Ekaterina I Semenova, Suzanna A Partevian, Marina V Shulskaya, Margarita M Rudenok, Maria V Lukashevich, Nina M Baranova, Olga B Doronina, Kseniya S Doronina, Anna V Rosinskaya, Ekaterina Y Fedotova, Sergey N Illarioshkin, Petr A Slominsky, Maria I Shadrina, Anelya Kh Alieva
Parkinson's disease (PD) is a common chronic, age-related neurodegenerative disease. This disease is characterized by a long prodromal period. In this context, it is important to search for the genes and mechanisms that are involved in the development of the pathological process in the earliest stages of the disease. Published data suggest that blood cells, particularly lymphocytes, may be a model for studying the processes that occur in the brain in PD. Thus, in the present work, we performed an analysis of changes in the expression of the genes ADORA2A , MTA1 , PTGDS , PTGS2 , NSF , and HNMT in the peripheral blood of patients with early stages of PD (stages 1 and 2 of the Hoehn-Yahr scale)...
2023: BioMed Research International