Mats W Johansson, Joseph Balnis, Laura K Muehlbauer, Yury V Bukhman, Matthew S Stefely, Katherine A Overmyer, Rachel Vancavage, Anupama Tiwari, Anish Raj Adhikari, Paul J Feustel, Bradford S Schwartz, Joshua J Coon, Ron Stewart, Ariel Jaitovich, Deane F Mosher
Cartilage acidic protein-1 (CRTAC1) is produced by several cell types, including Type 2 alveolar epithelial (T2AE) cells that are targeted by SARS-CoV2. Plasma CRTAC1 is known based on proteomic surveys to be low in patients with severe COVID-19. Using an ELISA, we found that patients treated for COVID-19 in an ICU almost uniformly had plasma concentrations of CRTAC1 below those of healthy controls. Magnitude of decrease in CRTAC1 distinguished COVID-19 from other causes of acute respiratory decompensation and correlated with established metrics of COVID-19 severity...
September 2023: Physiological Reports