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Translational Vision Science & Technology

Yohei Hashimoto, Tatsuya Inoue, Takashi Ono, Jinhee Lee, Saori Tsuneyoshi, Asahi Fujita, Yuji Inoue, Shun Ogawa, Ryo Asaoka, Ryo Obata
Purpose: To assess precision and accuracy of a new objective algorithm using binarization in a software for identifying the hyperautofluorescent ring (AF ring) in retinitis pigmentosa (RP) compared with subjective visual inspection. Methods: Ultra-widefield AF images were obtained from 23 eyes of 13 patients with retinitis pigmentosa (RP). We defined the borders of the AF rings using semiautomatic binarization algorithm in Fiji software. We compared the degree of precision (intra- and interrater agreements) of this algorithm and that of subjective visual inspection (freehand method) using Jaccard indices (JIs)...
January 2019: Translational Vision Science & Technology
Shrinivas Pundlik, Matteo Tomasi, Rui Liu, Kevin Houston, Gang Luo
Purpose: We evaluate a smartphone application (app) performing an automated photographic Hirschberg test for measurement of eye deviations. Methods: Three evaluation studies were conducted to measure eye deviations in the horizontal direction. First, gaze angles were measured with respect to the ground truth in nonstrabismic subjects ( n = 25) as they fixated monocularly on targets of known eccentricity covering an angular range of approximately ±13°. Second, phoria measurements with the app at near fixation (distance = 40 cm) were compared with the modified Thorington (MT) test in normally-sighted subjects ( n = 14)...
January 2019: Translational Vision Science & Technology
Justis P Ehlers, Atsuro Uchida, Sunil K Srivastava, Ming Hu
Purpose: To establish a predictive model of macular hole (MH) closure speed. Methods: This study was a post hoc analysis of eyes that underwent full-thickness MH repair in the prospective PIONEER intraoperative optical coherence tomography (iOCT) study. The Bioptigen SDOIS system was used for iOCT imaging. All patients underwent standard small-gauge vitrectomy with internal limiting membrane (ILM) peeling, gas tamponade, and postoperative facedown positioning. Before vitrectomy and after ILM peeling, various quantitative OCT measures related to MH were obtained, including MH geometry alterations and outer retinal features...
January 2019: Translational Vision Science & Technology
Pete R Jones, Nicholas D Smith, Wei Bi, David P Crabb
Purpose: Visual field (VF) examination by standard automated perimetry (SAP) is an important method of clinical assessment. However, the complexity of the test, and its use of bulky, expensive equipment makes it impractical for case-finding. We propose and evaluate a new approach to paracentral VF assessment that combines an inexpensive eye-tracker with a portable tablet computer ("Eyecatcher"). Methods: Twenty-four eyes from 12 glaucoma patients, and 12 eyes from six age-similar controls were examined...
January 2019: Translational Vision Science & Technology
Lisa M Hamm, Kishan Mistry, Joanna M Black, Cameron C Grant, Steven C Dakin
Purpose: Reliable estimation of visual acuity requires that observers maintain a constant distance from the target, but use of chin rests is not always feasible. Our aim was to quantify children's movement during community testing and its impact on near (40 cm) and intermediate (150 cm) acuity measures. Methods: Thirty-three 7-year-old children performed several acuity tests run on a tablet computer, administered in the child's home by a trained lay screener. The tablet webcam was used to derive a continuous estimate of the child's position during testing...
January 2019: Translational Vision Science & Technology
Susan S Lee, Alexandra Almazan, Sherri Decker, Yan Zhong, Alazar N Ghebremeskel, Patrick Hughes, Michael R Robinson, James A Burke, Robert N Weinreb
Purpose: To assess the intraocular pressure (IOP)-lowering effects of bimatoprost sustained-release implant (BimSR) in normotensive monkeys receiving topical bimatoprost. Methods: Six eyes from six female, normotensive, cynomolgus monkeys were treated with once-daily topical latanoprost 0.005% plus twice-daily fixed-combination dorzolamide 2%/timolol 0.5%. At week 5, topical latanoprost was switched to once-daily topical bimatoprost 0.03% and twice-daily dorzolamide 2%/timolol 0...
January 2019: Translational Vision Science & Technology
Wenqiang Liu, Marta Arias Borrell, David C Venerus, William F Mieler, Jennifer J Kang-Mieler
Purpose: To characterize a biodegradable microsphere-hydrogel drug delivery system (DDS) for controlled and extended release of ranibizumab. Methods: The degradable microsphere-hydrogel DDSs were fabricated by suspending ranibizumab-loaded or blank poly(lactic- co- glycolic acid) microspheres within a poly(ethylene glycol)- co -(L-lactic-acid) diacrylate/N-isopropylacrylamide (PEG-PLLA-DA/NIPAAm) hydrogel. The thermal responsive behavior of various DDS formulations was characterized in terms of volume phase transition temperature (VPTT) and swelling ratios changes from 22°C to 42°C...
January 2019: Translational Vision Science & Technology
Anne M Lynch, Brandie D Wagner, Sophie J Weiss, Kirsten M Wall, Alan G Palestine, Marc T Mathias, Frank S Siringo, Jennifer N Cathcart, Jennifer L Patnaik, Daniel W Drolet, Nebojsa Janjic, Naresh Mandava
Purpose: To explore top-ranked plasma proteins related to neovascular age-related macular degeneration (AMD) and geographic atrophy (GA), and explore pathways related to neovascular AMD and GA. Methods: We conducted a pilot study of patients with neovascular AMD ( n = 10), GA ( n = 10), and age-matched cataract controls ( n = 10) who were recruited into an AMD registry. We measured 4001 proteins in ethylenediaminetetraacetic acid plasma samples using an aptamer-based proteomic technology...
January 2019: Translational Vision Science & Technology
Gareth Lingham, Seyhan Yazar, Robyn M Lucas, John P Walsh, Kun Zhu, Michael Hunter, Ee Mun Lim, Brian R Cooke, David A Mackey
Purpose: To investigate the association between serum 25-hydroxyvitamin D (25[OH]D) concentration and refractive error in a community-based cohort of adults aged 46 to 69 years. Methods: Residents of the City of Busselton in Western Australia born between 1946 and 1964 were invited to participate. Participants underwent cycloplegic autorefraction and completed questionnaires on education, occupational sun exposure, and physical activity. Blood samples were collected and serum frozen at -80°C...
January 2019: Translational Vision Science & Technology
Shrinivas Pundlik, Gang Luo
Purpose: We evaluated the feasibility of a smartphone application-based dark adaptation (DA) measurement method (MOBILE-DA). Methods: On a Samsung Galaxy S8 smartphone, MOBILE-DA presented a 1.5° flashing stimulus (wavelength = 453 nm) between -1.15 and -4.33 log candela (cd)/m2 at 8° eccentricity using an adaptive staircase, and logged timing of user response (tapping on the screen) whenever the stimulus became visible (monocularly). In a dark room, the smartphone was placed ≈40 cm from the subject, and a white smartphone screen at maximum brightness (≈300 cd/m2 ) for 120 seconds was used for bleaching before testing...
January 2019: Translational Vision Science & Technology
Taly Gilat Schmidt, Rachel E Linderman, Margaret R Strampe, Toco Y P Chui, Richard B Rosen, Joseph Carroll
Purpose: This study proposes an optical coherence tomography angiography (OCTA) frame-averaging method and investigates the effects of the number of frames acquired and averaged on metrics quantifying the foveal avascular zone (FAZ), vessel morphology, and parafoveal intercapillary area (PICA). Methods: Ten OCTA frames were acquired for each of the 19 subjects without known retinal disease using the AngioVue OCTA system. For each subject, acquired frames were ranked by an image quality metric...
January 2019: Translational Vision Science & Technology
Justine R Smith, Jacob Pe'er, Rubens N Belfort, Fatima Cardoso, Richard D Carvajal, Carlos Carvalho, Sarah E Coupland, Laurence Desjardins, Jasmine H Francis, Brenda L Gallie, Dan S Gombos, Hans E Grossniklaus, Steffen Heegaard, Martine J Jager, Swathi Kaliki, Bruce R Ksander, Markus Maeurer, Eduardo Moreno, Jose S Pulido, Bettina Ryll, Arun D Singh, Junyang Zhao, António Parreira, David J Wilson, Joan M O'Brien
The 2018 Ocular Oncogenesis and Oncology Conference was held through a partnership of the Association for Research in Vision and Ophthalmology (ARVO) and the Champalimaud Foundation. Twenty-one experts from international ocular oncology centers, from the Champalimaud Clinical Centre and the Champalimaud Foundation Cancer Research Program, and from patient advocacy organizations, delivered lectures on subjects that ranged from global ocular oncology, to basic research in mechanisms of ocular malignancy, to clinical research in ocular cancers, and to anticipated future developments in the area...
January 2019: Translational Vision Science & Technology
Iain Livingstone, Laura Butler, Esther Misanjo, Alan Lok, Duncan Middleton, Janice Waterson Wilson, Silvija Delfin, Petros Kayange, Ruth Hamilton
Purpose: To evaluate two builds of the digital grating acuity test, "Peekaboo Vision" (PV), in young (6-60 months) populations in two hospital settings (Malawi and United Kingdom). Methods: Study 1 evaluated PV in Blantyre, Malawi ( N = 58, mean age 33 months); study 2 evaluated an updated build in Glasgow, United Kingdom ( N = 60, mean age 44 months). Acuities were tested-retested with PV and Keeler Acuity Cards for Infants (KACI). Bland-Altman techniques were used to compare results and repeatability...
January 2019: Translational Vision Science & Technology
Leon von der Emde, Maximilian Pfau, Sarah Thiele, Philipp T Möller, Ruth Hassenrik, Monika Fleckenstein, Frank G Holz, Steffen Schmitz-Valckenberg
Purpose: To determine the retest variability of mesopic and two-color dark-adapted (DA) fundus-controlled perimetry (FCP), to evaluate the predictive value of patient reliability indices, and to analyze the extent of impairment of rod- and cone function in neovascular age-related macular degeneration (nAMD). Methods: A total of 50 eyes of 50 patients with nAMD (mean age, 76.1 years) and 70 eyes of 70 age-similar normal subjects underwent multimodal imaging as well as mesopic and DA two-color perimetry using the S-MAIA device...
January 2019: Translational Vision Science & Technology
Gema Rebolleda, Laura Díez-Álvarez, Elisabet de Dompablo, Francisco J Muñoz-Negrete
No abstract text is available yet for this article.
January 2019: Translational Vision Science & Technology
Joseph D Bogaard, Jonathon B Young, Asad Movahedan, Iris S Kassem
Purpose: We used the juvenile rabbit as a model for investigating therapeutic interventions for postoperative inflammation and fibrin formation following intraocular lens (IOL) insertion for management of pediatric cataracts. Methods: Twelve 6- to 7-week-old, 600 to 900 g rabbits underwent bilateral clear-cornea lensectomy via irrigation and aspiration with IOL insertion. Following wound closure, enoxaparin 8 mg ( n = 6 eyes), preservative-free triamcinolone 0.5 mg ( n = 6), 8 mg enoxaparin plus 0...
January 2019: Translational Vision Science & Technology
Neda Rashidi, Vineet S Thomas, Rouzbeh Amini
Purpose: This study was conducted to investigate changes in intraocular pressure (IOP) in the presence of intravitreal gas bubbles in individuals who travel through subsea tunnels. Methods: Using a mathematical model, we simulated alterations in ocular globe shape, aqueous humor flow, volume of intravitreal gas bubbles, and IOP due to elevation changes during travel through subsea tunnels. We simulated five tunnels with different features as case studies. The role of key modeling parameters was further evaluated in a parametric study...
January 2019: Translational Vision Science & Technology
Carolyn Drews-Botsch, Marianne Celano, George Cotsonis, Lindreth DuBois, Scott R Lambert
Purpose: Using data from the Infant Aphakia Treatment Study, we examined the relationship between adherence to patching and parenting stress. Methods: Caregivers completed the Parenting Stress Index 3 months after surgery ( n = 106), after a visual acuity assessment at 12 months of age ( n = 97), and at 4.25 ( n = 96) years of age. Patching was reported in quarterly telephone interviews and annual 7-day patching diaries, and averaged across all assessments prior to and in the 6 months following the first stress assessment, and for 6 months before and after the other two stress assessments...
January 2019: Translational Vision Science & Technology
Rohit Shetty, Krishna Poojita Vunnava, Kamesh Dhamodaran, Himanshu Matalia, Subramani Murali, Chaitra Jayadev, Ponnulagu Murugeswari, Arkasubhra Ghosh, Debashish Das
Purpose: We studied the cellular characteristics of epithelial cells in the cone and extraconal periphery of corneas in keratoconus eyes. Methods: This prospective observational study was conducted at Narayana Nethralaya Eye Institute. A total of 83 and 42 eyes with keratoconus and normal topography, respectively, were included in the study. Corneal epithelial cells were collected and analyzed for apoptosis, proliferation, epithelial-mesenchymal transition, and differentiation status using molecular and biochemical tools...
January 2019: Translational Vision Science & Technology
Dong-Yi Lan, Pei-Wen Zhu, Ying He, Qian-Hui Xu, Ting Su, Biao Li, Wen-Qing Shi, Qi Lin, Yan-Chang Yang, Qing Yuan, Jian-Wen Fang, Qing-Hai Li, Yi Shao
Purpose: The present study was attempted to compare the differences in gray matter volume (GMV) between the acute eye pain (EP) patients and the healthy controls (HCs) using voxel-based morphometry (VBM), and to explore the relationship with clinical features and behavioral performance. Methods: A total of 24 patients (17 males, 7 females) with acute EP and 24 (17 males, 7 females) age-, sex-, and education-matched HCs were recruited from the Ophthalmology Department of the First Affiliated Hospital of Nanchang University...
January 2019: Translational Vision Science & Technology
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