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BMC Hematology

Jean-Robert Makulo, Karen Efombola Itokua, Rosette Kevani Lepira, Gloire Mavinga Bundutidi, Michel Ntetani Aloni, René Makuala Ngiyulu, Jean Lambert Gini, François Bompeka Lepira
Background: The serum ferritin assay is recommended in Sickle Cell Anemia (SCA) patients receiving regular transfusions. According to several authors, elevated iron stores indicating iron chelation corresponds to hyperferritinemia ≥500 ng/ml, and becomes detectable after twenty blood transfusions. The objectives of the study were to determine the prevalence of elevated iron stores and identify associated risk factors in a case series of Steady state SCA Congolese children. Material and methods: Serum ferritin was assayed in Steady state SCA children followed in 2 specialized hospitals in Kinshasa...
2019: BMC Hematology
Absra Solomon, Mintewab Hussein, Mikias Negash, Abdurezak Ahmed, Fitsum Bekele, Daniel Kahase
Background: Hemoglobin A1C (HbA1c) is the predominant hemoglobin found in HbA1 fractions. A1c assay is the recommended assay for diagnosing diabetes and any condition that changes red cell turnover such as Iron deficiency Anemia (IDA), will lead to spurious A1C results. Therefore, the present study was aimed at determining the effect of IDA on HbA1c in diabetic patients attending Black Lion Specialized Teaching Hospital, Addis Ababa, Ethiopia. Methods: A facility based comparative cross sectional study was conducted on 174 diabetic patients (87 with IDA and 87 without IDA) from April to July 2016...
2019: BMC Hematology
Misganaw Birhaneselassie Mengesha, Gezahegn Bekele Dadi
Introduction: Anemia is a public health problem in Ethiopia. In spite of the fact that anemia is a common health burden with much severe consequences, the prevalence of the different types of anemia and its severity have not yet been well documented in different parts of the country. The study aimed to assess the prevalence of different types of anemia, including severity and association with age and sex of study population. Materials and methods: Four hundred anemic patients who are men and non-pregnant women above 15 years of age were selected from patients visiting the laboratory for Complete Blood Count (CBC) investigation...
2019: BMC Hematology
Miruna Sudharshani Kalaimani Rabindrakumar, V Pujitha Wickramasinghe, Lallindra Gooneratne, Carukshi Arambepola, Hemantha Senanayake, Tharanga Thoradeniya
Background: Early detection and treatment of iron deficiency during pregnancy is crucial for optimum pregnancy outcomes. Anaemia is a late indictor of iron deficiency measured as Hb < 11 g/dL, and is widely used as a proxy for iron deficiency. We aimed to evaluate the role of red cell indices as a screening tool for early detection of iron deficiency among pregnant women in an urban area of Sri Lanka. Method: A cross-sectional study was conducted among 110 apparently healthy pregnant women ≤12 weeks of gestation attending antenatal clinics in Colombo, Sri Lanka...
2018: BMC Hematology
Awab Omer Babiker, Lamis AbdelGadir Kaddam
Background: Sickle cell disease is a hereditary disorder characterized by haematological anaemia. Several studies assumed that adult sickle patients might develop metabolic syndrome features as hyperglycaemia, hypertension and dyslipidaemia. The aim of this study was to evaluate the metabolic syndrome risk factors among adult Sudanese with sickle cell anemia in the steady state. Methods: A prospective cross sectional study design was conducted among thirty adult patients with sickle cell anemia Hb SS (mean age 23 ± 6...
2018: BMC Hematology
Shamsudeen Mohammed, Harry Barton Essel
Background: Blood transfusion is an essential component of the health care system of every country and patients who require blood transfusion service as part of the clinical management of their condition have the right to expect that sufficient and safe blood will be available to meet their needs. However, this is not always the case, especially in developing countries. To recruit and retain adequate regular voluntary non-remunerated blood donors the motivators and barriers of donors must be understood...
2018: BMC Hematology
Rapee Lertpongpiroon, Ekarat Rattarittamrong, Thanawat Rattanathammethee, Chatree Chai-Adisaksopha, Adisak Tantiworawit, Parichat Salee, Lalita Norasetthada
Background: Infection is a major complication in aplastic anemia (AA) patients. Primary objectives of this study were to determine the prevalence of infections and to determine types of pathogens associated with infections in patients with AA. Secondary objectives were to evaluate overall survival after infections as well as risk factors of infections in patients with AA. Methods: The authors retrospectively evaluated the infectious episodes (IEs), type of infections, associated pathogens, and outcomes of infections in patients with AA who were diagnosed and treated at Chiang Mai University between January 2010 and December 2015...
2018: BMC Hematology
Nurfatin Mohd Shah, Soon Eu Chong, Syahirah Mohamed Yusoff, Mohd Zulfakar Mazlan, Khairul Bariah Johan, Nizuwan Azman, Jo Anne Lim, Siti Mardhiana Mohamad, Siti Salmah Noordin, Zainab Abdul Ghaffar, Mohd Hasyizan Hassan, Muhammad Azrul Zabidi, Nur Arzuar Abdul Rahim
Background: Massive bleeding is one of the commonest salvageable causes of death. The search for an ideal haemostatic agent during massive bleeding is still ongoing. One of the novel haemostatic medications is recombinant activated factor VII (rFVIIa). To date, the usage of rFVIIa during massive haemorrhage among non-haemophiliac patients remains off-label. The aim of this study is to report our experience in using rFVIIa to treat refractory bleeding. Methods: Medical records of all patients treated with rFVIIa for massive bleeding over an eleven-year period in a single institution were recorded...
2018: BMC Hematology
Julie Makani, Furahini Tluway, Abel Makubi, Deogratius Soka, Siana Nkya, Raphael Sangeda, Josephine Mgaya, Stella Rwezaula, Fenella J Kirkham, Christina Kindole, Elisha Osati, Elineema Meda, Robert W Snow, Charles R Newton, David Roberts, Muhsin Aboud, Swee Lay Thein, Sharon E Cox, Lucio Luzzatto, Bruno P Mmbando
Background: Africa has the highest burden of Sickle cell disease (SCD) but there are few large, systematic studies providing reliable descriptions of the disease spectrum. Tanzania, with 11,000 SCD births annually, established the Muhimbili Sickle Cell program aiming to improve understanding of SCD in Africa. We report the profile of SCD seen in the first 10 years at Muhimbili National Hospital (MNH). Methods: Individuals seen at MNH known or suspected to have SCD were enrolled at clinic and laboratory testing for SCD, haematological and biochemical analyses done...
2018: BMC Hematology
Ayenew Negesse, Temesgen Getaneh, Habtamu Temesgen, Tesfahun Taddege, Dube Jara, Zeleke Abebaw
Background: Anemia is a common hematologic disorder among human Immunodeficiency virus (HIV) infected adult Individuals. However, there is no concrete scientific evidence established at national level in Ethiopia. Hence, this review gave special emphasis on Ethiopian HIV infected adult individuals to estimate pooled prevalence of anemia and its associated factors at national level. Methods: Studies were retrieved through search engines in PUBMED/Medline, Cochrane Library, and the web of science, Google and Google scholar following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P)...
2018: BMC Hematology
Ishag Adam, Yassin Ibrahim, Osama Elhardello
Background: Anemia during pregnancy is a public health problem especially in developing countries and it is associated with maternal and perinatal adverse outcomes. There is no meta-analysis on anemia during pregnancy in Sudan. The current systemic review and meta-analysis was conducted to assess the prevalence, types and determinant of anemia during pregnancy in Sudan. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed...
2018: BMC Hematology
Enoch Aninagyei, Emmanuel Tetteh Doku, Patrick Adu, Alexander Egyir-Yawson, Desmond Omane Acheampong
Background: In sub-Saharan Africa where sickle cell trait (SCT) and malaria is prevalent, significant proportions of blood donors may be affected by one or more of these abnormalities. The haemato-biochemical properties of SCT and asymptomatic malaria in donor blood have not been evaluated. This study evaluated the haemato-biochemical impact of SCT and asymptomatic malaria infections in citrate-phosphate-dextrose-adenine (CPDA-1) stored donor blood units. Methods: Fifty-milliliters of sterile CPDA-1 anti-coagulated blood were drained into the sample pouch attached to the main blood bag...
2018: BMC Hematology
Tadele Mulaw, Amare Tariku, Adino Tesfahun Tsegaye, Zegeye Abebe
Background: An individual with visceral Leishmaniasis (VL) commonly present with anemia and one of the VL treatment center in northwest Ethiopia has been recommended iron-folic acid supplementation to these patients. But there is no documented evidence whether iron-folic acid supplementation improves the hematological profile of patients. Therefore, the study aimed to assess change in hemoglobin (Hb) and its determinant factors among VL patients with and without iron-folic acid supplementation in northwest Ethiopia...
2018: BMC Hematology
Sara Aljarad, Ahmad Alhamid, Ahmad Sankari Tarabishi, Ameen Suliman, Ziad Aljarad
Background: Idiopathic (immune) thrombocytopenic purpura (ITP) is an acquired disorder characterized by autoantibodies against platelet membrane antigens. Several studies found an association between Helicobacter Pylori infection and the incidence of ITP. So far, It is still unclear whether H. pylori eradication will increase platelet counts in adult ITP patients. We conduct this study to investigate platelet recovery in ITP patients after H. pylori eradication. Methods: This is a prospective study...
2018: BMC Hematology
Hendry R Sawe, Teri A Reynolds, Juma A Mfinanga, Michael S Runyon, Brittany L Murray, Lee A Wallis, Julie Makani
Background: Sickle cell anaemia (SCA) is prevalent in sub-Saharan Africa, with high risk of complications requiring emergency care. There is limited information about presentation of patients with SCA to hospitals for emergency care. We describe the clinical presentation, resource utilization, and outcomes of SCA patients presenting to the emergency department (ED) at Muhimbili National Hospital (MNH) in Dar es Salaam, Tanzania. Methods: This was a prospective cohort study of consecutive patients with SCA presenting to ED between December 2014 and July 2015...
2018: BMC Hematology
Benjamin Ahenkorah, Kwabena Nsiah, Peter Baffoe, Enoch Odame Anto
Background: Anemia in pregnancy may not only be associated with maternal morbidity and mortality but can also be detrimental to the fetus. A definitive diagnosis of anemia is a pre-requisite to unravelling possible cause(s), to allow appropriate treatment intervention. It is hypothesised that measured hemoglobin (HGB), complemented by biochemical and other hematological parameters would enhance anemia diagnosis. Methods: This was a cross-sectional study among 400 pregnant women comprising 253 anemic and 147 non-anemic pregnant women, attending an antenatal clinic at Bolgatanga Regional Hospital, Ghana...
2018: BMC Hematology
Akueté Yvon Segbena, Aldiouma Guindo, Romain Buono, Irénée Kueviakoe, Dapa A Diallo, Gregory Guernec, Mouhoudine Yerima, Pierre Guindo, Emilie Lauressergues, Aude Mondeilh, Valentina Picot, Valériane Leroy
Background: Sickle cell disease (SCD) accounts for 5% of mortality in African children aged < 5 years. Improving the care management and quality of life of patients with SCD requires a reliable diagnosis in resource-limited settings. We assessed the diagnostic accuracy of the rapid Sickle SCAN® point-of-care (POC) test for SCD used in field conditions in two West-African countries. Methods: We conducted a case-control study in Bamako (Mali) and Lomé (Togo)...
2018: BMC Hematology
Zelalem Teklemariam, Habtamu Mitiku, Fitsum Weldegebreal
Background: The use of unscreened blood exposes the patient to many transfusion transmitted infections including Hepatitis B Virus (HBV), Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), and syphilis, among others. Thus, blood transfusion demands for meticulous pre-transfusion testing and screening. Trends of transfusion transmitted infections are important to take appropriate measures on blood bank services. Therefore the aim of this study was to assess seroprevalence and trends of transfusion transmitted infections at Harar blood bank in Harari regional state, Eastern Ethiopia from 2008 to 2015...
2018: BMC Hematology
Olivier Mukuku, Joseph K Sungu, Augustin Mulangu Mutombo, Paul Makan Mawaw, Michel Ntetani Aloni, Stanislas Okitotsho Wembonyama, Oscar Numbi Luboya
Background: Sickle Cell Anemia (SCA) is characterized by high levels of oxidative stress markers and low levels of antioxidant capacity. Antioxidant defence mechanisms against the harmful effects of ROS requires cellular and extracellular enzymes. These enzymes requires micronutrient for complete activity. Information on micronutrients such as manganese, cobalt and copper in SCA population was poorly documented in the literature. Methods: Plasma copper, manganese, cobalt and albumin concentrations determined by atomic absorption spectrophotometry were compared between two groups of children: 76 with SCA (Hb-SS) and 76 without SCA (controls)...
2018: BMC Hematology
Haileleul Micho, Yasin Mohammed, Daniel Hailu, Solomon Genet
Background: Tumor lysis syndrome (TLS) is a life-threatening emergency disorder, caused by an abrupt release of intracellular metabolites after tumor cell death. It is characterized by a series of metabolic manifestations, especially hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia. The aim of this study was to evaluate and characterize the incidence of tumor lysis syndrome among pediatric oncology patients before and after treatment. Methods: Hospital based prospective cohort study was conducted for 6 months on 61 newly diagnosed pediatric oncology patients...
2018: BMC Hematology
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