Omer Helwa-Shalom, Faris Saba, Elad Spitzer, Salem Hanhan, Koby Goren, Shany I Markowitz, Dekel Shilo, Nissim Khaimov, Yechiel N Gellman, Dan Deutsch, Anat Blumenfeld, Hani Nevo, Amir Haze
AIMS: Cartilage injuries rarely heal spontaneously and often require surgical intervention, leading to the formation of biomechanically inferior fibrous tissue. This study aimed to evaluate the possible effect of amelogenin on the healing process of a large osteochondral injury (OCI) in a rat model. METHODS: A reproducible large OCI was created in the right leg femoral trochlea of 93 rats. The OCIs were treated with 0.1, 0.5, 1.0, 2.5, or 5.0 μg/μl recombinant human amelogenin protein (rHAM+ ) dissolved in propylene glycol alginate (PGA) carrier, or with PGA carrier alone...
October 3, 2023: Bone & Joint Research