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BioMed Research International

Ivan Peres Costa, Fabiano Politti, Lawrence P Cahalin, Etiene Farah Teixeira de Carvalho, Dirceu Costa, João Carlos Ferrari Corrêa, Rodolfo P Vieira, Manoel Carneiro Oliveira-Junior, Kátia De Angelis, Roberto Stirbulov, Simone Dal Corso, Paulo de Tarso de Carvalho, Nivaldo Antonio Parizotto, Ross Arena, LucianaMaria Malosá Sampaio
The aim of this study was to evaluate the effectiveness of acute application of LEDT in improving peripheral muscle performance during isometric exercise in patients with asthma. Eleven patients, with a mean age 38 ± 10, underwent a single LEDT and sham application in the femoral quadriceps' dominant member (cluster with 50 LED λ = 850 nm, 50 mW, 15 s; 37.5 J), 48 h apart in a randomized crossover design. Before and after LEDT and sham application, the patients were submitted an isometric endurance test (60% of the maximum isometric voluntary contraction), up to the limit of tolerance simultaneous recording of surface electromyography...
2019: BioMed Research International
Renato T Souza, Jose G Cecatti, Maria L Costa, Jussara Mayrink, Rodolfo C Pacagnella, Renato Passini, Kleber G Franchini, Francisco E Feitosa, Iracema M Calderon, Edilberto A Rocha Filho, Débora F Leite, Janete Vettorazzi, Louise C Kenny, Philip N Baker, The Preterm Samba Study Group
Background: Our aim was to describe the steps in planning, implementing, and running a multicentre cohort study of maternal and perinatal health using a high-quality biobank comprised of maternal serum, plasma, and hair samples collected from five sites in Brazil. The Preterm SAMBA study, conducted by the Brazilian Network for Studies on Reproductive and Perinatal Health, was an innovative approach used to identify women at higher risk for preterm birth. It is also of great importance in the study of other maternal and perinatal complications in the context of Brazil, which is a middle-income country...
2019: BioMed Research International
Satoshi Tanaka, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Masaaki Machino, Kyotaro Ota, Koji Suzuki, Taisuke Seki, Naoki Ishiguro, Yukiharu Hasegawa, Shiro Imagama
Purpose: Osteoporosis is a common age-related disorder leading to increased bone fragility and risk of fracture. Early diagnosis of osteoporosis is a vital step in providing early therapeutic intervention. Serum cystatin C is a marker of early renal dysfunction, a predictor of cardiovascular and inflammatory diseases, and an inhibitor of the differentiation of osteoclast precursor cells. The purpose of this study was to evaluate the relationship between serum cystatin C and osteoporosis...
2019: BioMed Research International
Awdhesh Kumar Mishra, Jinhee Choi, Muhammad Fazle Rabbee, Kwang-Hyun Baek
ATP-binding cassette (ABC) transporters constitute one of the largest gene families in all living organisms, most of which mediate transport across biological membranes by hydrolyzing ATP. However, detailed studies of ABC transporter genes in the important oil crop, soybean, are still lacking. In the present study, we carried out genome-wide identification and phylogenetic and transcriptional analyses of the ABC gene family in G . max . A total of 261 G . max ABC (GmABCs) genes were identified and unevenly localized onto 20 chromosomes...
2019: BioMed Research International
J Vukelic, R Dobrila-Dintinjana, A Dekanic, B Marijic, A Cubranic, T Braut
The aim of study was to investigate the expression of the proliferation factor Ki-67 and its relationship with histological grade, cancer stage, and treatment outcome in squamous cell carcinoma of the larynx. Samples from 78 patients with laryngeal cancer were analysed retrospectively. Paraffin sections of tumors were immunohistochemically stained for Ki-67 expression. The patients were divided in two groups according to the proliferative factor values (a low Ki-67 index group - Ki-67≤34 and high Ki-67 index group-Ki-67 >34)...
2019: BioMed Research International
Kun-Ling Lin, Shih-Hsiang Chou, Cheng-Yu Long
Purpose: The aim of our study is to assess efficacy of noninvasive erbium-doped yttrium aluminium garnet laser (Er:YAG laser) for female stress urinary incontinence (SUI). Materials and Methods: Forty-one women with SUI were included in the study and scheduled for vaginal Er:YAG laser treatment. The procedure was performed with a 2940 nm, Er:YAG laser (Fotona Smooth ™ XS, Fotona, Ljubljana, Slovenia), designed to heat up the vaginal mucosa to around 60°C. All subjects had a baseline and 6 months' posttreatment assessment that included perineal sonography and lower urinary tract symptoms...
2019: BioMed Research International
Daniela Figueroa, Mohammad Asaduzzaman, Fiona Young
The combination of doxorubicin and cyclophosphamide commonly used to treat breast cancer can cause premature ovarian failure and infertility. α -Tocopherol is a potent antioxidant whereas γ -tocopherol causes apoptosis in a variety of cancer models in vitro including breast cancer. We hypothesised that the combination of doxorubicin (Dox) and 4-hydroperoxycyclophosphamide (4-Cyc) would be more cytotoxic in vitro than each agent alone, and that α -tocopherol would reduce and γ -tocopherol would augment the cytotoxicity of the combined chemotherapeutics...
2019: BioMed Research International
Carol C Choo, Peter K H Chew, Roger C Ho
Background: Mental illness is a pertinent risk factor related to suicide. However, research indicates there might be underdiagnosis of mental illness in Asian suicide attempters; this phenomenon is concerning. This study explored prediction of diagnosis of mental illness in suicide attempters in Singapore using available variables. Methods: Three years of medical records related to suicide attempters ( N = 462) who were admitted to the emergency department of a large teaching hospital in Singapore were subjected to analysis...
2019: BioMed Research International
Susanne Pehrsson, Mikko Hölttä, Gunilla Linhardt, Regina Fritsche Danielson, Leif Carlsson
Chemically modified mRNA is a novel, highly efficient, biocompatible modality for therapeutic protein expression that may overcome the challenges and safety concerns with current gene therapy strategies. We explored the efficiency of intradermally injected modified VEGF-A165 mRNA (VEGF-A mRNA) formulated in a biocompatible citrate/saline buffer to locally produce human VEGF-A165 protein. Rabbits (n=4) and minipigs (n=3) were implanted with subcutaneous microdialysis probes close to the injection sites and interstitial-fluid samples and skin biopsies were analysed for production of VEGF-A protein over time for up to 8 hours...
2019: BioMed Research International
Yanni Zhang, Qian Jiang, Shaobing Xie, Xuewen Wu, Jun Zhou, Hong Sun
Lead exposure causes or aggravates hearing damage to human or animal, but the detailed effects of lead exposure on auditory system including injury sites of the cochlea in mammal remain controversy. To investigate the effect of chronic lead exposure on auditory system, 40 adult guinea pigs with normal hearing were randomly divided into five groups. They were fed 2 mmol/L lead acetate in drinking water for 0, 15, 30, 60, and 90 days (n = 8), respectively. Lead concentrations in blood, cochlea, and brainstem were measured...
2019: BioMed Research International
Rita Bou Assaf, Mohammad Fayyad-Kazan, Fatima Al-Nemer, Rawan Makki, Hussein Fayyad-Kazan, Bassam Badran, Antoine Berbéri
Background: Novel treatments for bone defects, particularly in patients with poor regenerative capacity, are based on bone tissue engineering strategies which include mesenchymal stem cells (MSCs), bioactive factors, and convenient scaffold supports. Objective: In this study, we aimed at comparing the potential for different scaffolds to induce osteogenic differentiation of human maxillary Schneiderian sinus membrane- (hMSSM-) derived cells . Methods . hMSSM-derived cells were seeded on gelatin, collagen, or Hydroxyapatite β -Tricalcium phosphate-Fibrin (Ha β -TCP-Fibrin) scaffolds...
2019: BioMed Research International
Qing Yang, Jianwen Zhang, Shilei Xu, Changchang Jia, Wei Meng, Hui Tang, Xiaomei Zhang, Yi Zhang, Binsheng Fu
Background: Inflammation is the major risk factor for the progression of hepatocellular carcinoma (HCC), and the nuclear factor- κ B (NF- κ B) signaling plays the central role in the inflammation process. However, the activated mechanism of NF- κ B signaling in HCC is unclear. Methods: The expression of PHF5A is examined by qPCR, western blotting, and immunohistochemistry (IHC) assay. The potential of PHF5A (PHD-finger domain protein 5a) for migration and invasion is examined by wound healing and Transwell assay...
2019: BioMed Research International
Antonella Agodi, Martina Barchitta, Andrea Maugeri, Guido Basile, Matilde Zamboni, Giulia Bernardini, Daniela Corona, Massimiliano Veroux
The burden of chronic kidney disease is dramatically rising, making it a major public health concern worldwide. Kidney transplantation is now the best treatment for patients with end-stage renal disease. Although kidney transplantation may improve survival and quality of life, its long-term results are hampered by immune- and/or non-immune-mediated complications. Thus, the identification of transplanted patients with a higher risk of posttransplant complications has become a big challenge for public health...
2019: BioMed Research International
Ploysyne Rattanakaemakorn, Poonkiat Suchonwanit
Scalp pruritus is a frequent problem encountered in dermatological practice. This disorder is caused by various underlying diseases and is a diagnostic and therapeutic challenge. Scalp pruritus may be localized to the scalp or extended to other body areas. It is sometimes not only associated with skin diseases or specific skin changes, but also associated with lesions secondary to rubbing or scratching. Moreover, scalp pruritus may be difficult to diagnose and manage and may have a great impact on the quality of life of patients...
2019: BioMed Research International
Haocheng Xu, Minghao Shao, Fan Zhang, Cong Nie, Hongli Wang, Wei Zhu, Xinlei Xia, Xiaosheng Ma, Feizhou Lu, Jianyuan Jiang
Purpose: Because Hirayama disease is stereotyped as a self-limited disease in the absence of a definite pathology, we investigated the potential relationship between snake-eyes appearance (SEA) and Hirayama disease to bring a new perspective in the pathological process of Hirayama disease based on relevant radiological and clinical evidence. Methods: A total of 30 cases observed SEA were selected from 293 patients with Hirayama disease to constitute the SEA group, and an equal number of cases were randomly selected from the remaining patients to form the non-SEA group...
2019: BioMed Research International
Baoquan Zhang, Yue Dai, Hanqiang Chen, Changyi Yang
Objective: In this meta-analysis, we aim to investigate the neonatal mortality in hospitalized Chinese population in the recent 20 years in China, which may provide basis for decreasing the neonatal mortality. Methods: The merged mortality was estimated based on the random effect model, and subgroup analysis was performed for the gender, publication year, gestational age, and birth weight. Sensitivity analysis was utilized to evaluate the effects of research type and research quality on the effects...
2019: BioMed Research International
Bernd Fink, Konstantinos Anagnostakos, Heinz Winkler
No abstract text is available yet for this article.
2019: BioMed Research International
Yao Zhou, Li He, Xiao-Dan Liu, Hua Guan, Ying Li, Rui-Xue Huang, Ping-Kun Zhou
Objectives: As an epigenetic player, long noncoding RNAs (LncRNAs) have been reported to participate in multiple biological processes; however, their biological functions in silica-induced pulmonary fibrosis (SIPF) occurrence and development remain incompletely understood. Methods: Five case/control pairs were used to perform integrated transcriptomes analysis of lncRNA and mRNA. Prediction of lncRNA and mRNA functions was aided by the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases...
2019: BioMed Research International
Juan M Bueno, Francisco J Ávila, M Carmen Martínez-García
Corneal cross-linking (CXL) is a surgical procedure able to modify corneal biomechanics and stabilize keratoconus progression. Although it is known that CXL produces changes in corneal collagen distribution, these are still a topic of discussion. Here we quantitatively compare the corneal stroma architecture between two animal models four weeks after in vivo conventional CXL treatment, with second harmonic generation (SHG) imaging microscopy and the structure tensor (ST). The healing stage and the stroma recovery were also analyzed by means of histological sections...
2019: BioMed Research International
Sang Wook Kang, Je-Hoon Park, Hosik Seok, Hae Jeong Park, Joo-Ho Chung, Chang-Ju Kim, Young Ock Kim, Young Rok Han, DongWhan Hong, Young Sik Kim, Su Kang Kim
Chronic prostatitis typically occurs in aging men, and its symptoms include frequent and painful urination. In recent study, several studies have shown that Korean red ginseng (KRG) can be used in the prevention and treatment of various diseases. The objective of this study is to investigate whether KRG can play a role in repressing the development of chronic nonbacterial prostatitis (CNP) in male Wistar rats. To induce CNP, rats were castrated and beta-estradiol (0.25 mg/kg) was subcutaneously (s.c.) injected daily...
2019: BioMed Research International
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