Sofia F Melo, Alicia Nondonfaz, Abdelhafid Aqil, Anna Pierrard, Alexia Hulin, Céline Delierneux, Bartosz Ditkowski, Maxime Gustin, Maxime Legrand, Bibian M E Tullemans, Sanne L N Brouns, Alain Nchimi, Raoul Carrus, Astrid Dejosé, Johan W M Heemskerk, Marijke J E Kuijpers, Jan Ritter, Ulrich Steinseifer, Johanna C Clauser, Christine Jérôme, Patrizio Lancellotti, Cécile Oury
The sole effective treatment for most patients with heart valve disease is valve replacement by implantation of mechanical or biological prostheses. However, mechanical valves represent high risk of thromboembolism, and biological prostheses are prone to early degeneration. In this work, we aim to determine the potential of novel environmentally-friendly non-isocyanate polyurethanes (NIPUs) for manufacturing synthetic prosthetic heart valves. Polyhydroxyurethane (PHU) NIPUs are synthesized via an isocyanate-free route, tested in vitro , and used to produce aortic valves...
March 15, 2024: Biomaterials Science