J W A Sijbesma, A van Waarde, A Klooster, I Kion, R H J A Slart, A A Lammertsma, B Lima Giacobbo, H H Boersma, R A J O Dierckx, H van Goor, S J L Bakker
Reducing proteinuria is a crucial approach in preventing kidney function loss. Previous preclinical studies indicated that caloric restriction (CR) imposed at a young age protects against age-related proteinuria. However, these studies have not explored CR in established renal disease. Therefore, this study aimed to investigate the impact of CR on established proteinuria. Rats, aged 12 ± 2 weeks, were administered 2.1 mg/kg of Adriamycin. Six weeks after injection, protein excretion was measured, and a [13 N]ammonia positron emission tomography (PET) scan was conducted to assess kidney perfusion...
March 2024: Physiological Reports