journal
https://read.qxmd.com/read/37265475/glutathione-upregulates-the-expression-of-k-atp-channels-and-vasorelaxation-responses-and-inhibits-mptp-opening-and-oxidative-stress-in-the-heart-mitochondria-of-old-rats
#1
JOURNAL ARTICLE
Ruslan Strutynskyi, Nataliіa Strutynska, Lidiia Mys, Yulia Goshovska, Yuliia Korkach, Raisa Fedichkina, Iryna Okhai, Vladyslav Strutynskyi, Vadym Sagach
BACKGROUND: In the present work, we investigated the effect of exogenous glutathione in old rats on the expression of ATP-sensitive potassium (KATP ) channels, the mitochondrial permeability transition pore (mPTP) opening in the heart, and the vasorelaxation responses of isolated aortic rings to activation of KATP channels. METHODS: Experiments were performed on adult (6 months) and old (24 months) male Wistar rats, which were divided into three groups: adult, old, and glutathione-treated old rats...
2023: BioMed Research International
https://read.qxmd.com/read/37260852/the-antimicrobial-bifunctional-camel-lactoferrin-in-silico-and-molecular-dynamic-perspective
#2
JOURNAL ARTICLE
Maathir N Alhumam, Naser Alhumam, Mahmoud Kandeel
Lactoferrin (LF) is a major natural antimicrobial agent secreted in body fluids as a natural innate immunity protein. The action and structure of LF are closely related to its iron-binding capacity with structural reporting in open and closed conformations. This study looked at how lactoferrin structures change in camel (cLF), bovine (bLF), and human (hLF) lactoferrin closed forms after iron is removed from their binding sites. Initially, the sequence comparison between cLF and the LFs of marine mammals, bats, and domestic animals was the most intriguing conclusion...
2023: BioMed Research International
https://read.qxmd.com/read/37260851/antiangiogenic-potential-of-troxerutin-and-chitosan-loaded-troxerutin-on-chorioallantoic-membrane-model
#3
JOURNAL ARTICLE
Gowtham Kumar Subbaraj, Harini Elangovan, Prema Chandramouli, Santhosh Kumar Yasam, Kirubhanand Chandrasekaran, Langeswaran Kulanthaivel, Sangavi Pandi, Senthilkumar Subramanian
Angiogenesis is crucial to the development of cancer because it allows the transport of oxygen, nutrients, and growth factors as well as the spread of tumors to distant organs. Inhibitors of angiogenesis prevent the formation of blood vessels that allow tumor cells to shrink, rather than promote tumor growth. Chitosan acts as a carrier for many drugs, since the compound has various properties such as biodegradable, less toxicity, more stable, simple, easy to prepare, and biocompatible. The aim of the current study was to evaluate the efficacy of chitosan nanoparticles encapsulated with troxerutin (Chi-Trox NPs) against angiogenesis and cancer in ova chick chorioallantoic membrane (CAM) model...
2023: BioMed Research International
https://read.qxmd.com/read/37250751/factors-associated-with-utilization-of-sexual-and-reproductive-health-services-among-the-youth-in-lira-city-west-northern-uganda-a-cross-sectional-study
#4
JOURNAL ARTICLE
Tom Murungi, Deo Benyumiza, Juliet Apio, Catherine Nekesa, Aisha Nalubuuka, Ivan Misuk, Edward Kumakech
BACKGROUND: The youth in Uganda, as in much of sub-Saharan Africa, face numerous sexual and reproductive health (SRH) challenges, from human immunodeficiency virus HIV infection, and unsafe abortions to unwanted pregnancies. This study, therefore, assessed the utilization of sexual and reproductive health services and associated factors among the youth in Lira city west, northern Uganda. METHODS: This was a cross-sectional study conducted in January 2023 among 386 young people (15-24 years) in Lira city west division, Lira city...
2023: BioMed Research International
https://read.qxmd.com/read/37250750/-in-silico-method-for-the-screening-of-phytochemicals-against-methicillin-resistant-staphylococcus-aureus
#5
JOURNAL ARTICLE
Riaz Tabassum, Sumaira Kousar, Ghulam Mustafa, Amer Jamil, Syed Awais Attique
Methicillin-resistant Staphylococcus aureus (MRSA) has evolved resistance even against the last resort β -lactam antibiotics. This is because of the acquisition of an additional penicillin-binding protein 2a (PBP2a) which is a resistance determinant in MRSA. Currently, available PBP2a inhibitors are ineffective against life-threatening and fatal infections caused by microorganisms. Therefore, there is an urgent need to screen natural compounds that could overpass the resistance issue alone or in combination with antibacterial drugs...
2023: BioMed Research International
https://read.qxmd.com/read/37250749/recent-advances-in-pyridine-scaffold-focus-on-chemistry-synthesis-and-antibacterial-activities
#6
REVIEW
Md Badrul Islam, Md Inshaful Islam, Nikhil Nath, Talha Bin Emran, Md Rezaur Rahman, Rohit Sharma, Mohammed Mahbubul Matin
Multidrug-resistant (MDR) pathogens have created a fatal problem for human health and antimicrobial treatment. Among the currently available antibiotics, many are inactive against MDR pathogens. In this context, heterocyclic compounds/drugs play a vital role. Thus, it is very much essential to explore new research to combat the issue. Of the available nitrogen-bearing heterocyclic compounds/drugs, pyridine derivatives are of special interest due to their solubility. Encouragingly, some of the newly synthesized pyridine compounds/drugs are found to inhibit multidrug-resistant S...
2023: BioMed Research International
https://read.qxmd.com/read/37234845/level-set-image-feature-detection-and-application-in-covid-19-image-feature-knowledge-detection
#7
JOURNAL ARTICLE
Dongsheng Ji, Yafeng Liu, Qingyi Zhang, Wenjun Zheng
Artificial intelligence (AI) scholars and mediciners have reported AI systems that accurately detect medical imaging and COVID-19 in chest images. However, the robustness of these models remains unclear for the segmentation of images with nonuniform density distribution or the multiphase target. The most representative one is the Chan-Vese (CV) image segmentation model. In this paper, we demonstrate that the recent level set (LV) model has excellent performance on the detection of target characteristics from medical imaging relying on the filtering variational method based on the global medical pathology facture...
2023: BioMed Research International
https://read.qxmd.com/read/37228643/the-association-of-thyroid-stimulating-hormone-tsh-levels-and-lipid-profile-in-euthyroid-patients-with-familial-hypercholesterolemia
#8
JOURNAL ARTICLE
Maryam Heidarpour, Parastesh Rezvanian, Mohammad Amin Sadri, Parsa Keshavarzrad, Rezvan Zakeri, Omid Vakilbashi, Davood Shafie, Masood Shekarchizadeh, Sonia Zarfeshani, Najmeh Rabbanipour, Jamshid Najafian, Golnaz Vaseghi, Nizal Sarrafzadegan
Previous studies reported a relationship between thyroid-stimulating hormone (TSH) and low-density lipoprotein cholesterol (LDL-C) levels. In this study, we aim to evaluate the impact of TSH levels on lipid profile in patients with familial hypercholesterolemia (FH) and euthyroid state. Patients were selected from the Isfahan FH registry. The Dutch Lipid Clinic Network (DLCN) criteria are used to detect FH. Patients were classified into no FH, possible FH, probable FH, and definite FH groups based on the DLCN scores...
2023: BioMed Research International
https://read.qxmd.com/read/37223337/comparing-in-hospital-mortality-prediction-by-senior-emergency-resident-s-judgment-and-prognostic-models-in-the-emergency-department
#9
JOURNAL ARTICLE
Zahra Rahmatinejad, Samira Peiravi, Benyamin Hoseini, Fatemeh Rahmatinejad, Saeid Eslami, Ameen Abu-Hanna, Hamidreza Reihani
BACKGROUND: A comparison of emergency residents' judgments and two derivatives of the Sequential Organ Failure Assessment (SOFA), namely, the mSOFA and the qSOFA, was conducted to determine the accuracy of predicting in-hospital mortality among critically ill patients in the emergency department (ED). METHODS: A prospective cohort research was performed on patients over 18 years of age presented to the ED. We used logistic regression to develop a model for predicting in-hospital mortality by using qSOFA, mSOFA, and residents' judgment scores...
2023: BioMed Research International
https://read.qxmd.com/read/37223336/antibiotic-resistance-profiling-of-pathogenic-staphylococcus-species-from-urinary-tract-infection-patients-in-benin
#10
JOURNAL ARTICLE
Funkè F Assouma, Haziz Sina, Ange D Dossou, Akim Socohou, Milka C Hounsou, Patrice H Avogbe, Bawa Boya, Wassiyath Mousse, Adolphe Adjanohoun, Lamine Baba-Moussa
Staphylococci can cause urinary tract infections (UTIs). These UTIs are among the significant causes of antibiotic resistance and the spread of antibiotic-resistant diseases. The current study is aimed at establishing a resistance profile and determining the pathogenicity of Staphylococcus strains isolated from UTI samples collected in Benin. For this purpose, urine samples (one hundred and seventy) that were collected from clinics and hospitals showed UTI in patients admitted/visited in Benin. The biochemical assay method was used to identify Staphylococcus spp...
2023: BioMed Research International
https://read.qxmd.com/read/37214084/in-silico-identification-and-analysis-of-potentially-bioactive-antiviral-phytochemicals-against-sars-cov-2-a-molecular-docking-and-dynamics-simulation-approach
#11
JOURNAL ARTICLE
Sajal Kumar Halder, Ive Sultana, Md Nazmussakib Shuvo, Aparna Shil, Mahbubul Kabir Himel, Md Ashraful Hasan, Mohammad Mahfuz Ali Khan Shawan
SARS-CoV-2, a deadly coronavirus sparked COVID-19 pandemic around the globe. With an increased mutation rate, this infectious agent is highly transmissible inducing an escalated rate of infections and death everywhere. Hence, the discovery of a viable antiviral therapy option is urgent. Computational approaches have offered a revolutionary framework to identify novel antimicrobial treatment regimens and allow a quicker, cost-effective, and productive conversion into the health center by evaluating preliminary and safety investigations...
2023: BioMed Research International
https://read.qxmd.com/read/37206297/gene-signatures-and-associated-transcription-factors-of-allergic-rhinitis-klf4-expression-is-associated-with-immune-response
#12
JOURNAL ARTICLE
Youngsic Jeon, Tae Kyeom Kang, Wook-Bin Lee, Sang Hoon Jung, Young-Joo Kim
This study is aimed at investigating the potential molecular features of allergic rhinitis (AR) and identifying gene signatures and related transcription factors using transcriptome analysis and in silico datasets. Transcriptome profiles were obtained using three independent cohorts (GSE101720, GSE19190, and GSE46171) comprising healthy controls (HC) and patients with AR. The pooled dataset ( n = 82) was used to identify the critical signatures of AR compared with HC. Subsequently, key transcription factors were identified by a combined analysis using transcriptome and in silico datasets...
2023: BioMed Research International
https://read.qxmd.com/read/37205232/role-of-single-nucleotide-polymorphism-related-genes-in-tumour-immune-cell-infiltration-and-prognosis-of-cutaneous-melanoma
#13
JOURNAL ARTICLE
Baihe Wang, Fanxiao Liu, Yuanyuan Li, Nan Chen
BACKGROUND: Advances in cancer research have allowed for early diagnosis and improved treatment of cutaneous melanoma (CM). However, its invasiveness and recurrent metastasis, along with rising resistance to newer therapies, have lent urgency to the search for novel biomarkers and the underlying molecular mechanisms of CM. METHODS: Single nucleotide polymorphism- (SNP-) related genes were obtained from the sequencing data of 428 CM samples in The Cancer Genome Atlas...
2023: BioMed Research International
https://read.qxmd.com/read/37197593/mechanisms-of-ganweikang-tablets-against-chronic-hepatitis-b-a-comprehensive-study-of-network-analysis-molecular-docking-and-chemical-profiling
#14
JOURNAL ARTICLE
Jia-Qi Xu, Shi-Bing Su, C Y Chen, J Gao, Z M Cao, J L Guan, Lin-Xuan Xiao, Ming-Ming Zhao, Hua Yu, Yuan-Jia Hu
The hepatitis B virus (HBV) is one of the major viral infection problems worldwide in public health. The exclusive proprietary Chinese medicine Ganweikang (GWK) tablet has been marketed for years in the treatment of chronic hepatitis B (CHB). However, the pharmacodynamic material basis and underlying mechanism of GWK are not completely clear. This study is aimed at investigating the pharmacological mechanism of the GWK tablet in the treatment of CHB. The chemical ingredient information was obtained from the Traditional Chinese Medicine Database and Analysis Platform (TCMSP), Traditional Chinese Medicines Integrated Database (TCMID), and Shanghai Institute of Organic Chemistry of CAS...
2023: BioMed Research International
https://read.qxmd.com/read/37187465/az63-ti-zr-nanocomposite-for-bone-related-biomedical-applications
#15
JOURNAL ARTICLE
T Sathish, R Saravanan, Sarange Shreepad, T Amuthan, J Immanuel Durai Raj, Piyush Gaur, V Vijayan, S Rajkumar
Considering the unique properties of magnesium and its alloy, it has a vast demand in biomedical applications, particularly the implant material in tissue engineering due to its biodegradability. But the fixing spares must hold such implants till the end of the biodegradation of implant material. The composite technology will offer the added benefits of altering the material properties to match the requirements of the desired applications. Hence, this experimental investigation is aimed at developing a composite material for manufacturing fixing spares like a screw for implants in biomedical applications...
2023: BioMed Research International
https://read.qxmd.com/read/37181817/next-generation-vaccines-nanovaccines-in-the-fight-against-sars-cov-2-virus-and-beyond-sars-cov-2
#16
REVIEW
Maluta Steven Mufamadi, Mpho Phehello Ngoepe, Ofentse Nobela, Nhlanhla Maluleke, Bafedile Phorah, Banele Methula, Thapelo Maseko, Dipuo Ingrid Masebe, Hazel Tumelo Mufhandu, Lebogang Maureen Katata-Seru
The virus responsible for the coronavirus viral pandemic is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Emerging SARS-CoV-2 variants caused by distinctive mutations within the viral spike glycoprotein of SARS-CoV-2 are considered the cause for the rapid spread of the disease and make it challenging to treat SARS-CoV-2. The manufacturing of appropriate efficient vaccines and therapeutics is the only option to combat this pandemic. Nanomedicine has enabled the delivery of nucleic acids and protein-based vaccines to antigen-presenting cells to produce protective immunity against the coronavirus...
2023: BioMed Research International
https://read.qxmd.com/read/37168235/the-effect-of-mini-dental-implant-number-on-mandibular-overdenture-retention-and-attachment-wear
#17
JOURNAL ARTICLE
Rafif Alshenaiber, Craig Barclay, Nick Silikas
PURPOSE: Evaluate the effect of different mini-implant numbers on overdenture retention and evaluate attachment wear following one year of simulated placement/removal. Material and Methods . Nine models simulating atrophic mandibles held 27 mini dental implants in three groups of 2, 3, and 4 mini-implants. A total of 1080 simulated placement/removal cycles were carried out, and a digital force gauge was used to measure the overdenture dislodgment force. The means of the retention forces were analyzed using SPSS with one-way ANOVA and post hoc ( p < 0...
2023: BioMed Research International
https://read.qxmd.com/read/37152588/hiv-virologic-failure-among-patients-with-persistent-low-level-viremia-in-nairobi-kenya-it-is-time-to-review-the-1000-virologic-failure-threshold
#18
JOURNAL ARTICLE
Mirriam M Nzivo, Cecilia N Waruhiu, James M Kang'ethe, Nancy L M Budambula
Persistent low-level viremia (PLLV) of 200-999 copies/ml has been reported as a risk factor for HIV virologic failure (VF). This retrospective study was aimed at characterizing patients with PLLV, determining factors associated with VF, and determining the effect of regimen change. Data were extracted from electronic medical records for HIV care and treatment. Patients' characteristics ( N = 705) were as follows: a mean age of 42 years, majority female (55%), and 51% married. A majority (78.7%) had a history of opportunistic infections in their ART lifetime...
2023: BioMed Research International
https://read.qxmd.com/read/37152587/isolation-and-characterization-of-lactobacillus-crispatus-lactococcus-lactis-and-carnobacterium-divergens-as-potential-probiotic-bacteria-from-fermented-black-and-green-olives-olea-europaea-an-exploratory-study
#19
JOURNAL ARTICLE
Ayesha Saeed, Azra Yasmin, Mehreen Baig, Khalid Khan, Md Belal Bin Heyat, Faijan Akhtar, Zahra Batool, Abeer Kazmi, Abdul Wahab, Muhammad Shahid, Muhammad Arslan Ahmed, Sidra Abbas, Abdullah Y Muaad, Amir Shahzad, Imtiaz Ahmad
BACKGROUND: Table olives are becoming well recognized as a source of probiotic bacteria that might be used to create a health-promoting fermented food product by traditional procedures based on the activities of indigenous microbial consortia present in local environments. Methodology . In the present study, the characterization of probiotic bacteria isolated from mince, chunks, and brine of fermented green and black olives ( Olea europaea ) was done based on morphological, biochemical, and physiological characteristics...
2023: BioMed Research International
https://read.qxmd.com/read/37152586/nimotuzumab-concurrent-with-gemcitabine-as-first-line-treatment-of-locally-advanced-or-metastatic-pancreatic-adenocarcinoma
#20
JOURNAL ARTICLE
Yamirka Sánchez, Martha L Concepción, Yohan Amador, Angel Piriz, René Rabassa, Ariel Leyva, Odalys Arguelles, Lisett Leblanch, Sheyla Moret, Gilberto Rivero, Ana L Vasallo, Beatriz Martorell, Pedro P Guerra, Ana R Valls, Lisset Sánchez, Yaimarelis Saumell
BACKGROUND: Nimotuzumab exerts its antitumor effect (mainly antiproliferative, proapoptotic, and antiangiogenic) by blocking the epidermal growth factor receptor overexpressing between 30 and 95% in pancreatic tumors cells. METHODS: A prospective, nonrandomized, uncontrolled, open-label, and multicenter clinical trial was conducted to evaluate the safety and effectiveness of nimotuzumab combined with gemcitabine as first-line treatment in unresectable locally advanced or metastatic pancreatic tumors in a real-world condition...
2023: BioMed Research International
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