journal
https://read.qxmd.com/read/38529047/identification-and-validation-of-the-pyroptosis-related-hub-gene-signature-and-the-associated-regulation-axis-in-diabetic-keratopathy
#1
JOURNAL ARTICLE
Yi Cui, Li Wang, Wentao Liang, Li Huang, Shuting Zhuang, Hong Shi, Nuo Xu, Jianzhang Hu
BACKGROUND: Diabetic keratopathy (DK) poses a significant challenge in diabetes mellitus, yet its molecular pathways and effective treatments remain elusive. The aim of our research was to explore the pyroptosis-related genes in the corneal epithelium of the streptozocin-induced diabetic rats. METHODS: After sixteen weeks of streptozocin intraperitoneal injection, corneal epithelium from three diabetic rats and three normal groups underwent whole-transcriptome sequencing...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38529046/effects-of-glucagon-like-peptide-1-receptor-agonists-and-sodium-glucose-cotransporter-2-inhibitors-on-intima-media-thickness-systematic-review-and-meta-analysis
#2
REVIEW
Abolfazl Akbari, Shiva Hadizadeh, Leida Heidary
BACKGROUND: Beyond glycemic control, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) have been proposed to reduce the risk of cardiovascular events. The aim of the present systematic review and meta-analysis is to demonstrate the effects of GLP-1 RA and SGLT2is on intima-media thickness (IMT). METHODS: PubMed, EMBASE, Web of Science, SCOPUS, and Google Scholar databases were searched from inception to September 9, 2023...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38529045/the-role-of-probiotics-in-managing-glucose-homeostasis-in-adults-with-prediabetes-a-systematic-review-and-meta-analysis
#3
REVIEW
Chao Sun, Qingyin Liu, Xiaona Ye, Ronghua Li, Miaomiao Meng, Xingjun Han
METHODS: The Preferred Reporting Items for Systematic Reviews and Analysis checklist was used. A comprehensive literature search of the PubMed, Embase, and Cochrane Library databases was conducted through August 2022 to assess the impact of probiotics on blood glucose, lipid, and inflammatory markers in adults with prediabetes. Data were pooled using a random effects model and were expressed as standardized mean differences (SMDs) and 95% confidence interval (CI). Heterogeneity was evaluated and quantified as I 2 ...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38523631/jian-pi-gu-shen-hua-yu-decoction-alleviated-diabetic-nephropathy-in-mice-through-reducing-ferroptosis
#4
JOURNAL ARTICLE
Shuquan Lv, Lirong Fan, Xiaoting Chen, Xiuhai Su, Li Dong, Qinghai Wang, Yuansong Wang, Hui Zhang, Huantian Cui, Shufang Zhang, Lixin Wang
BACKGROUND: Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment of chronic kidney diseases such as DN, but the specific mechanism of action has not been fully elucidated yet. PURPOSE: The aim of this study is to clarify whether JPGS alleviates the progression of diabetic nephropathy by inhibiting ferroptosis...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38516324/does-treatment-with-sodium-glucose-cotransporter-2-inhibitors-affect-adherence-to-international-society-criteria-for-diabetic-ketoacidosis-in-adult-patients-with-type-2-diabetes-a-retrospective-cohort-analysis
#5
JOURNAL ARTICLE
Aongus O'Brolchain, Joshua Maletsky, Ibrahim Mian, Serena Edwards
DESIGN: Retrospective observational study. Setting . Inpatients at two teaching hospitals in Queensland, Australia. Primary Outcome Measure(s) . The number of patients meeting the Joint British Diabetes Society (JBDS) and American Association of Clinical Endocrinology/American College of Endocrinology (AACE/ACE) diagnostic criteria for DKA. Patients were divided into two groups by treatment with SGLT2i at the time of diagnosis. Participants . Adult patients (>18 years old) with type 2 diabetes diagnosed with DKA from April 2015 to January 2022...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38455850/beneficial-effects-of-ursodeoxycholic-acid-on-metabolic-parameters-and-oxidative-stress-in-patients-with-type-2-diabetes-mellitus-a-randomized-double-blind-placebo-controlled-clinical-study
#6
JOURNAL ARTICLE
Biljana Lakić, Ranko Škrbić, Snežana Uletilović, Nebojša Mandić-Kovačević, Milkica Grabež, Mirna Popović Šarić, Miloš P Stojiljković, Ivan Soldatović, Zorica Janjetović, Anastasija Stokanović, Nataša Stojaković, Momir Mikov
BACKGROUND: Oxidative stress and inflammation are closely related pathophysiological processes, both occurring in type 2 diabetes mellitus (T2DM). In addition to the standard treatment of T2DM, a potential strategy has been focused on the use of bile acids (BAs) as an additional treatment. Ursodeoxycholic acid (UDCA), as the first BA used in humans, improves glucose and lipid metabolism and attenuates oxidative stress. The aim of this study was to evaluate the potential metabolic, anti-inflammatory, and antioxidative effects of UDCA in patients with T2DM...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38455849/exosomes-as-emerging-regulators-of-immune-responses-in-type-2-diabetes-mellitus
#7
REVIEW
Wei Zheng, Xin Ji, Qiao Qiao Yin, Chensi Wu, Chengan Xu, Hongying Pan, Chun Wu
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by high blood glucose levels resulting from insulin resistance and impaired insulin secretion. Immune dysregulation-mediated chronic low-grade inflammation is a critical factor that poses a significant risk to the metabolic disorders of T2DM and its related complications. Exosomes, as small extracellular vesicles secreted by various cells, have emerged as essential regulators of intercellular communication and immune regulation. In this review, we summarize the current understanding of the role of exosomes derived from immune and nonimmune cells in modulating immune responses in T2DM by regulating immune cell functions and cytokine production...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38435452/the-effects-of-resistance-exercise-training-on-skeletal-muscle-metabolism-and-insulin-resistance-development-in-female-rodents-with-type-1-diabetes
#8
JOURNAL ARTICLE
Mitchell J Sammut, David P McBey, Amit P Sayal, C W James Melling
The etiology of insulin resistance (IR) development in type 1 diabetes mellitus (T1DM) remains unclear; however, impaired skeletal muscle metabolism may play a role. While IR development has been established in male T1DM rodents, female rodents have yet to be examined in this context. Resistance exercise training (RT) has been shown to improve IR and is associated with a lower risk of hypoglycemia onset in T1DM compared to aerobic exercise. The purpose of this study was to investigate the effects of RT on IR development in female T1DM rodents...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38375094/advances-in-research-related-to-microrna-for-diabetic-retinopathy
#9
REVIEW
Yahan Luo, Chunxia Li
Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and is one of the primary causes of blindness in the working-age population in Europe and the United States. At present, no cure is available for DR, but early detection and timely intervention can prevent the rapid progression of the disease. Several treatments for DR are known, primarily ophthalmic treatment based on glycemia, blood pressure, and lipid control, which includes laser photocoagulation, glucocorticoids, vitrectomy, and antivascular endothelial growth factor (anti-VEGF) medications...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38361965/translation-of-a-diabetes-remission-service-into-australian-primary-care-findings-from-the-evaluation-of-direct-australia
#10
JOURNAL ARTICLE
Ritesh Chimoriya, Kimberly Mitlehner, Chee L Khoo, Uchechukwu Levi Osuagwu, Russell Thomson, Lei Si, Michael Lean, David Simmons, Milan K Piya
BACKGROUND: The Diabetes Remission Clinical Trial (DiRECT) study demonstrated that an intensive and structured weight management program in UK primary care resulted in high rates of diabetes remission in adults with recent onset type 2 diabetes mellitus (T2DM). This study was aimed at evaluating the translation of the DiRECT intervention into an Australian primary care setting. METHODS: All patients enrolled in the DiRECT-Australia Type 2 Diabetes Remission Service in a region of Sydney (Macarthur region, South Western Sydney, Australia) were included...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38343427/does-pre-existing-diabetes-correlate-with-long-covid-19-in-europe-evidence-from-the-analysis-of-the-survey-of-health-ageing-and-retirement-in-europe-s-corona-surveys
#11
JOURNAL ARTICLE
Sarah Cuschieri, Piotr Wilk
BACKGROUND: A substantial proportion of those infected with COVID-19 are presenting with persistent symptoms, referred to as long COVID-19. Emerging evidence suggests that the presence of pre-existing chronic conditions, such as diabetes, may increase the risk of long COVID-19. OBJECTIVES: To investigate whether having pre-existing diabetes increases the risk of developing long COVID-19 in the population of middle-aged and older adults (≥50 years old) in Europe, while assessing if this relationship can be accounted for or is modified by the known long COVID-19 and diabetes risk factors (age, sex, hospitalization, pre-existing hypertension, and weight status)...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38292407/identification-of-senescence-associated-biomarkers-in-diabetic-glomerulopathy-using-integrated-bioinformatics-analysis
#12
JOURNAL ARTICLE
Li Zhang, Zhaoxiang Wang, Fengyan Tang, Menghuan Wu, Ying Pan, Song Bai, Bing Lu, Shao Zhong, Ying Xie
BACKGROUND: Cellular senescence is thought to play a significant role in the onset and development of diabetic nephropathy. The goal of this study was to explore potential biomarkers associated with diabetic glomerulopathy from the perspective of senescence. METHODS: Datasets about human glomerular biopsy samples related to diabetic nephropathy were systematically obtained from the Gene Expression Omnibus database. Hub senescence-associated genes were investigated by differential gene analysis and Least Absolute Shrinkage and Selection Operator analysis...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38288388/tailoring-type-ii-diabetes-treatment-investigating-the-effect-of-5-htt-polymorphisms-on-hba1c-levels-after-metformin-initiation
#13
JOURNAL ARTICLE
Taichi Ochi, Stijn de Vos, Daan Touw, Petra Denig, Talitha Feenstra, Eelko Hak
AIMS: To investigate the effect of serotonin transporter (5-HTT) polymorphisms on change in HbA1c levels six months after metformin initiation in type 2 diabetes patients. MATERIALS AND METHODS: Participants of PROVALID (PROspective cohort study in patients with type 2 diabetes mellitus for VALidation of biomarkers) within the GIANTT (Groningen Initiative to ANalyse Type 2 Diabetes Treatment) cohort who initiated metformin were genotyped for combined 5-HTTLPR/rs25531 (L∗ L∗ , L∗ S∗ , and S∗ S∗ ) and 5-HTT VNTR (STin 2...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38282659/explainable-machine-learning-based-prediction-model-for-diabetic-nephropathy
#14
JOURNAL ARTICLE
Jing-Mei Yin, Yang Li, Jun-Tang Xue, Guo-Wei Zong, Zhong-Ze Fang, Lang Zou
The aim of this study is to analyze the effect of serum metabolites on diabetic nephropathy (DN) and predict the prevalence of DN through a machine learning approach. The dataset consists of 548 patients from April 2018 to April 2019 in the Second Affiliated Hospital of Dalian Medical University (SAHDMU). We select the optimal 38 features through a least absolute shrinkage and selection operator (LASSO) regression model and a 10-fold cross-validation. We compare four machine learning algorithms, including extreme gradient boosting (XGB), random forest, decision tree, and logistic regression, by AUC-ROC curves, decision curves, and calibration curves...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38282658/unveiling-the-hidden-burden-estimating-all-cause-mortality-risk-in-older-individuals-with-type-2-diabetes
#15
JOURNAL ARTICLE
Dikang Pan, Hui Wang, Sensen Wu, Jingyu Wang, Yachan Ning, Jianming Guo, Cong Wang, Yongquan Gu
BACKGROUND: The mortality rate among older persons with diabetes has been steadily increasing, resulting in significant health and economic burdens on both society and individuals. The objective of this study is to develop and validate a predictive nomogram for estimating the 5-year all-cause mortality risk in older persons with T2D (T2D). METHODS: We obtained data from the National Health and Nutrition Survey (NHANES). A random 7 : 3 split was made between the training and validation sets...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38282657/huaju-xiaoji-formula-regulates-ers-lncmgc-mirna-to-enhance-the-renal-function-of-hypertensive-diabetic-mice-with-nephropathy
#16
JOURNAL ARTICLE
Zeng Zhang, Xiaodong Fu, Fengzhu Zhou, Duanchun Zhang, Yanqiu Xu, Zhaohua Fan, Shimei Wen, Yanting Shao, Zheng Yao, Yanming He
BACKGROUND: Better therapeutic drugs are required for treating hypertensive diabetic nephropathy. In our previous study, the Huaju Xiaoji (HJXJ) formula promoted the renal function of patients with diabetes and hypertensive nephropathy. In this study, we investigated the therapeutic effect and regulation mechanism of HJXJ in hypertensive diabetic mice with nephropathy. METHODS: We constructed a mouse hypertensive diabetic nephropathy (HDN) model by treating mice with streptozotocin (STZ) and nomega-nitro-L-arginine methyl ester (LNAME)...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38282656/glucose-fluctuation-inhibits-nrf2-signaling-pathway-in-hippocampal-tissues-and-exacerbates-cognitive-impairment-in-streptozotocin-induced-diabetic-rats
#17
JOURNAL ARTICLE
Haiyan Chi, Yujing Sun, Peng Lin, Junyu Zhou, Jinbiao Zhang, Yachao Yang, Yun Qiao, Deshan Liu
BACKGROUND: This research investigated whether glucose fluctuation (GF) can exacerbate cognitive impairment in streptozotocin-induced diabetic rats and explored the related mechanism. METHODS: After 4 weeks of feeding with diets containing high fats plus sugar, the rat model of diabetes mellitus (DM) was established by intraperitoneal injection of streptozotocin (STZ). Then, GF was triggered by means of alternating satiety and starvation for 24 h. The weight, blood glucose level, and water intake of the rats were recorded...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38268787/is-egfr-slope-a-novel-predictor-of-chronic-complications-of-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Giovanni Sartore, Eugenio Ragazzi, Elena Deppieri, Annunziata Lapolla
BACKGROUND: Diabetic kidney disease affects approximately 40% of patients with type 2 diabetes mellitus (T2DM) and is associated with an increased risk of end-stage kidney disease (ESKD) and cardiovascular (CV) events, as well as increased mortality. Among the indicators of decline in renal function, the eGFR slope is acquiring an increasing clinical interest. The aim of this study was to evaluate, through a systematic review of the literature and meta-analysis of the collected data, the association between the decline of the eGFR slope, chronic complications, and mortality of T2DM patients, in order to understand whether or not the eGFR slope can be defined as a predictive indicator of complications in T2DM...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38239233/association-of-monocyte-to-hdl-cholesterol-ratio-with-endothelial-dysfunction-in-patients-with-type-2-diabetes
#19
JOURNAL ARTICLE
Huihui Zhang, Jun Lu, Jie Gao, Wenjun Sha, Xinhua Cai, Mai Re Yan Mu Rouzi, Yuanying Xu, Wenjun Tang, Tao Lei
AIMS: To explore the relationship between monocyte-to-HDL cholesterol ratio (MHR) and endothelial function in patients with type 2 diabetes (T2DM). METHODS: 243 patients diagnosed with T2DM were enrolled in this cross-sectional study. Patients were divided into two groups by flow-mediated dilation (FMD) quintile as nonendothelial dysfunction (FMD ≥ 6.4%) and endothelial dysfunction (FMD < 6.4%). The relationship between MHR and FMD was analyzed using Spearman's correlation, partial correlation, and multiple logistic regression analysis...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38225984/pathology-of-ketoacidosis-in-emergency-of-diabetic-ketoacidosis-and-alcoholic-ketoacidosis-a-retrospective-study
#20
JOURNAL ARTICLE
Katsumasa Koyama, Takatoshi Anno, Yukiko Kimura, Fumiko Kawasaki, Kohei Kaku, Koichi Tomoda, Hideaki Kaneto
This study is aimed at examining which factors are useful for the diagnosis and distinction of ketoacidosis. We recruited 21 diabetic ketoacidosis (DKA) and alcoholic ketoacidosis (AKA) patients hospitalized in Kawasaki Medical School General Medical Center from April 2015 to March 2021. Almost all patients in this study were brought to the emergency room in a coma and hospitalized. All patients underwent blood gas aspiration and laboratory tests. We evaluated the difference in diagnosis markers in emergencies between DKA and alcoholic ketoacidosis AKA...
2024: Journal of Diabetes Research
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