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JACC. Heart Failure

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https://read.qxmd.com/read/30852236/prevalence-and-prognostic-implications-of-longitudinal-ejection-fraction-change-in-heart-failure
#1
Gianluigi Savarese, Ola Vedin, Domenico D'Amario, Alicia Uijl, Ulf Dahlström, Giuseppe Rosano, Carolyn S P Lam, Lars H Lund
OBJECTIVES: This study sought to evaluate the incidence, the predictors, and the associations with outcomes of changes in ejection fraction (EF) in heart failure (HF) patients. BACKGROUND: EF determines therapy in HF, but information is scarce about incidence, determinants, and prognostic implications of EF change over time. METHODS: Patients with ≥2 EF measurements were made in the Swedish Heart Failure Registry were categorized as heart failure with preserved ejection fraction (HFpEF) (EF ≥50%), heart failure with midrange ejection fraction (HFmrEF) (EF 40% to 49%), or heart failure with reduced ejection fraction (HFrEF) (EF <40%)...
March 1, 2019: JACC. Heart Failure
https://read.qxmd.com/read/30852235/central-and-peripheral-determinants-of-exercise-capacity-in-heart-failure-patients-with-preserved-ejection-fraction
#2
Emil Wolsk, David Kaye, Jan Komtebedde, Sanjiv J Shah, Barry A Borlaug, Daniel Burkhoff, Dalane W Kitzman, Carolyn S P Lam, Dirk J van Veldhuisen, Piotr Ponikowski, Mark C Petrie, Christian Hassager, Jacob E Møller, Finn Gustafsson
OBJECTIVES: This study sought to discern which central (e.g., heart rate, stroke volume [SV], filling pressure) and peripheral factors (e.g., oxygen use by skeletal muscle, body mass index [BMI]) during exercise were most strongly associated with the presence of heart failure and preserved ejection fraction (HFpEF) as compared with healthy control subjects exercising at the same workload. BACKGROUND: The underlying mechanisms limiting exercise capacity in patients with HFpEF are not fully understood...
March 1, 2019: JACC. Heart Failure
https://read.qxmd.com/read/30738981/income-inequality-and-outcomes-in-heart-failure-a-global-between-country-analysis
#3
Pooja Dewan, Rasmus Rørth, Pardeep S Jhund, Joao Pedro Ferreira, Faiez Zannad, Li Shen, Lars Køber, William T Abraham, Akshay S Desai, Kenneth Dickstein, Milton Packer, Jean L Rouleau, Scott D Solomon, Karl Swedberg, Michael R Zile, John J V McMurray
OBJECTIVES: This study examined the relationship between income inequality and heart failure outcomes. BACKGROUND: The income inequality hypothesis postulates that population health is influenced by income distribution within a society, with greater inequality associated with worse outcomes. METHODS: This study analyzed heart failure outcomes in 2 large trials conducted in 54 countries. Countries were divided by tertiles of Gini coefficients (where 0% represented absolute income equality and 100% represented absolute income inequality), and heart failure outcomes were adjusted for standard prognostic variables, country per capita income, education index, and hospital bed, and health worker density...
February 4, 2019: JACC. Heart Failure
https://read.qxmd.com/read/30738980/impact-of-degree-of-left-ventricular-remodeling-on-clinical-outcomes-from-cardiac-resynchronization-therapy
#4
Fadi Shamoun, Teresa De Marco, David DeMets, Chaoqun Mei, JoAnn Lindenfeld, Leslie A Saxon, John P Boehmer, Jill Leigh, Patrick Yong, Arthur M Feldman, Michael R Bristow
OBJECTIVES: This study tested the hypothesis that the extent of left ventricular (LV) eccentric structural remodeling in heart failure with reduced ejection fraction (HFrEF) is directly associated with clinical event responses to cardiac resynchronization therapy (CRT). BACKGROUND: Whether the severity of LV structural remodeling influences CRT treatment effects is unknown. METHODS: COMPANION (Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure) trial data were analyzed retrospectively...
February 4, 2019: JACC. Heart Failure
https://read.qxmd.com/read/30738979/reframing-global-variation-in-heart-failure-trials-thinking-beyond-location-on-the-map
#5
EDITORIAL
Stephen J Greene, Robert M Califf
No abstract text is available yet for this article.
February 4, 2019: JACC. Heart Failure
https://read.qxmd.com/read/30738978/target-doses-of-heart-failure-medical-therapy-and-blood-pressure-insights-from-the-champ-hf-registry
#6
Poghni A Peri-Okonny, Xiaojuan Mi, Yevgeniy Khariton, Krishna K Patel, Laine Thomas, Gregg C Fonarow, Puza P Sharma, Carol I Duffy, Nancy M Albert, Javed Butler, Adrian F Hernandez, Kevin McCague, Fredonia B Williams, Adam D DeVore, J Herbert Patterson, John A Spertus
OBJECTIVES: This study sought to determine the rate of use of target doses of foundational guideline-directed medical therapy (GDMT) in a contemporary cohort of patients with heart failure with reduced ejection fraction (HFrEF) across systolic blood pressure (SBP) categories. BACKGROUND: Patients with HFrEF are infrequently titrated to recommended doses of GDMT. The relationship between SBP and achieving GDMT target doses is not well studied. METHODS: Patients enrolled in the CHAMP-HF (Change the Management of Patients With Heart Failure) registry without documented intolerance to angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), angiotensin receptor-neprilysin inhibitors (ARNIs), and beta blockers (BBs) were assessed at enrollment...
February 4, 2019: JACC. Heart Failure
https://read.qxmd.com/read/30738977/identification-of-frailty-in-chronic-heart-failure
#7
Shirley Sze, Pierpaolo Pellicori, Jufen Zhang, Joan Weston, Andrew L Clark
OBJECTIVES: This study sought to report the prevalence of frailty, classification performance, and agreement among 3 frailty assessment tools and 3 screening tools in chronic heart failure (CHF) patients. BACKGROUND: Frailty is common in patients with CHF. There are many available frailty tools, but no standard method for evaluating frailty. METHODS: We used the following frailty screening tools: the clinical frailty scale (CFS); the Derby frailty index; and the acute frailty network frailty criteria...
February 4, 2019: JACC. Heart Failure
https://read.qxmd.com/read/30738976/if-you-cannot-measure-frailty-you-cannot-improve-it
#8
EDITORIAL
Jonathan Afilalo, Aayushi Joshi, Rita Mancini
No abstract text is available yet for this article.
February 4, 2019: JACC. Heart Failure
https://read.qxmd.com/read/30611721/the-risk-of-takotsubo-syndrome-seeing-the-light
#9
EDITORIAL
L Christian Napp
No abstract text is available yet for this article.
January 2, 2019: JACC. Heart Failure
https://read.qxmd.com/read/30611719/influenza-and-heart-failure-a-catchy-comorbid-combination
#10
EDITORIAL
Orly Vardeny, Scott D Solomon
No abstract text is available yet for this article.
January 2, 2019: JACC. Heart Failure
https://read.qxmd.com/read/30819389/reply-increasingly-recognized-role-of-right-ventricle-assessment-in-cardiac-amyloidosis
#11
LETTER
Myriam Amsallem, Ronald Witteles, Francois Haddad
No abstract text is available yet for this article.
March 2019: JACC. Heart Failure
https://read.qxmd.com/read/30819388/increasingly-recognized-role-of-right-ventricle-assessment-in-cardiac-amyloidosis
#12
LETTER
Tushar Mishra, Mohit Pahuja, Aiden Abidov
No abstract text is available yet for this article.
March 2019: JACC. Heart Failure
https://read.qxmd.com/read/30819387/reply-safety-of-alpha-adrenergic-receptor-antagonists-in-heart-failure
#13
LETTER
Cynthia A Jackevicius, Zunera Ghaznavi, Lingyun Lu, Alberta L Warner
No abstract text is available yet for this article.
March 2019: JACC. Heart Failure
https://read.qxmd.com/read/30819386/safety-of-alpha-adrenergic-receptor-antagonists-in-heart-failure
#14
LETTER
Wen-Qin Guo, Ling-Yue Zhao, Hong-Lei Zhao, Xie-Hui Chen
No abstract text is available yet for this article.
March 2019: JACC. Heart Failure
https://read.qxmd.com/read/30819385/heart-failure-in-women
#15
EDITORIAL
JoAnn Lindenfeld, Christopher M O'Connor
No abstract text is available yet for this article.
March 2019: JACC. Heart Failure
https://read.qxmd.com/read/30819384/clinical-trial-outcomes-what-matters-to-patients
#16
LETTER
Robin Martinez
No abstract text is available yet for this article.
March 2019: JACC. Heart Failure
https://read.qxmd.com/read/30819383/do-women-and-men-respond-similarly-to-therapies-in-contemporary-heart-failure-clinical-trials
#17
REVIEW
Muthiah Vaduganathan, Ayman Samman Tahhan, Alaaeddin Alrohaibani, Stephen J Greene, Gregg C Fonarow, Orly Vardeny, JoAnn Lindenfeld, Mariell Jessup, Mona Fiuzat, Christopher M O'Connor, Javed Butler
No abstract text is available yet for this article.
March 2019: JACC. Heart Failure
https://read.qxmd.com/read/30819382/adverse-drug-reactions-to-guideline-recommended-heart-failure-drugs-in-women-a-systematic-review-of-the-literature
#18
Sophie H Bots, Floor Groepenhoff, Anouk L M Eikendal, Cara Tannenbaum, Paula A Rochon, Vera Regitz-Zagrosek, Virginia M Miller, Danielle Day, Folkert W Asselbergs, Hester M den Ruijter
OBJECTIVES: This study sought to summarize all available evidence on sex differences in adverse drug reactions (ADRs) to heart failure (HF) medication. BACKGROUND: Women are more likely to experience ADRs than men, and these reactions may negatively affect women's immediate and long-term health. HF in particular is associated with increased ADR risk because of the high number of comorbidities and older age. However, little is known about ADRs in women with HF who are treated with guideline-recommended drugs...
March 2019: JACC. Heart Failure
https://read.qxmd.com/read/30819381/sex-related-differences-in-use-and-outcomes-of-left-ventricular-assist-devices-as-bridge-to-transplantation
#19
Ersilia M DeFilippis, Lauren K Truby, A Reshad Garan, Raymond C Givens, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Jennifer H Haythe, Maryjane A Farr, Veli K Topkara
OBJECTIVES: This study examined sex-related differences in use and outcomes of continuous-flow left ventricular assist devices (CF-LVADs) among individuals awaiting heart transplantation using the United Network for Organ Sharing registry. BACKGROUND: Advanced therapies for heart failure including CF-LVADs remain underused in women. There have been contradictory results regarding sex-specific outcomes. Many studies have been limited by small sample sizes or included pulsatile-flow devices...
March 2019: JACC. Heart Failure
https://read.qxmd.com/read/30819380/sex-differences-in-heart-failure-with-preserved-ejection-fraction-pathophysiology-a-detailed-invasive-hemodynamic-and-echocardiographic-analysis
#20
Anna L Beale, Shane Nanayakkara, Louise Segan, Justin A Mariani, Micha T Maeder, Vanessa van Empel, Donna Vizi, Shona Evans, Carolyn S P Lam, David M Kaye
OBJECTIVES: This study sought to identify sex differences in central and peripheral factors that contribute to the pathophysiology of heart failure with preserved ejection fraction (HFpEF) by using complementary invasive hemodynamic and echocardiographic approaches. BACKGROUND: Women are overrepresented among patients with HFpEF, and there are established sex differences in myocardial structure and function. Exercise intolerance is a fundamental feature of HFpEF; however, sex differences in the physiological determinants of exercise capacity in HFpEF are yet to be established...
March 2019: JACC. Heart Failure
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