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Journal of Allergy and Clinical Immunology in Practice

https://read.qxmd.com/read/36925102/severe-anaphylactic-reactions-to-home-doses-of-oral-immunotherapy-for-food-allergy
#1
JOURNAL ARTICLE
Liat Nachshon, Naama Schwartz, Michael B Levy, Michael Goldberg, Naama Epstein-Rigbi, Yitzhak Katz, Arnon Elizur
BACKGROUND: Severe anaphylactic reactions to home-doses may occur during food allergy oral immunotherapy (OIT). OBJECTIVE: To study the rate and risk factors for such reactions. METHODS: All patients aged >3.5 years who completed OIT in a single center, between April-2010 and January-2020, were studied. All home epinephrine-treated reactions (HETRs) were identified. High-grade HETRs (HG-HETRs) were defined as HETR involving respiratory (SpO2 ≤94%), cardiovascular (low blood pressure), or CNS (loss of consciousness) impairment...
March 14, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36921799/association-between-social-needs-and-asthma-control-among-children-evaluated-at-a-single-center-high-risk-asthma-clinic
#2
JOURNAL ARTICLE
Rachel H F Margolis, Shilpa J Patel, Julie Krueger, Taylor Brewer, Andrea Williams, Shayla Stringfield, Stephen J Teach, Kavita Parikh
No abstract text is available yet for this article.
March 13, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36918098/living-with-hereditary-angioedema-in-australia-findings-from-a-national-observational-study-using-sms-to-monitor-the-burden-of-disease
#3
JOURNAL ARTICLE
Constance H Katelaris, PhD Fenton, Peter H Button, Philip I McCloud, Pamela K Burton, Fiona A Perram, Sherif Youssef, David Tognarini
BACKGROUND: To better understand the impact and burden of disease experienced by patients with hereditary angioedema (HAE). OBJECTIVE: To determine if use of SMS to communicate with patients with HAE facilitates collection of attack rate, medication usage and quality of life measurements. METHODS: Patients aged ≥12 years with doctor-confirmed hereditary angioedema C1-inhibitor deficiency types I and II were invited to participate. We devised a novel method for monitoring attacks by using questions via SMS on a weekly basis to gain a more accurate picture of the burden of hereditary angioedema in Australian patients in real time...
March 12, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36907355/safety-of-multi-food-oral-immunotherapy-in-children-aged-1-18-years-at-an-academic-pediatric-clinic
#4
JOURNAL ARTICLE
Kim Nguyen, Megan O Lewis, Elizabeth Hanna, Maria Katerina C Alfaro, Kristen Corrigan, Jillian Buonanno, Rahul Datta, Terri Brown-Whitehorn, Jonathan M Spergel, Antonella Cianferoni
BACKGROUND: Oral immunotherapy (OIT) aims to increase the reaction threshold to a food allergen and decrease the risk of a potentially life-threatening allergic reaction in the event of an accidental ingestion. While single-food OIT is the most extensively studied, data on multi-food OIT are limited. OBJECTIVE: Our study aimed to examine the safety and feasibility of single-food and multi-food immunotherapy in a large cohort in an outpatient pediatric allergy clinic setting...
March 10, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36907354/factors-associated-with-asthma-biologic-prescribing-and-primary-adherence-among-adults-in-a-large-health-system
#5
JOURNAL ARTICLE
Patrick K Gleeson, Knashawn H Morales, Christopher Hvisdas, Anthony F LaCava, Michael O Harhay, Matthew A Rank, Andrea J Apter, Blanca E Himes
BACKGROUND: The availability of asthma biologics may not benefit all patients equally. OBJECTIVE: We sought to identify patient characteristics associated with asthma biologic prescribing, primary adherence, and effectiveness. METHODS: A retrospective, observational cohort study of 9,147 adults with asthma who established care with a Penn Medicine asthma subspecialist was conducted using Electronic Health Record data from 1/1/2016 to 10/18/2021...
March 10, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36898527/post-covid-recurrent-fever-in-children-with-polymorphisms-in-the-innate-immunity-regulator-pyrin-mefv-gene
#6
JOURNAL ARTICLE
Levi Keller, Nathan Rabinovitch
No abstract text is available yet for this article.
March 8, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36893848/drug-reaction-with-eosinophilia-and-systemic-symptoms-a-systematic-review
#7
JOURNAL ARTICLE
Andrew Awad, Michelle S Goh, Jason A Trubiano
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially life-threatening drug reaction; recognising the diversity of its clinical presentations, implicated drugs and management modalities can aid in diagnosis and reduce morbidity and mortality. OBJECTIVE: To review the clinical features, drug causes and treatments deployed in DRESS. METHODS: This review was performed in accordance with the PRISMA guidelines to review publications relating to DRESS published between 1979 and 2021...
March 7, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36893847/the-impact-of-treatable-traits-on-asthma-control-and-quality-of-life
#8
JOURNAL ARTICLE
Steffi Mj Janssen, Hanneke Ac van Helvoort, Tjitske A Tjalma, Jeanine C Antons, Remco S Djamin, Sami O Simons, Prof Martijn A Spruit, Alex J van 't Hul
BACKGROUND: Many adult patients with asthma have uncontrolled disease and impaired quality of life, despite current asthma-specific drug therapies. OBJECTIVE: This study aimed to investigate the prevalence of nine traits in asthma patients, their associations with disease control and quality of life, and referral rates to non-medical healthcare professionals. METHODS: Retrospectively, data from asthma patients were collected in two Dutch hospitals (Amphia Breda, RadboudUMC Nijmegen)...
March 7, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36889671/risk-factors-and-age-related-patterns-of-asthma-like-symptoms-in-early-childhood
#9
JOURNAL ARTICLE
Julie Nyholm Kyvsgaard, Bo Lund Krogsgaard Chawes, David Lyle George Horner, Laura Marie Hesselberg, Mathias Elsner Melgaard, Signe Kjeldgaard Jensen, Ann-Marie Malby Schoos, Jonathan Thorsen, Casper-Emil Tingskov Pedersen, Nicklas Brustad, Klaus Bønnelykke, Hans Bisgaard, Jakob Stokholm
BACKGROUND: Episodes of asthma-like symptoms in young children are common, but little is known about risk factors and their patterns for the daily symptom burden. OBJECTIVE: We investigated a variety of possible risk factors and their age-related impact on the number of asthma-like episodes during age 0-3 years. METHODS: The study population included 700 children from the COPSAC2010 mother-child cohort followed prospectively from birth. Asthma-like symptoms were recorded until age three by daily diaries...
March 6, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36889670/evening-ingestion-as-a-potential-reaction-cofactor-during-peanut-oral-immunotherapy-in-children
#10
JOURNAL ARTICLE
Emily Morris, Jennifer Lp Protudjer, Samira Jeimy, Sarah Edgerley, Natalie Rondilla, Kara Robertson, Rongbo Zhu, Harold Kim
No abstract text is available yet for this article.
March 6, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36878750/phenytoin-induced-toxic-epidermal-necrolysis-in-a-pediatric-patient
#11
JOURNAL ARTICLE
Ana Raquel Pinto, Inês Machado Cunha, Eva Rebelo Gomes
No abstract text is available yet for this article.
March 4, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36868475/identification-of-epx-variants-in-human-eosinophilic-granulomatosis-with-polyangiitis-churg-strauss
#12
JOURNAL ARTICLE
Clémence David, Yamina Hamel, Asma Smahi, Elisabeth Diot, Ygal Benhamou, Nicolas Girszyn, Thomas Le Gallou, François Lifermann, Pascal Godmer, François Maurier, Vincent Cottin, Aurélie Grados, Olivier Aumaitre, Antoine Néel, Grégory Pugnet, Cecile Masson, Xavier Puéchal, Luc Mouthon, Loïc Guillevin, Thierry Bienvenu, Benjamin Terrier
No abstract text is available yet for this article.
March 1, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36868474/the-short-food-allergy-quality-of-life-questionnaire-faqlq-12-for-adults
#13
JOURNAL ARTICLE
Gabriel Lins de Holanda Coelho, Melanie Lloyd, Mimi L K Tang, Audrey DunnGalvin
BACKGROUND: The Food Allergy Quality of Life Questionnaire (FAQLQ) is the most widely used measure to assess health-related quality of life in food allergy (FA). However, its length can lead to a series of disadvantages, such as reduced or incomplete participation and boredom and disengagement, affecting data quality, reliability, and validity. OBJECTIVE: In the present research, we shortened the well-known FAQLQ for adults, and proposed the FAQLQ-12. METHODS: We applied gold-standard statistical analyses, mixing classic test theory and item response theory (IRT) to identify relevant items for the new short form, and confirm its structure fit and reliability...
March 1, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36868473/chronic-spontaneous-urticaria-the-role-and-relevance-of-autoreactivity-autoimmunity-and-autoallergy
#14
JOURNAL ARTICLE
Riccardo Asero, Marta Ferrer, Emek Kocaturk, Marcus Maurer
Chronic spontaneous urticaria (CSU) is a frequent and often severely disabling disease. A large number of studies were performed during the last 2 decades to clarify its pathogenesis. These studies shed further light on the underlying autoimmune mechanisms of CSU pathogenesis and have led us to understand that different mechanisms may exist and sometimes co-exist behind the same clinical presentation. The present article reviews the meaning of the terms autoreactivity, autoimmunity, and autoallergy, which have been variably used over the years to define different endotypes of the disease...
March 1, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36868472/poorer-caregiver-mental-and-social-health-is-associated-with-worse-respiratory-outcomes-in-preschool-children-with-recurrent-wheezing
#15
JOURNAL ARTICLE
Anne M Fitzpatrick, Badiallo Diani, Dio Kavalieratos, Alison Corace, Carrie Mason, Morgan Van Dresser, Jocelyn R Grunwell
BACKGROUND: Mental and social health in preschool caregivers has been inadequately studied but may influence respiratory symptom recognition and management. OBJECTIVE: This study identified preschool caregivers at highest risk for poor mental and social health outcomes based on patient-reported outcome measures. We hypothesized that caregivers with the poorest mental and social health would have worse quality of life and preschool children with more wheezing episodes...
March 1, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36868471/clinical-implications-of-longitudinal-blood-eosinophil-counts-in-patients-with-severe-asthma
#16
JOURNAL ARTICLE
Eugene R Bleecker, Deborah A Meyers, Dean Billheimer, Huashi Li, Paul Newbold, Justin Kwiatek, Ian Hirsch, Rohit Katial, Xingnan Li
BACKGROUND: The stability and variability of blood eosinophil counts (BECs) to phenotype patients with severe asthma is not fully understood. OBJECTIVE: This post hoc, longitudinal, pooled analysis of placebo-arm patients from 2 phase 3 studies evaluated the clinical implications of BEC stability and variability in moderate-to-severe asthma. METHODS: This analysis included patients from SIROCCO and CALIMA who received maintenance medium- to high-dosage inhaled corticosteroids plus long-acting β2 -agonists; 2:1 patients with BECs ≥300 and <300 cells/μL were enrolled...
March 1, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36868470/european-competence-network-on-mastocytosis-ecnm-20-year-jubilee-updates-and-future-perspectives
#17
REVIEW
Peter Valent, Karin Hartmann, Patrizia Bonadonna, Wolfgang R Sperr, Marek Niedoszytko, Olivier Hermine, Hanneke C Kluin-Nelemans, Karl Sotlar, Gregor Hoermann, Boguslaw Nedoszytko, Sigurd Broesby-Olsen, Roberta Zanotti, Magdalena Lange, Michael Doubek, Knut Brockow, Ivan Alvarez-Twose, Judit Varkonyi, Selim Yavuz, Gunnar Nilsson, Deepti Radia, Clive Grattan, Juliana Schwaab, Theo Gülen, Hanneke N G Oude Elberink, Hans Hägglund, Frank Siebenhaar, Emir Hadzijusufovic, Vito Sabato, Jiri Mayer, Andreas Reiter, Alberto Orfao, Hans-Peter Horny, Massimo Triggiani, Michel Arock
In 2002, the European Competence Network on Mastocytosis (ECNM) was launched as a multidisciplinary collaborative initiative to increase the awareness and to improve diagnosis and management of patients with mast cell disorders. The ECNM consists of a net of specialized centers, expert physicians and scientists who dedicate their work to mast cell diseases. One essential aim of the ECNM is to timely distribute all available information about the disease to patients, doctors, and scientists. In the past 20 years, the ECNM has expanded substantially and contributed successfully to the development of new diagnostic concepts, the classification, prognostication, and treatments of patients with mastocytosis and mast cell activation disorders...
March 1, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36863614/increased-excretion-of-mast-cell-mediator-metabolites-during-mast-cell-activation-syndrome
#18
JOURNAL ARTICLE
Joseph Henry Butterfield
BACKGROUND: One requirement for diagnosing mast cell activation syndrome (MCAS) is an increase, above an established baseline level, of the serum tryptase by 20% plus 2 ng/mL. However, here is no consensus of what constitutes excretion of a substantial metabolite increase from prostaglandin D2 , histamine or leukotrieneE4 in MCAS. OBJECTIVE: The ratios of acute/baseline levels for for each of the urinary metabolites that accompanied tryptase increases of 20% + 2 ng/mLwere determined...
February 28, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36863613/nutritional-treatment-of-atopic-diseases-according-to-youtube-videos
#19
JOURNAL ARTICLE
Simon Høj, Hanieh Meteran, Simon Francis Thomsen, Torben Sigsgaard, Howraman Meteran
No abstract text is available yet for this article.
February 28, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/36858279/selective-iga-deficiency-and-covid-19
#20
JOURNAL ARTICLE
Eli Magen, Eugene Merzon, Ilan Green, Avivit Golan-Cohen, Shlomo Vinker, Ariel Israel
No abstract text is available yet for this article.
February 27, 2023: Journal of Allergy and Clinical Immunology in Practice
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