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Journal of Materials Chemistry. B, Materials for Biology and Medicine

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https://read.qxmd.com/read/30740226/hybrid-lipid-nanoparticle-complexes-for-biomedical-applications
#1
Kevin M Vargas, Young-Seok Shon
Biomolecule-nanoparticle hybrids have proven to be one of most promising frontiers in biomedical research. In recent years, there has been an increased focus on the development of hybrid lipid-nanoparticle complexes (HLNCs) which inherit unique properties of both the inorganic nanoparticles and the lipid assemblies (i.e. liposomes, lipoproteins, solid lipid nanoparticles, and nanoemulsions) that comprise them. In combination of their component parts, HLNCs also gain new functionalities which are utilized for numerous biomedical applications (i...
February 7, 2019: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30740225/highly-selective-red-emitting-bodipy-based-fluorescent-indicators-for-intracellular-mg-2-imaging
#2
Qitian Lin, Daniela Buccella
Most fluorescent indicators for Mg2+ suffer from poor selectivity against other divalent cations, especially Ca2+ , thus do not provide reliable information on cellular Mg2+ concentrations in processes in which such metals are involved. We report a new set of highly selective fluorescent indicators based on alkoxystyryl-functionalized BODIPY fluorophores decorated with a 4-oxo-4 H -quinolizine-3-carboxylic acid metal binding moiety. The new sensors, MagQ1 and MagQ2 , display absorption and emission maxima above 600 nm, with a 29-fold fluorescence enhancement and good quantum yields (Φ > 0...
November 28, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30555698/sub-zero-temperature-mechanically-stable-low-molecular-weight-hydrogels
#3
Alice E R Fayter, Matthew I Gibson, Emily R Draper
We show here a low molecular weight hydrogelator based on a functionalised-dipeptide which is stable down to temperatures of -12 °C despite being made from >99% water. This stabilty at low temperature can be extended to ∼-40 °C by gelling water : glycerol mixtures. The temperature range is wider than that of the glycerol : water mixtures alone. The rheological properties of the gels do not change at this low temperature compared to that of gels at 25 °C. This freezing point depression offers a potentially new method of transporting gels and offers the prospect of hydrogels being used at much lower working temperatures whilst retaining the desired rheological properties, this is useful for cryopreservation...
November 28, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30555697/barcoding-chemical-modifications-into-nucleic-acids-improves-drug-stability-in-vivo
#4
Cory D Sago, Sujay Kalathoor, Jordan P Fitzgerald, Gwyneth N Lando, Naima Djeddar, Anton V Bryksin, James E Dahlman
The efficacy of nucleic acid therapies can be limited by unwanted degradation. Chemical modifications are known to improve nucleic acid stability, but the (i) types, (ii) positions, and (iii) numbers of modifications all matter, making chemically optimizing nucleic acids a combinatorial problem. As a result, in vivo studies of nucleic acid stability are time consuming and expensive. We reasoned that DNA barcodes could simultaneously study how chemical modification patterns affect nucleic acid stability, saving time and resources...
November 28, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30283632/elastic-serum-albumin-based-hydrogels-mechanism-of-formation-and-application-in-cardiac-tissue-engineering
#5
Nadav Amdursky, Manuel M Mazo, Michael R Thomas, Eleanor J Humphrey, Jennifer L Puetzer, Jean-Philippe St-Pierre, Stacey C Skaalure, Robert M Richardson, Cesare M Terracciano, Molly M Stevens
Hydrogels are promising materials for mimicking the extra-cellular environment. Here, we present a simple methodology for the formation of a free-standing viscoelastic hydrogel from the abundant and low cost protein serum albumin. We show that the mechanical properties of the hydrogel exhibit a complicated behaviour as a function of the weight fraction of the protein component. We further use X-ray scattering to shed light on the mechanism of gelation from the formation of a fibrillary network at low weight fractions to interconnected aggregates at higher weight fractions...
September 21, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30386619/antibacterial-and-potentiation-properties-of-charge-optimized-polyrotaxanes-for-combating-opportunistic-bacteria
#6
Jing Qiao, Zhi Liu, Max Purro, May P Xiong
Bacteria are now becoming more resistant to most conventional antibiotics. Approaches for the treatment of multidrug-resistant bacterial infections are urgently required. Cationic polymers have broad-spectrum antibacterial activity but can also induce non-specific damage to mammalian cells. Herein, we report on the design of cationic polyrotaxanes (cPRs) with variable charge densities. cPRs were prepared by conjugating neutral ethanolamine and cationic ethylenediamine at various ratios onto threaded alpha-cyclodextrins and their antimicrobial and cytocompatible properties were investigated in vitro...
September 7, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30245822/cancer-cell-targeting-controlled-drug-release-and-intracellular-fate-of-biomimetic-membrane-encapsulated-drug-loaded-nano-graphene-oxide-nanohybrids
#7
Kun Ma, Duo Fu, Yajun Liu, Rui Dai, Dongli Yu, Zhaoming Guo, Changhao Cui, Li Wang, Jinaqiang Xu, Chuanbin Mao
Nano-graphene oxide (NGO) has been proposed as a novel drug carrier. However, the poor biocompatibility and physiological stability as well as lack of cancer targeting capability have limited its further applications in cancer therapy. To solve this problem, we developed a novel nanohybrid of NGO/DOX@SPC-FA by first allowing soy phosphatidylcholine membrane (SPC) to encapsulate DOX-loaded NGO (NGO/DOX) and then modifying the SPC membrane with PEGylated lipid-FA conjugate to achieve the display of cancer targeting FA on the nanohybrid surface...
August 21, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30746148/orthogonal-click-reactions-enable-the-synthesis-of-ecm-mimetic-peg-hydrogels-without-multi-arm-precursors
#8
Faraz Jivan, Natalia Fabela, Zachary Davis, Daniel L Alge
Click chemistry reactions have become an important tool for synthesizing user-defined hydrogels consisting of poly(ethylene glycol) (PEG) and bioactive peptides for tissue engineering. However, because click crosslinking proceeds via a step-growth mechanism, multi-arm telechelic precursors are required, which has some disadvantages. Here, we report for the first time that this requirement can be circumvented to create PEG-peptide hydrogels solely from linear precursors through the use of two orthogonal click reactions, the thiol-maleimide Michael addition and thiol-norbornene click reaction...
August 14, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30450208/a-highly-hemocompatible-erythrocyte-membrane-coated-ultrasmall-selenium-nanosystem-for-simultaneous-cancer-radiosensitization-and-precise-antiangiogenesis
#9
Ting Liu, Changzheng Shi, Linqi Duan, Zehang Zhang, Liangping Luo, Shreya Goel, Weibo Cai, Tianfeng Chen
Radiotherapy is a vitally important strategy for clinical treatment of malignant cancers. Therefore, rational design and development of radiosensitizers that could enhance radiotherapeutic efficacy has attracted tremendous attention. Antiangiogenesis therapy could be a potentially effective strategy to regulate tumor growth and metastasis due to angiogenesis plays a pivotal role for tumor growth, invasion and metastasis to other organs. Herein, we have rationally designed a smart and effective nanosystem by combining ultrasmall selenium nanoparticles and bevacizumab (Avastin™ , Av), for simultaneous radiotherapy and antiangiogenic therapy of cancer...
August 7, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30574331/growth-factor-free-salt-leached-silk-scaffolds-for-differentiating-endothelial-cells
#10
Liying Xiao, Caihong Zhu, Zhaozhao Ding, Shanshan Liu, Danyu Yao, Qiang Lu, David L Kaplan
Recently, controllable kinetic assembly was introduced into the salt-leaching process with silk proteins to form scaffolds, which achieved improvement in tuning the micro-structural and mechanical properties. Here, more control of the kinetic assembly of silk in the process was integrated into salt-leaching process, resulting in significant mechanical modification of the scaffolds generated. Both glycerol additions and treatment to concentrate the protein were used to tune hydrophilic interactions during aqueous solution processing and to reduce beta-sheet formation during the salt-leaching process...
July 14, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30505446/cell-secreted-extracellular-matrix-independent-of-cell-source-promotes-the-osteogenic-differentiation-of-human-stromal-vascular-fraction
#11
Jenna N Harvestine, Hakan Orbay, Jonathan Y Chen, David E Sahar, J Kent Leach
Lipoaspirates contain a readily accessible heterogeneous cell source for use in bone regeneration collectively referred to as the stromal vascular fraction (SVF). However, the osteogenic potential of SVF is inferior to other progenitor cell populations, thereby requiring alternative strategies to potentiate its effective use in cell-based therapies of bone repair. Cell-secreted extracellular matrix (ECM) is a promising substrate to guide cell phenotype or for use in biomaterial design, yet the instructional capacity of ECMs produced by various cell types is unknown...
June 28, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30467524/unraveling-the-molecular-mechanisms-of-thermo-responsive-properties-of-silk-elastin-like-proteins-by-integrating-multiscale-modeling-and-experiment
#12
Jingjie Yeo, Wenwen Huang, Anna Tarakanova, Yong-Wei Zhang, David L Kaplan, Markus J Buehler
Adaptive hydrogels tailor-made from silk-elastin-like proteins (SELPs) possess excellent biocompatibility and biodegradability with properties that are tunable and responsive to multiple simultaneous external stimuli. To unravel the molecular mechanisms of their physical response to external stimuli in tandem with experiments, here we predict and measure the variation in structural properties as a function of temperature through coarse-grained (CG) modeling of individual and crosslinked SE8Y and S4 E8Y molecules, which have ratios of 1:8 and 4:8 of silk to elastin blocks respectively...
June 14, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30455952/promoting-endothelial-cell-affinity-and-antithrombogenicity-of-polytetrafluoroethylene-ptfe-by-mussel-inspired-modification-and-rgd-heparin-grafting
#13
Hao-Yang Mi, Xin Jing, James A Thomsom, Lih-Sheng Turng
When used as small-diameter vascular grafts (SDVGs), synthetic biomedical materials like polytetrafluoroethylene (PTFE) may induce thrombosis and intimal hyperplasia due to the lack of an endothelial cell layer. Modification of the PTFE in an aqueous solution is difficult because of its hydrophobicity. Herein, aiming to simultaneously promote endothelial cell affinity and antithrombogenicity, a mussel-inspired modification approach was employed to enable the grafting of various bioactive molecules like RGD and heparin...
June 7, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/29910955/towards-deployable-meta-implants
#14
F S L Bobbert, S Janbaz, A A Zadpoor
Meta-biomaterials exhibit unprecedented or rare combinations of properties not usually found in nature. Such unusual mechanical, mass transport, and biological properties could be used to develop novel categories of orthopedic implants with superior performance, otherwise known as meta-implants. Here, we use bi-stable elements working on the basis of snap-through instability to design deployable meta-implants. Deployable meta-implants are compact in their retracted state, allowing them to be brought to the surgical site with minimum invasiveness...
June 7, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30464839/enhancing-surface-immobilization-of-bioactive-molecules-via-a-silica-nanoparticle-based-coating
#15
K M Woeppel, X S Zheng, X T Cui
Surface modification is of significant interest in biomaterials, biosensors, and device biocompatibility. Immobilization of bioactive or biomimetic molecules is a common method of disguising a foreign body as host tissue to decrease the foreign body response (FBR) and/or increase device-tissue integration. For example, in neural interfacing devices, immobilization of L1, a neuron-specific adhesion molecule, has been shown to increase neuron adhesion and reduce inflammatory gliosis on and around the implants...
May 21, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30345059/impedance-spectroscopic-detection-of-binding-and-reactions-in-acid-labile-dielectric-polymers-for-biosensor-applications
#16
Jennifer Dailey, Michelangelo Fichera, Ellen Silbergeld, Howard Katz
We synthesized previously unreported copolymers with cleavable acid-labile side chains for use as electrochemical sensing layers in order to demonstrate a novel architecture for a one-step immunosensor. This one-step system is in contrast to most antigen-capture signal amplification methods that involve complicated secondary labeling techniques, or require the addition of redox probes to achieve a sensing response. A series of novel copolymers composed of various trityl-containing monomers were synthesized and characterized to determine their dielectric properties...
May 21, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30345058/bioactive-silk-hydrogels-with-tunable-mechanical-properties
#17
Xue Wang, Zhaozhao Ding, Chen Wang, Xiangdong Chen, Hui Xu, Qiang Lu, David L Kaplan
Developing bioactive hydrogels with potential to guide the differentiation behavior of stem cells has become increasingly important in the biomaterials field. Here, silk hydrogels with tunable mechanical properties were developed by introducing inert silk fibroin nanofibers (SNF) within an enzyme crosslinked system of regenerated silk fibroin (RSF). After the crosslinking reaction of RSF, the inert SNF was embedded into the RSF hydrogel matrix, resulting in improved mechanical properties. Tunable stiffness in the range of 9-60 KPa was achieved by adjusting the amount of the added NSF, significantly higher than SNF-free hydrogels formed under same conditions (about 1 KPa)...
May 14, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30319779/nanoscale-3d-printing-of-hydrogels-for-cellular-tissue-engineering
#18
Shangting You, Jiawen Li, Wei Zhu, Claire Yu, Deqing Mei, Shaochen Chen
Hydrogel scaffolds that mimic the native extracellular matrix (ECM) environment is a crucial part of tissue engineering. It has been demonstrated that cell behaviors can be affected by not only the hydrogel's physical and chemical properties, but also its three dimensional (3D) geometrical structures. In order to study the influence of 3D geometrical cues on cell behaviors as well as the maturation and function of engineered tissues, it is imperative to develop 3D fabrication techniques to create micro and nanoscale hydrogel constructs...
April 21, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30294445/the-in-vivo-fates-of-plant-viral-nanoparticles-camouflaged-using-self-proteins-overcoming-immune-recognition
#19
N M Gulati, A S Pitek, A E Czapar, P L Stewart, N F Steinmetz
Nanoparticles offer a promising avenue for targeted delivery of therapies. To slow clearance, nanoparticles are frequently stealth-coated to prevent opsonization and immune recognition. Serum albumin (SA) has been used as a bio-inspired stealth coating. To develop this shielding strategy for clinical applications, it is critical to understand the interactions between the immune system and SA-camouflaged nanoparticles. This work investigates the in vivo processing of SA-coated nanoparticles using tobacco mosaic virus (TMV) as a model system...
April 21, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/30221004/time-lapse-live-cell-imaging-to-monitor-doxorubicin-release-from-dna-origami-nanostructures
#20
Yun Zeng, Jiajun Liu, Shuo Yang, Wenyan Liu, Liang Xu, Risheng Wang
Self-assembled DNA nanostructures have attracted significant research interest in biomedical applications because of their excellent programmability and biocompatibility. To develop multifunctional drug delivery from DNA nanostructures, considerable key information is still needed for clinical application. Traditional fixed endpoint assays do not reflect the dynamic and heterogeneous responses of cells with regard to drugs, and may lead to the misinterpretation of experimental results. For the first time, an integrated time-lapse live cell imaging system was used to study the cellular internalization and controlled drug release profile of three different shaped DNA origami/doxorubicin (DOX) complexes for three days...
March 21, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
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