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NeuroImage: Clinical

Hugo C Baggio, Alexandra Abos, Barbara Segura, Anna Campabadal, Carme Uribe, Darly M Giraldo, Alexandra Perez-Soriano, Esteban Muñoz, Yaroslau Compta, Carme Junque, Maria Jose Marti
BACKGROUND: Recent studies using resting-state functional connectivity and machine-learning to distinguish patients with neurodegenerative diseases from other groups of subjects show promising results. This approach has not been tested to discriminate between Parkinson's disease (PD) and multiple system atrophy (MSA) patients. OBJECTIVES: Our first aim is to characterize possible abnormalities in resting-state functional connectivity between the cerebellum and a set of intrinsic-connectivity brain networks and between the cerebellum and different regions of the striatum in PD and MSA...
February 13, 2019: NeuroImage: Clinical
Kit Melissa Larsen, Morten Mørup, Michelle Rosgaard Birknow, Elvira Fischer, Line Olsen, Michael Didriksen, William Frans Christiaan Baaré, Thomas Mears Werge, Marta Isabel Garrido, Hartwig Roman Siebner
One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated with an aberrant neural response to repeated stimuli through both reduced adaptation and prediction, we here hypothesized that this may also be the case in nonpsychotic individuals with a 22q11.2 deletion. We recorded high-density EEG from 19 individuals with 22q11.2 deletion syndrome (12-25 years), as well as 27 healthy volunteers with comparable age and sex distribution, while they listened to a sequence of sounds arranged in a roving oddball paradigm...
February 13, 2019: NeuroImage: Clinical
Jie Fan, Ivy F Tso, Daniel F Maixner, Tessa Abagis, Luis Hernandez-Garcia, Stephan F Taylor
BACKGROUND: The present study tested the hypothesis that network segregation, a graph theoretic measure of functional organization of the brain, is correlated with treatment response in patients with major depressive disorder (MDD) undergoing repetitive transcranial magnetic stimulation (rTMS). METHODS: Network segregation, calculated from resting state functional magnetic resonance imaging scans, was measured in 32 patients with MDD who entered a sham-controlled, double-blinded, randomized trial of rTMS to the left dorsolateral prefrontal cortex, and a cohort of 20 healthy controls (HCs)...
February 13, 2019: NeuroImage: Clinical
Jing Du, Yao Wang, Nan Zhi, Jieli Geng, Wenwei Cao, Ling Yu, Jianhua Mi, Yan Zhou, Qun Xu, Wei Wen, Perminder Sachdev
OBJECTIVES: In this cross-sectional study, we aimed to explore the mechanisms of early cognitive impairment in a post stroke non-dementia cerebral small vessel disease (SVD) cohort by comparing the SVD score with the structural brain network measures. METHOD: 127 SVD patients were recruited consecutively from a stroke clinic, comprising 76 individuals with mild cognitive impairment (MCI) and 51 with no cognitive impairment (NCI). Detailed neuropsychological assessments and multimodal MRI were performed...
February 5, 2019: NeuroImage: Clinical
Valentina Pergher, Philippe Demaerel, Olivier Soenen, Carina Saarela, Jos Tournoy, Birgitte Schoenmakers, Mira Karrasch, Marc M Van Hulle
Aging is often associated with changes in brain structures as well as in cognitive functions. Structural changes can be visualized with Magnetic Resonance Imaging (MRI) using voxel-based grey matter morphometry (VBM) and visual rating scales to assess atrophy level. Several MRI studies have shown that possible neural correlates of cognitive changes can be seen in normal aging. It is still not fully understood how cognitive function as measured by tests and demographic factors are related to brain changes in the MRI...
February 5, 2019: NeuroImage: Clinical
Igor Petrusic, Marko Dakovic, Jasna Zidverc-Trajkovic
BACKGROUND: The brainstem plays a significant role in migraine pathogenesis, but a relationship between volume alterations of brainstem subregions and migraine aura characteristics has not been sufficiently investigated. The aim of this study is to compare the volume of the brainstem, and its subregions, between patients with a migraine with aura (MwA) and healthy controls (HC), and also to correlate characteristics of MwA and the volume of the brainstem subregions. METHODS: Forty-two MwA and 42 HCs, balanced by sex and age, were selected for this study...
February 4, 2019: NeuroImage: Clinical
Till-Karsten Hauser, Achim Seeger, Benjamin Bender, Uwe Klose, Johannes Thurow, Ulrike Ernemann, Marcos Tatagiba, Philipp T Meyer, Nadia Khan, Constantin Roder
BACKGROUND AND PURPOSE: Patients with Moyamoya Disease (MMD) need hemodynamic evaluation of vascular territories at risk of stroke. Today's investigative standards include H2 15 O PET/CT with pharmacological challenges with acetazolamide (ACZ). Recent developments suggest that CO2 -triggered blood‑oxygen-level-dependent (BOLD) functional MRI might provide comparable results to current standard methods for evaluation of territorial hemodynamics, while being a more widely available and easily implementable method...
February 4, 2019: NeuroImage: Clinical
Marie Bruun, Juha Koikkalainen, Hanneke F M Rhodius-Meester, Marta Baroni, Le Gjerum, Mark van Gils, Hilkka Soininen, Anne M Remes, Päivi Hartikainen, Gunhild Waldemar, Patrizia Mecocci, Frederik Barkhof, Yolande Pijnenburg, Wiesje M van der Flier, Steen G Hasselbalch, Jyrki Lötjönen, Kristian S Frederiksen
BACKGROUND: Diagnosing frontotemporal dementia may be challenging. New methods for analysis of regional brain atrophy patterns on magnetic resonance imaging (MRI) could add to the diagnostic assessment. Therefore, we aimed to develop automated imaging biomarkers for differentiating frontotemporal dementia subtypes from other diagnostic groups, and from one another. METHODS: In this retrospective multicenter cohort study, we included 1213 patients (age 67 ± 9, 48% females) from two memory clinic cohorts: 116 frontotemporal dementia, 341 Alzheimer's disease, 66 Dementia with Lewy bodies, 40 vascular dementia, 104 other dementias, 229 mild cognitive impairment, and 317 subjective cognitive decline...
February 4, 2019: NeuroImage: Clinical
Irene Cano-López, Anna Calvo, Teresa Boget, Mar Carreño, Antonio Donaire, Xavier Setoain, Luis Pintor, Jordi Rumià, Esperanza González-Bono, Carme Junqué, Núria Bargalló
No abstract text is available yet for this article.
February 4, 2019: NeuroImage: Clinical
Clara Rodriguez-Sabate, Ingrid Morales, Jesus N Lorenzo, Manuel Rodriguez
The motor symptoms in Parkinson's disease (PD) have been linked to changes in the excitatory/inhibitory interactions of centers involved in the cortical-subcortical closed-loop circuits which connect basal ganglia (BG) and the brain cortex. This approach may explain some motor symptoms of PD but not others, which has driven the study of BG from new perspectives. Besides their cortical-subcortical linear circuits, BG have a number of subcortical circuits which directly or indirectly connect each BG with all the others...
February 3, 2019: NeuroImage: Clinical
Roisin McMackin, Peter Bede, Niall Pender, Orla Hardiman, Bahman Nasseroleslami
There is strong clinical, imaging and pathological evidence that neurodegeneration is associated with altered brain connectivity. While functional imaging (fMRI) can detect resting and activated states of metabolic activity, its use is limited by poor temporal resolution, cost and confounding vascular parameters. By contrast, electrophysiological (e.g. EEG/MEG) recordings provide direct measures of neural activity with excellent temporal resolution, and source localization methodologies can address problems of spatial resolution, permitting measurement of functional activity of brain networks with a spatial resolution similar to that of fMRI...
February 2, 2019: NeuroImage: Clinical
Roisin McMackin, Stefan Dukic, Michael Broderick, Parameswaran M Iyer, Marta Pinto-Grau, Kieran Mohr, Rangariroyashe Chipika, Amina Coffey, Teresa Buxo, Christina Schuster, Brighid Gavin, Mark Heverin, Peter Bede, Niall Pender, Edmund C Lalor, Muthuraman Muthuraman, Orla Hardiman, Bahman Nasseroleslami
OBJECTIVE: To localise and characterise changes in cognitive networks in Amyotrophic Lateral Sclerosis (ALS) using source analysis of mismatch negativity (MMN) waveforms. RATIONALE: The MMN waveform has an increased average delay in ALS. MMN has been attributed to change detection and involuntary attention switching. This therefore indicates pathological impairment of the neural network components which generate these functions. Source localisation can mitigate the poor spatial resolution of sensor-level EEG analysis by associating the sensor-level signals to the contributing brain sources...
February 2, 2019: NeuroImage: Clinical
Kendra E Hinton, Benjamin B Lahey, Victoria Villalta-Gil, Francisco A C Meyer, Leah L Burgess, Laura K Chodes, Brooks Applegate, Carol A Van Hulle, Bennett A Landman, David H Zald
Increasing data indicate that prevalent forms of psychopathology can be organized into second-order dimensions based on their correlations, including a general factor of psychopathology that explains the common variance among all disorders and specific second-order externalizing and internalizing factors. Nevertheless, most existing studies on the neural correlates of psychopathology employ case-control designs that treat diagnoses as independent categories, ignoring the highly correlated nature of psychopathology...
February 1, 2019: NeuroImage: Clinical
Joanna Sierpowska, Andreu Gabarrós, Alejandro Fernández-Coello, Àngels Camins, Sara Castañer, Montserrat Juncadella, Clément François, Antoni Rodríguez-Fornells
In the present study, we aimed to test the association between the correct function of the left ventral white matter pathways and semantic processing (dual stream models for language processing, Hickok & Poeppel, 2004), using a new set of language tasks during intraoperative electrical stimulation at white matter level. Additionally, we evaluated brain regions needed for correct performance on the different semantic tasks using lesion-symptom analyses (voxel lesion-symptom mapping and track-wise lesion analysis) in a sample of 62 candidates for the awake brain surgery...
January 31, 2019: NeuroImage: Clinical
Silvia De Santis, Tobias Granberg, Russell Ouellette, Constantina A Treaba, Elena Herranz, Qiuyun Fan, Caterina Mainero, Nicola Toschi
Irreversible white matter (WM) damage, including severe demyelination and axonal loss, is a main determinant of long-term disability in multiple sclerosis (MS). Non-invasive detection of changes in microstructural WM integrity in the disease is challenging since commonly used imaging metrics lack the necessary sensitivity, especially in the early phase of the disease. This study aims at assessing microstructural WM abnormalities in early-stage MS by using ultra-high gradient strength multi-shell diffusion MRI and the restricted signal fraction (FR) from the Composite Hindered and Restricted Model of Diffusion (CHARMED), a metric sensitive to the volume fraction of axons...
January 30, 2019: NeuroImage: Clinical
Brendan M Caldwell, Nathaniel E Anderson, Keith A Harenski, Miranda H Sitney, Michael F Caldwell, Greg J Van Rybroek, Kent A Kiehl
Youth with severe conduct problems impose a significant cost on society by engaging in high levels of antisocial and aggressive behavior. Within this group, adolescents with high levels of callous- unemotional traits have been found to exhibit more severe and persistent patterns of antisocial behavior than youth with severe conduct problems but normative levels of callous-unemotional traits. Existing neuroimaging studies, along with theoretical accounts of psychopathology, suggest that dysfunction within the paralimbic cortex and limbic system may underlie elevated levels of callous-unemotional traits...
January 30, 2019: NeuroImage: Clinical
Lampros Perogamvros, Hyeong-Dong Park, Laurence Bayer, Aurore A Perrault, Olaf Blanke, Sophie Schwartz
Nightmares are characterized by the experience of strong negative emotions occurring mainly during REM sleep. Some people suffer from nightmare disorder, which is defined by the repeated occurrence of nightmares and by significant distress in wakefulness. Yet, whether frequent nightmares relate to a general increase in emotional reactivity or arousal during sleep remains unclear. To address this question, we recorded heartbeat-evoked potentials (HEPs) during wakefulness, NREM and REM sleep in patients with nightmare disorder and healthy participants...
January 29, 2019: NeuroImage: Clinical
Nefize Yalin, Aybala Saricicek, Ceren Hidiroglu, Andre Zugman, Nese Direk, Emel Ada, Berrin Cavusoglu, Ayşe Er, Gizem Isik, Deniz Ceylan, Zeliha Tunca, Matthew J Kempton, Aysegul Ozerdem
OBJECTIVES: So far, few studies have investigated cortical thickness (CT) and surface area (SA) measures in bipolar disorder type I (BDI) in comparison to a high genetic risk group such as first-degree relatives (FR). This study aimed to examine CT and SA differences between BDI, FR and healthy controls (HC). METHODS: 3D T1 magnetic resonance images were acquired from 27 euthymic BDI patients, 24 unaffected FR and 29 HC. CT and SA measures were obtained with FreeSurfer version 5...
January 29, 2019: NeuroImage: Clinical
Patrick W Hales, Felice d'Arco, Jessica Cooper, Josef Pfeuffer, Darren Hargrave, Kshitij Mankad, Chris Clark
BACKGROUND: Diffusion- and perfusion-weighted MRI are valuable tools for measuring the cellular and vascular properties of brain tumours. This has been well studied in adult patients, however, the biological features of childhood brain tumours are unique, and paediatric-focused studies are less common. We aimed to assess the diagnostic utility of apparent diffusion coefficient (ADC) values derived from diffusion-weighted imaging (DWI) and cerebral blood flow (CBF) values derived from arterial spin labelling (ASL) in paediatric brain tumours...
January 29, 2019: NeuroImage: Clinical
Laura E Jonkman, Yvon Galis-de Graaf, Marjolein Bulk, Eliane Kaaij, Petra J W Pouwels, Frederik Barkhof, Annemieke J M Rozemuller, Louise van der Weerd, Jeroen J G Geurts, Wilma D J van de Berg
Well-characterized, high-quality brain tissue of non-neurological control subjects is a prerequisite to study the healthy aging brain, and can serve as a control for the study of neurological disorders. The Normal Aging Brain Collection Amsterdam (NABCA) provides a comprehensive collection of post-mortem (ultra-)high-field MRI (3Tesla and 7 Tesla) and neuropathological datasets of non-neurological controls. By providing MRI within the pipeline, NABCA uniquely stimulates translational neurosciences; from molecular and morphometric tissue studies to the clinical setting...
January 29, 2019: NeuroImage: Clinical
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