journal
https://read.qxmd.com/read/38248787/immunotherapy-combined-with-radiation-in-malignant-melanoma-without-braf-mutations-brain-metastases-favorable-response-after-immunotherapy-continued-beyond-progression
#41
Roxana-Andreea Rahnea-Nita, Laura-Florentina Rebegea, Radu-Valeriu Toma, Horia Mocanu, Ioana Soare, Raul Mihailov, Alexandru Nechifor, Mădălin Guliciuc, Georgiana Bianca Constantin, Gabriela Rahnea-Nita
We present the case of a patient who was diagnosed in 2018 with nodular Malignant Melanoma (MM) without BRAF V 600 mutations stage 3 C (pT4b pN1a M0), and who underwent adjuvant citokines treatment with Interferon alpha 2b-48 weeks. Immunotherapy was initiated in January 2021 for lung and lymph node metastases. In June 2021, there was a partial response of the lung and lymph node metastases, but there was also progression to brain metastases. Immunotherapy was continued and Whole Brain Radiotherapy (WBRT) was performed...
January 12, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248786/assessing-the-efficacy-of-laser-therapy-and-autologous-platelet-rich-plasma-prp-treatment-for-chronic-wounds
#42
JOURNAL ARTICLE
Sandor Mircea, Maghiar Laura, Horgos Maur Sebastian, Borza Ioan Lucian, Farcas Dorina Maria, Ciurescu Daniel, Cheregi Cornel Dragos, Hurjui Liliana Loredana, Sachelarie Liliana, Maghiar Paula Bianca
(1) Background: The management of persistent wounds is a topic of significant concern, particularly when they become chronic. Clinicians are focused on reducing the healing duration of chronic wounds and employing the most efficient treatments. Successful wound management requires an understanding of standard healing processes, the elements that can impede healing progress, and strategies to manage these impediments. (2) Methods: We participated in a study involving a cohort of 115 patients. Data were collected through subjective assessments via questionnaires, examining the comparative effects of laser therapy and platelet-rich plasma (PRP) on patients' conditions and monitored the progression of chronic wounds...
January 11, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248785/health-policy-for-prostate-cancer-early-detection-in-the-european-union-and-the-impact-of-opportunistic-screening-praise-u-consortium
#43
REVIEW
Katharina Beyer, Renée Leenen, Lionne D F Venderbos, Jozien Helleman, Frederique Denijs, Wichor Bramer, Vera Vasilyeva, Erik Briers, Juan Gomez Rivas, Renata Chloupkova, Ondrej Majek, Lieven Annemans, Pieter Vynckier, Partha Basu, Arunah Chandran, Roderick van den Bergh, Sarah Collen, Hendrik van Poppel, Monique J Roobol, On Behalf Of The Praise-U Consortium
With the new policy recommendation in 2022 to explore the possibilities of screening for prostate cancer by the European Commission, the landscape for prostate cancer early detection is evolving. In line with this recommendation, the PRAISE-U project aims to evaluate the early detection and diagnosis of prostate cancer through customised and risk-based screening programmes, with the goal to align protocols across European Union member states. This systematic review is part of the PRAISE-U project, with the goal to review the policy, medical guideline recommendations, and the current level of opportunistic screening presented in the scientific literature on prostate cancer early detection from 2016 to 2023 in European Union member states...
January 11, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248784/effects-of-adding-extracorporeal-shockwave-therapy-eswt-to-platelet-rich-plasma-prp-among-patients-with-rotator-cuff-partial-tear-a-prospective-randomized-comparative-study
#44
JOURNAL ARTICLE
Shu-Jui Kuo, Yu-Hsiang Su, Shih-Chan Hsu, Po-Hua Huang, Chia-Chun Hsia, Chin-Yi Liao, Sung-Hsiung Chen, Re-Wen Wu, Chieh-Cheng Hsu, Yen-Chun Lai, De-Yi Liu, Nien-En Ku, Jui-Feng Chen, Jih-Yang Ko
A rotator cuff tear is a prevalent ailment affecting the shoulder joint. The clinical efficacy of combined therapy remains uncertain for partial rotator cuff tears. In this study, we integrated extracorporeal shockwave therapy (ESWT) with platelet-rich plasma (PRP) injection, juxtaposed with PRP in isolation. Both cohorts exhibited significant improvements in visual analogue scale (VAS), Constant-Murley score (CMS), degrees of forward flexion, abduction, internal rotation, and external rotation, and the sum of range of motion (SROM) over the six-month assessment period...
January 10, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248783/a-multidisciplinary-skull-base-board-for-tumour-and-non-tumour-diseases-initial-experiences
#45
JOURNAL ARTICLE
Jure Urbančič, Saba Battelino, Roman Bošnjak, Tomislav Felbabić, Nejc Steiner, Matej Vouk, Matej Vrabec, Domen Vozel
The skull base is the area where various cancerous and non-cancerous diseases occur and represents the intersection of several medical fields. The key is an integrated treatment by specialists of multiple disciplines. We prospectively analysed patients with a skull base disease between August 2022 and 2023 and presented to the Multidisciplinary Skull Base Board (MDT-SB), which takes place once a month hybridly (in-person and remotely). Thirty-nine patients (median age of 58.2 years) were included, of which twelve (30...
January 10, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248782/systematic-review-of-current-audiological-treatment-options-for-patients-with-treacher-collins-syndrome-tcs-and-surgical-and-audiological-experiences-of-an-otorhinolaryngologist-with-tcs
#46
REVIEW
Ivana Marinac, Robert Trotić, Andro Košec
Treacher Collins syndrome (TCS) is a rare congenital craniofacial condition that affects approximately one out of fifty thousand births. Different ratios of TCS patients have conductive hearing loss: 88%1 vs. 91.4-100.00%2 . For this reason, it was examined which hearing solutions can be used with this condition and how effective they are. A systematic literature review was conducted, which showed that the bone-anchored hearing aid (BAHA, OSIA), the bone conduction implant (Bonebridge) or the active implant of the middle ear (Soundbridge) are reliable methods for the treatment of conductive hearing loss in TCS patients...
January 10, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248781/predicting-short-and-long-term-functional-outcomes-based-on-serum-s100b-protein-levels-in-patients-with-ischemic-stroke
#47
JOURNAL ARTICLE
Rakesh Jalali, Jacek Zwiernik, Ewa Rotkiewicz, Beata Zwiernik, Adam Kern, Jacek Bil, Anita Jalali, Joanna Manta, Jerzy Romaszko
BACKGROUND: Ischemic stroke is one of the leading causes of mortality and disability. The neuroimaging methods are the gold standard for diagnostics. Biomarkers of cerebral ischemia are considered to be potentially helpful in the determination of the etiology and prognosis of patients with ischemic stroke. AIM: This study aimed to investigate the usefulness of serum S100B protein levels as a short- and long-term prognostic factor in patients with ischemic stroke...
January 10, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248780/progesterone-hypersensitivity-in-assisted-reproductive-technologies-implications-for-safety-and-efficacy
#48
REVIEW
Florica Sandru, Mihai Cristian Dumitrascu, Aida Petca, Razvan-Cosmin Petca, Alexandra-Maria Roman
The global rise in the age of childbirth, influenced by changing sociodemographic patterns, has had a notable impact on fertility rates. Simultaneously, assisted reproductive techniques (ARTs) have become increasingly prevalent due to advancements in reproductive medicine. The paper explores the intersection between the surge in ARTs and the rising number of iatrogenic autoimmune progesterone dermatitis (APD). Autoimmune progesterone dermatitis, commonly known as progesterone hypersensitivity, manifests itself as a mucocutaneous hypersensitivity syndrome...
January 10, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248779/multi-omics-reveals-the-role-of-osteopontin-secreted-phosphoprotein-1-in-regulating-ovarian-aging
#49
JOURNAL ARTICLE
Li-Chuan Hsu, Chia-Jung Li, Li-Te Lin, Li-Fei Pan, Zhi-Hong Wen, Jim Jinn-Chyuan Sheu, Kuan-Hao Tsui
Secreted phosphoprotein 1 (SPP1), also known as osteopontin (OPN), is located on chromosome 4q22.1. This multifunctional secreted acidic glycoprotein is expressed intracellularly and extracellularly in various tissues, where it interacts with regulatory proteins and pro-inflammatory immune chemokines, contributing to the pathogenesis of multiple diseases. Nevertheless, the intricate genetic connections between SPP1 and ovarian aging remain largely unexplored. This study aims to bridge this knowledge gap by delving into ovarian aging and its associations with SPP1 using multi-omics data analysis...
January 9, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248778/paediatric-neurology-current-trends-rehabilitation-and-future-challenges
#50
EDITORIAL
Domenico M Romeo, Claudia Brogna
Over the past 20 years, the introduction of new neurodevelopmental assessments and neurophysiological techniques has improved the knowledge of the complexity of the central nervous system in the first period of development [...].
January 9, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248777/vulvar-lichen-sclerosus-navigating-sex-hormone-dynamics-and-pioneering-personalized-treatment-paradigm
#51
REVIEW
Adelina Popa, Mihai Cristian Dumitrascu, Aida Petca, Razvan-Cosmin Petca, Florica Sandru
Vulvar lichen sclerosus (VLS) is a frequently overlooked inflammatory disorder affecting the skin and mucous membranes of the vulva. With a propensity for atrophy, severe scarring, functional impairment, and malignant evolution, VLS is a disease that recurs frequently; early diagnosis, rapid treatment, and ongoing patient follow-up are essential. Potent topical corticosteroids (TCSs) are now widely recognized as the most effective treatment for achieving remission in VLS, but considering the potential complications of long-term treatment with potent TCSs, understanding the evolution of VLS during puberty becomes particularly crucial in determining the necessity for aggressive or more conservative therapeutic interventions...
January 8, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248776/perceived-health-benefits-in-vestibular-schwannoma-patients-with-long-term-postoperative-headache-insights-from-personality-traits-and-pain-coping-a-cross-sectional-study
#52
JOURNAL ARTICLE
Mareike Thomas, Hannah Führes, Maximilian Scheer, Stefan Rampp, Christian Strauss, Robby Schönfeld, Bernd Leplow
Postoperative headaches (POHs) following retrosigmoid microsurgery for vestibular schwannoma (VS) can significantly impact patients' perceived health benefits (PHBs). In this cross-sectional observational study, 101 VS patients were investigated. For the assessment of pain, the Rostock Headache Compendium (RoKoKo) and the German pain processing questionnaire (FESV) were used. The perceived health benefits (PHBs) were assessed by the Glasgow Benefit Inventory (GBI) and Big Five personality traits were measured using the Ten-Item Personality Inventory (TIPI-G)...
January 8, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248775/the-impact-of-clinical-pharmacist-diabetes-education-on-medication-adherence-in-patients-with-type-2-diabetes-mellitus-an-interventional-study-from-khartoum-sudan
#53
JOURNAL ARTICLE
Safaa Badi, Sara Zainelabdein Suliman, Rayan Almahdi, Mohammed A Aldomah, Mohamed ELsir Marzouq, Eiman Eltayeb M Ibrahim, Musaab Ahmed, Mohamed H Ahmed, Habab Khalid Elkheir, Mohamed Izham Mohamed Ibrahim
BACKGROUND: Continuous therapeutic care with good medication adherence is the cornerstone of management of all chronic diseases including diabetes. This study aimed to evaluate the impact of clinical pharmacist intervention on the medication adherence in individuals with type 2 diabetes (T2DM). METHODS: This was a randomized, double-blind, controlled trial conducted at a diabetes clinic located at Omdurman Military Hospital, Sudan. Individuals with T2DM attending the diabetes clinic within 1 year were selected...
January 8, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248774/is-augmented-reality-technology-effective-in-locating-the-apex-of-teeth-undergoing-apicoectomy-procedures
#54
JOURNAL ARTICLE
Nuria Tamayo-Estebaranz, María José Viñas, Patricia Arrieta-Blanco, Álvaro Zubizarreta-Macho, Juan Manuel Aragoneses-Lamas
This study seeks to assess the accuracy of apical location using an augmented reality (AR) device with a free-hand method. Sixty (60) osteotomy site preparations were randomly assigned to one of two study groups: A. AR device (AR) ( n = 30), and B. conventional free-hand method (FHM) ( n = 30). Preoperative CBCT scans and intraoral scans were taken and uploaded to specialized implant-planning software to virtually plan preparations for the apical location osteotomy sites. The planning software was then used to automatically segment the teeth in each experimental model for their complete visualization using the AR device...
January 7, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248773/frontal-fibrosing-alopecia-and-reproductive-health-assessing-the-role-of-sex-hormones-in-disease-development
#55
REVIEW
Alexandra-Maria Roman, Răzvan-Cosmin Petca, Mihai Cristian Dumitrașcu, Aida Petca, Andreea-Iuliana Ionescu Miron, Florica Șandru
Frontal Fibrosing Alopecia (FFA) is a distinctive form of cicatricial alopecia characterized by gradual hairline recession, predominantly affecting postmenopausal individuals, thus implying a potential hormonal origin. This narrative review, spanning 2000 to 2023, delves into PubMed literature, focusing on the menopausal and hormonal status of women with FFA. The objective is to unravel the intricate nature of FFA and its plausible associations with hormonal dysregulations in women. While menopause remains a pivotal demographic characteristic linked to FFA, existing data suggest that its hormonal imbalances may not fully account for the development of FFA...
January 5, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248772/prognostic-value-of-radiomic-analysis-using-pre-and-post-treatment-18-f-fdg-pet-ct-in-patients-with-laryngeal-cancer-and-hypopharyngeal-cancer
#56
JOURNAL ARTICLE
Joon Ho Choi, Joon Young Choi, Sang-Keun Woo, Ji Eun Moon, Chae Hong Lim, Soo Bin Park, Seongho Seo, Yong Chan Ahn, Myung-Ju Ahn, Seung Hwan Moon, Jung Mi Park
BACKGROUND: The prognostic value of conducting 18 F-FDG PET/CT imaging has yielded different results in patients with laryngeal cancer and hypopharyngeal cancer, but these results are controversial, and there is a lack of dedicated studies on each type of cancer. This study aimed to evaluate whether combining radiomic analysis of pre- and post-treatment 18 F-FDG PET/CT imaging features and clinical parameters has additional prognostic value in patients with laryngeal cancer and hypopharyngeal cancer...
January 5, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248771/chatgpt-may-offer-an-adequate-substitute-for-informed-consent-to-patients-prior-to-total-knee-arthroplasty-yet-caution-is-needed
#57
JOURNAL ARTICLE
Arne Kienzle, Marcel Niemann, Sebastian Meller, Clemens Gwinner
Prior to undergoing total knee arthroplasty (TKA), surgeons are often confronted with patients with numerous questions regarding the procedure and the recovery process. Due to limited staff resources and mounting individual workload, increased efficiency, e.g., using artificial intelligence (AI), is of increasing interest. We comprehensively evaluated ChatGPT's orthopedic responses using the DISCERN instrument. Three independent orthopedic surgeons rated the responses across various criteria. We found consistently high scores, predominantly exceeding a score of three out of five in almost all categories, indicative of the quality and accuracy of the information provided...
January 5, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248770/rethinking-fluid-responsiveness-during-septic-shock-ameliorate-accuracy-of-noninvasive-cardiac-output-measurements-through-evaluation-of-arterial-biomechanical-properties
#58
JOURNAL ARTICLE
Vasileios Papaioannou, Theodoros Papaioannou
Beat-to-beat estimates of cardiac output from the direct measure of peripheral arterial blood pressure rely on the assumption that changes in the waveform morphology are related to changes in blood flow and vasomotor tone. However, in septic shock patients, profound changes in vascular tone occur that are not uniform across the entire arterial bed. In such cases, cardiac output estimates might be inaccurate, leading to unreliable evaluation of fluid responsiveness. Pulse wave velocity is the gold-standard method for assessing different arterial biomechanical properties...
January 5, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248769/inhibitors-of-immune-checkpoints-small-molecule-and-peptide-based-approaches
#59
REVIEW
Natalie Fuchs, Longfei Zhang, Laura Calvo-Barreiro, Katarzyna Kuncewicz, Moustafa Gabr
The revolutionary progress in cancer immunotherapy, particularly the advent of immune checkpoint inhibitors, marks a significant milestone in the fight against malignancies. However, the majority of clinically employed immune checkpoint inhibitors are monoclonal antibodies (mAbs) with several limitations, such as poor oral bioavailability and immune-related adverse effects (irAEs). Another major limitation is the restriction of the efficacy of mAbs to a subset of cancer patients, which triggered extensive research efforts to identify alternative approaches in targeting immune checkpoints aiming to overcome the restricted efficacy of mAbs...
January 4, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38248768/clinical-technical-and-mri-features-associated-with-patients-outcome-at-3-months-and-2-years-following-prostate-artery-embolization-is-there-an-added-value-of-radiomics
#60
JOURNAL ARTICLE
Antoine Martin, Clément Marcelin, François Petitpierre, Eva Jambon, Rim Maaloum, Nicolas Grenier, Yann Le Bras, Amandine Crombé
Our aim was to investigate which features were associated with clinical successes at short- and mid-terms following prostate artery embolization (PAE) for symptomatic benign prostate hypertrophy (BPH). All adults treated by PAE for BPH at our referral center between January 2017 and March 2021, with pre-treatment MRI, technical success, and follow-up at 3 months and 2 years were included in this single-center retrospective study. Radiologists reviewed the prostatic protrusion index (PPI), adenomatous dominant BPH (adBPH), and Wasserman classification on pre-treatment MRI...
January 4, 2024: Journal of Personalized Medicine
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