journal
Journals Contemporary Oncology Wspó�...

Contemporary Oncology Współczesna Onkologia

https://read.qxmd.com/read/38800536/survival-after-docetaxel-for-metastatic-castration-resistant-prostate-cancer-in-a-rural-health-care-setting
#1
JOURNAL ARTICLE
Carsten Nieder, Luka Stanisavljevic, Astrid Dalhaug, Ellinor Haukland
INTRODUCTION: The aim of this study was to evaluate overall survival of men who received systemic therapy with docetaxel for metastatic castration- resistant prostate cancer (MCRPC) in rural Nordland County, Norway. Prognostic factors related to treatment and other variables were evaluated. MATERIAL AND METHODS: Overall, 132 pa- tients were included in this retrospective study covering the years 2009-2022. Uni- and multivariate survival analyses were performed. RESULTS: In this elderly cohort (median age 72 years), weekly low-dose docetaxel was the preferred regimen (44%)...
2024: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38800535/high-tumour-infiltrating-lymphocytes-correlate-with-distinct-gene-expression-profile-and-favourable-survival-in-single-hormone-receptor-positive-breast-cancer
#2
JOURNAL ARTICLE
Aleksandra Ciarka, Michał Kunc, Marta Popęda, Aleksandra Łacko, Barbara Radecka, Marcin Braun, Joanna Pikiel, Maria Litwiniuk, Katarzyna Pogoda, Ewa Iżycka-Świeszewska, Anna Zeller, Magdalena Niemira, Rafał Pęksa, Wojciech Biernat, Elżbieta Senkus
INTRODUCTION: This study aimed to evaluate the impact of tumour-infiltrating lymphocytes (TILs) on the expression of immune-related genes and prognosis in single hormone receptor-positive breast cancer. Material and methods: Tumour-infiltrating lymphocytes were analysed according to the guidelines of the International TILs Working Group in a cohort of 206 patients with single hormone receptor-positive breast cancer. Of these, 44.7% were classified as ER+/PgR-/HER2-, 18.4% as ER+/PgR-/HER2+, 26...
2024: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38800534/combination-of-modified-folfirinox-with-stereotactic-body-radiotherapy-as-an-induction-therapy-for-locally-advanced-pancreatic-adenocarcinoma-a-prospective-single-arm-study
#3
JOURNAL ARTICLE
Michał Piątek, Michał Bieńkowski, Katarzyna Kuśnierz, Joanna Pilch-Kowalczyk, Dorota Imielska-Zdunek, Sławomir Mrowiec, Paweł Lampe, Barbara Radecka, Sergiusz Nawrocki
INTRODUCTION: Radical resection is the only potentially curative treatment for pancreatic adenocarcinoma; however, only a minor fraction of patients are eligible for resection. Induction therapy may be offered to patients, but the response rate in cases with significant vascular involvement is limited. This study aimed to evaluate the efficacy and safety of modified of FOLFIRINOX chemotherapy (mFFX) + stereotactic body radiotherapy (SBRT) in combination as induction therapy for locally advanced pancreatic carcinoma...
2024: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38800533/deep-feature-extraction-and-fine-%C3%AE%C2%BA-nearest-neighbour-for-enhanced-human-papillomavirus-detection-in-cervical-cancer-a-comprehensive-analysis-of-colposcopy-images
#4
JOURNAL ARTICLE
Lipsarani Jena, Santi Kumari Behera, Srikanta Dash, Prabira Kumar Sethy
INTRODUCTION: This study introduces a novel methodology for classifying human papillomavirus (HPV) using colposcopy images, focusing on its potential in diagnosing cervical cancer, the second most prevalent malignancy among women globally. Addressing a crucial gap in the literature, this study highlights the unexplored territory of HPV-based colposcopy image diagnosis for cervical cancer. Emphasising the suitability of colposcopy screening in underdeveloped and low-income regions owing to its small, cost-effective setup that eliminates the need for biopsy specimens, the methodological framework includes robust dataset augmentation and feature extraction using EfficientNetB0 architecture...
2024: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38800532/exploring-ras-mutation-incidence-and-temporal-heterogeneity-in-metastatic-colorectal-cancer-patients-a-single-institution-experience-utilising-circulating-tumour-dna
#5
JOURNAL ARTICLE
George Zarkavelis, Anna Lea Amylidi, Nanteznta Torounidou, Melina Yerolatsite, Athanasia Keravasili, Varvara Keramisanou, Davide Mauri
INTRODUCTION: Colorectal cancer (CRC) remains a significant global health challenge, ranking among the leading causes of neoplastic mortality. Despite transformative therapeutic advances, a considerable proportion of patients are diagnosed with metastatic disease, and 15-30% of those initially presenting with early-stage CRC eventually experience recurrence. Comprehensive molecular testing, especially the evaluation of microsatellite instability and mutations in KRAS/NRAS or BRAF genes, is essential upon diagnosis of stage IV disease, guiding treatment decisions...
2024: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38800531/the-assessment-of-dickkopf-1-and-dickkopf-2-protein-concentration-in-different-subtypes-of-non-small-cell-lung-cancer-subtypes
#6
JOURNAL ARTICLE
Dorota Hudy, Jadwiga Gaździcka, Agata Świętek, Karolina Gołąbek, Mateusz Rydel, Damian Czyżewski, Joanna Katarzyna Strzelczyk
INTRODUCTION: Lung cancer is one of the most prevalent cancers worldwide. Dickkopf-1 (DKK-1) and -2 (DKK-2) are important proteins for the regulated Wnt signalling pathway. Alternations in the Wnt pathway are associated with tumour progression. The aim of the study was to analyse the concentration of DKK-1 and DKK-2 in tumour and matched non-tumour (NT) samples of 65 patients with non-small cell lung cancer (NSCLC), including 3 subtypes: adenocarcinoma (AC), squamous cell carcinoma (SCC), and large cell carcinoma (LCC)...
2024: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38800530/clinicopathological-significance-of-protein-disulphide-isomerase-a3-and-phosphorylated-signal-transducer-and-activator-of-transcription-3-in-cervical-carcinoma
#7
JOURNAL ARTICLE
Asmaa Abdullatif, Aziza E Abdelrahman, Adel Bakry, Shimaa A Gharieb, Mohamed Sh Ramadan, Mohamed A Wasfy, Abdelfatah H Abdelwanis, Enas M Fouad
INTRODUCTION: Death in cervical cancer patients is usually due to invasion and metastasis due to the aggressive nature of the tumour. Therefore, it is critical to identify potent therapeutic targets and prognostic markers to detect high-risk patients. MATERIAL AND METHODS: We assessed the immunohistochemical expression of protein disulphide isomerase A3 (PDIA3) and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in 50 cases of cervical carcinoma, and we investigated their association with clinicopathological characteristics...
2024: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38800529/application-of-nitroxoline-in-urologic-oncology-a-review-of-evidence
#8
REVIEW
Wojciech Andrzej Tomczak, Wojciech Krajewski, Joanna Chorbińska, Łukasz Nowak, Jan Łaszkiewicz, Katarzyna Grunwald, Adam Chełmoński, Szymon Pisarski, Tomasz Szydełko
The persistence of high incidence and mortality rates associated with urologic cancers underscores the urgent need for effective and safe treatments. Conventional chemotherapy regimens are often limited by their high toxicity, the cancer's drug resistance, and the challenge of managing independently evolving multifocal spread. In this context, a repurposing strategy is particularly enticing. It allows for the introduction of a drug with a known safety profile, thus significantly reducing the costs and time necessary to introduce a new treatment...
2024: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38800528/health-and-coping-styles-including-resources-of-close-family-members-supporting-leukaemia-patients
#9
JOURNAL ARTICLE
Anna Magda Kaczmarska-Tabor
INTRODUCTION: Illness in the family is a new and difficult situation. Illness frequently causes radical changes both in patients' lives and in their closest family situation. It often threatens currently performed tasks or values pursued by patients and those who support them. The aim of the study was to determine the relationship between the health condition of people supporting leukaemia patients, strategies for coping with stress, and the level of subjective resources. MATERIAL AND METHODS: The research involved 100 people supporting leukaemia patients...
2024: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38800527/the-impact-of-altering-the-concentration-of-coffee-constituents-on-their-anticancer-effect-on-oral-squamous-cell-carcinoma-cell-line-in-vitro-study
#10
JOURNAL ARTICLE
Asmaa Emad El-Din Mohammed Rashad, Mostafa Abdelwanis Mohamed Abdelaziz, Manar Abdulwaniss Mohammed Abdulaziz
INTRODUCTION: Oral squamous cell carcinoma (OSCC) is one of the most common malignancies of the head and neck, which attracts much attention because of its increasing incidence and poor outcome. Coffee is one of the most popular beverages that are globally consumed. It consists of several phytochemical constituents, such as polyphenols, caffeine, and chlorogenic acid (CGA). Those constituents account for the potential effects on several diseases, including cancer. It has been reported that coffee exerts significant cytotoxicity against OSCC via inhibition of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and up-regulation of apoptotic proteins, such as caspase-3 and caspase-9...
2024: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38405214/preoperative-cell-free-dna-concentration-in-plasma-as-a-diagnostic-and-prognostic-biomarker-of-clear-cell-renal-cell-carcinoma
#11
JOURNAL ARTICLE
Tomasz Milecki, Katarzyna Kluzek, Natalia Pstrąg, Andrzej Antczak, Wojciech A Cieślikowski, Mateusz Wichtowski, Łukasz Kuncman, Zbigniew Kwias, Joanna Wesoły
INTRODUCTION: Assessment of renal tumour masses is based on conventional imaging studies (computer tomography or magnetic resonance), which does not allow characterisation of the histopathological type. Moreover, the prediction of prognosis in localised and metastatic renal cell carcinoma requires improvement as well. Analysis of circulating free DNA (cfDNA) in blood is one of the variants of liquid biopsy that may improve diagnostics and prognosis issues of patients with renal tumour masses suspected to be renal cell carcinoma...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38405213/defining-the-mutational-profile-of-lower-risk-myelodysplastic-neoplasm-patients-with-respect-to-disease-progression-using-next-generation-sequencing-and-pyrosequencing
#12
JOURNAL ARTICLE
Monika Adamska, Ewelina Kowal-Wiśniewska, Joanna Czerwińska-Rybak, Katarzyna Kiwerska, Marta Barańska, Weronika Gronowska, Jagoda Loba, Katarzyna Brzeźniakiewicz-Janus, Ewa Wasilewska, Aleksandra Łanocha, Małgorzata Jarmuż-Szymczak, Lidia Gil
INTRODUCTION: Lower-risk myelodysplastic neoplasms (LR-MDS) comprise the majority of MDS. Despite favourable prognoses, some patients remain at risk of rapid progression. We aimed to define the mutational profile of LR-MDS using next-generation sequencing (NGS), Sanger Sequencing (SSeq), and pyrosequencing. MATERIAL AND METHODS: Samples from 5 primary LR-MDS (67 exons of SF3B1, U2AF1, SRSF2, ZRSR2, TET2, ASXL1, DNMT3A, TP53 , and RUNX1 genes) were subjected to NGS...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38405212/prognostic-value-of-pan-immune-inflammation-value-and-body-mass-index-in-geriatric-patients-with-metastatic-renal-cell-carcinoma-treated-with-tyrosine-kinase-inhibitors-as-first-line-treatment-a-single-center-retrospective-study
#13
JOURNAL ARTICLE
Piotr Domański, Jadwiga Jarosińska, Barbara Kruczyk, Mateusz Piętak, Anna Mydlak, Tomasz Demkow, Łukasz Kuncman, Marta Darewicz, Bożena Sikora-Kupis, Wojciech Michalski, Jakub Kucharz
INTRODUCTION: Geriatric patients with metastatic renal cell carcinoma (mRCC) are underrepresented in clinical trials. Evaluation of the efficacy of the treatment and assignation of individuals to proper prognostic groups is an absolute necessity to guarantee them the best possible care. MATERIAL AND METHODS: A total of 138 geriatric patients with mRCC treated with first-line tyrosine kinase inhibitors (TKIs) at the Maria Skłodowska-Curie National Research Institute of Oncology were retrospectively analyzed to determine whether the body mass index (BMI) and pan-immune-inflammation value (PIV) are prognostic values for overall survival (OS) and progression-free survival (PFS) in this type of cancer...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38405211/first-experience-in-treating-advanced-urothelial-cancer-with-enfortumab-vedotin-single-centre-retrospective-study-of-patients-qualified-for-a-rescue-access-procedure
#14
JOURNAL ARTICLE
Bożena Sikora-Kupis, Piotr Domański, Weronika Fortuniak, Barbara Kruczyk, Szymon Staneta, Mateusz Piętak, Anna Mydlak, Tomasz Demkow, Paulina Dumnicka, Jakub Kucharz
INTRODUCTION: Urothelial carcinoma is the most common type of urinary tract malignancy. Current treatment options, including platinum-based chemotherapy or immunotherapy, present significant challenges, ranging from limited efficacy to severe toxicities. Recent developments in antibody-drug conjugates (ADC), such as enfortumab vedotin (EV), promise to significantly improve overall survival. The study aims to evaluate the efficacy and tolerability of EV. In addition, we highlight the observed benefits of next-line treatment after progression...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38405210/clustered-regularly-interspaced-short-palindromic-repeats-crispr-cas9-transfection-of-guide-rna-targeting-on-mmp9-as-anti-cancer-therapy-in-human-cutaneous-squamous-cell-carcinoma-cell-line-a431
#15
JOURNAL ARTICLE
Seoh Wei Teh, Abozer Elderdery, Sanjiv Rampal, Suresh Kumar Subbiah, Pooi Ling Mok
INTRODUCTION: Cutaneous squamous cell carcinoma (SCC) is the second most common form of skin malignancy, representing around 20% of all skin cancers. It is the main cause of death due to non-melanoma skin cancer every year. Metastatic cutaneous SCC is associated with poor prognosis in patients and warrants a more effective and specific approach such as disruption of genes associated with cancer metastasis. MATERIAL AND METHODS: Matrix metalloproteinases (MMPs) are enzymes involved in cancer progression and are regarded as major oncotargets...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38405209/side-effects-of-treatment-with-tyrosine-kinase-inhibitors-in-patients-with-chronic-myeloid-leukaemia-and-the-occurrence-of-depressive-symptoms
#16
JOURNAL ARTICLE
Katarzyna Gibek
INTRODUCTION: The aim of the study was to check whether individual side effects of treatment with tyrosine kinase inhibitors (TKI) in patients suffering from chronic myeloid leukaemia (CML) contribute to the occurrence of depressive symptoms. In addition, it was decided to check whether there is any correlation between the age, sex, and duration of treatment and the intensity of depressive symptoms, in relation to the occurrence of individual side effects. MATERIAL AND METHODS: The study included 91 patients with CML treated with TKI...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38405208/high-dose-alectinib-for-ret-fusion-positive-non-small-cell-lung-cancer-in-the-blood-first-assay-screening-trial
#17
Rafal Dziadziuszko, Nir Peled, Tony Mok, Solange Peters, Santiago Ponce Aix, Jorge Alatorre-Alexander, Brian D Vicuna, Margaret Maclennan, Vijay Bhagawati-Prasad, Sarah M Shagan, Erica Schleifman, Thorsten Ruf, Michael S Mathisen, Shirish M Gadgeel
INTRODUCTION: This paper presents results from Cohort B (rearranged during transfection [ RET ], fusion-positive) of the Blood First Assay Screening Trial in patients with advanced non-small cell lung cancer (NSCLC) screened for genetic alterations using blood-based next-generation sequencing. MATERIAL AND METHODS: Adults with advanced RET fusion-positive NSCLC received alectinib 900 mg twice daily (BID) in Phase I. Enrolment closed prematurely with Phase II uninitiated...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38405207/lower-fluorodeoxyglucose-positron-emission-tomography-maximum-standardized-uptake-value-may-show-a-better-response-to-stereotactic-body-radiotherapy-of-adrenals-in-oligometastatic-disease
#18
JOURNAL ARTICLE
Kiril Zhelev, Maria Mihaylova-Hristov, Nikolay Conev, Manoela Cholakova, Bilyana Korabova, Ivaylo Petrov, Nedyalka Georgieva, Nikolay Nedev, Iglika Mihaylova, Mila Petrova, Zahari Zahariev, Ivan Donev
INTRODUCTION: Stereotactic body radiotherapy (SBRT) is well established for oligometastatic disease, and it is increasingly used to treat adrenal metastases. MATERIAL AND METHODS: In this retrospective study we performed an analysis of 75 metastatic adrenal lesions in 64 patients with oligometastatic disease. According to the fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) maximum standardized uptake value (SUVmax ) of adrenal metastases, patients were categorized into three groups: low, intermediate, and high SUVmax...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38405206/brain-tumour-detection-from-magnetic-resonance-imaging-using-convolutional-neural-networks
#19
JOURNAL ARTICLE
Irene Rethemiotaki
INTRODUCTION: The aim of this work is to detect and classify brain tumours using computational intelligence techniques on magnetic resonance imaging (MRI) images. MATERIAL AND METHODS: A dataset of 3264 MRI brain images consisting of 4 categories: unspecified glioma, meningioma, pituitary, and healthy brain, was used in this study. Twelve convolutional neural networks (GoogleNet, MobileNetV2, Xception, DesNet-BC, ResNet 50, SqueezeNet, ShuffleNet, VGG-16, AlexNet, Enet, EfficientB0, and MobileNetV2 with meta pseudo-labels) were used to classify gliomas, meningiomas, pituitary tumours, and healthy brains to find the most appropriate model...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/38405205/characteristics-and-treatment-results-of-refractory-and-relapsed-acute-myeloid-leukaemia-in-paediatric-patients-treated-in-polish-paediatric-leukaemia-lymphoma-study-group-institutions-according-to-the-protocol-acute-myeloid-leukaemia-berlin-frankfurt-munster
#20
JOURNAL ARTICLE
Magdalena Samborska, Jolanta Skalska-Sadowska, Robert Achkar, Jacek Wachowiak, Katarzyna Derwich, Małgorzata Czogała, Walentyna Balwierz, Szymon Skoczeń, Grzegorz Dobaczewski, Alicja Chybicka, Krzysztof Kałwak, Maryna Krawczuk-Rybak, Katarzyna Muszyńska-Rosłan, Elżbieta Adamkiewicz-Drożyńska, Lucyna Maciejka-Kapuscińska, Ninela Irga-Jaworska, Joanna Pohorecka, Agnieszka Chodała-Grzywacz, Grażyna Karolczyk, Beata Wójcik, Jerzy R Kowalczyk, Katarzyna Drabko, Joanna Zawitkowska, Katarzyna Mycko, Wanda Badowska, Tomasz Ociepa, Tomasz Urasiński, Barbara Sikorska-Fic, Michał Matysiak, Paweł Laguna, Anna Dąbrowska-Pawliszyn, Renata Tomaszewska, Tomasz Szczepański, Grażyna Sobol, Agnieszka Mizia-Malarz, Małgorzata Ciebiera, Radosław Chaber, Sylwia Kołtan, Mariusz Wysocki, Jan Styczyński, Mariola Woszczyk, Maria Wieczorek, Irena Karpińska-Derda, Justyna Urbańska-Rakus, Katarzyna Bobeff, Joanna Trelińska, Wojciech Młynarski
INTRODUCTION: This study aimed to present the clinical features and results of treatment of patients diagnosed with refractory or relapsed acute myeloid leukaemia (AML) in Polish Paediatric Leukaemia/Lymphoma Study Group (PPL/LSG) institutions, treated in accordance with the Protocol Acute Myeloid Leukaemia Berlin-Frankfurt-Munster 2012, as their first-line therapy. MATERIAL AND METHODS: The outcome data of 10 patients with refractory AML (median age 9.5 years) and 30 with relapsed AML (median age 12 years) were analysed retrospectively...
2023: Contemporary Oncology Współczesna Onkologia
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