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Cancer Biology & Medicine

Amina Maimaitiaili, Di Wu, Zhenyu Liu, Haimeng Liu, Xiamusiye Muyiduli, Zhimin Fan
No abstract text is available yet for this article.
November 2018: Cancer Biology & Medicine
Ming Gao, Minghua Ge, Qinghai Ji, Ruochuan Cheng, Hankui Lu, Haixia Guan, Wei Cui, Li Gao, Zairong Gao, Lin Guo, Zhuming Guo, Tao Huang, Xiaoming Huang, Yansong Lin, Qinjiang Liu, Xin Ni, Jianwu Qin, Li Ren, Zhongyan Shan, Hui Sun, Xudong Wang, Zhengang Xu, Yang Yu, Bin Zhang, Daiwei Zhao, Ying Zheng, Jingqiang Zhu, Xiangqian Zheng, Chinese Association Of Thyroid Oncology Cato China Anti-Cancer Association
No abstract text is available yet for this article.
November 2018: Cancer Biology & Medicine
Qiujuan Huang, Changxu Liu, Ruijun Tang, Jie Li, Wei Li, Lei Zhu, Yuhong Guo, Lin Zhang, Tongyuan Qu, Lingyi Yang, Lingmei Li, Yalei Wang, Baocun Sun, Bin Meng, Jie Yan, Wengui Xu, Huilai Zhang, Dengfeng Cao, Wenfeng Cao
Extragonadal primary yolk sac tumor of the intestinal tract origin is exceedingly rare. Through a multiple disciplinary team, the diagnosis and treatment of primary intestinal yolk sac tumor were further defined. We report 2 such cases with detailed histologic and immunohistochemical analysis. The two patients were a 7-year-old girl and a 29-year-old woman. Both of them preoperatively had an elevated serum alpha fetoprotein (AFP) level (≥ 1,210 ng/mL). The tumors are located in the intestine and imaging examination indicated the rectum as the primary site...
November 2018: Cancer Biology & Medicine
Long Yuan, Xiaowei Qi, Yi Zhang, Xinhua Yang, Fan Zhang, Linjun Fan, Li Chen, Kongyong Zhang, Ling Zhong, Yanling Li, Sijie Gan, Wenying Fu, Jun Jiang
Objective: This randomized study aimed to compare the clinical efficacy between the novel dual tracer composed of indocyanine green (ICG) and blue dye (BD) and the conventional dual tracer composed of radioisotope and BD for sentinel lymph node (SLN) mapping in patients with breast cancer. Methods: This study enrolled 471 clinically lymph node-negative patients with primary breast cancer. All patients underwent mastectomy, and those undergoing sentinel lymph node biopsy (SLNB) were randomized to receive blue dye plus radioisotope (RB group) or BD plus ICG (IB group)...
November 2018: Cancer Biology & Medicine
Jing Wang, Yizhuo Zhao, Qiming Wang, Li Zhang, Jianhua Shi, Zhehai Wang, Ying Cheng, Jianxing He, Yuankai Shi, Hao Yu, Yang Zhao, Weiqiang Chen, Yi Luo, Xiuwen Wang, Kejun Nan, Faguang Jin, Jian Dong, Baolan Li, Zhujun Liu, Baohui Han, Kai Li
Objective: Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor, fibroblast growth factor receptor, platelet-derived growth factor receptor, c-Kit, and c-MET; therefore, it exhibits both antitumor and anti-angiogenetic activities. A phase III trial has shown that anlotinib improved progression-free survival (PFS) and overall survival (OS) in patients with advanced non-small cell lung cancer (NSCLC), who presented with progressive disease or intolerance after standard chemotherapy...
November 2018: Cancer Biology & Medicine
Yuchen Bai, Xiaoxia Chen, Likun Hou, Jun Qian, Tao Jiang, Caicun Zhou, Maciej Ciebiada
Objective: Epidermal growth factor receptor (EGFR) activation was reported to upregulate programmed death-ligand 1 (PD-L1) expression in lung cancer cells and subsequently contribute to immune escape, indicating its critical role in EGFR-driven lung tumors. This study characterized PD-L1 expression in patients with surgically resected EGFR-mutant non-small cell lung cancer (NSCLC). The effect of PD-L1 expression on clinical outcomes was also investigated in advanced EGFR-mutant NSCLC treated with EGFR-tyrosine kinase inhibitors (TKIs)...
November 2018: Cancer Biology & Medicine
Feng Fang, Xiaoqing Wang, Tianqiang Song
Objective: Hepatocellular carcinoma (HCC) is a common malignancy associated with high morbidity and mortality rates worldwide. Early diagnosis plays an important role in the improvement of HCC prognosis. Methods: In this study, we conducted a comprehensive analysis of HCC DNA methylation and gene expression datasets in The Cancer Genome Atlas (TCGA), to identify a prognostic signature for HCC diagnosis and survival prediction. First, we identified differential methylation CpG (dmCpG) sites in HCC samples and compared them with those in adjacent normal liver tissues; this was followed by univariate analysis and Sure Independence Screening (SIS) in the training set...
November 2018: Cancer Biology & Medicine
Jingjing Wu, Peng Zhu, Zhanguo Zhang, Bixiang Zhang, Chang Shu, Lin Chen, Renjie Feng, Abdoul Aziz Mba'nbo Koumpa, Ganxun Li, Qianyun Ge
Objective: Spontaneous hepatocellular carcinoma (HCC) rupture can be fatal, and hepatic resection could achieve a favorable long-term survival among all strategies of tumor rupture. However, there is no available prognostic scoring system for patients with ruptured HCC who underwent partial hepatectomy. Methods: From January 2005 to May 2015, 129 patients with spontaneous HCC rupture underwent partial hepatectomy. Preoperative clinical data were collected and analyzed...
November 2018: Cancer Biology & Medicine
Lianmei Zhao, Jie Li, Yueping Liu, Wei Zhou, Yanan Shan, Xinyi Fan, Xinliang Zhou, Baoen Shan, Yongmei Song, Qimin Zhan
Objective: Small cell lung carcinoma (SCLC) is considered one of the most aggressive types of lung cancer due to its rapid growth and early metastasis. No tumor markers or therapeutic targets have been demonstrated to be specific or effective in SCLC to date. This study aims to evaluate the potential of Flotillin1 (Flot1) as a target of SCLC treatment. Methods: Flot1 expression level in the tissue of SCLC and other tissue of lung disease was detected using immunohistochemical staining...
November 2018: Cancer Biology & Medicine
Maria Bonello, Andrew Harvey Sims, Simon Peter Langdon
Ovarian cancer is the second most lethal gynecological cancer worldwide and while most patients respond to initial therapy, they often relapse with resistant disease. Human epidermal growth factor receptors (especially HER1/EGFR and HER2/ERBB2) are involved in disease progression; hence, strategies to inhibit their action could prove advantageous in ovarian cancer patients, especially in patients resistant to first line therapy. Monoclonal antibodies and tyrosine kinase inhibitors are two classes of drugs that act on these receptors...
November 2018: Cancer Biology & Medicine
Angel Mauricio Castro-Gamero, Julia Alejandra Pezuk, María Sol Brassesco, Luiz Gonzaga Tone
Glioblastoma (GBM) is one of the deadliest tumors and has a median survival of 3 months if left untreated. Despite advances in rationally targeted pharmacological approaches, the clinical care of GBM remains palliative in intent. Since the majority of altered signaling cascades involved in cancer establishment and progression eventually affect cell cycle progression, an alternative approach for cancer therapy is to develop innovative compounds that block the activity of crucial molecules needed by tumor cells to complete cell division...
November 2018: Cancer Biology & Medicine
Dan Zou, Daxiang Cui
Circulating tumor cells (CTCs) are the cancer cells that circulate in the peripheral blood after escaping from the original or metastatic tumors. CTCs could be used as non-invasive source of clinical information in early diagnosis of cancer and evaluation of cancer development. In recent years, CTC research has become a hotspot field wherein many novel CTC detection technologies based on microfluidics have been developed. Great advances have been made that exhibit obvious technical advantages, but cannot yet satisfy the current clinical requirements...
November 2018: Cancer Biology & Medicine
Natalia Pinello, Stephanie Sun, Justin Jong-Leong Wong
N6 -methyladenosine (m6 A) is an essential RNA modification that regulates key cellular processes, including stem cell renewal, cellular differentiation, and response to DNA damage. Unsurprisingly, aberrant m6 A methylation has been implicated in the development and maintenance of diverse human cancers. Altered m6 A levels affect RNA processing, mRNA degradation, and translation of mRNAs into proteins, thereby disrupting gene expression regulation and promoting tumorigenesis. Recent studies have reported that the abnormal expression of m6 A regulatory enzymes affects m6 A abundance and consequently dysregulates the expression of tumor suppressor genes and oncogenes, including MYC , SOCS2 , ADAM19 , and PTEN ...
November 2018: Cancer Biology & Medicine
Yehui Shi, Wenwen Zhang, Yingnan Ye, Yanan Cheng, Lei Han, Pengpeng Liu, Weipeng Zhao, Zhongsheng Tong, Jinpu Yu
A postmenopausal patient with a diagnosis of estrogen receptor (ER) (+), progesterone receptor (PR) (+), and human epidermal growth factor receptor-2 (HER2) (-) breast cancer was reported. The patient refused surgery and was resistant to conventional chemotherapy regimens. Computed tomography and the circulating tumor cell test indicated that the patient's tumor burden increased rapidly even after several chemotherapy sessions. Multiple genetic aberrances in the phosphatidylinositol3-kinases (PI3K) signaling pathway were detected via next-generation sequencing (NGS)-based liquid biopsy, including a p...
August 2018: Cancer Biology & Medicine
Zhuang Kang, Shoubo Yang, Hongmei Zhang, Quan Zhou, Jianxin Chen, Yan Li, Xun Kang, Shan Li, Wenbin Li
Extracranial metastasis (ECM) of glioma is a rare condition that occurs in the internal nervous axis. A 23-year-old woman presented with anaplastic oligoastrocytoma (WHO III) in a left temporal tumor. The patient received chemoradiotherapy after surgery in our center. Three years after treatment, the patient experienced multiple ECMs in the right lung, left iliac bone, and multiple swollen subcutaneous nodules including the right clavicle, back of the neck, left forearm, right upper arm, and right clavicle...
August 2018: Cancer Biology & Medicine
Yi Yang, Tongguo Si
Objective: To compare the effects and safety of conventional transarterial chemoembolization (cTACE) and yttrium-90 transarterial radioembolization [TARE (90Y)] for hepatocellular carcinoma (HCC). Methods: Nine high-quality observational studies, one low bias-risk randomized controlled trial (RCT), and one moderate bias-risk RCT included 1,652 patients [cTACE, 1,124; TARE (90Y), 528], from whom data were extracted for this systematic review and meta-analysis. Results: The extracted study outcomes included 1-year and 2-year overall survival (OS) rates, objective responses (ORs), and serious adverse events (AEs)...
August 2018: Cancer Biology & Medicine
Shu Zhao, Minghui Zhang, Yu Zhang, Hongxue Meng, Yan Wang, Yupeng Liu, Jing Jing, Lan Huang, Mengqi Sun, Yue Zhang, Qingyuan Zhang
Objective: Although the prognostic value of programmed cell death-ligand 1 (PD-L1) expression in non-Hodgkin lymphoma (NHL) has been evaluated in many studies, the results remain controversial. To investigate the prognostic role of PD-L1 expression and the association between PD-L1 expression and clinicopathological features of NHL, we performed a meta-analysis. Methods: The PubMed, EMBASE, and Cochrane Library databases were searched up to November 30, 2017. The hazard ratio (HR), 95% confidence interval (CI), and odds ratios (OR) with 95% CIs were combined to evaluate the association of PD-L1 expression with overall survival (OS) and clinicopathological features...
August 2018: Cancer Biology & Medicine
Amina Maimaitiaili, Di Wu, Zhenyu Liu, Haimeng Liu, Xiamusiye Muyiduli, Zhimin Fan
Objective: Axillary lymph node dissection (ALND) may be unnecessary in 20%-60% of breast cancer patients with sentinel lymph node (NSLN) metastasis. The aim of the present study was to review the medical records of Chinese patients with early-stage breast cancer and positive NSLN metastasis to identify clinicopathological characteristics as risk factors for non-NSLN metastasis. Methods: The medical records of 2008 early-stage breast cancer patients who received intraoperative sentinel lymph node biopsy (SLNB) between 2006 and 2016 were retrospectively reviewed...
August 2018: Cancer Biology & Medicine
Chih-Che Lin, Chun-Hsien Wu, Li-Yu Chen, Ming-Chao Tsai, Ahmed M Elsarawy, Kuang-Tzu Huang
Objective: : Coagulation factor VII (FVII) triggers the extrinsic pathway of blood coagulation. In our previous study, we showed that FVII plays an important role in tumorigenesis of hepatocellular carcinoma (HCC). However, the role of FVII polymorphism in HCC is still unknown. The present study aimed to investigate the relationship between HCC carcinogenesis and single nucleotide polymorphism of FVII. Methods: : Thirty-seven HCC patients and 30 healthy donors were recruited in this study...
August 2018: Cancer Biology & Medicine
Achilleas G Mitrakas, Dimitra Kalamida, Alexandra Giatromanolaki, Stamatia Pouliliou, Avgi Tsolou, Rafail Kyranas, Michael I Koukourakis
Objective: Glioblastoma is the most common primary brain tumor in adults and one of the most lethal human tumors. It constitutes a unique non-metastasizing human tumor model with high resistance to radiotherapy and chemotherapy. The current study investigates the association between autophagic flux and glioblastoma cell resistance. Methods: The expression kinetics of autophagy- and lysosome-related proteins following exposure of two glioblastoma cell lines (T98 and U87) to clinically relevant radiation doses was examined...
August 2018: Cancer Biology & Medicine
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