journal
https://read.qxmd.com/read/38597866/eligibility-and-projected-benefits-of-rapid-initiation-of-quadruple-medical-therapy-for-newly-diagnosed-heart%C3%A2-failure
#1
JOURNAL ARTICLE
Stephen J Greene, Iyanuoluwa Ayodele, Jacob B Pierce, Muhammad Shahzeb Khan, Sabra C Lewsey, Clyde W Yancy, Brooke Alhanti, Harriette G C Van Spall, Larry A Allen, Gregg C Fonarow
BACKGROUND: U.S. nationwide estimates of the proportion of patients newly diagnosed with heart failure with reduced ejection fraction (HFrEF) eligible for quadruple medical therapy, and the associated benefits of rapid implementation, are not well characterized. OBJECTIVES: This study sought to characterize the degree to which patients newly diagnosed with HFrEF are eligible for quadruple medical therapy, and the projected benefits of in-hospital initiation. METHODS: Among patients hospitalized for newly diagnosed HFrEF in the Get With The Guidelines-Heart Failure registry from 2016 to 2023, eligibility criteria based on regulatory labeling, guidelines, and expert consensus documents were applied for angiotensin receptor-neprilysin inhibitor, beta-blocker, mineralocorticoid receptor antagonist, and sodium-glucose cotransporter 2 inhibitor therapies...
March 25, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38573261/prevalence-of-pathogenic-variants-in%C3%A2-cardiomyopathy-associated-genes-in%C3%A2-acute-myocarditis-a-systematic-review-and-meta-analysis
#2
JOURNAL ARTICLE
Emanuele Monda, Athanasios Bakalakos, Douglas Cannie, Constantinos O'Mahony, Petros Syrris, Juan Pablo Kaski, Giuseppe Limongelli, Perry Mark Elliott
BACKGROUND: Acute myocarditis is an inflammatory condition that may precede the development of dilated or arrhythmogenic cardiomyopathy. OBJECTIVES: The aim of this study was to investigate the reported prevalence of pathogenic or likely pathogenic (P/LP) variants in cardiomyopathy-associated genes in patients with acute myocarditis. METHODS: For this systematic review and meta-analysis, the PubMed and Embase databases were searched on March 4, 2023...
March 25, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38573268/national-trends-in-hospital-performance%C3%A2-in-guideline-recommended-pharmacologic-treatment-for-heart%C3%A2-failure-at-discharge
#3
JOURNAL ARTICLE
Paul L Hess, Paula Langner, Paul A Heidenreich, Utibe Essien, Chelsea Leonard, Stanley A Swat, Vincenzo Polsinelli, Steven T Orlando, Gary K Grunwald, P Michael Ho
BACKGROUND: The use of recommended heart failure (HF) medications has improved over time, but opportunities for improvement persist among women and at rural hospitals. OBJECTIVES: This study aims to characterize national trends in performance in the use of guideline-recommended pharmacologic treatment for HF at U.S. Department of Veterans Affairs (VA) hospitals, at which medication copayments are modest. METHODS: Among patients discharged from VA hospitals with HF between January 1, 2013, and December 31, 2019, receipt of all guideline-recommended HF pharmacotherapy among eligible patients was assessed, consisting of evidence-based beta-blockers; angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, or angiotensin receptor neprilysin inhibitors; mineralocorticoid receptor antagonists; and oral anticoagulation...
March 23, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38573266/elevated-tricuspid-regurgitation-velocity-in-left-ventricular-dysfunction-a-not-so-innocent-bystander
#4
EDITORIAL
Mukta C Srivastava, Bradley A Maron
No abstract text is available yet for this article.
March 23, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38530701/training-the-next-generation-of-data-monitoring-committee-members-an-initiative-of-the-heart%C3%A2-failure-collaboratory
#5
REVIEW
Thomas R Fleming, Janet Wittes, Mona Fiuzat, Michael R Bristow, Frank W Rockhold, Jason T Connor, Benjamin R Saville, Brian Claggett, Isabella Cavagna, William T Abraham, Thomas D Cook, JoAnn Lindenfeld, Christopher O'Connor, David L DeMets
Clinical trials are vital for assessing therapeutic interventions. The associated data monitoring committees (DMCs) safeguard patient interests and enhance trial integrity, thus promoting timely, reliable evaluations of those interventions. We face an urgent need to recruit and train new DMC members. The Heart Failure Collaboratory (HFC), a multidisciplinary public-private consortium of academics, trialists, patients, industry representatives, and government agencies, is working to improve the clinical trial ecosystem...
March 23, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38573267/vericiguat-and-total-heart%C3%A2-failure%C3%A2-hospitalizations
#6
EDITORIAL
Mark H Drazner
No abstract text is available yet for this article.
March 22, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38573265/the-eat-lancet-diet-index-plasma-proteins-and-risk-of-heart%C3%A2-failure-in%C3%A2-a%C3%A2-population-based-cohort
#7
JOURNAL ARTICLE
Shunming Zhang, Ida Marken, Anna Stubbendorff, Ulrika Ericson, Lu Qi, Emily Sonestedt, Yan Borné
BACKGROUND: The landmark EAT-Lancet Commission proposed that a planetary health diet is comprised mainly of plant-based foods. However, studies examining whether this diet is associated with heart failure (HF) are currently lacking. In addition, the potential proteomics mechanism on the association between diet and HF warrants further elucidation. OBJECTIVES: This study aims to both examine the association between the EAT-Lancet diet index and risk of HF and identify plasma proteins underlying such an association...
March 22, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38573264/asymmetric-dimethylarginine-and-nt-probnp-levels-provide-synergistic%C3%A2-information-in-pulmonary%C3%A2-arterial-hypertension
#8
JOURNAL ARTICLE
Inbal Shafran, Victoria Probst, Adelheid Panzenböck, Roela Sadushi-Kolici, Christian Gerges, Michael Wolzt, Michael J Segel, David S Celermajer, Irene Marthe Lang, Nika Skoro-Sajer
BACKGROUND: Plasma asymmetric dimethylarginine (ADMA) is elevated in pulmonary arterial hypertension (PAH) and is associated with unfavorable outcomes. OBJECTIVES: The aim of this study was to assess changes in ADMA plasma levels for monitoring disease progression and outcomes during PAH-specific therapy. METHODS: ADMA was measured at baseline and after at least 6 months of follow-up using enzyme-linked immunosorbent assay and high-performance liquid chromatography...
March 22, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38573263/smartphone-based-recognition-of%C3%A2-heart%C3%A2-failure-by-means-of-microelectromechanical-sensors
#9
JOURNAL ARTICLE
Francois Haddad, Antti Saraste, Kristiina M Santalahti, Mikko Pänkäälä, Matti Kaisti, Riina Kandolin, Piia Simonen, Wail Nammas, Kamal Jafarian Dehkordi, Tero Koivisto, Juhani Knuuti, Kenneth W Mahaffey, Juuso I Blomster
BACKGROUND: Heart failure (HF) is the leading cause of hospitalization in individuals over 65 years of age. Identifying noninvasive methods to detect HF may address the epidemic of HF. Seismocardiography which measures cardiac vibrations transmitted to the chest wall has recently emerged as a promising technology to detect HF. OBJECTIVES: In this multicenter study, the authors examined whether seismocardiography using commercially available smartphones can differentiate control subjects from patients with stage C HF...
March 22, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38573262/dapagliflozin-and-timing-of-prior-heart%C3%A2-failure-hospitalization-a-patient-level-meta-analysis-of-dapa-hf-and-deliver
#10
JOURNAL ARTICLE
Jawad H Butt, Pardeep S Jhund, Kieran F Docherty, Brian L Claggett, Muthiah Vaduganathan, Erasmus Bachus, Adrian F Hernandez, Carolyn S P Lam, Silvio E Inzucchi, Felipe A Martinez, Rudolf A de Boer, Mikhail N Kosiborod, Akshay S Desai, Lars Køber, Piotr Ponikowski, Marc S Sabatine, Scott D Solomon, John J V McMurray
BACKGROUND: Patients recently hospitalized for heart failure (HF) are at a higher risk of adverse clinical outcomes, but they may experience a greater absolute and relative benefit from effective therapies than individuals who are considered more "stable." OBJECTIVES: The authors examined the effects of dapagliflozin according to the timing of prior HF hospitalization in a patient-level pooled analysis of DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) and DELIVER (Dapagliflozin Evaluation to Improve the Lives of Patients with Preserved Ejection Fraction Heart Failure)...
March 22, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38597865/aging-in-heart%C3%A2-failure-embracing-biology-over-chronology-jacc-family-series
#11
REVIEW
Parag Goyal, Mathew S Maurer, Jason Roh
Age is among the most potent risk factors for developing heart failure and is strongly associated with adverse outcomes. As the global population continues to age and the prevalence of heart failure rises, understanding the role of aging in the development and progression of this chronic disease is essential. Although chronologic age is on a fixed course, biological aging is more variable and potentially modifiable in patients with heart failure. This review describes the current knowledge on mechanisms of biological aging that contribute to the pathogenesis of heart failure...
March 21, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38583168/sodium-glucose-co-transporter-2%C3%A2-inhibition-following-acute-myocardial%C3%A2-infarction-the-dapa-mi-and-empact-mi-trials
#12
EDITORIAL
Alexander Peikert, Muthiah Vaduganathan
No abstract text is available yet for this article.
March 21, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38530702/clinical-trial-inclusion-and-impact-on-early-adoption-of-medical-innovation-in%C3%A2-diverse-populations
#13
JOURNAL ARTICLE
Philip B Adamson, Melvin Echols, Ersilia M DeFilippis, Alanna A Morris, Mosi Bennett, William T Abraham, JoAnn Lindenfeld, John R Teerlink, Christopher M O'Connor, Allison T Connolly, Huanan Li, Mona Fiuzat, Muthiah Vaduganathan, Orly Vardeny, Wayne Batchelor, Kelly C McCants
BACKGROUND: Inadequate inclusion in clinical trial enrollment may contribute to health inequities by evaluating interventions in cohorts that do not fully represent target populations. OBJECTIVES: The aim of this study was to determine if characteristics of patients with heart failure (HF) enrolled in a pivotal trial are associated with who receives an intervention after approval. METHODS: Demographics from 2,017,107 Medicare patients hospitalized for HF were compared with those of the first 10,631 Medicare beneficiaries who received implantable pulmonary artery pressure sensors...
March 21, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38583167/contemporary-american-and-european%C3%A2-guidelines-for-heart-failure-management-jacc-heart%C3%A2-failure-guideline-comparison
#14
REVIEW
John W Ostrominski, Ersilia M DeFilippis, Kannu Bansal, Ralph J Riello, Biykem Bozkurt, Paul A Heidenreich, Muthiah Vaduganathan
This review serves to compare contemporary clinical practice recommendations for the management of heart failure (HF), as codified in the 2021 European Society of Cardiology (ESC) guideline, the 2022 American College of Cardiology (ACC)/American Heart Association (AHA)/Heart Failure Society of America (HFSA) guideline, and the 2023 focused update of the 2021 ESC document. Overall, these guidelines aim to solidify significant advances throughout the HF continuum since the publication of previous full guideline iterations (2013 and 2016 for the ACC/AHA and ESC, respectively)...
March 13, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38551522/factors-impacting-physician-prognostic%C3%A2-accuracy-in-heart%C3%A2-failure-patients-with-reduced-left-ventricular-ejection-fraction
#15
JOURNAL ARTICLE
Ana C Alba, Tayler A Buchan, Sudipta Saha, Steve Fan, Stephanie Poon, Susanna Mak, Abdul Al-Hesayen, Mustafa Toma, Shelley Zieroth, Kim Anderson, Catherine Demers, Faizan Amin, Liane Porepa, Sharon Chih, Nadia Giannetti, Valeria Rac, Heather J Ross, Gordon H Guyatt
BACKGROUND: A recent study showed that the accuracy of heart failure (HF) cardiologists and family doctors to predict mortality in outpatients with HF proved suboptimal, performing less well than models. OBJECTIVES: The authors sought to evaluate patient and physician factors associated with physician accuracy. METHODS: The authors included outpatients with HF from 11 HF clinics. Family doctors and HF cardiologists estimated patient 1-year mortality...
March 13, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38520460/association-of-pulmonary-artery-pressures-with-mortality-in-adults%C3%A2-with%C3%A2-reduced-left-ventricular-ejection%C3%A2-fraction
#16
JOURNAL ARTICLE
Seshika Ratwatte, Simon Stewart, Geoff Strange, David Playford, David S Celermajer
BACKGROUND: The independent effect of pulmonary hypertension (PHT) severity on mortality in those with reduced left ventricular ejection fraction (LVEF) is not well known. OBJECTIVES: The authors aimed to examine the prognostic impact of increasingly elevated pulmonary pressures in a large clinical cohort of adults with reduced LVEF. METHODS: The authors analyzed data from the National Echocardiography Database of Australia, a large clinical registry linking routine echocardiographic investigations to mortality...
March 12, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38530700/heart%C3%A2-failure-risk-among-african-american-women-with-an-icam1-missense-variant
#17
JOURNAL ARTICLE
Prarthana J Dalal, Pedro Giro, Laura J Rasmussen-Torvik, Clyde W Yancy, Sanjiv J Shah, Alex P Reiner, Bernhard Haring, Lisa Warsinger Martin, Gretchen L Wells, JoAnn E Manson, Charles Kooperberg, Charles B Eaton, Ravi B Patel
BACKGROUND: A common genetic variant of ICAM1 among African-American individuals (rs5491; p.K56M) is associated with heart failure (HF) hospitalization, but whether this risk is specific to heart failure with preserved ejection fraction (HFpEF) remains unclear. Older women are at high risk for HFpEF, and the relationship between rs5491 and HFpEF across the age spectrum is unknown. OBJECTIVES: This study assessed risk of HF and its subtypes conferred by ICAM1 p.K56M (rs5491)...
March 11, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38520461/utility-and-validity-of-the-hfa-peff-and%C3%A2-h-2-fpef-scores-in-patients-with-symptomatic-atrial-fibrillation
#18
JOURNAL ARTICLE
Jonathan P Ariyaratnam, Ricardo S Mishima, Kadhim Kadhim, Mehrdad Emami, John L Fitzgerald, Anand Thiyagarajah, Jenelle K Dziano, Jackson O Howie, Melissa E Middeldorp, Prashanthan Sanders, Adrian D Elliott
BACKGROUND: Diagnosis of heart failure with preserved ejection fraction (HFpEF) in patients with atrial fibrillation (AF) represents a significant clinical challenge. Two diagnostic scoring tools have been developed to aid the noninvasive diagnosis of HFpEF: the HFA-PEFF (Heart Failure Association Pre-test assessment, Echocardiography and natriuretic peptide, Functional testing, Final etiology) and the H2 FPEF scoring systems. OBJECTIVES: The purpose of this study was to evaluate the performance of these 2 scoring tools for the diagnosis of HFpEF against a gold standard of invasive evaluation in a cohort of patients with AF...
March 8, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38483431/heart%C3%A2-failure-training-for-the-internist-a-potential-solution-for-the-heart%C3%A2-failure-workforce-shortage
#19
EDITORIAL
Eiran Z Gorodeski, Andrew J Lenneman, Brett W Sperry
No abstract text is available yet for this article.
March 1, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38456853/is-reducing-heart%C3%A2-failure-hospitalization-associated-with-reducing-mortality-in-heart%C3%A2-failure-trials
#20
EDITORIAL
Pedro Marques, Abhinav Sharma, João Pedro Ferreira
No abstract text is available yet for this article.
February 27, 2024: JACC. Heart Failure
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