Fernanda Lopes de Souza, Mariana Oliveira, Marianne Brochado Nunes, Lucas Horstmann Serafim, Alan Arrieira Azambuja, Luisa Maria G de M Braga, Lisiani Saur, Maria Antonieta Lopes de Souza, Léder Leal Xavier
Oral squamous cell carcinoma (OSCC) is a public health problem. The hamster buccal pouch model is ideal for analyzing the development of OSCC. This research analysed the effects of sunitinib (tyrosine kinase inhibitor) in precancerous lesions induced by 7,12-dimethylbenz(a)anthracene (DMBA) in this model. Thirty-four male hamsters, divided into six groups: control-C (n = 7), acetone-A (n = 12), carbamide peroxide-CP (n = 5 ), acetone and CP-A+CP (n = 8), 1% DMBA in acetone and CP-DA+CP (n = 6), and 1% DMBA in acetone and CP and 4-week treatment with sunitinib-DA+CP+S (n = 7)...
2014: ISRN Otolaryngology