Richard A Johnston, Albert W Pilkington, Constance L Atkins, Theresa E Boots, Philip L Brown, William T Jackson, Chantal Y Spencer, Saad R Siddiqui, Ikram U Haque
We executed this study to determine if chemerin-like receptor 1 (CMKLR1), a Gi/o protein-coupled receptor expressed by leukocytes and non-leukocytes, contributes to the development of phenotypic features of non-atopic asthma, including airway hyperresponsiveness (AHR) to acetyl-β-methylcholine chloride, lung hyperpermeability, airway epithelial cell desquamation, and lung inflammation. Accordingly, we quantified sequelae of non-atopic asthma in wild-type mice and mice incapable of expressing CMKLR1 (CMKLR1-deficient mice) following cessation of acute inhalation exposure to either filtered room air (air) or ozone (O3 ), a criteria pollutant and non-atopic asthma stimulus...
April 2024: Physiological Reports