Catherine M Stein, Lindsay Sausville, Christian Wejse, Rafal S Sobota, Nicola M Zetola, Philip C Hill, W Henry Boom, William K Scott, Giorgio Sirugo, Scott M Williams
Purpose of review: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a major public health threat globally. Several lines of evidence support a role for host genetic factors in resistance/susceptibility to TB disease and MTB infection. However, results across candidate gene and genome-wide association studies (GWAS) are largely inconsistent, so a cohesive genetic model underlying TB risk has not emerged. Recent Findings: Despite the difficulties in identifying consistent genetic associations, genetic studies of TB and MTB infection have revealed a few well-documented loci...
December 2017: Current Genetic Medicine Reports