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Journals Journal of Allergy and Clinica...

Journal of Allergy and Clinical Immunology in Practice

https://read.qxmd.com/read/38316183/ockham-s-razor-the-application-of-parsimonious-medicine-in-allergy-immunology
#21
JOURNAL ARTICLE
John O Warner
The spectacular advances of modern medicine have distracted clinicians from applying the age-old principles of thorough history and examination followed by only ordering tests relevant to the patient's presentation. The most obvious diagnosis is the most likely and should be addressed first. Ockham's razor, or parsimonious medicine, should be applied because plurality of diagnoses is less likely than a single explanation. Component resolved diagnostics and highly effective biological therapies for allergy/immune mediated diseases have been highly effective when used by specialist allergy services...
February 3, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38316182/the-use-of-albuterol-budesonide-as-reliever-therapy-to-reduce-asthma-exacerbations
#22
JOURNAL ARTICLE
Reynold A Panettieri, Bradley Chipps, Neil Skolnik, Maureen George, Kevin Murphy, Njira Lugogo
Prevention of asthma exacerbations and reduction of systemic corticosteroid burden remain unmet needs in asthma. US asthma guidelines recommend concomitant short-acting β2 -agonist (SABA) and inhaled corticosteroid (ICS) as alternative reliever at Step 2. The FDA approved a pressurized metered-dose inhaler containing albuterol and budesonide for as-needed treatment or prevention of bronchoconstriction and to reduce exacerbation risk in patients with asthma aged ≥18 years. This combination is approved for use as a reliever with or without maintenance therapy but it is not indicated for maintenance therapy (or for single maintenance and reliever therapy)...
February 3, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38309696/baseline-characteristics-and-ics-lama-laba-response-in-asthma-analyses-from-the-captain-study
#23
JOURNAL ARTICLE
Louis-Philippe Boulet, Carl Abbott, Guy Brusselle, Dawn Edwards, John Oppenheimer, Ian D Pavord, Emilio Pizzichini, Hironori Sagara, David Slade, Michael E Wechsler, Peter G Gibson
BACKGROUND: Findings from CAPTAIN (NCT02924688) suggest treatment response to fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) differs according to baseline type 2 (T2) inflammation markers in patients with moderate-to-severe asthma. Understanding how other patient physiologic and clinical characteristics affect response to inhaled therapies may guide physicians toward a personalized approach for asthma management. OBJECTIVE: To investigate, using CAPTAIN data, the predictive value of key demographic and baseline physiologic variables in patients with asthma (lung function, bronchodilator reversibility, age, age at asthma onset) on response to addition of the long-acting muscarinic antagonist UMEC to inhaled corticosteroid/long-acting β2 -agonist combination FF/VI, or doubling FF dose...
February 1, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38307206/occupational-asthma-in-ontario-canada-2000-2022-a-retrospective-clinic-based-study-evaluating-sex-differences
#24
JOURNAL ARTICLE
Felix L Chan, Joshua Lipszyc, Ben Dekoven, Victor Nguyen, Marcos Ribeiro, Susan M Tarlo
The findings of our clinic-based study substantiate historical sex difference trends in occupational asthma distribution and exposures and suggest increased disease severity and a trend to a longer time to diagnosis in men compared to women.
January 31, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38307205/sublingual-tablet-immunotherapy-improves-quality-of-life-in-adults-with-allergic-rhinoconjunctivitis
#25
JOURNAL ARTICLE
Michael S Blaiss, Stephen R Durham, David Bernstein, Thomas Stranzl, Morten Lindholm, Hendrik Nolte, Kristian Funding Andersen, Graham Roberts
BACKGROUND: Allergic rhinitis with or without conjunctivitis (AR/C) can negatively impact many aspects of quality of life (QoL). The efficacy and safety of SQ sublingual immunotherapy (SLIT)-tablets have been confirmed across large clinical trials in adults with grass, tree, ragweed, and house dust mite (HDM) AR/C. OBJECTIVE: This pooled analysis investigates whether the reduction in symptom burden found across the clinical trials is supported by improvements in QoL...
January 31, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38307204/clinical-picture-outcomes-and-predictors-of-relapse-in-eosinophilia-associated-coronary-vasospasm-data-from-a-european-multicentric-study
#26
JOURNAL ARTICLE
Florent Huang, Lucas Rémi Khellaf, Guillaume Lefèvre, Alvise Berti, Thomas d'Humières, Alessandro Sionis, Albert Ariza Solé, Federica Bello, Juan Andres Bermeo Garrido, Etienne Crickx, Paolo Delvino, Giacomo Emmi, Antoine Gaillet, Gilles Garcia, Pierre-Edouard Gavand, Jean-Louis George, Floriane Gilles, Cécile Golden, Pascal de Groote, Aurélien Guffroy, Nihal Martis, Sara Monti, Pierre Mourlanette, Marc Pineton de Chambrun, Fabrice Prunier, Francesca Regola, Gabriel Seret, Benjamin Terrier, Ludovic Tréfond, Géraud Souteyrand, Olivier Varenne, Filippo Zilio, Franck Haziza, Hakim Benamer, Jean-Emmanuel Kahn, Alexandre Vallée, Matthieu Groh
No abstract text is available yet for this article.
January 31, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38300169/factors-influencing-career-choice-of-allergy-and-immunology-fellows-in-training-a-work-group-report-of-the-aaaai-program-directors-assembly-executive-committee
#27
JOURNAL ARTICLE
Kasey Lanier, Rebecca Scherzer, Christian Coletta, Princess U Ogbogu, Kimberly A Risma, Margaret Redmond
BACKGROUND: As the burden of allergic and immunologic disease continues to increase, there is increased demand for a larger Allergy and Immunology (AI) subspecialty workforce. The field must prioritize the expansion of our workforce and the recruitment of exceptional and diverse trainees to ensure the vitality of the specialty. Although the AI fellowship match has traditionally been competitive, recent trends in fellowship applications have demonstrated fewer applicants per fellowship position...
January 29, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38296051/clinical-characteristics-and-impact-of-inducible-laryngeal-obstruction-in-the-uk-national-registry
#28
JOURNAL ARTICLE
Jemma Haines, Andrew J Simpson, Claire Slinger, Julia Selby, Nicola Pargeter, Stephen J Fowler, James H Hull
BACKGROUND: Inducible laryngeal obstruction (ILO) describes inappropriate laryngeal closure during respiration, with airflow obstruction occurring at the glottic and/or supraglottic level, leading to breathlessness. OBJECTIVE: There is a paucity of data describing the demographics and impact of ILO. We aimed to report the clinical and demographic features of ILO in individuals entered prospectively in the UK national ILO registry. METHODS: Data were entered into a web-based registry from participants with endoscopically confirmed ILO, attending four established UK-wide specialist ILO centres between March 2017-November 2019...
January 29, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38290607/living-with-asthma-and-vocal-cord-dysfunction-inducible-laryngeal-obstruction-i-just-can-t-get-air-in
#29
JOURNAL ARTICLE
Eleanor C Majellano, Vanessa L Clark, Anne Vertigan, Peter G Gibson, Philip Bardin, Paul Leong, Vanessa M McDonald
BACKGROUND: Asthma and vocal cord dysfunction (VCD) also known as inducible laryngeal obstruction (ILO) may coexist, resulting in worse outcomes for patients. The experience of people with VCD/ILO and coexisting asthma is unknown. OBJECTIVE: We sought to determine if coexistent VCD/ILO and asthma have deleterious impacts on quality of life. METHODS: A descriptive qualitative study utilising, one-to-one semi-structured interviews with 30 purposively recruited adult participants with prior confirmed doctor asthma diagnosis and laryngoscopy confirmed VCD/ILO was undertaken...
January 28, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38281585/could-corticosteroid-antihistamine-combination-nasal-sprays-be-used-as-anti-inflammatory-reliever-therapy-for-allergic-rhinitis
#30
EDITORIAL
Brian Lipworth, Kirsten Stewart, Chris RuiWen Kuo, Rory Chan
No abstract text is available yet for this article.
January 26, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38281584/absolute-eosinophil-counts-in-aspirin-exacerbated-respiratory-disease-are-distinctly-elevated-and-correlate-inversely-with-respiratory-function
#31
JOURNAL ARTICLE
Andrew D Supron, Victor Omilabu, Laura Bailey, Kathleen M Buchheit, Tanya M Laidlaw
No abstract text is available yet for this article.
January 26, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38280454/phenotyping-of-severe-asthma-in-the-era-of-broad-acting-anti-asthma-biologics
#32
JOURNAL ARTICLE
Arnaud Bourdin, Guy Brusselle, Simon Couillard, Merritt L Fajt, Liam G Heaney, Elliot Israel, P Jane McDowell, Andrew Menzies-Gow, Neil Martin, Patrick D Mitchell, Nayia Petousi, Santiago Quirce, Florence Schleich, Ian D Pavord
Severe asthma is associated with significant morbidity and mortality despite maximal use of inhaled corticosteroids and additional controller medications, and has a high economic burden. Biologic therapies are recommended for the management of severe, uncontrolled asthma to help prevent exacerbations and to improve symptoms and health-related quality of life. Effective management of severe asthma requires consideration of clinical heterogeneity that is driven by varying clinical and inflammatory phenotypes, which are reflective of distinct underlying disease mechanisms...
January 25, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38280453/evaluation-of-pharmacological-treatments-for-acute-urticaria-a-systematic-review-and-meta-analysis
#33
JOURNAL ARTICLE
Sirinda Jamjanya, Pojsakorn Danpanichkul, Sorawit Ongsupankul, Supakarn Taweesap, Kednapa Thavorn, Brian Hutton, Chidchanok Ruengorn, Jonathan A Bernstein, Mati Chuamanochan, Surapon Nochaiwong
BACKGROUND: The effectiveness and safety of pharmacological treatments for acute urticaria remain unclear. OBJECTIVE: To systematically review and meta-analysis the efficacy and safety of pharmacological treatments for acute urticaria in emergency department (ED) and non-ED settings. METHODS: We searched electronic databases and grey literature up to July 8, 2023, without language restrictions. Randomized clinical trials (RCTs) relating to pharmacological interventions in patients with acute urticaria, regardless of age, were eligible for inclusion...
January 25, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38280452/identifying-children-at-risk-of-growth-and-nutrient-deficiencies-in-the-food-allergy-clinic
#34
JOURNAL ARTICLE
Carina Venter, Rosan Meyer, Maureen Bauer, J Andrew Bird, David M Fleischer, Anna Nowak-Wegrzyn, Aikaterini Anagnostou, Brian P Vickery, Julie Wang, Marion Groetch
BACKGROUND: Food allergies affect growth in children by decreasing the availability of nutrients through decreased dietary intake, increased dietary needs, food-medication interactions, and psychosocial burden. Guidelines on food allergy management frequently recommend nutrition counseling and growth monitoring of children with food allergies. OBJECTIVE: To provide clear guidance for clinicians to identify children with food allergies who are at nutritional risk and ensure prompt intervention...
January 25, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38280451/addressing-health-equity-in-food-allergy
#35
JOURNAL ARTICLE
Sara Dehborzogi, Nicole Ramsey, Ashley Sang Eun Lee, Amaziah Coleman, Pooja Varshney, Carla Davis
Social determinants of health can lead to poor health outcomes for food allergic patients, including limited access to allergen-free foods and specialty care. Housing and transportation limitations can worsen social factors including food insecurity, poor early food introduction, increased reactivity to foods, lower tertiary/allergy care utilization, and increased emergency room utilization. A key component of addressing health equity involves valuing all people with sustained, focused efforts to address social determinants of health...
January 25, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38280450/diagnosis-and-management-of-pollen-food-allergy-syndrome-to-nuts
#36
JOURNAL ARTICLE
Mattia Giovannini, Isabel J Skypala, Jean Christoph Caubet, George Du Toit, Anna Nowak-Wegrzyn
Oral allergy syndrome or pollen food allergy syndrome (PFAS) represents a common clinical conundrum when the reported trigger food is a tree nut (usually almond or hazelnut) or peanut. The PFAS may give rise to uncertainty about the potential severity of the future reactions, indications for prescribing epinephrine, and the extent of the necessary dietary avoidance. As a food allergy, secondary to cross-reactivity with airborne pollen, PFAS usually manifests toward the end of the first decade of life as contact urticaria of the oropharyngeal mucous membranes...
January 25, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38278325/severe-multiple-drug-intolerance-syndrome-in-fibromyalgia-and-irritable-bowel-syndrome
#37
JOURNAL ARTICLE
Alicia A Alvarez, Jayme M Palka, David A Khan
BACKGROUND: Multiple drug intolerance syndrome (MDIS) describes patients with multiple non-immunologically mediated adverse reactions to medications. Patients with more than 10 medication intolerance labels are considered to have severe MDIS. There is overlap in the characteristics of patients with MDIS and fibromyalgia and irritable bowel syndrome (IBS). Severe MDIS can limit treatment options in this already complex patient group. OBJECTIVE: This study assessed the prevalence of severe MDIS in patients with fibromyalgia and IBS and its associated risk factors...
January 24, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38278324/treatable-traits-in-asthma-the-importance-of-extra-pulmonary-traits-gerd-crswnp-atopic-dermatitis-and-depression-anxiety
#38
JOURNAL ARTICLE
Vanessa M McDonald, Yuto Hamada, Alvar Agusti, Peter G Gibson
Treatable traits is a personalised medicine approach to the management of airway disease. Assessing traits within the three domains of pulmonary, extra pulmonary and behavioral/lifestyle/risk-factors traits, and applying targeted treatments to effectively manage these traits enables a holistic and personalised approach to care. Asthma is a heterogeneous and complex airway disease that is frequently complicated by several extrapulmonary traits that impact asthma outcomes and predict future outcomes. We propose that the identification of extra pulmonary, and behavioral risk factor traits and the implementation of targeted therapy will lead to improved management of people with asthma...
January 24, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38246560/what-a-clinician-needs-to-know-about-genome-editing-status-and-opportunities-for-inborn-errors-of-immunity
#39
JOURNAL ARTICLE
Anne Ca Mudde, Caroline Y Kuo, Donald B Kohn, Claire Booth
During the past twenty years, gene editing has emerged as a novel form of gene therapy. Since the publication of the first potentially therapeutic gene editing platform for genetic disorders, increasingly sophisticated editing technologies have been developed. As with viral vector mediated gene addition, inborn errors of immunity (IEIs) are excellent candidate diseases for a corrective autologous haematopoietic stem cell gene editing strategy. Research on gene editing for IEIs is still entirely preclinical, with no trials yet underway...
January 19, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38244013/contact-leukoderma-following-allergic-contact-dermatitis-to-a-smartwatch-a-consequence-of-nickel-allergy
#40
JOURNAL ARTICLE
Lingling Zhang, Yangyang Ma, Wenting Hu, Ai-E Xu
No abstract text is available yet for this article.
January 19, 2024: Journal of Allergy and Clinical Immunology in Practice
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