journal
https://read.qxmd.com/read/37241027/highly-selective-targeting-of-pancreatic-cancer-in-the-liver-with-a-near-infrared-anti-muc5ac-probe-in-a-pdox-mouse-model-a-proof-of-concept-study
#21
JOURNAL ARTICLE
Michael A Turner, Kristin E Cox, Nicholas Neel, Siamak Amirfakhri, Hiroto Nishino, Bryan M Clary, Mojgan Hosseini, Gopalakrishnan Natarajan, Kavita Mallya, Aaron M Mohs, Robert M Hoffman, Surinder K Batra, Michael Bouvet
Accurately identifying metastatic disease is critical to directing the appropriate treatment in pancreatic cancer. Mucin 5AC is overexpressed in pancreatic cancer but absent in normal pancreas tissue. The present proof-of-concept study demonstrates the efficacy of an anti-mucin 5AC antibody conjugated to an IR800 dye (MUC5AC-IR800) to preferentially label a liver metastasis of pancreatic cancer ( Panc Met ) in a unique patient-derived orthotopic xenograft (PDOX) model. In orthotopic models, the mean tumor to background ratio was 1...
May 20, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241026/the-comparison-of-predicting-factors-and-outcomes-of-minoca-and-stemi-patients-in-the-5-year-follow-up
#22
JOURNAL ARTICLE
Patryk Buller, Adam Kern, Maciej Tyczyński, Wojciech Rosiak, Włodzimierz Figatowski, Robert J Gil, Jacek Bil
The long-term outcomes of patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) are still not well known. This study aimed to compare the characteristics and outcomes between MINOCA and STEMI patients in a 5-year follow-up. Between 2010 and 2015 we identified 3171 coronary angiography procedures performed due to acute coronary syndrome, from which 153 had a working MINOCA diagnosis, and the final diagnosis of MINOCA was ascribed to 112 (5.8%) patients. Additionally, we matched 166 patients with STEMI and obstructive coronary arteries as the reference group...
May 19, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241025/the-deep-mcl-line-a-reliable-anatomical-landmark-to-optimize-the-tibial-cut-in-uka
#23
JOURNAL ARTICLE
Sébastien Parratte, Jeremy Daxhelet, Jean-Noel Argenson, Cécile Batailler
The extramedullary guides for the tibial resection during medial unicompartmental knee arthroplasty (UKA) are inaccurate, with an error risk in coronal and sagittal planes and cut thickness. It was our hypothesis that the use of anatomical landmarks for the tibial cut can help the surgeon to improve accuracy. The technique described in this paper is based on the use of a simple and reproducible anatomical landmark. This landmark is the line of insertion of the fibers of the deep medial collateral ligament (MCL) around the anterior half of the medial tibial plateau called the "Deep MCL insertion line"...
May 19, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241024/morphological-variation-of-the-mandible-in-the-orthognathic-population-a-morphological-study-using-statistical-shape-modelling
#24
JOURNAL ARTICLE
Hylke van der Wel, Bingjiang Qiu, Fred K L Spijkervet, Johan Jansma, Rutger H Schepers, Joep Kraeima
The aim of this study was to investigate the value of 3D Statistical Shape Modelling for orthognathic surgery planning. The goal was to objectify shape variations in the orthognathic population and differences between male and female patients by means of a statistical shape modelling method. Pre-operative CBCT scans of patients for whom 3D Virtual Surgical Plans (3D VSP) were developed at the University Medical Center Groningen between 2019 and 2020 were included. Automatic segmentation algorithms were used to create 3D models of the mandibles, and the statistical shape model was built through principal component analysis...
May 19, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241023/ligand-gated-ion-channels-prognostic-and-therapeutic-implications-for-gliomas
#25
REVIEW
Grace Hey, Rohan Rao, Ashley Carter, Akshay Reddy, Daisy Valle, Anjali Patel, Drashti Patel, Brandon Lucke-Wold, Daniel Pomeranz Krummel, Soma Sengupta
Gliomas are common primary brain malignancies that remain difficult to treat due to their overall aggressiveness and heterogeneity. Although a variety of therapeutic strategies have been employed for the treatment of gliomas, there is increasing evidence that suggests ligand-gated ion channels (LGICs) can serve as a valuable biomarker and diagnostic tool in the pathogenesis of gliomas. Various LGICs, including P2X, SYT16, and PANX2, have the potential to become altered in the pathogenesis of glioma, which can disrupt the homeostatic activity of neurons, microglia, and astrocytes, further exacerbating the symptoms and progression of glioma...
May 19, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241022/the-changing-environment-in-postgraduate-education-in-orthopedic-surgery-and-neurosurgery-and-its-impact-on-technology-driven-targeted-interventional-and-surgical-pain-management-perspectives-from-europe-latin-america-asia-and-the-united-states
#26
JOURNAL ARTICLE
Kai-Uwe Lewandrowski, John C Elfar, Zong-Ming Li, Benedikt W Burkhardt, Morgan P Lorio, Peter A Winkler, Joachim M Oertel, Albert E Telfeian, Álvaro Dowling, Roth A A Vargas, Ricardo Ramina, Ivo Abraham, Marjan Assefi, Huilin Yang, Xifeng Zhang, Jorge Felipe Ramírez León, Rossano Kepler Alvim Fiorelli, Mauricio G Pereira, Paulo Sérgio Teixeira de Carvalho, Helton Defino, Jaime Moyano, Kang Taek Lim, Hyeun-Sung Kim, Nicola Montemurro, Anthony Yeung, Pietro Novellino
Personalized care models are dominating modern medicine. These models are rooted in teaching future physicians the skill set to keep up with innovation. In orthopedic surgery and neurosurgery, education is increasingly influenced by augmented reality, simulation, navigation, robotics, and in some cases, artificial intelligence. The postpandemic learning environment has also changed, emphasizing online learning and skill- and competency-based teaching models incorporating clinical and bench-top research. Attempts to improve work-life balance and minimize physician burnout have led to work-hour restrictions in postgraduate training programs...
May 18, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241021/perceptions-and-usability-of-prevention-a-breast-cancer-risk-assessment-e-platform
#27
JOURNAL ARTICLE
Samar Attieh, Marika Monarque, Andrew Durand, Saima Ahmed, Bartha M Knoppers, Jacques Simard, Carmen G Loiselle
BACKGROUND: The PREVENTION e-platform was developed to provide accessible and evidence-based health information tailored to different Breast Cancer (BC) risk levels. The demonstration study objectives were to (1) assess the usability and perceived impact of PREVENTION on women with assigned hypothetical BC risk levels (i.e., near population, intermediate or high) and (2) explore perceptions and recommendations for e-platform improvement. METHODS: Thirty women with no history of cancer were recruited through social media, commercial centers, health clinics, and community settings in Montreal, Qc, Canada...
May 18, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241020/forecasting-individual-patients-best-time-for-surgery-in-colon-rectal-cancer-by-tumor-regression-during-and-after-neoadjuvant-radiochemotherapy
#28
JOURNAL ARTICLE
Emanuele Martorana, Paolo Castorina, Gianluca Ferini, Stefano Forte, Marzia Mare
The standard treatment of locally advanced rectal cancer is neoadjuvant chemoradiotherapy before surgery. For those patients experiencing a complete clinical response after the treatment, a watch-and-wait strategy with close monitoring may be practicable. In this respect, the identification of biomarkers of the response to therapy is extremely important. Many mathematical models have been developed or used to describe tumor growth, such as Gompertz's Law and the Logistic Law. Here we show that the parameters of those macroscopic growth laws, obtained by fitting the tumor evolution during and immediately after therapy, are a useful tool for evaluating the best time for surgery in this type of cancer...
May 18, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241019/predicting-hospital-ward-admission-from-the-emergency-department-a-systematic-review
#29
REVIEW
Nekane Larburu, Laiene Azkue, Jon Kerexeta
BACKGROUND: The emergency department (ED) is often overburdened, due to the high influx of patients and limited availability of attending physicians. This situation highlights the need for improvement in the management of, and assistance provided in the ED. A key point for this purpose is the identification of patients with the highest risk, which can be achieved using machine learning predictive models. The objective of this study is to conduct a systematic review of predictive models used to detect ward admissions from the ED...
May 18, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241018/systematic-literature-review-and-early-benefit-of-cochlear-implantation-in-two-pediatric-auditory-neuropathy-cases
#30
Thomas Keintzel, Tobias Raffelsberger, Lisa Niederwanger, Gina Gundacker, Thomas Rasse
Approximately 1 in 10 children with hearing loss is affected by auditory neuropathy spectrum disorder (ANSD). People who have ANSD usually have great difficulty understanding speech or communicating. However, it is possible for these patients to have audiograms that may indicate profound hearing loss up to normal hearing. This disorder is prognosed with positive, intact or present otoacoustic emissions (OAE) and/or cochlear microphonics (CM) as well as abnormal or absent auditory brainstem responses (ABR). Treatment methods include conventional hearing aids as well as cochlear implants...
May 17, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241017/sentinel-lymph-node-impact-on-the-quality-of-life-of-patients-with-endometrial-cancer
#31
JOURNAL ARTICLE
Virginia García-Pineda, Alicia Hernández, Sonia Garrido-Mallach, Elena Rodríguez-González, María Alonso-Espías, Myriam Gracia, Rocío Arnedo, Ignacio Zapardiel
OBJECTIVE: Given the improvement in the surgical treatment of endometrial cancer with the inclusion of sentinel lymph node biopsy (SLNB), our aim was to evaluate the impact of this minimally invasive and tailored nodal assessment on patients' quality of life (QoL). METHODS: This was a cross-sectional study conducted in a single-centre, tertiary-level hospital. Patients diagnosed with preoperative early-stage endometrial cancer, who underwent primary surgical treatment between August 2015 and November 2021, were included...
May 17, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241016/comparison-of-anatomical-preformed-titanium-implants-and-patient-specific-cad-cam-implants-in-the-primary-reconstruction-of-isolated-orbital-fractures-a-retrospective-study
#32
JOURNAL ARTICLE
Sebastian Pietzka, Markus Wenzel, Karsten Winter, Frank Wilde, Alexander Schramm, Marcel Ebeling, Robin Kasper, Mario Scheurer, Andreas Sakkas
BACKGROUND/AIM: Reconstruction of the fractured orbit remains a challenge. The aim of this study was to compare anatomical preformed titanium orbital implants with patient-specific CAD/CAM implants for precision and intraoperative applicability. MATERIAL AND METHODS: A total of 75 orbital reconstructions from 2012 to 2022 were retrospectively assessed for their precision of implant position and intra- and postoperative revision rates. For this purpose, the implant position after digital orbital reconstruction was checked for deviations by mirroring the healthy orbit at 5 defined points, and the medical records of the patients were checked for revisions...
May 17, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241015/mechanisms-of-allergen-immunotherapy-and-potential-biomarkers-for-clinical-evaluation
#33
REVIEW
Umit M Sahiner, Mattia Giovannini, Maria M Escribese, Giovanni Paoletti, Enrico Heffler, Montserrat Alvaro Lozano, Domingo Barber, Giorgio Walter Canonica, Oliver Pfaar
Allergen-immunotherapy (AIT) is an efficacious and disease-modifying treatment option for IgE-mediated diseases. Among these allergic rhinitis, insect venom allergy, food allergy, and allergic asthma are the most common candidates for AIT. AIT gives rise to clinical immunotolerance which may last for years after the treatment cessation. Mechanisms of AIT include suppression of allergic inflammation in target tissues and stimulation of the production of blocking antibodies, especially IgG4 and IgA. These mechanisms are followed by a reduction of underlying allergen-specific Th2 cell-driven responses to the allergens...
May 17, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241014/depression-and-anxiety-in-heart-transplant-recipients-prevalence-and-impact-on-post-transplant-outcomes
#34
JOURNAL ARTICLE
Emyal Alyaydin, Juergen Reinhard Sindermann, Jeanette Köppe, Joachim Gerss, Patrik Dröge, Thomas Ruhnke, Christian Günster, Holger Reinecke, Jannik Feld
BACKGROUND: Depression and anxiety (DA) are common mental disorders in patients with chronic diseases, but the research regarding their prevalence in heart transplantation (HTx) is still limited. METHODS: We performed an analysis of the prevalence and prognostic relevance of DA in patients who underwent HTx between 2010 and 2018 in Germany. Data were obtained from Allgemeine Ortskrankenkasse (AOK), which is the largest public health insurance provider. RESULTS: Overall, 694 patients were identified...
May 17, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241013/increased-red-blood-cell-distribution-predicts-severity-of-chronic-obstructive-pulmonary-disease-exacerbation
#35
JOURNAL ARTICLE
Elias Saad, Basheer Maamoun, Assy Nimer
INTRODUCTION: Increased red blood cell distribution width (RDW) has been reported to be related to underlying chronic inflammation. Our aim is to investigate the relationship of different complete blood count (CBC) parameters such as hemoglobin level, mean corpuscular volume (MCV), mean platelet volume (MPV) or RDW with COPD exacerbation severity. METHODS: In the present retrospective analysis, consecutive patients admitted with the diagnosis of "COPD Exacerbation" between 1 January 2012 and 31 December 2015 were evaluated...
May 17, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241012/introducing-radiotherapy-in-metastatic-merkel-cell-carcinoma-patients-with-limited-progression-on-avelumab-an-effective-step-against-primary-and-secondary-immune-resistance
#36
JOURNAL ARTICLE
Gianluca Ferini, Valentina Zagardo, Paola Critelli, Anna Santacaterina, Serena Sava, Mandara Muralidhar Harikar, Tejas Venkataram, Giuseppe Emmanuele Umana, Anna Viola, Vito Valenti, Stefano Forte
PURPOSE: To investigate the ability of radiotherapy (RT) to prolong progression-free survival (PFS) and to report treatment-related toxicities among oligoprogressive metastatic Merkel cell carcinoma (mMCC) patients on avelumab. METHODS: We retrospectively collected clinical data on mMCC patients who underwent radiotherapy for limited progression on avelumab. Patients were categorized as primary or secondary immune refractory depending on the time of onset of resistance to immunotherapy (at the first or subsequent follow-up visits after avelumab initiation)...
May 17, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241011/comparative-evaluation-of-sildenafil-citrate-and-estrogen-as-an-adjuvant-therapy-for-treatment-of-unexplained-infertility-in-women
#37
JOURNAL ARTICLE
Ahmed E Altyar, Marian S Boshra, Ahmed Essam Abou Warda, Sherwet M Shawkey, Sara Abdallah Mohamed Salem, Rania M Sarhan, Neven Sarhan
BACKGROUND: Uterine blood flow determines endometrial thickness. This study examined how vaginal sildenafil citrate and estradiol valerate altered endometrial thickness, blood flow, and fertility in infertile women. METHODS: This study observed 148 infertile women whose infertility was unexplained. Group 1 comprised 48 patients who received oral estradiol valerate (Cyclo-Progynova 2 mg/12 h white tablets) from day 6 till ovulation was initiated with clomiphene citrate...
May 17, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241010/neuroendocrine-influencers-and-associated-factors-that-shape-jaw-movement-and-growth-in-temporomandibular-joint-disorder-management-a-systematic-review-of-clinical-and-radiographic-evidence
#38
REVIEW
Taseef Hasan Farook, James Dudley
OBJECTIVE: To investigate the influence of endogenous and exogenous neuroendocrine analogues on the range and motion of jaw movement, mandibular growth, and factors affecting condylar guidance in patients with temporomandibular joint disorders using clinical assessment and radiographic imaging. MATERIAL AND METHODS: Eligible articles were extracted from eleven databases in early 2023 and screened following PRISMA protocols. Certainty of evidence and potential biases were assessed using the GRADE approach...
May 16, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241009/clinical-application-of-circular-rnas-as-biomarkers-in-acute-ischemic-stroke
#39
REVIEW
Chiara Siracusa, Niccolò Vono, Maria Benedetta Morano, Jolanda Sabatino, Isabella Leo, Ceren Eyileten, Eleonora Cianflone, Marek Postula, Daniele Torella, Salvatore De Rosa
Despite the substantial improvement in diagnosis and treatment within the last decades, ischemic stroke still represents a challenge, responsible still for a high burden of morbidity and mortality. Among the unmet clinical needs are the difficulties in identifying those subjects with the greatest risk of developing a stroke, the challenges in obtaining a timely diagnosis, the prompt recognition of the different clinical forms of stroke, the assessment of the response to treatments and the prognostic assessment...
May 16, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37241008/open-heart-cardio-thoracic-biological-valve-replacement-following-complicated-transcatheter-aortic-valve-implantation
#40
Aneta Klotzka, Patrycja Woźniak, Marcin Misterski, Michał Rodzki, Mateusz Puślecki, Marek Jemielity, Marek Grygier, Aleksander Araszkiewicz, Sylwia Iwańczyk, Piotr Buczkowski
Transcatheter aortic valve implantation (TAVI) is currently becoming the method of choice in high-risk patients with severe aortic valve stenosis. Post-TAVI complications are more common owing to the increasing use of the method. The majority of TAVI complications derive from concomitant aortic stenosis with moderate/severe aortic insufficiency, paravalvular leak, and atrioventricular block. The contemporary TAVI qualification process includes a thorough echocardiography and angio-CT of the aorta, which is crucial in assessing valve measurements, determining the position of the coronary arteries branching from the aorta, and choosing the optimal valve size...
May 16, 2023: Journal of Personalized Medicine
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