Ewelina Kowal-Wiśniewska, Joanna Czerwińska-Rybak, Katarzyna Kiwerska, Marta Barańska, Weronika Gronowska, Jagoda Loba, Katarzyna Brzeźniakiewicz-Janus, Ewa Wasilewska, Aleksandra Łanocha, Małgorzata Jarmuż-Szymczak, Lidia Gil
INTRODUCTION: Lower-risk myelodysplastic neoplasms (LR-MDS) comprise the majority of MDS. Despite favourable prognoses, some patients remain at risk of rapid progression. We aimed to define the mutational profile of LR-MDS using next-generation sequencing (NGS), Sanger Sequencing (SSeq), and pyrosequencing. MATERIAL AND METHODS: Samples from 5 primary LR-MDS (67 exons of SF3B1, U2AF1, SRSF2, ZRSR2, TET2, ASXL1, DNMT3A, TP53 , and RUNX1 genes) were subjected to NGS...
2023: Contemporary Oncology Współczesna Onkologia
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JOURNAL ARTICLE
Piotr Domański, Jadwiga Jarosińska, Barbara Kruczyk, Mateusz Piętak, Anna Mydlak, Tomasz Demkow, Łukasz Kuncman, Marta Darewicz, Bożena Sikora-Kupis, Wojciech Michalski, Jakub Kucharz
INTRODUCTION: Geriatric patients with metastatic renal cell carcinoma (mRCC) are underrepresented in clinical trials. Evaluation of the efficacy of the treatment and assignation of individuals to proper prognostic groups is an absolute necessity to guarantee them the best possible care. MATERIAL AND METHODS: A total of 138 geriatric patients with mRCC treated with first-line tyrosine kinase inhibitors (TKIs) at the Maria Skłodowska-Curie National Research Institute of Oncology were retrospectively analyzed to determine whether the body mass index (BMI) and pan-immune-inflammation value (PIV) are prognostic values for overall survival (OS) and progression-free survival (PFS) in this type of cancer...
2023: Contemporary Oncology Współczesna Onkologia
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JOURNAL ARTICLE
Bożena Sikora-Kupis, Piotr Domański, Weronika Fortuniak, Barbara Kruczyk, Szymon Staneta, Mateusz Piętak, Anna Mydlak, Tomasz Demkow, Paulina Dumnicka, Jakub Kucharz
INTRODUCTION: Urothelial carcinoma is the most common type of urinary tract malignancy. Current treatment options, including platinum-based chemotherapy or immunotherapy, present significant challenges, ranging from limited efficacy to severe toxicities. Recent developments in antibody-drug conjugates (ADC), such as enfortumab vedotin (EV), promise to significantly improve overall survival. The study aims to evaluate the efficacy and tolerability of EV. In addition, we highlight the observed benefits of next-line treatment after progression...
2023: Contemporary Oncology Współczesna Onkologia
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JOURNAL ARTICLE
Seoh Wei Teh, Abozer Elderdery, Sanjiv Rampal, Suresh Kumar Subbiah, Pooi Ling Mok
INTRODUCTION: Cutaneous squamous cell carcinoma (SCC) is the second most common form of skin malignancy, representing around 20% of all skin cancers. It is the main cause of death due to non-melanoma skin cancer every year. Metastatic cutaneous SCC is associated with poor prognosis in patients and warrants a more effective and specific approach such as disruption of genes associated with cancer metastasis. MATERIAL AND METHODS: Matrix metalloproteinases (MMPs) are enzymes involved in cancer progression and are regarded as major oncotargets...
2023: Contemporary Oncology Współczesna Onkologia
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JOURNAL ARTICLE
Katarzyna Gibek
INTRODUCTION: The aim of the study was to check whether individual side effects of treatment with tyrosine kinase inhibitors (TKI) in patients suffering from chronic myeloid leukaemia (CML) contribute to the occurrence of depressive symptoms. In addition, it was decided to check whether there is any correlation between the age, sex, and duration of treatment and the intensity of depressive symptoms, in relation to the occurrence of individual side effects. MATERIAL AND METHODS: The study included 91 patients with CML treated with TKI...
2023: Contemporary Oncology Współczesna Onkologia
#7
Rafal Dziadziuszko, Nir Peled, Tony Mok, Solange Peters, Santiago Ponce Aix, Jorge Alatorre-Alexander, Brian D Vicuna, Margaret Maclennan, Vijay Bhagawati-Prasad, Sarah M Shagan, Erica Schleifman, Thorsten Ruf, Michael S Mathisen, Shirish M Gadgeel
INTRODUCTION: This paper presents results from Cohort B (rearranged during transfection [ RET ], fusion-positive) of the Blood First Assay Screening Trial in patients with advanced non-small cell lung cancer (NSCLC) screened for genetic alterations using blood-based next-generation sequencing. MATERIAL AND METHODS: Adults with advanced RET fusion-positive NSCLC received alectinib 900 mg twice daily (BID) in Phase I. Enrolment closed prematurely with Phase II uninitiated...
2023: Contemporary Oncology Współczesna Onkologia
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JOURNAL ARTICLE
Kiril Zhelev, Maria Mihaylova-Hristov, Nikolay Conev, Manoela Cholakova, Bilyana Korabova, Ivaylo Petrov, Nedyalka Georgieva, Nikolay Nedev, Iglika Mihaylova, Mila Petrova, Zahari Zahariev, Ivan Donev
INTRODUCTION: Stereotactic body radiotherapy (SBRT) is well established for oligometastatic disease, and it is increasingly used to treat adrenal metastases. MATERIAL AND METHODS: In this retrospective study we performed an analysis of 75 metastatic adrenal lesions in 64 patients with oligometastatic disease. According to the fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) maximum standardized uptake value (SUVmax ) of adrenal metastases, patients were categorized into three groups: low, intermediate, and high SUVmax...
2023: Contemporary Oncology Współczesna Onkologia
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JOURNAL ARTICLE
Irene Rethemiotaki
INTRODUCTION: The aim of this work is to detect and classify brain tumours using computational intelligence techniques on magnetic resonance imaging (MRI) images. MATERIAL AND METHODS: A dataset of 3264 MRI brain images consisting of 4 categories: unspecified glioma, meningioma, pituitary, and healthy brain, was used in this study. Twelve convolutional neural networks (GoogleNet, MobileNetV2, Xception, DesNet-BC, ResNet 50, SqueezeNet, ShuffleNet, VGG-16, AlexNet, Enet, EfficientB0, and MobileNetV2 with meta pseudo-labels) were used to classify gliomas, meningiomas, pituitary tumours, and healthy brains to find the most appropriate model...
2023: Contemporary Oncology Współczesna Onkologia
#10
JOURNAL ARTICLE
Magdalena Samborska, Jolanta Skalska-Sadowska, Robert Achkar, Jacek Wachowiak, Katarzyna Derwich, Małgorzata Czogała, Walentyna Balwierz, Szymon Skoczeń, Grzegorz Dobaczewski, Alicja Chybicka, Krzysztof Kałwak, Maryna Krawczuk-Rybak, Katarzyna Muszyńska-Rosłan, Elżbieta Adamkiewicz-Drożyńska, Lucyna Maciejka-Kapuscińska, Ninela Irga-Jaworska, Joanna Pohorecka, Agnieszka Chodała-Grzywacz, Grażyna Karolczyk, Beata Wójcik, Jerzy R Kowalczyk, Katarzyna Drabko, Joanna Zawitkowska, Katarzyna Mycko, Wanda Badowska, Tomasz Ociepa, Tomasz Urasiński, Barbara Sikorska-Fic, Michał Matysiak, Paweł Laguna, Anna Dąbrowska-Pawliszyn, Renata Tomaszewska, Tomasz Szczepański, Grażyna Sobol, Agnieszka Mizia-Malarz, Małgorzata Ciebiera, Radosław Chaber, Sylwia Kołtan, Mariusz Wysocki, Jan Styczyński, Mariola Woszczyk, Maria Wieczorek, Irena Karpińska-Derda, Justyna Urbańska-Rakus, Katarzyna Bobeff, Joanna Trelińska, Wojciech Młynarski
INTRODUCTION: This study aimed to present the clinical features and results of treatment of patients diagnosed with refractory or relapsed acute myeloid leukaemia (AML) in Polish Paediatric Leukaemia/Lymphoma Study Group (PPL/LSG) institutions, treated in accordance with the Protocol Acute Myeloid Leukaemia Berlin-Frankfurt-Munster 2012, as their first-line therapy. MATERIAL AND METHODS: The outcome data of 10 patients with refractory AML (median age 9.5 years) and 30 with relapsed AML (median age 12 years) were analysed retrospectively...
2023: Contemporary Oncology Współczesna Onkologia
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JOURNAL ARTICLE
Ilham Kandoussi, Hanane Abbou, Ghyzlane El Haddoumi, Mariam Mansouri, Lahcen Belyamani, Azeddine Ibrahimi
INTRODUCTION: The mechanistic target of rapamycin (mTOR) coordinates the growth and metabolism of eukaryotic cells with a central role in the regulation of many fundamental cellular processes. It is strongly connected to phosphatidylinositol 3-kinase (PI3K) and AKT signaling. Activation of the PI3K/AKT/mTOR pathway leads to a profound disruption in the control of cell growth and survival, which ultimately leads to competitive growth advantage, metastatic competence, angiogenesis and therapeutic resistance...
2023: Contemporary Oncology Współczesna Onkologia
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JOURNAL ARTICLE
Liang Jin, Xiaojing Zhang, Ming Fan, Weimin Li, Xuan Zhang
INTRODUCTION: Mutations of kinetochore-localized astrin/sperm-associated antigen 5 (KNSTRN) can interfere with chromatid cohesion, increase aneuploidy in tumours, and enhance tumourigenesis. However, the role of the KNSTRN-binding protein in hepatocellular carcinoma (HCC) remains unclear. MATERIAL AND METHODS: Using The Cancer Genome Atlas databases, we investigated the potential oncogenic functions of KNSTRN in HCC along with R and various computational tools. RESULTS: Detailed results revealed that elevated expression of KNSTRN was considerably associated with poor overall survival (HR = 1...
2023: Contemporary Oncology Współczesna Onkologia
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REVIEW
Maciej Michalak, Piotr Tomczak, Tomasz Milecki, Andrzej Antczak
The role of cytoreductive nephrectomy (CN), i.e. the removal of a kidney involved by cancer in patients with advanced kidney cancer with distant metastases, is the subject of intense debate among urologists and oncologists. For many years, CN has been considered the gold standard in the treatment of patients at this stage of the disease, especially in patients in good general health with no significant contraindications to surgical treatment. The starting point for questioning the validity of CN was the publication of the results of the cancer du rein metastatique nephrectomie et antiangiogéniques and SURTIME clinical trials (2018 and 2019, respectively), which questioned the validity of surgery in some patients with late-stage cancer...
2023: Contemporary Oncology Współczesna Onkologia
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JOURNAL ARTICLE
Chenglin Kang, Xiaomei Li, Peng Liu, Yue Liu, Yuan Niu, Xianhai Zeng, Jiangqi Liu, Hailiang Zhao, Shuqi Qiu
INTRODUCTION: To investigate the inhibitory effect of quercetin (QUE) on dendritic cells (DCs) through the toll-like receptor 4/interleukin-1 receptor-associated kinase 4/nuclear factor kappa-B (TLR4/IRAK4/NF-κB) signalling pathway. MATERIAL AND METHODS: CCK-8 and apoptosis assays were performed to determine the optimal concentration and action time of QUE to inhibit DCs. Protein extracts from treated DCs were used for Western blotting experiments to determine the relative expression levels of TLR4, IRAK4, and NF-κB p65 proteins...
2023: Contemporary Oncology Współczesna Onkologia
#15
Julia Pikul, Anna Rzepakowska, Marcin Machnicki, Tomasz Stokłosa
INTRODUCTION: Salivary gland tumours are rare neoplasms. Pleomorphic adenoma (PA) is the most frequent benign lesion. Myoepithelial carcinoma (MECA) is rarely recognized malignancy, but the prognosis is unfavourable. The aim of this study was to identify genetic rearrangements that might be responsible for dynamic MECA progression in patients with primary radical PA excision. MATERIAL AND METHODS: Next-generation sequencing (NGS) of 1500 gene coding sequences was performed in primary and recurrent tumour tissue collected from 2 patients, in whom PA was initially diagnosed and within one year multifocal MECA was detected...
2023: Contemporary Oncology Współczesna Onkologia
#16
JOURNAL ARTICLE
Przemysław Stefaniak, Bartłomiej Emil Kraziński, Jacek Kieżun, Hanna Majewska, Janusz Godlewski
INTRODUCTION: The study aimed to determine the immunoexpression levels of polymerase delta 1 catalytic subunit (POLD1), a catalytic and proofreading subunit of DNA polymerase delta, in the sections of colorectal cancer (CRC), and to evaluate the significance of POLD1 as a potential prognostic factor in CRC. MATERIAL AND METHODS: Paired, tumour and non-cancerous tissue samples of the large intestine distant to the neoplasm were collected from the postoperative material of 78 patients who underwent surgical resection of CRC tumours...
2023: Contemporary Oncology Współczesna Onkologia
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JOURNAL ARTICLE
Damian Mikulski, Paweł Robak, Grzegorz Mirocha, Wiktoria Ryżewska, Kamila Stańczak, Karol Okoński, Kacper Kościelny, Tadeusz Robak
INTRODUCTION: The systemic inflammation index (SII) might serve as an indicator of the equilibrium between the inflammatory and immune responses. The aim of the study was to determine the clinical value and prognostic significance of SII in the cohort of multiple myeloma (MM) patients treated with a regimen of pomalidomide and dexamethasone (Pd). MATERIAL AND METHODS: This retrospective, real-life study included patients who received a Pd regimen in our centre between November 2018 and July 2022...
2023: Contemporary Oncology Współczesna Onkologia
#18
JOURNAL ARTICLE
Mariam Hamad, Radwa Ali Mehana, Mohammad M Abd-Al Haseeb, Maha Houssen
INTRODUCTION: Colorectal cancer (CRC) is a significant contributor to cancer-related mortality worldwide, ranking as the second leading cause of such deaths. Central to the progression of this malignancy is angiogenesis - a complex process orchestrated by vascular endothelial growth factor (VEGF). Regorafenib, a potent multikinase inhibitor, acts as a critical antagonist of multiple kinases involved in angiogenesis, proliferation, and metastasis. Conversely, all-trans retinoic acid (ATRA) has demonstrated compelling antitumour effects across various cancer types...
2023: Contemporary Oncology Współczesna Onkologia
#19
REVIEW
Circulating tumor cells in colorectal cancer - a review of detection methods and clinical relevance.
Salma Saadi, Meryem Aarab, Imane Tabyaoui, Nadia Tahiri Jouti
Colorectal cancer (CRC) is the third most common cancer; it is one of the leading malignancies contributing to cancer mortality. Colorectal cancer is the third most diagnosed cancer in men and the second in women worldwide. Diagnosis of CRC depends on several clinical features such as age, primary site, tumor-node-metastasis stage, genetic parameters and the presence or absence of metastasis. The latter is a phenomenon that is induced by the shedding of tumor cells in the blood circulation by the primary tumor...
2023: Contemporary Oncology Współczesna Onkologia
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JOURNAL ARTICLE
Wawrzyniec Mantorski, Piotr Feusette, Andrzej Tukiendorf, Edyta Idalia Wolny-Rokicka
INTRODUCTION: Extensive research has focused on emergency department (ED) and post-admission deaths, seeking to understand their frequency and causative factors. With the rising prevalence of advanced diseases, it is crucial to identify patients in need of end-of-life care and ensure its high quality. In this epidemiological study, we analyse routine ED blood tests to identify early warning signs of deteriorating patients with common non-traumatic and non-infectious (chronic) conditions...
2023: Contemporary Oncology Współczesna Onkologia
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