Journal of Allergy and Clinical Immunology in Practice

BACKGROUND: Severe anaphylactic reactions to home-doses may occur during food allergy oral immunotherapy (OIT). OBJECTIVE: To study the rate and risk factors for such reactions. METHODS: All patients aged >3.5 years who completed OIT in a single center, between April-2010 and January-2020, were studied. All home epinephrine-treated reactions (HETRs) were identified. High-grade HETRs (HG-HETRs) were defined as HETR involving respiratory (SpO2 ≤94%), cardiovascular (low blood pressure), or CNS (loss of consciousness) impairment...

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BACKGROUND: To better understand the impact and burden of disease experienced by patients with hereditary angioedema (HAE). OBJECTIVE: To determine if use of SMS to communicate with patients with HAE facilitates collection of attack rate, medication usage and quality of life measurements. METHODS: Patients aged ≥12 years with doctor-confirmed hereditary angioedema C1-inhibitor deficiency types I and II were invited to participate. We devised a novel method for monitoring attacks by using questions via SMS on a weekly basis to gain a more accurate picture of the burden of hereditary angioedema in Australian patients in real time...

BACKGROUND: Oral immunotherapy (OIT) aims to increase the reaction threshold to a food allergen and decrease the risk of a potentially life-threatening allergic reaction in the event of an accidental ingestion. While single-food OIT is the most extensively studied, data on multi-food OIT are limited. OBJECTIVE: Our study aimed to examine the safety and feasibility of single-food and multi-food immunotherapy in a large cohort in an outpatient pediatric allergy clinic setting...

BACKGROUND: The availability of asthma biologics may not benefit all patients equally. OBJECTIVE: We sought to identify patient characteristics associated with asthma biologic prescribing, primary adherence, and effectiveness. METHODS: A retrospective, observational cohort study of 9,147 adults with asthma who established care with a Penn Medicine asthma subspecialist was conducted using Electronic Health Record data from 1/1/2016 to 10/18/2021...

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BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially life-threatening drug reaction; recognising the diversity of its clinical presentations, implicated drugs and management modalities can aid in diagnosis and reduce morbidity and mortality. OBJECTIVE: To review the clinical features, drug causes and treatments deployed in DRESS. METHODS: This review was performed in accordance with the PRISMA guidelines to review publications relating to DRESS published between 1979 and 2021...

BACKGROUND: Many adult patients with asthma have uncontrolled disease and impaired quality of life, despite current asthma-specific drug therapies. OBJECTIVE: This study aimed to investigate the prevalence of nine traits in asthma patients, their associations with disease control and quality of life, and referral rates to non-medical healthcare professionals. METHODS: Retrospectively, data from asthma patients were collected in two Dutch hospitals (Amphia Breda, RadboudUMC Nijmegen)...

BACKGROUND: Episodes of asthma-like symptoms in young children are common, but little is known about risk factors and their patterns for the daily symptom burden. OBJECTIVE: We investigated a variety of possible risk factors and their age-related impact on the number of asthma-like episodes during age 0-3 years. METHODS: The study population included 700 children from the COPSAC2010 mother-child cohort followed prospectively from birth. Asthma-like symptoms were recorded until age three by daily diaries...

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No abstract text is available yet for this article.

No abstract text is available yet for this article.

BACKGROUND: The Food Allergy Quality of Life Questionnaire (FAQLQ) is the most widely used measure to assess health-related quality of life in food allergy (FA). However, its length can lead to a series of disadvantages, such as reduced or incomplete participation and boredom and disengagement, affecting data quality, reliability, and validity. OBJECTIVE: In the present research, we shortened the well-known FAQLQ for adults, and proposed the FAQLQ-12. METHODS: We applied gold-standard statistical analyses, mixing classic test theory and item response theory (IRT) to identify relevant items for the new short form, and confirm its structure fit and reliability...

Chronic spontaneous urticaria (CSU) is a frequent and often severely disabling disease. A large number of studies were performed during the last 2 decades to clarify its pathogenesis. These studies shed further light on the underlying autoimmune mechanisms of CSU pathogenesis and have led us to understand that different mechanisms may exist and sometimes co-exist behind the same clinical presentation. The present article reviews the meaning of the terms autoreactivity, autoimmunity, and autoallergy, which have been variably used over the years to define different endotypes of the disease...

BACKGROUND: Mental and social health in preschool caregivers has been inadequately studied but may influence respiratory symptom recognition and management. OBJECTIVE: This study identified preschool caregivers at highest risk for poor mental and social health outcomes based on patient-reported outcome measures. We hypothesized that caregivers with the poorest mental and social health would have worse quality of life and preschool children with more wheezing episodes...

BACKGROUND: The stability and variability of blood eosinophil counts (BECs) to phenotype patients with severe asthma is not fully understood. OBJECTIVE: This post hoc, longitudinal, pooled analysis of placebo-arm patients from 2 phase 3 studies evaluated the clinical implications of BEC stability and variability in moderate-to-severe asthma. METHODS: This analysis included patients from SIROCCO and CALIMA who received maintenance medium- to high-dosage inhaled corticosteroids plus long-acting β2 -agonists; 2:1 patients with BECs ≥300 and <300 cells/μL were enrolled...

In 2002, the European Competence Network on Mastocytosis (ECNM) was launched as a multidisciplinary collaborative initiative to increase the awareness and to improve diagnosis and management of patients with mast cell disorders. The ECNM consists of a net of specialized centers, expert physicians and scientists who dedicate their work to mast cell diseases. One essential aim of the ECNM is to timely distribute all available information about the disease to patients, doctors, and scientists. In the past 20 years, the ECNM has expanded substantially and contributed successfully to the development of new diagnostic concepts, the classification, prognostication, and treatments of patients with mastocytosis and mast cell activation disorders...

BACKGROUND: One requirement for diagnosing mast cell activation syndrome (MCAS) is an increase, above an established baseline level, of the serum tryptase by 20% plus 2 ng/mL. However, here is no consensus of what constitutes excretion of a substantial metabolite increase from prostaglandin D2 , histamine or leukotrieneE4 in MCAS. OBJECTIVE: The ratios of acute/baseline levels for for each of the urinary metabolites that accompanied tryptase increases of 20% + 2 ng/mLwere determined...

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No abstract text is available yet for this article.