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Journal of Stem Cells & Regenerative Medicine

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https://read.qxmd.com/read/30679895/shimoji-s-cranioplasty-yielding-life-quality-improvements-in-mild-trigonocephaly-scylimit
#1
Shimoji Takeyoshi
No abstract text is available yet for this article.
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30679894/germ-line-stem-cells-in-myocardial-regeneration-secretion-of-cardiogenic-paracrine-effectors-may-be-the-future
#2
G Ian Gallicano
Stem cell research for treating or curing ischemic heart disease has, to date, culminated in identifying which scenario is more important; 1) stem cell differentiation into cardiomyocytes that integrate electrically with the heart, 2) stem cells that secrete paracrine factors that promote healing, or 3) a combination of both. We consistently found that unipotent germline stem cells, when removed from their niche and cultured in the correct medium endogenously express pluripotency genes, which induce them to become human germline pluripotent stem cells (hgPSCs)...
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30679893/an-insight-into-pluripotency-and-cellular-aging-through-glycan-analysis
#3
Hirabayashi Jun
All kinds of cells from all kinds of organisms (i.e., animals, plants, fungi and bacteria) are covered by a dense layer of glycans. The origin of glycans or carbohydrates is not known[1] , however, the above fact implies that they are widely and closely associated with various biological phenomena based on cellular communications, which include development, differentiation, morphogenesis, carcinogenesis, immunity and infection. It is also notable that glycoproteins, one of existing forms of glycans (i.e., glycoconjugates) are generally synthesized in lumen sites of endoplasmic reticulum and the following Golgi apparatus, distinct from cytoplasmic proteins, which are not subjected to glycosylation, a major event of posttranslational modifications...
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30679892/mitochondrial-distribution-violation-and-nuclear-indentations-in-neurons-differentiated-from-ipscs-of-huntington-s-disease-patients
#4
Evgeny D Nekrasov, Sergey L Kiselev
AIM: Huntington's disease (HD) is an inherited disease caused by an expansion of cytosine-adenine-guanine (CAG) repeats in the huntingtin gene ( HTT ) that ultimately leads to neurodegeneration. To study the molecular basis of this disease, induced pluripotent stem cells (iPSCs) generated from patients' fibroblasts were used to investigate axonal mitochondrial trafficking and the nature of nuclear indentations. METHODS: Pathological and control iPSCs generated from patients with a low number of repeats were differentiated in striatal neurons of the brain...
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30679891/intra-arterial-transplantation-of-human-umbilical-cord-blood-mononuclear-cells-in-sub-acute-ischemic-stroke-increases-vegf-expression-in-rats
#5
Yetty Ramli, Ahmad Sulaiman Alwahdy, Mohammad Kurniawan, Berry Juliandi, Puspita Eka Wuyung
Thrombolysis (rt-PA) is the only United States Food and Drug Administration (FDA) approved drug currently available. Unfortunately, its effect has been limited by the narrow therapeutic time window. Human cord blood mononuclear cells (cbMNC) is a promising treatment for ischemic stroke by forming collateral and neo-vascularization where it is one of the important factors that contribute to cell repair. Therefore, evaluation of neo-vascularization in sub-acute stroke may be beneficial for recovery. One group for healthy rat and three groups (n=6 per group) of male wistar rats have undergone permanent middle cerebral artery occlusion (MCAO)...
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30679890/bone-marrow-derived-osteoblasts-in-the-management-of-ovariectomy-induced-osteoporosis-in-rats
#6
Mir Sadat-Ali, Haifa A Al-Turki, Sadananda Acharya, Dakheel A Al-Dakheel
Background : The objective of this study is to assess if infusion of osteoblasts can temporarily reverse osteoporosis in rats. Methods: Osteoporosis was induced in 20 female Sprague-Dawley rats by performing ovariectomy (OVX) that was carried out at 4 weeks of age. At 3 months a biopsy of the iliac crest was made to assess the bone quality and the same site bone marrow was harvested. From the bone marrow aspirate, MSCs were separated. Osteoblasts were then generated and were characterized using Alizarin red staining...
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30679889/induced-pluripotent-stem-cells-ips-derived-disease-models-in-vivo-to-in-vitro-gaps
#7
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30018474/letter-safety-and-feasibility-of-autologous-mesenchymal-stem-cell-transplantation-in-chronic-stroke-in-indian-patients-a-four-year-follow-up
#8
Oliver Davis
No abstract text is available yet for this article.
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30018473/granulation-tissue-derived-mesenchymal-stromal-cells-a-potential-application-for-burn-wound-healing-in-pediatric-patients
#9
Gloria Pelizzo, Maria Antonietta Avanzini, Melissa Mantelli, Stefania Croce, Alice Maltese, Elettra Vestri, Annalisa De Silvestri, Elena Percivalle, Valeria Calcaterra
Objective: Multipotential cells are mobilized into peripheral blood in response to trauma, in particular in severe burns. These cells migrate to the site of injury in response to chemotactic signals to modulate inflammation, repair damaged tissue and facilitate tissue regeneration. We evaluated the possibility of isolating and in vitro expand mesenchymal stromal cells (MSCs) from granulation tissue (GT) during debridement of a burn wound, as a persective strategy to improve skin regeneration. Methods: GT obtained from a 12-month-old burn patient was in vitro cultured...
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30018472/proliferation-migration-and-differentiation-potential-of-human-mesenchymal-progenitor-cells-derived-from-osteoarthritic-subchondral-cancellous-bone
#10
Jan Philipp Krüger, Andreas Enz, Sylvia Hondke, Alice Wichelhaus, Michaela Endres, Thomas Mittlmeier
Background: For regenerative therapies in the orthopedic field, one prerequisite for therapeutic success in the treatment of cartilage defects is the potential of body's own cells to migrate, proliferate and differentiate into functional cells. While this has been demonstrated for mesenchymal stem and progenitor cells (MPC) from healthy tissue sources, the potential of cells from degenerative conditions is unclear. In this study the regenerative potential of MPC derived from subchondral cancellous bone with diagnosed osteoarthritis is evaluated in vitro ...
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30018471/generation-of-dopamine-neuronal-like-cells-from-induced-neural-precursors-derived-from-adult-human-cells-by-non-viral-expression-of-lineage-factors
#11
Rebecca Playne, Kathryn Jones, Bronwen Connor
Reprogramming technology holds great promise for the study and treatment of Parkinson's disease (PD) as patient-specific ventral midbrain dopamine (vmDA) neurons can be generated. This should facilitate the investigation of early changes occurring during PD pathogenesis, permitting the identification of new drug targets and providing a platform for drug screening. To date, most studies using reprogramming technology to study PD have employed induced pluripotent stem cells. Research into PD using direct reprogramming has been limited due to an inability to generate high yields of authentic human vmDA neurons...
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30018470/cardiomyogenic-heterogeneity-of-clonal-subpopulations-of-human-bone-marrow-mesenchymal-stem-cells
#12
Naresh Kumar Tripathy, Syed Husain Mustafa Rizvi, Saurabh Pratap Singh, Venkata Naga Srikanth Garikpati, Soniya Nityanand
We have evaluated the cardiomyogenic potential of clonal populations of human bone marrow mesenchymal stem cells (BM-MSC). Four rapidly proliferating clones of BM-MSC were obtained from the BM of a healthy donor which were then treated with 5-azacytidine and evaluated for the expression of GATA-4, NKx-2.5, FOG-2, TDGF-1, β-MHC, MEF2D and NPPA genes and cTnT, Desmin and β-MHC proteins. Of the four clones (i) Clone-1 had high expression of GATA-4 (1.89 fold (p<0.05), Nkx2.5 (2.29 fold; p<0.05), FOG2 (2...
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30018469/re-defining-stem-cell-cardiomyocyte-interactions-focusing-on-the-paracrine-effector-approach
#13
Samiksha Mahapatra, Dianna Martin, G Ian Gallicano
Stem cell research for treating or curing ischemic heart disease has, till date, culminated in three basic approaches: the use of induced pluripotent stem cell (iPSC) technology; reprogramming cardiac fibroblasts; and cardiovascular progenitor cell regeneration. As each approach has been shown to have its advantages and disadvantages, exploiting the advantages while minimizing the disadvantages has been a challenge. Using human germline pluripotent stem cells (hgPSCs) along with a modified version of a relatively novel cell-expansion culture methodology to induce quick, indefinite expansion of normally slow growing hgPSCs, it was possible to emphasize the advantages of all three approaches...
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30018468/the-role-of-micrornas-in-embryonic-and-induced-pluripotency
#14
REVIEW
Abbas Beh-Pajooh, Tobias Cantz
Research on stem cells is one of the fastest growing areas of regenerative medicine that paves the way for a comprehensive solution to cell therapy. Today, stem cells are precious assets for generating different types of cells derived from either natural embryonic stem (ES) cells or induced pluripotent stem (iPS) cells. The iPS technology can revolutionize the future of clinics by offering personalized medicine, which will provide the future treatment for curing untreatable diseases. Although iPS cell therapy is now at its infancy, promising research has motivated scientists to pursue this therapeutic approach...
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/30018467/germline-stem-cells-in-myocardial-regeneration-a-new-hope-worth-a-delve
#15
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
2018: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/29391753/randomized-controlled-trial-comparing-hyaluronic-acid-platelet-rich-plasma-and-the-combination-of-both-in-the-treatment-of-mild-and-moderate-osteoarthritis-of-the-knee-letter-to-the-editor-author-response
#16
Sandeep Patel, M S Dhillon, Tungish Bansal
No abstract text is available yet for this article.
2017: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/29391752/stemregenin-1-selectively-promotes-expansion-of-multipotent-hematopoietic-progenitors-derived-from-human-embryonic-stem-cells
#17
Lihong Tao, Padma Priya Togarrati, Kyung-Dal Choi, Kran Suknuntha
Human embryonic stem cell (hESC)-derived hematopoietic stem/progenitor cells hold tremendous potential as alternative cell sources for the treatment of various hematological diseases, drug discovery and toxicological screening. However, limited number of hematopoietic stem/progenitor cells generated from the differentiation of hESCs hinders their downstream applications. Here, we show that aryl hydrocarbon receptor antagonist StemRegenin 1 (SR1) selectively promotes expansion of hESC-derived lin- CD34+ hematopoietic progenitors in a concentration-dependent manner...
2017: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/29391751/increased-motility-of-mesenchymal-stem-cells-is-correlated-with-inhibition-of-stimulated-peripheral-blood-mononuclear-cells-in-vitro
#18
Alessandro Bertolo, David Pavlicek, Armin Gemperli, Martin Baur, Tobias Pötzel, Jivko Stoyanov
Immunomodulatory properties of mesenchymal stem cells (MSC) are key components of their successful applications in clinical setting. However, treatments based on MSC immunomodulation need understanding of cell characteristics before cell transplantation. We used live-imaging to test the suitability of the MSC motility as a parameter for quick prediction of the immunomodulatory potential of human MSC in regulating the activity of stimulated peripheral blood mononuclear cells (PBMC) in vitro . Bone marrow MSC, from various donors and in vitro passages, were cultured with or without stimulated PBMC...
2017: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/29391750/neural-stem-progenitor-cells-maintained-in-vitro-under-different-culture-conditions-alter-differentiation-capacity-of-monocytes-to-generate-dendritic-cells
#19
Alexey Yu Lupatov, Rimma A Poltavtseva, Oxana A Bystrykh, Konstantin N Yarygin, Gennady T Sukhikh
Cell therapy of the nervous system disorders using neural stem/progenitor cells (NSPCs) proved its efficacy in preclinical and pilot clinical studies. The mechanisms of the beneficial effects of NSPCs transplantation include replacement of damaged cells, paracrine activation of the regeneration, and immunomodulation. Detailed assessment of NSPCs-induced immunomodulation can contribute to better control of autoimmune reactions and inflammation in patients with neurodegenerative diseases. Interactions of NSPCs with dendritic cells (DCs), the key players in the induction of the immune system response to antigens are of particular interest...
2017: Journal of Stem Cells & Regenerative Medicine
https://read.qxmd.com/read/29391749/cathepsin-k-localizes-to-equine-bone-in-vivo-and-inhibits-bone-marrow-stem-and-progenitor-cells-differentiation-in-vitro
#20
Hayam Hussein, Prosper Boyaka, Jennifer Dulin, Duncan Russell, Lauren Smanik, Mohamed Azab, Alicia L Bertone
Selective inhibition of Cathepsin K (CatK) has a promising therapeutic potential for diseases associated with bone loss and osseous inflammation, such as osteoarthritis, periodontitis, and osteoporosis. In horses, stress-related bone injuries are common and accompanied by bone pain and inflammation resulting in excessive bone resorption and periostitis. VEL-0230 is a highly selective inhibitor of CatK that significantly decreased bone resorption and increased bone formation biomarkers. The goal of this study was to demonstrate the presence of CatK in equine bone and a simultaneous influence on the bone marrow cellular components including function and differentiation...
2017: Journal of Stem Cells & Regenerative Medicine
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