journal
https://read.qxmd.com/read/38464682/alleviating-neonatal-intensive-care-unit-stress-a-chinese-medicine-approach-in-neonatal-rats
#1
JOURNAL ARTICLE
Yingxin Li, Xi Huang, Yanlin Hu, Liming Yang, Xiujuan Zhang, Qiong Chen
BACKGROUND: Premature infants are exposed to numerous stressors in neonatal intensive care unit (NICU) during a crucial period for brain development; this period exerts long-term influences on cognitive and behavioral development. AIMS: To evaluate the effect of NICU-related stress on neonatal rat pups and explore the effect of Chinese medicine treatment (CMT). METHODS: Sixty male rat pups were randomly assigned to three groups: the control group, the NICU group (NICU-related stress), and the CMT group (NICU-related stress plus CMT)...
2024: BioMed Research International
https://read.qxmd.com/read/38464681/deep-learning-combined-with-radiologist-s-intervention-achieves-accurate-segmentation-of-hepatocellular-carcinoma-in-dual-phase-magnetic-resonance-images
#2
JOURNAL ARTICLE
Yufeng Ye, Naiwen Zhang, Dasheng Wu, Bingsheng Huang, Xun Cai, Xiaolei Ruan, Liangliang Chen, Kun Huang, Zi-Ping Li, Po-Man Wu, Jinzhao Jiang, Guo Dan, Zhenpeng Peng
PURPOSE: Segmentation of hepatocellular carcinoma (HCC) is crucial; however, manual segmentation is subjective and time-consuming. Accurate and automatic lesion contouring for HCC is desirable in clinical practice. In response to this need, our study introduced a segmentation approach for HCC combining deep convolutional neural networks (DCNNs) and radiologist intervention in magnetic resonance imaging (MRI). We sought to design a segmentation method with a deep learning method that automatically segments using manual location information for moderately experienced radiologists...
2024: BioMed Research International
https://read.qxmd.com/read/38456098/screening-marine-microbial-metabolites-as-promising-inhibitors-of-borrelia-garinii-a-structural-docking-approach-towards-developing-novel-lyme-disease-treatment
#3
JOURNAL ARTICLE
Zarrin Basharat, Sadia Sattar, Ammar Abdulraheem Bahauddin, Abdulaziz K Al Mouslem, Ghallab Alotaibi
Lyme disease caused by the Borrelia species is a growing health concern in many parts of the world. Current treatments for the disease may have side effects, and there is also a need for new therapies that can selectively target the bacteria. Pathogens responsible for Lyme disease include B. burgdorferi , B. afzelii , and B. garinii . In this study, we employed structural docking-based screening to identify potential lead-like inhibitors against the bacterium. We first identified the core essential genome fraction of the bacterium, using 37 strains...
2024: BioMed Research International
https://read.qxmd.com/read/38456097/quercetin-as-a-promising-antiprotozoan-phytochemical-current-knowledge-and-future-research-avenues
#4
REVIEW
Hamed Memariani, Mojtaba Memariani, Abdolmajid Ghasemian
Despite tremendous advances in the prevention and treatment of infectious diseases, only few antiparasitic drugs have been developed to date. Protozoan infections such as malaria, leishmaniasis, and trypanosomiasis continue to exact an enormous toll on public health worldwide, underscoring the need to discover novel antiprotozoan drugs. Recently, there has been an explosion of research into the antiprotozoan properties of quercetin, one of the most abundant flavonoids in the human diet. In this review, we tried to consolidate the current knowledge on the antiprotozoal effects of quercetin and to provide the most fruitful avenues for future research...
2024: BioMed Research International
https://read.qxmd.com/read/38449509/identifying-g6pc3-as-a-potential-key-molecule-in-hypoxic-glucose-metabolism-of-glioblastoma-derived-from-the-depiction-of-18-f-fluoromisonidazole-and-18-f-fluorodeoxyglucose-positron-emission-tomography
#5
JOURNAL ARTICLE
Michinari Okamoto, Shigeru Yamaguchi, Ryosuke Sawaya, Sumire Echizenya, Yukitomo Ishi, Sadahiro Kaneko, Hiroaki Motegi, Takuya Toyonaga, Kenji Hirata, Miki Fujimura
PURPOSE: Glioblastoma is the most aggressive primary brain tumor, characterized by its distinctive intratumoral hypoxia. Sequential preoperative examinations using fluorine-18-fluoromisonidazole (18 F-FMISO) and fluorine-18-fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET) could depict the degree of glucose metabolism with hypoxic condition. However, molecular mechanism of glucose metabolism under hypoxia in glioblastoma has been unclear. The aim of this study was to identify the key molecules of hypoxic glucose metabolism...
2024: BioMed Research International
https://read.qxmd.com/read/38445167/assessment-of-violence-during-covid-19-among-reproductive-age-women-in-arsi-zone-south-east-ethiopia
#6
JOURNAL ARTICLE
Gebi Agero, Kelil Haji Bedane, Mesfin Tafa Segni, Abdene Weya Kaso, Aman Nebi Ayato, Dida Batu Bedada, Akalu Ermias Mieso
BACKGROUND: Preventive measures, like staying at home during lockdown, are mandatory during the COVID-19 pandemic. Particularly as a result of staying at home, violence against women is beginning to increase in correlation with these measures. Therefore, the purpose of this study was to assess the prevalence of violence against women of reproductive age during the COVID-19 pandemic in the Arsi Zone. METHODS: A community-based cross-sectional study design was employed from February 15 to March 30, 2021...
2024: BioMed Research International
https://read.qxmd.com/read/38435541/anatomical-bases-of-the-temporal-muscle-trigger-points
#7
JOURNAL ARTICLE
Luis Carlos Fernandez Garrido, Giulianna Simonetti, Samir Omar Saleh, Flávio Hojaij, Mauro Andrade, Alfredo Luiz Jacomo, Flavia Emi Akamatsu
METHOD: Temporal muscles of 14 adult cadavers were studied. The muscle bellies were divided into six areas, three superior (1.2 and 3) and three inferior areas (4, 5, and 6) lower, according to a Cartesian plane to analyze and describe the entry points of the branches of the deep temporal nerves into the muscle. The branching distribution was analyzed using Poisson log-linear tests with Bonferroni post hoc tests for comparison between groups (sextants) ( p < 0.05). RESULTS: Deep temporal nerve entry points were found in the temporal muscle in all areas...
2024: BioMed Research International
https://read.qxmd.com/read/38435540/analysis-of-characteristics-of-endometrial-carcinoma-in-peri-and-postmenopausal-women-with-abnormal-uterine-bleeding
#8
JOURNAL ARTICLE
Ye Yanli, Wang Tian Mei, Li Cong
OBJECTIVE: To analyze the menstrual characteristics of endometrial carcinoma and investigate whether abnormal uterine bleeding in the perimenopausal period differs from postmenopausal bleeding. METHODS: We conducted a retrospective analysis of 928 cases of endometrial carcinoma in patients admitted from January 2016 to December 2022. We gathered fundamental clinical data and analyzed distinct clinical risk factors between the perimenopausal and postmenopausal groups...
2024: BioMed Research International
https://read.qxmd.com/read/38435539/the-oxidative-status-and-na-k-atpase-activity-in-obsessive-compulsive-disorder-a-case-control-study
#9
JOURNAL ARTICLE
Amir Hossein Mohammadi, Ebrahim Balandeh, Jila Hasani, Mohammad Karimian, Vajiheh Arabshahi, Morteza Pourfarzam, Fereshteh Bahmani, Gholamreza Namazi
BACKGROUND: Oxidative stress is involved in pathogenesis of some psychiatric disorders. To examine the role of oxidative stress in the etiopathogenesis of obsessive-compulsive disorder (OCD), we aimed to determine oxidative stress indices, including malondialdehyde (MDA) levels in serum and red blood cells (RBC) membrane, total antioxidant capacity (TAC), serum glutathione (GSH) levels, serum antioxidant vitamins (A and E), and Na+ /K+ -ATPase activity, in patients with the mentioned disorder vs...
2024: BioMed Research International
https://read.qxmd.com/read/38435538/a-systematic-review-of-oral-modifications-caused-by-the-prolonged-application-of-continuous-positive-airway-pressure-cpap-and-intraoral-appliances-in-patients-with-obstructive-sleep-apnea-osa
#10
REVIEW
Niloofar Jafarimehrabady, Andrea Scribante, Patrizia Defabianis, Giuseppe Merlati, Marina Consuelo Vitale
OBJECTIVE: Prolonged use of oral devices as a substitute for traditional treatments has been studied in relation to the dental and skeletal changes associated with obstructive sleep apnea syndrome (OSA), which is a sleep-breathing disorder. MATERIALS AND METHODS: A review of articles indexed in PubMed, Google Scholar, Cochrane Library, Scopus, Web of Sciences, and CINHAL databases in September 2022 based on MeSH-based keywords with "dental and skeletal" and "oral appliance" and "obstructive sleep apnea" was examined to ensure that the keywords alone or cross-linked, depending on which base of the searched data, were used...
2024: BioMed Research International
https://read.qxmd.com/read/38435537/knowledge-attitude-practice-and-associated-factors-of-implant-use-in-women-ethiopia
#11
JOURNAL ARTICLE
Kaleab Tesfaye Tegegne, Girma Teferi, Tadele Kassahun Wudu, Yideg Abinew, Eleni Tesfaye Tegegne, Mekibib Kassa Tessema
BACKGROUND: The world is in a dramatic expansion of population that resulted from the continued high birth rates in developing countries. At present, only a handful of countries have reduced fertility rates. That is enough to make gains as a result of reduced fertility or to ensure that their population will stabilize unforeseeable future. Ethiopia is the second largest country by population in Africa, but contraceptive use in Ethiopia is still low. OBJECTIVE: The main objective of the study was to assess knowledge, attitude, and practice and associated factors towards implant use among married reproductive age group women...
2024: BioMed Research International
https://read.qxmd.com/read/38419693/retracted-physical-exercise-and-patients-with-chronic-renal-failure-a-meta-analysis
#12
BioMed Research International
[This retracts the article DOI: 10.1155/2017/7191826.].
2024: BioMed Research International
https://read.qxmd.com/read/38410788/anticancer-action-of-silver-nanoparticles-in-skbr3-breast-cancer-cells-through-promotion-of-oxidative-stress-and-apoptosis
#13
JOURNAL ARTICLE
Mohammad Vahabirad, Sajedeh Daei, Roghayeh Abbasalipourkabir, Nasrin Ziamajidi
Silver nanoparticles (AgNPs) are known as one of the highly utilized NPs owing to their unique characteristics in the field of cancer research. The goal of this research was to explore the oxidative stress, apoptosis, and angiogenesis in SKBR3 breast cancer cells after exposure to AgNPs. The survival rate of SKBR3 cancer cells and MCF-10A normal breast cells was assessed under the effects of different concentrations (0, 32, 64, 128, and 250  μ g/ml) by MTT method. The oxidative condition was assessed by measuring reactive oxygen species (ROS) production, total oxidant status (TOS), total antioxidant capacity (TAC), malondialdehyde (MDA), and antioxidant enzyme activity (CAT, GPx, and CAT) using colorimetric-based kits...
2024: BioMed Research International
https://read.qxmd.com/read/38405427/patient-satisfaction-with-the-implementation-of-telehealth-in-ambulatory-care-during-the-covid-19-pandemic-a-single-institution-experience
#14
JOURNAL ARTICLE
Berhane Yohannes Hailu, Ephrem Berhe, Awol Yemane, Merhawit Atsbha Abera, Samuel Berhane, Fikaden Berhe, Saba Abraham Belay, Abraha Gebreegziabher Hailu, Bereket Berhe Abreha, Hailemariam Gebrearegay Haileeyesus, Kidu Gidey
BACKGROUND: COVID-19 has reduced the capacity for delivering essential health services due to lockdown restrictions. Telehealth is an effective alternative option to improve healthcare access. However, there remain implementation challenges to patient adoption in resource-limited settings such as Ethiopia. Therefore, the purpose of this study was to assess patient satisfaction following the implementation of telehealth in ambulatory settings during the COVID-19 pandemic. METHODS: A cross-sectional study was conducted at Ayder Comprehensive Specialized Hospital in the Tigray region of Northern Ethiopia...
2024: BioMed Research International
https://read.qxmd.com/read/38380127/n-substituted-phenylhydrazones-kill-the-ring-stage-of-plasmodium-falciparum
#15
JOURNAL ARTICLE
Cedric Dzidzor Kodjo Amengor, Prince Danan Biniyam, Abena Amponsaa Brobbey, Francis Klenam Kekessie, Felix Kwame Zoiku, Sherif Hamidu, Patrick Gyan, Billy Mawunyo Abudey
Antimalarial resistance has hampered the effective treatment of malaria, a parasitic disease caused by Plasmodium species. As part of our campaign on phenotypic screening of phenylhydrazones, a library of six phenylhydrazones was reconstructed and evaluated for their in vitro antimalarial and in silico receptor binding and pharmacokinetic properties. The structures of the phenylhydrazone hybrids were largely confirmed using nuclear magnetic resonance techniques. We identified two compounds which exhibited significant antimalarial potential against the ring stage (trophozoite) of 3D7 chloroquine-sensitive (CS) strain and DD2 chloroquine-resistant (CR) strains of Plasmodium falciparum with monosubstituted analogs bearing meta or para electron-donating groups showing significant activity in the single-digit micromolar range...
2024: BioMed Research International
https://read.qxmd.com/read/38374955/retracted-dynamic-data-infrastructure-security-for-interoperable-e-healthcare-systems-a-semantic-feature-driven-nosql-intrusion-attack-detection-model
#16
BioMed Research International
[This retracts the article DOI: 10.1155/2022/4080199.].
2024: BioMed Research International
https://read.qxmd.com/read/38374954/two-main-cancer-biomarkers-as-molecular-targets-of-binase-antitumor-activity
#17
JOURNAL ARTICLE
Elena Dudkina, Vera Ulyanova, Violetta Asmandiyarova, Valentina Vershinina, Olga Ilinskaya
Cancer is frequently coupled with the disturbance of key signaling pathways. Aberrant activation of the mitogen-activated protein kinase (MAPK) signaling cascade, occurring in over 85% of cancers, is mainly caused by the genetic alterations of its main components-oncogenes EGFR and RAS, and plays a crucial role in cell fate. The importance of EGFR and RAS proteins in a variety of tumors suggests that they would be good therapeutic targets, but at present, no effective targeted therapy against these two oncogenes has been proven...
2024: BioMed Research International
https://read.qxmd.com/read/38374953/retracted-downregulation-of-mir-221-3p-by-lncrna-tug1-promoting-the-healing-of-closed-tibial-fractures-in-mice
#18
BioMed Research International
[This retracts the article DOI: 10.1155/2022/1624446.].
2024: BioMed Research International
https://read.qxmd.com/read/38347907/cystic-fibrosis-mice-are-highly-susceptible-to-repeated-acute-pseudomonas-aeruginosa-pneumonia-after-intranasal-inoculation
#19
JOURNAL ARTICLE
Mariel Manzor, Sophia Koutsogiannaki, Marco DiBlasi, Matthew Schaefers, Gregory Priebe, Koichi Yuki
Cystic fibrosis (CF) is a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) that controls chloride current. A number of different CFTR transgenic mouse lines have been developed and subjected to both acute and chronic infection models. However, prior studies showed no substantial differences in bacterial clearance between CF and non-CF mice after single inoculations. Here, using F508del transgenic CF mice, we examined the role of repeated acute Pseudomonas aeruginosa (PA) infection, with the second inoculation 7 days after the first...
2024: BioMed Research International
https://read.qxmd.com/read/38327803/pharmacological-manipulation-of-corticotropin-releasing-factor-receptors-in-the-anterior-and-posterior-subregions-of-the-insular-cortex-differently-affects-anxiety-like-behaviors-in-the-elevated-plus-maze-in-rats
#20
JOURNAL ARTICLE
Lucas M Lopes, Lilian L Reis-Silva, Bruno Rodrigues, Carlos C Crestani
Neuroimaging data in humans and neurobiological studies in rodents have suggested an involvement of the insular cortex (IC) in anxiety manifestations. However, the local neurochemical mechanisms involved are still poorly understood. Corticotropin-releasing factor (CRF) neurotransmission has been described as a prominent neurochemical mechanism involved in the expression of anxiety-like behaviors, but the brain sites related are poorly understood. Additionally, several findings indicate that control of physiological and behavioral responses by the IC occurs in a site-specific manner along its rostrocaudal axis...
2024: BioMed Research International
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