Marco G Hermann, Nils Schröter, Alexander Rau, Marco Reisert, Nadja Jarc, Michel Rijntjes, Jonas A Hosp, Peter C Reinacher, Wolfgang H Jost, Horst Urbach, Cornelius Weiller, Volker A Coenen, Bastian E A Sajonz
BACKGROUND: Nigrostriatal microstructural integrity has been suggested as a biomarker for levodopa response in Parkinson's disease (PD), which is a strong predictor for motor response to deep brain stimulation (DBS) of the subthalamic nucleus (STN). This study aimed to explore the impact of microstructural integrity of the substantia nigra (SN), STN, and putamen on motor response to STN-DBS using diffusion microstructure imaging. METHODS: Data was collected from 23 PD patients (mean age 63 ± 7, 6 females) who underwent STN-DBS, had preoperative 3 T diffusion magnetic resonance imaging including multishell diffusion-weighted MRI with b-values of 1000 and 2000 s/mm2 and records of motor improvement available...
April 18, 2024: NeuroImage: Clinical
Jiaji Lin, Xiaopeng Kang, Jiayou Zhou, Dekang Zhang, Jianxing Hu, Haoxuan Lu, Longsheng Pan, Xin Lou
BACKGROUND: MR-guided focused ultrasound (MRgFUS) thalamotomy is a novel and effective treatment for medication-refractory tremor in essential tremor (ET), but how the brain responds to this deliberate lesion is not clear. OBJECTIVE: The current study aimed to evaluate the immediate and longitudinal alterations of functional networks after MRgFUS thalamotomy. METHODS: We retrospectively obtained preoperative and postoperative 30-day, 90-day, and 180-day data of 31 ET patients subjected with MRgFUS thalamotomy from 2018 to 2020...
April 15, 2024: NeuroImage: Clinical
Zeus Gracia-Tabuenca, Elise B Barbeau, Yu Xia, Xiaoqian Chai
Depression is an incapacitating psychiatric disorder with increased risk through adolescence. Among other factors, children with family history of depression have significantly higher risk of developing depression. Early identification of pre-adolescent children who are at risk of depression is crucial for early intervention and prevention. In this study, we used a large longitudinal sample from the Adolescent Brain Cognitive Development (ABCD) Study (2658 participants after imaging quality control, between 9-10 years at baseline), we applied advanced machine learning methods to predict depression risk at the two-year follow-up from the baseline assessment, using a set of comprehensive multimodal neuroimaging features derived from structural MRI, diffusion tensor imaging, and task and rest functional MRI...
April 8, 2024: NeuroImage: Clinical
Nicholas Riccardi, Satvik Nelakuditi, Dirk B den Ouden, Chris Rorden, Julius Fridriksson, Rutvik H Desai
Discourse is a fundamentally important aspect of communication, and discourse production provides a wealth of information about linguistic ability. Aphasia commonly affects, in multiple ways, the ability to produce discourse. Comprehensive aphasia assessments such as the Western Aphasia Battery-Revised (WAB-R) are time- and resource-intensive. We examined whether discourse measures can be used to estimate WAB-R Aphasia Quotient (AQ), and whether this can serve as an ecologically valid, less resource-intensive measure...
April 6, 2024: NeuroImage: Clinical
Yongfeng Yang, Xueyan Jin, Yongjiang Xue, Xue Li, Yi Chen, Ning Kang, Wei Yan, Peng Li, Xiaoge Guo, Binbin Luo, Yan Zhang, Qing Liu, Han Shi, Luwen Zhang, Xi Su, Bing Liu, Lin Lu, Luxian Lv, Wenqiang Li
Antipsychotic drug treatment for schizophrenia (SZ) can alter brain structure and function, but it is unclear if specific regional changes are associated with treatment outcome. Therefore, we examined the effects of antipsychotic drug treatment on regional grey matter (GM) density, white matter (WM) density, and functional connectivity (FC) as well as associations between regional changes and treatment efficacy. SZ patients (n = 163) and health controls (HCs) (n = 131) were examined by structural magnetic resonance imaging (sMRI) at baseline, and a subset of SZ patients (n = 77) were re-examined after 8 weeks of second-generation antipsychotic treatment to assess changes in regional GM and WM density...
April 3, 2024: NeuroImage: Clinical
Christiane Dahms, Alexander Noll, Franziska Wagner, Alexander Schmidt, Stefan Brodoehl, Carsten M Klingner
BACKGROUND: Strokes frequently result in long-term motor deficits, imposing significant personal and economic burdens. However, our understanding of the underlying neural mechanisms governing motor learning in stroke survivors remains limited - a fact that poses significant challenges to the development and optimisation of therapeutic strategies. OBJECTIVE: This study investigates the diversity in motor learning aptitude and its associated neurological mechanisms...
April 2, 2024: NeuroImage: Clinical
Julia G Mannheim, Jessie Fanglu Fu, Tilman Wegener, Ivan S Klyuzhin, Nasim Vafai, Elham Shahinfard, Jessamyn McKenzie, Audrey Strongosky, Zbigniew K Wszolek, A Jon Stoessl, Vesna Sossi
Several genetic pathogenic variants increase the risk of Parkinson's disease (PD) with pathogenic variants in the leucine-rich repeat kinase 2 (LRRK2) gene being among the most common. A joint pattern analysis based on multi-set canonical correlation analysis (MCCA) was utilized to extract PD and LRRK2 pathogenic variant-specific spatial patterns in relation to healthy controls (HCs) from multi-tracer Positron Emission Tomography (PET) data. Spatial patterns were extracted for individual subject cohorts, as well as for pooled subject cohorts, to explore whether complementary spatial patterns of dopaminergic denervation are different in the asymptomatic and symptomatic stages of PD...
April 1, 2024: NeuroImage: Clinical
Elena Olgiati, Ines R Violante, Shuler Xu, Toby G Sinclair, Lucia M Li, Jennifer N Crow, Marianna E Kapsetaki, Roberta Calvo, Korina Li, Meenakshi Nayar, Nir Grossman, Maneesh C Patel, Richard J S Wise, Paresh A Malhotra
Right hemisphere stroke patients frequently present with a combination of lateralised and non-lateralised attentional deficits characteristic of the neglect syndrome. Attentional deficits are associated with poor functional outcome and are challenging to treat, with non-lateralised deficits often persisting into the chronic stage and representing a common complaint among patients and families. In this study, we investigated the effects of non-invasive brain stimulation on non-lateralised attentional deficits in right-hemispheric stroke...
March 30, 2024: NeuroImage: Clinical
Cui Ci Voon, Tun Wiltgen, Benedikt Wiestler, Sarah Schlaeger, Mark Mühlau
BACKGROUND: Quantitative susceptibility mapping (QSM) is a quantitative measure based on magnetic resonance imaging sensitive to iron and myelin content. This makes QSM a promising non-invasive tool for multiple sclerosis (MS) in research and clinical practice. OBJECTIVE: We performed a systematic review and meta-analysis on the use of QSM in MS. METHODS: Our review was prospectively registered on PROSPERO (CRD42022309563). We searched five databases for studies published between inception and 30th April 2023...
March 25, 2024: NeuroImage: Clinical
Matin Mortazavi, Lisa Ann Gerdes, Öznur Hizarci, Tania Kümpfel, Katja Anslinger, Frank Padberg, Sophia Stöcklein, Daniel Keeser, Birgit Ertl-Wagner
OBJECTIVE: Intracranial volume (ICV) represents the maximal brain volume for an individual, attained prior to late adolescence and remaining constant throughout life after. Thus, ICV serves as a surrogate marker for brain growth integrity. To assess the potential impact of adult-onset multiple sclerosis (MS) and its preceding prodromal subclinical changes on ICV in a large cohort of monozygotic twins clinically discordant for MS. METHODS: FSL software was used to derive ICV estimates from 3D-T1-weighted-3 T-MRI images by using an atlas scaling factor method...
March 22, 2024: NeuroImage: Clinical
Deanne K Thompson, Claire E Kelly, Thijs Dhollander, Evelyne Muggli, Stephen Hearps, Sharon Lewis, Thi-Nhu-Ngoc Nguyen, Alicia Spittle, Elizabeth J Elliott, Anthony Penington, Jane Halliday, Peter J Anderson
BACKGROUND: The effects of low-moderate prenatal alcohol exposure (PAE) on brain development have been infrequently studied. AIM: To compare cortical and white matter structure between children aged 6 to 8 years with low-moderate PAE in trimester 1 only, low-moderate PAE throughout gestation, or no PAE. METHODS: Women reported quantity and frequency of alcohol consumption before and during pregnancy. Magnetic resonance imaging was undertaken for 143 children aged 6 to 8 years with PAE during trimester 1 only (n = 44), PAE throughout gestation (n = 58), and no PAE (n = 41)...
March 21, 2024: NeuroImage: Clinical
R Bhome, S Verdi, S A Martin, N Hannaway, I Dobreva, N P Oxtoby, G Castro Leal, S Rutherford, A F Marquand, R S Weil, J H Cole
INTRODUCTION: Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) show heterogeneous brain atrophy patterns which group-average analyses fail to capture. Neuroanatomical normative modelling overcomes this by comparing individuals to a large reference cohort. Patient-specific atrophy patterns are measured objectively and summarised to index overall neurodegeneration (the 'total outlier count'). We aimed to quantify patterns of neurodegenerative dissimilarity in participants with PD and DLB and evaluate the potential clinical relevance of total outlier count by testing its association with key clinical measures in PD and DLB...
March 21, 2024: NeuroImage: Clinical
Colin Vanden Bulcke, Anna Stölting, Dragan Maric, Benoît Macq, Martina Absinta, Pietro Maggi
In multiple sclerosis (MS), accurate in vivo characterization of the heterogeneous lesional and extra-lesional tissue pathology remains challenging. Marshalling several advanced imaging techniques - quantitative relaxation time (T1) mapping, a model-free average diffusion signal approach and four multi-shell diffusion models - this study investigates the performance of multi-shell diffusion models and characterizes the microstructural damage within (i) different MS lesion types - active, chronic active, and chronic inactive - (ii) their respective periplaque white matter (WM), and (iii) the surrounding normal-appearing white matter (NAWM)...
March 18, 2024: NeuroImage: Clinical
Xiaolong Yin, Junchao Yang, Qing Xiang, Lixin Peng, Jian Song, Shengxiang Liang, Jingsong Wu
BACKGROUND: Hierarchy is the organizing principle of human brain network. How network hierarchy changes in subthreshold depression (StD) is unclear. The aim of this study was to investigate the altered brain network hierarchy and its clinical significance in patients with StD. METHODS: A total of 43 patients with StD and 43 healthy controls matched for age, gender and years of education participated in this study. Alterations in the hierarchy of StD brain networks were depicted by connectome gradient analysis...
March 18, 2024: NeuroImage: Clinical
Alexander Calvano, Urs Kleinholdermann, Amelie-Sophie Heun, Miriam H A Bopp, Christopher Nimsky, Lars Timmermann, David J Pedrosa
BACKGROUND: A reduction in stride length is considered a key characteristic of gait kinematics in Parkinson's disease (PD) and has been identified as a predictor of falls. Although low-frequency stimulation (LFS) has been suggested as a method to improve gait characteristics, the underlying structural network is not well understood. OBJECTIVE: This study aims to investigate the structural correlates of changes in stride length during LFS (85 Hz). METHODS: Objective gait performance was retrospectively evaluated in 19 PD patients who underwent deep brain stimulation (DBS) at 85 Hz and 130 Hz...
March 18, 2024: NeuroImage: Clinical
T Ratneswaren, N Chan, J Aeron-Thomas, S Sait, O Adesalu, M Alhawamdeh, M Benger, J Garnham, L Dixon, F Tona, C McNamara, E Taylor, K Lobotesis, E Lim, O Goldberg, N Asmar, O Evbuomwan, S Banerjee, L Holm-Mercer, J Senor, Y Tsitsiou, P Tantrige, A Taha, K Ballal, A Mattar, A Daadipour, K Elfergani, R Barker, R Chakravartty, A G Murchison, B J Kemp, R Simister, I Davagnanam, O Y Wong, D Werring, A Banaras, M Anjari, J C L Rodrigues, C A S Thompson, I R Haines, T A Burnett, R E Y Zaher, V L Reay, M Banerjee, C S L Sew Hee, A P Oo, A Lo, P Rogers, T Hughes, A Marin, S Mukherjee, H Jaber, E Sanders, S Owen, M Bhandari, S Sundayi, A Bhagat, M Elsakka, O H Hashmi, M Lymbouris, Y Gurung-Koney, M Arshad, I Hasan, N Singh, V Patel, M Rahiminejad, T C Booth
BACKGROUND: Apical ground-glass opacification (GGO) identified on CT angiography (CTA) performed for suspected acute stroke was developed in 2020 as a coronavirus-disease-2019 (COVID-19) diagnostic and prognostic biomarker in a retrospective study during the first wave of COVID-19. OBJECTIVE: To prospectively validate whether GGO on CTA performed for suspected acute stroke is a reliable COVID-19 diagnostic and prognostic biomarker and whether it is reliable for COVID-19 vaccinated patients...
March 15, 2024: NeuroImage: Clinical
Cecilia Boccalini, Nicolas Nicastro, Daniela Perani, Valentina Garibotto
A proportion of patients clinically diagnosed with Parkinson's disease (PD) can have a 123 I-FP-CIT-SPECT scan without evidence of dopaminergic deficit (SWEDD), generating a debate about the underlying biological mechanisms. This study investigated differences in clinical features, 123 I-FP-CIT binding, molecular connectivity, as well as clinical and imaging progression between SWEDD and PD patients. We included 36 SWEDD, 49 de novo idiopathic PD, and 49 healthy controls with 123 I-FP-CIT-SPECT from the Parkinson's Progression Markers Initiative...
March 14, 2024: NeuroImage: Clinical
Noa van der Knaap, Marcel J H Ariës, Iwan C C van der Horst, Jacobus F A Jansen
Many Coronavirus Disease 2019 (COVID-19) patients are suffering from long-term neuropsychological sequelae. These patients may benefit from a better understanding of the underlying neuropathophysiological mechanisms and identification of potential biomarkers and treatment targets. Structural clinical neuroimaging techniques have limited ability to visualize subtle cerebral abnormalities and to investigate brain function. This scoping review assesses the merits and potential of advanced neuroimaging techniques in COVID-19 using literature including advanced neuroimaging or postmortem analyses in adult COVID-19 patients published from the start of the pandemic until December 2023...
March 6, 2024: NeuroImage: Clinical
Karen Caeyenberghs, Phoebe Imms, Andrei Irimia, Martin M Monti, Carrie Esopenko, Nicola L de Souza, Juan F Dominguez D, Mary R Newsome, Ekaterina Dobryakova, Andrew Cwiek, Hollie A C Mullin, Nicholas J Kim, Andrew R Mayer, Maheen M Adamson, Kevin Bickart, Katherine M Breedlove, Emily L Dennis, Seth G Disner, Courtney Haswell, Cooper B Hodges, Kristen R Hoskinson, Paula K Johnson, Marsh Königs, Lucia M Li, Spencer W Liebel, Abigail Livny, Rajendra A Morey, Alexandra M Muir, Alexander Olsen, Adeel Razi, Matthew Su, David F Tate, Carmen Velez, Elisabeth A Wilde, Brandon A Zielinski, Paul M Thompson, Frank G Hillary
Resting state functional magnetic resonance imaging (rsfMRI) provides researchers and clinicians with a powerful tool to examine functional connectivity across large-scale brain networks, with ever-increasing applications to the study of neurological disorders, such as traumatic brain injury (TBI). While rsfMRI holds unparalleled promise in systems neurosciences, its acquisition and analytical methodology across research groups is variable, resulting in a literature that is challenging to integrate and interpret...
March 5, 2024: NeuroImage: Clinical
Hans-Christoph Aster, Maria Waltmann, Anika Busch, Marcel Romanos, Matthias Gamer, Betteke Maria van Noort, Anne Beck, Viola Kappel, Lorenz Deserno
Reward-based learning and decision-making are prime candidates to understand symptoms of attention deficit hyperactivity disorder (ADHD). However, only limited evidence is available regarding the neurocomputational underpinnings of the alterations seen in ADHD. This concerns flexible behavioral adaption in dynamically changing environments, which is challenging for individuals with ADHD. One previous study points to elevated choice switching in adolescent ADHD, which was accompanied by disrupted learning signals in medial prefrontal cortex...
March 1, 2024: NeuroImage: Clinical
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