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Journal of Diabetes and Metabolic Disorders

Nadeem Akhter, Amal Hasan, Steve Shenouda, Ajit Wilson, Shihab Kochumon, Shamsha Ali, Jaakko Tuomilehto, Sardar Sindhu, Rasheed Ahmad
Background: Obese human and mice were reported to have higher circularity endotoxin (LPS) levels as compared to their lean counter parts. The current study was aimed to reveal the molecular mechanisms underlying the LPS mediated induction of CCL2 in human monocytes/macrophages. Methods: Human monocytic cell line THP-1, THP-1 cells derived macrophages and primary macrophages were treated with LPS and TNF-α (positive control). CCL2 expression was determined with real-time RT-PCR and ELISA...
June 2018: Journal of Diabetes and Metabolic Disorders
Farideh Razi, Ensieh Nasli-Esfahani, Fatemeh Bandarian
Background: Diabetic nephropathy (DN) is the major cause of end-stage renal disease. Recent studies suggest that it is probable that uric acid is involved in the pathogenesis of diabetic nephropathy. This study aim was to investigate the association between serum uric acid and kidney function in Iranian patients with type 2 diabetes mellitus. Methods: In this case-control study, a total of 201 diabetic patients with or without impaired kidney function (glomerular filtration rate/GFR < 60 and GFR ≥ 60) were selected...
June 2018: Journal of Diabetes and Metabolic Disorders
Zahra Sarrafan-Chaharsoughi, Masoud Reza Manaviat, Nasim Namiranian, Pouria Yazdian-Anari, Masoud Rahmanian
Background: Type 2 diabetes mellitus (T2DM) is one of the most important leading causes of disability, premature mortality and Diabetic Retinopathy (DR) that is one of the diabetes-related complications in diabetic patients and the most common cause of vision loss in diabetic patients. The aim of the study was to evaluate the association between DR and body mass index (BMI) in those patients with T2DM. Methods: This was a central-based, cross-sectional study on 518 diabetic patients...
June 2018: Journal of Diabetes and Metabolic Disorders
Ali Bijani, Robert G Cumming, Seyed-Reza Hosseini, Masoumeh Yazdanpour, Mahdis Rahimi, Abbas Sahebian, Reza Ghadimi
Background and objectives: Overweight and obesity are among the important challenges in health issues and survival of elderly people. The current study aimed to evaluate the survival rate of elderly patients with diabetes, and its influencing factors, on the basis of body mass index (BMI). Methods and materials: The design of the current study was based on the Amirkola Health and Aging Project (AHAP) cohort. The 5-year survival rate of elderly people with diabetes and the factors that influence the mortality rate by Cox regression model were analyzed...
June 2018: Journal of Diabetes and Metabolic Disorders
Eric Lontchi-Yimagou, Philippe Boudou, Jean Louis Nguewa, Jean Jacques Noubiap, Vicky Kamwa, Eric Noel Djahmeni, Babara Atogho-Tiedeu, Marcel Azabji-Kenfack, Martine Etoa, Gaelle Lemdjo, Mesmin Yefou Dehayem, Jean Claude Mbanya, Jean-Francois Gautier, Eugène Sobngwi
No abstract text is available yet for this article.
June 2018: Journal of Diabetes and Metabolic Disorders
Reza Safdari, Mostafa Langarizadeh, Alireza Ramezani, Taleb Khodaveisi, Ahmadreza Farzaneh Nejad
Background: The present study describes the development and identity phases of a teleophthalmology system used for screening of diabetic retinopathy. Methods: A questionnaire was used to identify the main factors necessary for diagnosis of diabetic retinopathy and the features required for a teleophthalmology system. In the second phase, a web-based prototype of the system was designed using the data collected in the previous phase. In the final phase, the system was optimized based on the users' ideas and comments; then, it was evaluated through a standard usability testing questionnaire...
June 2018: Journal of Diabetes and Metabolic Disorders
Fatemeh Khatami, Seyed Mohammad Tavangar
The heterogeneity of tumor is considered as a major difficulty to victorious personalized cancer medicine. There is an extremeneed of consistent response evaluation for in vivo tumor heterogeneity anditscoupledconflict mechanisms. In this occasion researchers will be able to keep pace withpredictive, preventive, personalized, and Participatory (P4) medicine for cancer managements. In fact tumor heterogeneity is a central part of cancer evolution,soin order to progress in understanding of the dynamics within a tumor some diagnostic apparatus should be improved...
June 2018: Journal of Diabetes and Metabolic Disorders
Juliana Vallim Jorgetto, Laercio Joel Franco
Objective: To determine whether there are gender differences in the impact of the disease in the quality of life of individuals with Diabetes Mellitus type 2. Methods: The sample consisted of 192 individuals distributed in equal numbers by gender. Data were collected between the months of August 2013 to May 2014, by sociodemographic and clinical questionnaires and instruments for assessing quality of life (PAID) and adherence to treatment. Results: The age of the patients ranged from 30 to 80 years old with a mean of 61 years of age (± 11)...
June 2018: Journal of Diabetes and Metabolic Disorders
Durdi Qujeq, Abdolkarim Mahrooz, Ahad Alizadeh, Parisa Masoumi, Saleh Annemohammadzadeh, Ruzbeh Boorank
Background: Paraoxonase 1 (PON1) and lipid abnormalities contribute to the development of cardiovascular disease, which is the principal cause of mortality in patients with type 2 diabetes (T2D). Data are not available on the potential association between salt-stimulated activity of PON1 (PON1-salt) and the atherogenic indices in T2D, therefore, we focused on these associations and evaluated whether the functional variants PON1-Q192R and PON1-L55M influence the associations. Methods: Paraoxonase activity (PON1-para), arylesterase activity (PON1-aryl) and salt-stimulated activity (PON1-salt) were measured by spectrophotometric assays...
June 2018: Journal of Diabetes and Metabolic Disorders
Laurentia Mihardja, Delima Delima, Roy G A Massie, Muhammad Karyana, Pringgodigdo Nugroho, Em Yunir
Background: The prevalence of diabetes mellitus is increasing in Indonesia due to population growth, urbanization, and lifestyle. Diabetes mellitus (DM) is the leading cause of chronic kidney disease that escalates mortality rate, but not all DM develop into chronic kidney disease. Aims: To estimate the prevalence of kidney dysfunction (KD) in DM and the associated dominant risk factors among productive age Indonesian based on the National Health Survey ( Riskesdas ) 2013...
June 2018: Journal of Diabetes and Metabolic Disorders
Maryam Karkhaneh, Mostafa Qorbani, Mohamad Reza Mohajeri-Tehrani, Saeed Hoseini
Background: Increased serum complement C3 has been related to body fat mass, metabolic syndrome and chronic diseases. The purpose of this study was to evaluate the levels of C3 in the subjects of normal weight obese (hereafter NWO) as well as their possible relationships with metabolic syndrome and inflammation. Methods: In this case-control study, 40 obese women with normal weight (body mass index (BMI) = 18.5-24.9 kg/m2 ) and body fat percentage above 30% (fat mass (FM) > 30%) and 30 non-obese women (BMI = 18...
2017: Journal of Diabetes and Metabolic Disorders
Masoume Mansouri, Farshad Sharifi, Mehdi Varmaghani, Hamid Yaghubi, Yousef Moghadas Tabrizi, Maede Raznahan, Alireza Khajavi, Maryam Ghodsi, Payam Roshanfekr, Gita Shafiee, Abasali Keshtkar, Mahdi Ebrahimi
Background: The physical health assessment of university students in Iran is a national large scale assessment examining health behaviors among tertiary education students. Understanding risky health behaviors which are the major sources of global mortality and morbidity in adulthood is the key objective of this assessment. Methods: In academic year of 2012-2013, newly admitted students ( N  = 151,671) at 74 governmental eligible universities that had health center from 28 provinces were invited to participate in the health assessment program...
2017: Journal of Diabetes and Metabolic Disorders
Pawan Krishan, Gaaminepreet Singh, Onkar Bedi
Background: Carbohydrate restricted diet regimen is widely accepted as therapeutic approach for the treatment of kidney disease associated with type-2 diabetes, obesity and hypertensive disorders. The present study tested the influence of carbohydrate-energy restricted diet (CR) on type-1 diabetes induced renal dysfunction, hypoxia and structural alterations against diabetic rat group fed control diet ( ad libitium ). Methods: Male wistar rats weighing between 180 and 190 g were subjected to 30% carbohydrate energy restricted diet (CR) and diabetes was induced by administration of streptozotocin (45 mg/kg...
2017: Journal of Diabetes and Metabolic Disorders
Shivani Srivastava, Priya Shree, Yamini Bhusan Tripathi
Background: We had earlier reported that the extract of Pueraria tuberosa significantly inhibits DPP-IV enzyme, resulting in glucose tolerance response in rats. In this study, we have explored the active phytochemicals responsible for this potential. The results have been validated in both fasting and postprandial states in the plasma of normal rats and also in fasting blood and intestinal homogenates of diabetic models. Methods: Pueraria tuberosa water extract (PTWE) was administered to normal Charles Foster rats for 35 days and to diabetic model (65 mg/kg bw) for 10 days...
2017: Journal of Diabetes and Metabolic Disorders
Shuang Liang, Hang Yin, Chunxiang Wei, Linjun Xie, Hua He, Xiaoquan Liu
Aims: It is consensus that glucose variability (GV) plays an important role in maccomplications of type 2 diabetes, but whether GV has a causal role is not yet clear for cardiovascular disease (CVD). This study sought to explore the effect on GV for CVD risk factors with type 2 diabetes. Methods: The systematic literature search was performed to identify all GV and CVD risk factors, including total cholesterol (TC), LDL cholesterol (LDL-C), triglyceride (TG), HDL cholesterol (HDL-C), Body Mass Index (BMI), waist circumference (WC), High-Sensitivity C-reactive protein (Hs-CRP), Homeostasis model assessment (HOMA) and carotid intima-media thickness (IMT)...
2017: Journal of Diabetes and Metabolic Disorders
Miyako Kishimoto, Saori Tamada, Yoko Oshiba
Background: Glucose control for pregnant women with glucose intolerance is important, as hyperglycemia may adversely affect the mother and the fetus. Case presentation: We report the case of a pregnant Japanese woman who experienced gestational diabetes mellitus during her first pregnancy and developed impaired glucose tolerance after the delivery. During her second pregnancy with twins, she required up to 75 units of injected insulin to control her postprandial hyperglycemia and occasionally experienced hypoglycemia...
2017: Journal of Diabetes and Metabolic Disorders
Farideh Razi, Katayoon Forouzanfar, Fatemeh Bandarian, Ensieh Nasli-Esfahani
Background: Low density lipoprotein -Cholesterol (LDL-C) is one of the main factors for assessment of cardiovascular disease risk and it is more important in diabetic patients. Various methods are currently used for LDL-C measurements which are compared in this study. Methods: This study was conducted in Diabetes Research Center based on laboratory results of 1721 diabetic patients who referred to laboratory for regular follow-up of lipid profile. LDL-C was measured directly and also estimated according to Friedwald, Anandraja and Chen formulas...
2017: Journal of Diabetes and Metabolic Disorders
Akbar Soltani, Mandana Pourian, Babak Mostafazadeh Davani
[This corrects the article DOI: 10.1186/s40200-016-0226-x.].
2017: Journal of Diabetes and Metabolic Disorders
Yaghooblou Fatemeh, Fereydoun Siassi, Abbas Rahimi, Fariba Koohdani, Farideh Doostan, Mostafa Qorbani, Gity Sotoudeh
BACKGROUND: Spice consumption helps the treatment of diseases due to their antioxidant and anti-inflammatory contents. Cardamom is one of this spices; therefore, this study is designed to determine the effect of cardamom supplementation on serum lipids, glycemic indices, and blood pressure in pre-diabetic women. METHODS: Eighty overweight or obese pre-diabetic women were randomly allocated to two groups. The intervention group received 3 g of green cardamom and the placebo group received 3 g of rusk powder for 2 months...
2017: Journal of Diabetes and Metabolic Disorders
Abdulmonim A Alqasim, Essam Eldin M Noureldin, Sami H Hammadi, Ghada E Esheba
BACKGROUND: Diabetes mellitus (DM) is a serious chronic disease, with multiple complications including hepatopathy associated with imbalance of the oxidative status. The purpose of this study is to observe possible protective effects of vitamin-D and melatonin on glucose profile, antioxidant-oxidant status, lipid peroxidation, and histopathological protection of the liver in streptozotocin-induced diabetic rats. METHODS: Eighty three male albino rats were divided into nine groups as follows: G1 ( n  = 10) Normal control rats; G2 ( n  = 8) were normal rats treated with melatonin only; G3 ( n  = 10) were normal rats treated with vitamin D only; G4 ( n  = 9) were diabetic rats, which received no medications; G5 ( n  = 8) were diabetic rat treated with insulin only; G6 ( n  = 10) were diabetic rats treated with melatonin only; G7 ( n  = 9) were diabetic rats treated with melatonin and insulin; G8 ( n  = 9) were diabetic rats treated with vitamin D only; G9 ( n  = 10) were diabetic rats treated with vitamin D and insulin...
2017: Journal of Diabetes and Metabolic Disorders
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