journal
https://read.qxmd.com/read/38525280/-tbx5-genetic-variants-and-scd-cad-susceptibility-insights-from-chinese-han-cohorts
#21
JOURNAL ARTICLE
Yukun Rui, Ju Zhou, Xiaoyuan Zhen, Jianhua Zhang, Shiquan Liu, Yuzhen Gao
BACKGROUND: The prevention and prediction of sudden cardiac death (SCD) present persistent challenges, prompting exploration into common genetic variations for potential insights. T-box 5 (TBX5), a critical cardiac transcription factor, plays a pivotal role in cardiovascular development and function. This study systematically examined variants within the 500-bp region downstream of the TBX5 gene, focusing on their potential impact on susceptibility to SCD associated with coronary artery disease (SCD-CAD) in four different Chinese Han populations...
2024: PeerJ
https://read.qxmd.com/read/38525279/laboratory-evaluation-of-a-bio-insecticide-candidate-from-tangerine-peel-extracts-against-trialeurodes-vaporariorum-homoptera-aleyrodidae
#22
JOURNAL ARTICLE
Nancy Flores, Julia Prado, Rosario Espin, Hortensia Rodríguez, José-Manuel Pais-Chanfrau
BACKGROUND: The excessive use of synthetic insecticides in modern agriculture has led to environmental contamination and the development of insect resistance. Also, the prolonged use of chemical insecticides in producing flowers and tomatoes in greenhouses has caused health problems for workers and their offspring. In this study, we analyzed the efficacy of mandarin peel ( Citrus reticulata L.) essential oil (EO) as a natural insecticide against greenhouse whitefly ( Trieurodes vaporariorum W...
2024: PeerJ
https://read.qxmd.com/read/38525278/overview-of-chicken-embryo-genes-related-to-sex-differentiation
#23
JOURNAL ARTICLE
Xiaolu Luo, Jiancheng Guo, Jiahang Zhang, Zheng Ma, Hua Li
Sex determination in chickens at an early embryonic stage has been a longstanding challenge in poultry production due to the unique ZZ:ZW sex chromosome system and various influencing factors. This review has summarized the genes related to the sex differentiation of chicken early embryos (mainly Dmrt1 , Sox9 , Amh , Cyp19a1 , Foxl2 , Tle4z1 , Jun , Hintw , Ube2i , Spin1z , Hmgcs1 , Foxd1 , Tox3 , Ddx4 , cHemgn and Serpinb11 in this article), and has found that these contributions enhance our understanding of the genetic basis of sex determination in chickens, while identifying potential gene targets for future research...
2024: PeerJ
https://read.qxmd.com/read/38525277/beliefs-barriers-and-promotion-practices-of-indian-nurses-regarding-healthy-eating-for-cancer-survivors-in-a-tertiary-care-hospital-a-cross-sectional-survey
#24
JOURNAL ARTICLE
Hritika D Pai, Stephen Rajan Samuel, K Vijaya Kumar, Charu Eapen, Alicia Olsen, Justin W L Keogh
PURPOSE: To describe the beliefs, barriers and promotion practices of Indian nurses' regarding healthy eating (HE) behaviours amongst cancer survivors, and to gain insights into whether their educational qualifications might affect the promotion of HE. METHODS: Data was gathered using a validated questionnaire, 388 of the approached 400 nurses who worked at a tertiary care hospital in India gave informed consent to participate in the study. The Mann-Whitney U test and the Chi square analysis (for continuous and categorical variables respectively) were performed to carry out sub-group comparisons based on the qualification of the nurses i...
2024: PeerJ
https://read.qxmd.com/read/38525276/endosymbiont-and-gut-bacterial-communities-of-the-brown-banded-cockroach-supella-longipalpa
#25
JOURNAL ARTICLE
Kylene Guse, Jose E Pietri
The brown-banded cockroach ( Supella longipalpa ) is a widespread nuisance and public health pest. Like the German cockroach ( Blattella germanica ), this species is adapted to the indoor biome and completes the entirety of its life cycle in human-built structures. Recently, understanding the contributions of commensal and symbiotic microbes to the biology of cockroach pests, as well as the applications of targeting these microbes for pest control, have garnered significant scientific interest. However, relative to B...
2024: PeerJ
https://read.qxmd.com/read/38525275/sex-differences-in-strength-at-the-shoulder-a-systematic-review
#26
JOURNAL ARTICLE
Tamar D Kritzer, Cameron J Lang, Michael W R Holmes, Alan C Cudlip
BACKGROUND: Understanding differential strength capability between sexes is critical in ergonomics and task design. Variations in study designs and outcome measures generates challenges in establishing workplace guidelines for strength requirements to minimize upper extremity risk for workers. The purpose of this systematic review was to collate and summarize sex differences in strength at the shoulder across movement directions and contraction types. METHODS: A total of 3,294 articles were screened from four databases (Embase, Medline, SCOPUS, and Web of Science)...
2024: PeerJ
https://read.qxmd.com/read/38525274/does-novelty-influence-the-foraging-decisions-of-a-scavenger
#27
JOURNAL ARTICLE
Debottam Bhattacharjee, Shubhra Sau, Jayjit Das, Anindita Bhadra
Acquiring knowledge about the environment is crucial for survival. Animals, often driven by their exploratory tendencies, gather valuable information regarding food resources, shelter, mating partners, etc . However, neophobia, or avoiding novel environmental stimuli, can constrain their exploratory behaviour. While neophobia can reduce potential predation risks, decreased exploratory behaviour resulting from it may limit the ability to discover highly rewarding resources. Dogs ( Canis familiaris ) living in semi-urban and urban environments as free-ranging populations, although subject to various selection forces, typically have negligible predation pressure...
2024: PeerJ
https://read.qxmd.com/read/38525273/gene%C3%A2-environment-interaction-effect-of-hypothalamic%C3%A2-pituitary%C3%A2-adrenal-axis-gene-polymorphisms-and-job-stress-on-the-risk-of-sleep-disturbances
#28
JOURNAL ARTICLE
Min Zhao, Yuxi Wang, Yidan Zeng, Huimin Huang, Tong Xu, Baoying Liu, Chuancheng Wu, Xiufeng Luo, Yu Jiang
BACKGROUND: Studies have shown that chronic exposure to job stress may increase the risk of sleep disturbances and that hypothalamic‒pituitary‒adrenal (HPA) axis gene polymorphisms may play an important role in the psychopathologic mechanisms of sleep disturbances. However, the interactions among job stress, gene polymorphisms and sleep disturbances have not been examined from the perspective of the HPA axis. This study aimed to know whether job stress is a risk factor for sleep disturbances and to further explore the effect of the HPA axis gene × job stress interaction on sleep disturbances among railway workers...
2024: PeerJ
https://read.qxmd.com/read/38525272/predictive-nomogram-for-lymph-node-metastasis-and-survival-in-gastric-cancer-using-contrast-enhanced-computed-tomography-based-radiomics-a-retrospective-study
#29
JOURNAL ARTICLE
Weiteng Zhang, Sujun Wang, Qiantong Dong, Wenjing Chen, Pengfei Wang, Guanbao Zhu, Xiaolei Chen, Yiqi Cai
BACKGROUND: Lymph node involvement significantly impacts the survival of gastric cancer patients and is a crucial factor in determining the appropriate treatment. This study aimed to evaluate the potential of enhanced computed tomography (CT)-based radiomics in predicting lymph node metastasis (LNM) and survival in patients with gastric cancer before surgery. METHODS: Retrospective analysis of clinical data from 192 patients diagnosed with gastric carcinoma was conducted...
2024: PeerJ
https://read.qxmd.com/read/38515461/integrating-single-cell-and-bulk-sequencing-data-to-identify-glycosylation-based-genes-in-non-alcoholic-fatty-liver-disease-associated-hepatocellular-carcinoma
#30
JOURNAL ARTICLE
Zhijia Zhou, Yanan Gao, Longxin Deng, Xiaole Lu, Yancheng Lai, Jieke Wu, Shaodong Chen, Chengzhong Li, Huiqing Liang
BACKGROUND: The incidence of non-alcoholic fatty liver disease (NAFLD) associated hepatocellular carcinoma (HCC) has been increasing. However, the role of glycosylation, an important modification that alters cellular differentiation and immune regulation, in the progression of NAFLD to HCC is rare. METHODS: We used the NAFLD-HCC single-cell dataset to identify variation in the expression of glycosylation patterns between different cells and used the HCC bulk dataset to establish a link between these variations and the prognosis of HCC patients...
2024: PeerJ
https://read.qxmd.com/read/38515460/anti-eno1-antibody-combined-with-metformin-against-tumor-resistance-a-novel-antibody-based-platform
#31
JOURNAL ARTICLE
Xiong Shu, Hui Wen Zhang, Shi Ya Liu, Li Xin Sun, Tao Zhang, Yu Liang Ran
BACKGROUND: Antibody-based platforms ( i.e. , ADC) have emerged as one of the most encouraging tools for the cancer resistance caused by cancer stem cells (CSCs) enrichment. Our study might provide a promising therapeutic direction against drug resistance and serve as a potential precursor platform for screening ADC. METHODS: The cell migration, invasion, drug resistance, and self-renewal were assessed by the cell invasion and migration assay, wound healing assay, CCK-8 assay, colony formation assay, and sphere formation assay, respectively...
2024: PeerJ
https://read.qxmd.com/read/38515459/deciphering-the-genomes-of-motility-deficient-mutants-of-vibrio-alginolyticus-138-2
#32
JOURNAL ARTICLE
Kazuma Uesaka, Keita Inaba, Noriko Nishioka, Seiji Kojima, Michio Homma, Kunio Ihara
The motility of Vibrio species plays a pivotal role in their survival and adaptation to diverse environments and is intricately associated with pathogenicity in both humans and aquatic animals. Numerous mutant strains of Vibrio alginolyticus have been generated using UV or EMS mutagenesis to probe flagellar motility using molecular genetic approaches. Identifying these mutations promises to yield valuable insights into motility at the protein structural physiology level. In this study, we determined the complete genomic structure of 4 reference specimens of laboratory V ...
2024: PeerJ
https://read.qxmd.com/read/38515458/validation-of-cdc45-as-a-novel-biomarker-for-diagnosis-and-prognosis-of-gastric-cancer
#33
JOURNAL ARTICLE
Lihua Wu, Gan Gao, Hui Mi, Zhou Luo, Zheng Wang, Yongdong Liu, Liangyan Wu, Haihua Long, Yongqi Shen
BACKGROUND: Cell division cycle protein 45 (CDC45) has been demonstrated to play vital roles in the progression of various malignancies. However, the clinical significance of CDC45 in gastric cancer (GC) remains unreported. METHOD: In this study, we employed the TCGA database and the TCGA & GTEx dataset to compare the mRNA expression levels of CDC45 between gastric cancer tissues and adjacent or normal tissues ( p < 0.05 was considered statistically significant), which was further validated in multiple datasets including GSE13911, GSE29272, GSE118916, GSE66229, as well as RT-qPCR...
2024: PeerJ
https://read.qxmd.com/read/38515457/biochar-s-role-in-improving-pakchoi-quality-and-microbial-community-structure-in-rhizosphere-soil
#34
JOURNAL ARTICLE
Xia Wu, Fengjun Yang, Jili Zhang, Feng Gao, Yi Chen Hu, Kejun Yang, Peng Wang
BACKGROUND: Biochar amendments enhance crop productivity and improve agricultural quality. To date, studies on the correlation between different amounts of biochar in pakchoi ( Brassica campestris L.) quality and rhizosphere soil microorganisms are limited, especially in weakly alkaline soils. The experiment was set up to explore the effect of different concentrations of biochar on vegetable quality and the correlation between the index of quality and soil bacterial community structure changes...
2024: PeerJ
https://read.qxmd.com/read/38510545/changes-in-hamstring-contractile-properties-during-the-competitive-season-in-young-football-players
#35
JOURNAL ARTICLE
Paweł Pakosz, Mariusz Konieczny, Przemysław Domaszewski, Tomasz Dybek, Mariusz Gnoiński, Elżbieta Skorupska
BACKGROUND: The study aimed to examine alterations and imbalances in hamstring muscle contractile properties among young football players throughout their competitive season, and to understand how these changes might contribute to the risk of muscle injuries. Hamstring injuries are particularly common in football, yet the underlying causes and effective prevention methods remain unclear. METHODS: The research involved 74 young footballers who were assessed before the season (pre-test) and after 12 weeks of training (post-test)...
2024: PeerJ
https://read.qxmd.com/read/38500534/assessing-the-professional-quality-of-life-in-the-context-of-pediatric-care
#36
JOURNAL ARTICLE
Manal F Alharbi, Aljawharah M Alkhamshi
BACKGROUND: This study examines the professional quality of life (ProQOL), including compassion satisfaction (CS) and compassion fatigue (CF), burnout (BO) and secondary traumatic stress (STS) among registered nurses in the context of pediatric care in Riyadh city in Saudi Arabia. METHODS: This study utilised a random multistage sampling method and a survey to collect data from 250 participants on personal characteristics, work-related aspects, lifestyle, and professional quality of life...
2024: PeerJ
https://read.qxmd.com/read/38500533/clinical-significance-of-small-nuclear-ribonucleoprotein-u1-subunit-70-in-patients-with-hepatocellular-carcinoma
#37
JOURNAL ARTICLE
Dong Jiang, Xia-Ling Zhu, Yan An, Yi-Ran Li
BACKGROUND & AIMS: Small nuclear ribonucleoprotein U1 subunit 70 (SNRNP70) as one of the components of the U1 small nuclear ribonucleoprotein (snRNP) is rarely reported in cancers. This study aims to estimate the application potential of SNRNP70 in hepatocellular carcinoma (HCC) clinical practice. METHODS: Based on the TCGA database and cohort of HCC patients, we investigated the expression patterns and prognostic value of SNRNP70 in HCC. Then, the combination of SNRNP70 and alpha-fetoprotein (AFP) in 278 HCC cases was analyzed...
2024: PeerJ
https://read.qxmd.com/read/38500532/an-elisa-based-method-for-galleria-mellonella-apolipophorin-iii-quantification
#38
JOURNAL ARTICLE
Uriel Ramírez-Sotelo, Laura C García-Carnero, José A Martínez-Álvarez, Manuela Gómez-Gaviria, Héctor Manuel Mora-Montes
Mammalian models, such as murine, are used widely in pathophysiological studies because they have a high degree of similarity in body temperature, metabolism, and immune response with humans. However, non-vertebrate animal models have emerged as alternative models to study the host-pathogen interaction with minimal ethical concerns. Galleria mellonella is an alternative model that has proved useful in studying the interaction of the host with either bacteria or fungi, performing drug testing, and assessing the immunological response to different microorganisms...
2024: PeerJ
https://read.qxmd.com/read/38500531/mammal-dung-dung-beetle-trophic-networks-an-improved-method-based-on-gut-content-dna
#39
JOURNAL ARTICLE
Karen M Pedersen, Christoph von Beeren, Arianna Oggioni, Nico Blüthgen
BACKGROUND: Dung beetles provide many important ecosystem services, including dung decomposition, pathogen control, soil aeration, and secondary seed dispersal. Yet, the biology of most dung beetles remains unknown. Natural diets are poorly studied, partly because previous research has focused on choice or attraction experiments using few, easily accessible dung types from zoo animals, farm animals, or humans. This way, many links within natural food webs have certainly been missed. In this work, we aimed to establish a protocol to analyze the natural diets of dung beetles using DNA gut barcoding...
2024: PeerJ
https://read.qxmd.com/read/38500530/the-role-of-temperature-on-the-development-of-circadian-rhythms-in-honey-bee-workers
#40
JOURNAL ARTICLE
Manuel A Giannoni-Guzmán, Eddie Perez Claudio, Janpierre Aleman-Rios, Gabriel Diaz Hernandez, Melina Perez Torres, Alexander Melendez Moreno, Darimar Loubriel, Darrell Moore, Tugrul Giray, Jose L Agosto-Rivera
Circadian rhythms in honey bees are involved in various processes that impact colony survival. For example, young nurses take care of the brood constantly throughout the day and lack circadian rhythms. At the same time, foragers use the circadian clock to remember and predict food availability in subsequent days. Previous studies exploring the ontogeny of circadian rhythms of workers showed that the onset of rhythms is faster in the colony environment (~2 days) than if workers were immediately isolated after eclosion (7-9 days)...
2024: PeerJ
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