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Journal of Diabetes Research

Janet Ya-An Chang, Fei Yu, Liheng Shi, Michael L Ko, Gladys Y-P Ko
Mitochondrial fission and fusion are dependent on cellular nutritional states, and maintaining this dynamics is critical for the health of cells. Starvation triggers mitochondrial fusion to maintain bioenergetic efficiency, but during nutrient overloads (as with hyperglycemic conditions), fragmenting mitochondria is a way to store nutrients to avoid waste of energy. In addition to ATP production, mitochondria play an important role in buffering intracellular calcium (Ca2+ ). We found that in cultured 661W cells, a photoreceptor-derived cell line, hyperglycemic conditions triggered an increase of the expression of dynamin-related protein 1 (DRP1), a protein marker of mitochondrial fission, and a decrease of mitofusin 2 (MFN2), a protein for mitochondrial fusion...
2019: Journal of Diabetes Research
Keke Wang, Qiong Chen, Yongliang Feng, Hailan Yang, Weiwei Wu, Ping Zhang, Ying Wang, Jamie Ko, Feng Zhao, Wenqiong Du, Feifei Yang, Tianbi Han, Suping Wang, Yawei Zhang
Gestational diabetes mellitus (GDM) is a growing public health concern for many reasons, and its etiology remains unclear. Due to the similarity of its pathophysiology with type 2 diabetes (T2DM), we evaluated the relationship between published T2DM susceptibility genes and the risk of GDM. A total of 303 SNPs from genes including IRS1 , IGF2BP2 , CDKAL1 , GCK , TCF7L2 , KCNQ1 , and KCNJ11 and the risk of GDM were examined in a nested case-control study with 321 GDM cases and 316 controls. The odds ratios (ORs) and their 95% confidence interval (95% CI) were estimated by unconditional logistical regression as a measure of the associations between genotypes and GDM in additive, recessive, dominant, and codominant models adjusting for maternal age, maternal BMI, parity, and family history of diabetes...
2019: Journal of Diabetes Research
Juanjuan Zou, Fan Song, Huajun Xu, Yiqun Fu, Yunyan Xia, Yingjun Qian, Jianyin Zou, Suru Liu, Fang Fang, Lili Meng, Hongliang Yi, Jian Guan, Huaming Zhu, Bin Chen, Shankai Yin
Purpose: This cross-sectional study was performed to assess the relationship between simple snoring and metabolic syndrome (MetS). Methods: A total of 5635 participants including 300 healthy volunteers without snoring allegedly were initially included from 2007 to 2016. Polysomnographic variables, anthropometric measurements, and biochemical indicators were collected. The polynomial linear trend test was used to assess the linear trend across snoring intensity for metabolic score, and logistic regression was used to evaluate the odds ratios (ORs) for MetS after controlling for age, sex, obesity, smoking status, and alcohol consumption...
2019: Journal of Diabetes Research
Halefom Kahsay, Bereket Fantahun, Teshome Nedi, Gebre Teklemariam Demoz
Background: Hypoglycemia is one of the most common acute complications of type 1 diabetes mellitus (T1DM). The knowledge of the factors associated with hypoglycemia will help in the prevention and management of the problem. Therefore, this study was conducted to assess hypoglycemia and its associated factors among T1DM patients who attended the diabetes outpatient clinic of St. Paul's Hospital Millennium Medical College (SPHMMC). Methods: A cross-sectional study was conducted at the diabetes clinic of SPHMMC...
2019: Journal of Diabetes Research
Yupu Liu, Juanjuan Zou, Xinyi Li, Xiaolong Zhao, Jianyin Zou, Suru Liu, Lili Meng, Yingjun Qian, Huajun Xu, Hongliang Yi, Jian Guan, Shankai Yin
Both obstructive sleep apnea (OSA) and decreased serum lipoprotein(a) (Lp(a)) concentrations are associated with insulin resistance. However, their interaction effect on insulin resistance has never been investigated. Therefore, we performed a cross-sectional study on OSA-suspected Chinese Han participants. Laboratory-based polysomnographic variables, biochemical indicators, anthropometric measurements, and medical history were collected. Linear regression and binary logistic regression analyses with interaction terms were used to investigate the potential effects of the interaction between the severity of OSA (assessed by the apnea-hypopnea index (AHI)) and Lp(a) concentrations on insulin resistance (assessed by the homeostasis model assessment of insulin resistance (HOMA-IR)), after adjusting for potential confounders including age, gender, body mass index, waist-to-hip circumference ratio, mean arterial pressure, smoking status, drinking status, and lipid profiles...
2019: Journal of Diabetes Research
Paolo Severino, Andrea D'Amato, Lucrezia Netti, Mariateresa Pucci, Fabio Infusino, Viviana Maestrini, Massimo Mancone, Francesco Fedele
Ischemic heart disease (IHD) has several risk factors, among which diabetes mellitus represents one of the most important. In diabetic patients, the pathophysiology of myocardial ischemia remains unclear yet: some have atherosclerotic plaque which obstructs coronary blood flow, others show myocardial ischemia due to coronary microvascular dysfunction in the absence of plaques in epicardial vessels. In the cross-talk between myocardial metabolism and coronary blood flow (CBF), ion channels have a main role, and, in diabetic patients, they are involved in the pathophysiology of IHD...
2019: Journal of Diabetes Research
Mona Hegazy, Naglaa M Elsayed, Hala M Ali, Hanan G Hassan, Laila Rashed
Background and Objective: Type 2 DM and obesity are the coming epidemics and their association with NAFLD is well established; essential fatty acids are vital for body health yet the body cannot make them; 2 essential fatty acids are especially important: linoleic (omega-6) and alpha-linoleic (omega-3) acids; they can be considered as "bioactive lipids" and serve as functional foods. Methods: 50 type 2 Egyptian diabetic patients controlled on oral hypoglycemic drugs together with 20 age- and sex-matched healthy participants were enrolled in the study; all were subjected to complete history taking, BMI, fasting plasma glucose, HOMA-IR, ALT, AST, GGT, urea and creatinine, total lipid profile, hepatitis markers including hepatitis B surface antigen and hepatitis C virus antibodies, conjugated linoleic fatty acid "CLA," and abdominal ultrasound for grading of NAFLD...
2019: Journal of Diabetes Research
Qiong Chen, Yongliang Feng, Hailan Yang, Weiwei Wu, Ping Zhang, Keke Wang, Ying Wang, Jamie Ko, Jiaxin Shen, Lingling Guo, Feng Zhao, Wenqiong Du, Shouhang Ru, Suping Wang, Yawei Zhang
Identification of modifiable dietary factors, which are involved in the development of gestational diabetes mellitus (GDM), could inform strategies to prevent GDM. Therefore, we examined the dietary nutrient patterns and evaluated their relationship with GDM risk in a Chinese population using a case control study design. A total of 1,464 GDM cases and 8,092 non-GDM controls were included in the final analysis. Dietary intake was assessed using a 33-item food frequency questionnaire, and nutrients were estimated using the Chinese Standard Tables of Food Consumption...
2019: Journal of Diabetes Research
Daniel Asmelash, Netsanet Abdu, Samson Tefera, Habtamu Wondifraw Baynes, Cherie Derbew
Background: Diabetes mellitus is a metabolic disorder of multiple etiologic factors characterized by chronic hyperglycemia with disturbance of carbohydrate metabolism. It can play the vital role in the cause of morbidity and mortality through continued clinical consequence. Therefore, good knowledge, attitude, and practices of glycemic control are necessary in promoting care, in enhancing better therapeutic outcomes, and in the prevention and management of diabetes complications. Methods: A cross-sectional study design was conducted to determine knowledge, attitude, and practice towards glycemic control and its associated factors...
2019: Journal of Diabetes Research
Matthew P Johnson, Ryan Keyho, Nicholas B Blackburn, Sandra Laston, Satish Kumar, Juan Peralta, Suman S Thapa, Bradford Towne, Janardan Subedi, John Blangero, Sarah Williams-Blangero
Measurements of fasting glucose (FG) or glycated hemoglobin A1c (HbA1c) are two clinically approved approaches commonly used to determine glycemia, both of which are influenced by genetic factors. Obtaining accurate measurements of FG or HbA1c is not without its challenges, though. Measuring glycated serum protein (GSP) offers an alternative approach for assessing glycemia. The aim of this study was to estimate the heritability of GSP and GSP expressed as a percentage of total serum albumin (%GA) using a variance component approach and localize genomic regions (QTLs) that harbor genes likely to influence GSP and %GA trait variation in a large extended multigenerational pedigree from Jiri, Nepal ( n = 1,800)...
2019: Journal of Diabetes Research
Gang Xi, Christine Wai, David Clemmons
Hyperglycemia results in inhibition of cleavage of integrin-associated protein (IAP) thereby allowing it to bind to SHPS-1 which results in pathophysiologic changes in endothelial function. This study determined if an anti-rat IAP antibody directed against the SHPS-1 binding site which disrupts IAP/SHPS-1 association could inhibit these pathophysiologic changes. The anti-IAP antibody inhibited IGF-I-stimulated SHPS-1, p52Shc, MAP kinase phosphorylation, and proliferation in endothelial cells. To determine if it could reverse established pathophysiologic changes in vivo, this antibody or normal rat IgG F(ab)2 was injected intraperitoneally for 6 weeks into rats that had diabetes for 4 weeks...
2019: Journal of Diabetes Research
Joanna Wojtasik-Bakalarz, Zoltan Ruzsa, Tomasz Rakowski, Andreas Nyerges, Krzysztof Bartuś, Agata Stanek, Dariusz Dudek, Andrzej Surdacki, Paweł Kleczyński, Stanisław Bartuś
The most relevant comorbidities in patients with peripheral artery disease (PAD) are coronary artery disease (CAD) and diabetes mellitus (DM). However, data of long-term follow-up of patients with chronic total occlusion (CTO) are scarce. The aim of the study was to assess the impact of CAD and DM on long-term follow-up patients after superficial femoral artery (SFA) CTO retrograde recanalization. In this study, eighty-six patients with PAD with diagnosed CTO in the femoropopliteal region and at least one unsuccessful attempt of antegrade recanalization were enrolled in 2 clinical centers...
2019: Journal of Diabetes Research
Maha T Mohammad, Jennifer Muhaidat, Munther S Momani, Lara Al-Khlaifat, Rasha Okasheh, Dania Qutishat, Emad Al-Yahya
Objective: To translate the patient questionnaire section of the Michigan Neuropathy Screening Instrument (MNSI) into Arabic, examine the reliability of the translated version, and provide descriptive data on a sample of patients with type 2 diabetes. Methods: Researchers used the translation-back translation method to obtain MNSI Arabic. The test was then applied on 76 patients with type 2 diabetes. A subgroup of 25 patients answered MNSI Arabic twice to examine reliability...
2019: Journal of Diabetes Research
Qinghua Zhang, Yingying Huang, Xiaojin Li, Hongyi Liu, Baichuan He, Bin Wang, Yuntao Ma, Xiang Zhou, Yaqin Liu, Shentao Wu
Insulin resistance (IR) is a vital hallmark of type 2 diabetes mellitus, which is characterized by an impaired ability of insulin to promote glucose uptake and utilization. Lipid deposition is closely associated with impaired insulin sensitivity. PPAR γ plays an important role in glucose homeostasis, adipocyte differentiation, and insulin sensitivity. Likewise, DGAT2 also exerts a crucial role in integrating carbohydrate and lipid metabolism in the liver. The present study is aimed at evaluating a Chinese medicinal formula, Tangduqing granules (TDQ), with multifaceted actions against lipid and glucose metabolism disorder and IR of type 2 diabetes...
2019: Journal of Diabetes Research
Jie Wang, Yijun Li, Kang Chen, Wenhua Yan, Anping Wang, Weiqing Wang, Zhengnan Gao, Xulei Tang, Li Yan, Qin Wan, Zuojie Luo, Guijun Qin, Lulu Chen, Yiming Mu
Background: Physical activity is effective in preventing chronic diseases. However, the impact of different durations of exercise on human health is unknown, especially among people with diabetes or prediabetes. Objective: To explore the relationship between high MET hours per week and the change in glomerular filtration rate (eGFR) in the total population and different subgroups. Methods: A total of 43767 individuals from eight provinces, in China, were recruited...
2019: Journal of Diabetes Research
Xubin Yang, Qiongyan Lin, Xiaoshan Li, Lin Wu, Wen Xu, Yanhua Zhu, Hongrong Deng, Yao Zhang, Bin Yao
Background: Cardiovascular autonomic dysfunction is closely related to increased mortality in patients with diabetes. Previous studies have proved that cystatin C (CysC) is an important predictor of both peripheral neuropathy and cardiovascular events. However, whether CysC is also associated with cardiovascular autonomic dysfunction remains unclear. Therefore, the aim of this study was to investigate the relationship between CysC and cardiovascular autonomic dysfunction in type 2 diabetic patients without renal dysfunction...
2019: Journal of Diabetes Research
Anna Zaleska-Żmijewska, Zbigniew M Wawrzyniak, Anna Dąbrowska, Jacek P Szaflik
Background: Diabetic retinopathy (DR) is the leading cause of impaired vision in patients with diabetes mellitus. An adaptive optics retinal camera (rtx1™; Imagine Eyes, France) was used to capture images of cones and retinal arteries from patients with DR. Objective: Cone parameters (density, interphotoreceptor distance, and regularity) and retinal artery parameters (wall thickness, lumen diameter, WLR, and WCSA) were analyzed in 36 patients with nonproliferative DR (NPDR; 22 with mild NPDR and 14 with moderate NPDR) and in 20 healthy volunteers (the control group)...
2019: Journal of Diabetes Research
Peng Sun, Qingyan Jin, Shengnan Nie, Shijie Jia, Yuanyuan Li, Xiaoxue Li, Fang Guo
Introduction: Type 2 diabetes is a worldwide disease which is associated with chronic, low-grade inflammation. The PD-1/PD-L1 pathway has been reported to be a negative regulatory element in immune homeostasis and to be involved in many diseases. Materials and Methods: Peripheral blood mononuclear cells (PBMCs) were obtained from type 2 diabetes patients ( n = 23) and healthy donors ( n = 20). The PD-L1 and PD-1 expressions on corresponding immune cells were evaluated by flow cytometry...
2019: Journal of Diabetes Research
Zhen Zhang, Yinghui Hu, Ningning Xu, Wenjun Zhou, Lei Yang, Rongping Chen, Rui Yang, Jia Sun, Hong Chen
Recent studies showed that alpha cells, especially immature cells and proalpha cells, might be the precursors of beta cells. Exposure to glucagon-like peptide 1 (GLP1) can ameliorate hyperglycemia in diabetic mice and restore the beta cell mass. In the present study, we adopted single high-dose (60 mg/kg, i.p.) streptozotocin (STZ) to model diabetes mellitus (DM) and randomly assigned short-tail (SD) rats to a normal group, a diabetic group, GLP1 groups (50  μ g/kg, 100  μ g/kg, and 200  μ g/kg), a GLP1 (200  μ g/kg) with exendin (9-39) group, and a GLP1 with LY294002 group...
2019: Journal of Diabetes Research
Yoshihiro Numata, Toshihide Ohya, Yasuhiko Nitta, Yumiko Yoshinaka, Azusa Shogakiuchi, Akihiro Toyota
We attempted to clarify the severity of the risk of diabetes mellitus (DM) in the individuals who repeatedly fulfill the criteria for prediabetes in both fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c). The subjects were 2347 individuals who underwent annual health checkup at our hospital. They were classified as normal glucose tolerance or prediabetes as their yearly status of glucose tolerance for three years; furthermore, the individuals classified as prediabetes were subclassified into 3 groups...
2019: Journal of Diabetes Research
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