journal
https://read.qxmd.com/read/38172538/emerging-mechanisms-and-implications-of-cgas-sting-signaling-in-cancer-immunotherapy-strategies
#1
REVIEW
Jiawen Zhang, Sihui Yu, Qiao Peng, Ping Wang, Lan Fang
The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer treatment. Within this landscape, the innate immune system, a critical sentinel protecting against tumor incursion, is a key player. The cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) pathway has been found to be a linchpin of innate immunity: activation of this signaling pathway orchestrates the production of type I interferon (IFN-α/β), thus fostering the maturation, differentiation, and mobilization of immune effectors in the tumor microenvironment...
January 3, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38172499/prognostic-significance-of-grade-of-malignancy-based-on-histopathological-differentiation-and-ki-67-in-pancreatic-ductal-adenocarcinoma
#2
JOURNAL ARTICLE
Yuexiang Liang, Guannan Sheng, Yu Guo, Yiping Zou, Hanhan Guo, Zhifei Li, Shaofei Chang, Quan Man, Song Gao, Jihui Hao
OBJECTIVE: Tumor cell malignancy is indicated by histopathological differentiation and cell proliferation. Ki-67, an indicator of cellular proliferation, has been used for tumor grading and classification in breast cancer and neuroendocrine tumors. However, its prognostic significance in pancreatic ductal adenocarcinoma (PDAC) remains uncertain. METHODS: Patients who underwent radical pancreatectomy for PDAC were retrospectively enrolled, and relevant prognostic factors were examined...
January 3, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38172555/cervical-cancer-prevention-in-china-where-are-we-now-and-what-s-next
#3
JOURNAL ARTICLE
Huijiao Yan, Qiankun Wang, Youlin Qiao
No abstract text is available yet for this article.
January 2, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38172526/current-status-of-early-gastric-cancer-screening-research
#4
JOURNAL ARTICLE
Can Hu, Li Yuan, Xiangdong Cheng
No abstract text is available yet for this article.
January 2, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38172525/cancer-educated-neutrophils-promote-lung-cancer-progression-via-parp-1-alox5-mediated-mmp-9-expression
#5
JOURNAL ARTICLE
Lulu Han, Yuxin Chen, Nan Huang, Xiaowan Zhou, Yanfang Lv, Huizhong Li, Dafei Chai, Junnian Zheng, Gang Wang
OBJECTIVE: Neutrophils are one of the most predominant infiltrating leukocytes in lung cancer tissues and are associated with lung cancer progression. How neutrophils promote lung cancer progression, however, has not been established. METHODS: Kaplan-Meier plotter online analysis and tissue immunohistochemistry were used to determine the relationship between neutrophils and overall survival in lung cancer patients. The effect of neutrophils on lung cancer was determined using the Transwell migration assay, a proliferation assay, and a murine tumor model...
January 2, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38164743/cancer-stem-cells-a-target-for-overcoming-therapeutic-resistance-and-relapse
#6
REVIEW
Shuo Zhang, Rui Yang, Yujie Ouyang, Yang Shen, Lanlin Hu, Chuan Xu
Cancer stem cells (CSCs) are a small subset of cells in cancers that are thought to initiate tumorous transformation and promote metastasis, recurrence, and resistance to treatment. Growing evidence has revealed the existence of CSCs in various types of cancers and suggested that CSCs differentiate into diverse lineage cells that contribute to tumor progression. We may be able to overcome the limitations of cancer treatment with a comprehensive understanding of the biological features and mechanisms underlying therapeutic resistance in CSCs...
December 29, 2023: Cancer Biology & Medicine
https://read.qxmd.com/read/38164737/bronchoalveolar-lavage-fluid-assessment-facilitates-precision-medicine-for-lung-cancer
#7
REVIEW
Hantao Zhang, Dan Deng, Shujun Li, Jing Ren, Wei Huang, Dan Liu, Weiya Wang
Lung cancer is the most common and fatal malignant disease worldwide and has the highest mortality rate among tumor-related causes of death. Early diagnosis and precision medicine can significantly improve the survival rate and prognosis of lung cancer patients. At present, the clinical diagnosis of lung cancer is challenging due to a lack of effective non-invasive detection methods and biomarkers, and treatment is primarily hindered by drug resistance and high tumor heterogeneity. Liquid biopsy is a method for detecting circulating biomarkers in the blood and other body fluids containing genetic information from primary tumor tissues...
December 29, 2023: Cancer Biology & Medicine
https://read.qxmd.com/read/38164734/neoantigen-cancer-vaccines-a-new-star-on-the-horizon
#8
REVIEW
Xiaoling Li, Jian You, Liping Hong, Weijiang Liu, Peng Guo, Xishan Hao
Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient's own immune system and eliminate cancer cells. One of the most exciting advances within this field is the targeting of neoantigens, which are peptides derived from non-synonymous somatic mutations that are found exclusively within cancer cells and absent in normal cells. Although neoantigen-based therapeutic vaccines have not received approval for standard cancer treatment, early clinical trials have yielded encouraging outcomes as standalone monotherapy or when combined with checkpoint inhibitors...
December 29, 2023: Cancer Biology & Medicine
https://read.qxmd.com/read/38164723/hodgkin-s-lymphoma-2023-update-on-treatment
#9
EDITORIAL
Sicong Zhang, Xianming Liu, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Xianhuo Wang, Huilai Zhang
No abstract text is available yet for this article.
December 29, 2023: Cancer Biology & Medicine
https://read.qxmd.com/read/38164720/dna-damage-response-related-immune-activation-signature-predicts-the-response-to-immune-checkpoint-inhibitors-from-gastrointestinal-cancer-analysis-to-pan-cancer-validation
#10
JOURNAL ARTICLE
Junya Yan, Shibo Wang, Jing Zhang, Qiangqiang Yuan, Xianchun Gao, Nannan Zhang, Yan Pan, Haohao Zhang, Kun Liu, Jun Yu, Linbin Lu, Hui Liu, Xiaoliang Gao, Sheng Zhao, Wenyao Zhang, Abudurousuli Reyila, Yu Qi, Qiujin Zhang, Shundong Cang, Yuanyuan Lu, Yanglin Pan, Yan Kong, Yongzhan Nie
OBJECTIVE: DNA damage response (DDR) deficiency has emerged as a prominent determinant of tumor immunogenicity. This study aimed to construct a DDR-related immune activation (DRIA) signature and evaluate the predictive accuracy of the DRIA signature for response to immune checkpoint inhibitor (ICI) therapy in gastrointestinal (GI) cancer. METHODS: A DRIA signature was established based on two previously reported DNA damage immune response assays. Clinical and gene expression data from two published GI cancer cohorts were used to assess and validate the association between the DRIA score and response to ICI therapy...
December 29, 2023: Cancer Biology & Medicine
https://read.qxmd.com/read/38148394/first-line-immunotherapy-for-advanced-non-small-cell-lung-cancer-current-progress-and-future-prospects
#11
EDITORIAL
Jingyi Wang, Lin Wu
No abstract text is available yet for this article.
December 26, 2023: Cancer Biology & Medicine
https://read.qxmd.com/read/38148328/the-role-of-intestinal-flora-on-tumorigenesis-progression-and-the-efficacy-of-pd-1-pd-l1-antibodies-in-colorectal-cancer
#12
REVIEW
Sen Wang, Benling Xu, Yangyang Zhang, Guangyu Chen, Peng Zhao, Quanli Gao, Long Yuan
Intestinal flora affects the maturation of the host immune system, serves as a biomarker and efficacy predictor in the immunotherapy of several cancers, and has an important role in the development of colorectal cancer (CRC). Anti-PD-1/PD-L1 antibodies have shown satisfactory results in MSI-H/dMMR CRC but performed poorly in patients with MSS/pMMR CRC. In recent years an increasing number of studies have shown that intestinal flora has an important impact on anti-PD-1/PD-L1 antibody efficacy in CRC patients...
December 23, 2023: Cancer Biology & Medicine
https://read.qxmd.com/read/38148327/phase-ib-study-of-anti-egfr-antibody-sct200-in-combination-with-anti-pd-1-antibody-sct-i10a-for-patients-with-ras-braf-wild-type-metastatic-colorectal-cancer
#13
JOURNAL ARTICLE
Ming Bai, Yao Lu, Chunmei Shi, Jianwei Yang, Wei Li, Xianli Yin, Chenghui Huang, Lin Shen, Liangzhi Xie, Yi Ba
OBJECTIVE: This study evaluated the safety and efficacy of an anti-epidermal growth factor receptor (EGFR) antibody (SCT200) and an anti-programmed cell death 1 (PD-1) antibody (SCT-I10A) as third-line or subsequent therapies in patients with rat sarcoma viral oncogene (RAS)/v-raf murine sarcoma viral oncogene homolog B (BRAF) wild-type (wt) metastatic colorectal cancer (mCRC). METHODS: We conducted a multicenter, open-label, phase Ib clinical trial. Patients with histologically confirmed RAS/BRAF wt mCRC with more than two lines of treatment were enrolled and treated with SCT-I10A and SCT200...
December 23, 2023: Cancer Biology & Medicine
https://read.qxmd.com/read/38148326/bile-acids-gut-microbiota-and-therapeutic-insights-in-hepatocellular-carcinoma
#14
REVIEW
Yang Song, Harry Ch Lau, Xiang Zhang, Jun Yu
Hepatocellular carcinoma (HCC) is a prevalent and aggressive liver malignancy. The interplay between bile acids (BAs) and the gut microbiota has emerged as a critical factor in HCC development and progression. Under normal conditions, BA metabolism is tightly regulated through a bidirectional interplay between gut microorganisms and BAs. The gut microbiota plays a critical role in BA metabolism, and BAs are endogenous signaling molecules that help maintain liver and intestinal homeostasis. Of note, dysbiotic changes in the gut microbiota during pathogenesis and cancer development can disrupt BA homeostasis, thereby leading to liver inflammation and fibrosis, and ultimately contributing to HCC development...
December 23, 2023: Cancer Biology & Medicine
https://read.qxmd.com/read/38098274/from-dichotomy-to-diversity-deciphering-the-multifaceted-roles-of-tumor-associated-macrophages-in-cancer-progression-and-therapy
#15
JOURNAL ARTICLE
Xiumei Wang, Jun Chen, Guangshuai Jia
No abstract text is available yet for this article.
December 14, 2023: Cancer Biology & Medicine
https://read.qxmd.com/read/38062861/peptide-drugs-a-new-direction-in-cancer-immunotherapy
#16
EDITORIAL
Xinghua Sui, Xiaoshuang Niu, Xiuman Zhou, Yanfeng Gao
No abstract text is available yet for this article.
December 7, 2023: Cancer Biology & Medicine
https://read.qxmd.com/read/38062785/dna-methylation-profiles-in-cancer-functions-therapy-and-beyond
#17
EDITORIAL
Jinrong Zhu, Yongjie Yang, Li Li, Jiuren Tang, Rongxin Zhang
No abstract text is available yet for this article.
December 7, 2023: Cancer Biology & Medicine
https://read.qxmd.com/read/38062748/large-scale-loss-of-function-perturbations-reveal-a-comprehensive-epigenetic-regulatory-network-in-breast-cancer
#18
JOURNAL ARTICLE
Yumei Wang, Haiyan Wang, Wei Shao, Yuhui Chen, Yu Gui, Chao Hu, Xiaohong Yi, Lijun Huang, Shasha Li, Dong Wang
OBJECTIVE: Epigenetic abnormalities have a critical role in breast cancer by regulating gene expression; however, the intricate interrelationships and key roles of approximately 400 epigenetic regulators in breast cancer remain elusive. It is important to decipher the comprehensive epigenetic regulatory network in breast cancer cells to identify master epigenetic regulators and potential therapeutic targets. METHODS: We employed high-throughput sequencing-based high-throughput screening (HTS2 ) to effectively detect changes in the expression of 2,986 genes following the knockdown of 400 epigenetic regulators...
December 7, 2023: Cancer Biology & Medicine
https://read.qxmd.com/read/38356245/current-and-future-trends-in-whole-genome-sequencing-in-cancer
#19
REVIEW
Yuki Katsuya
No abstract text is available yet for this article.
February 15, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38318978/dna-methylation-biomarkers-for-early-detection-of-gastric-and-colorectal-cancers
#20
JOURNAL ARTICLE
Xianchun Gao, Hui Liu, Jun Yu, Yongzhan Nie
No abstract text is available yet for this article.
February 5, 2024: Cancer Biology & Medicine
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