Chris S Pridgeon, Shiva Seyed Forootan, Fang Zhang, Nicholas Harper, Daniel Palmer, Richard Weightmann, Sian Gregory, Zoe Hewitt, Duncan Baker, Jason Halliwell, Harry Moore, Emanuele Ricci, Peter W Andrews, Harish Poptani, David C Hay, B Kevin Park, Chris E P Goldring
Human pluripotent stem cells (hPSCs) are a promising source of somatic cells for clinical applications and disease modelling. However, during culture they accumulate genetic aberrations such as amplification of 20q11.21 which occurs in approximately 20% of extensively cultured hPSC lines and confers a BCL2L1-mediated survival advantage. During the production of the large number of cells required for transplantation and therapy these aberrations may become unavoidable which has important safety implications for therapies and may also impact upon disease modelling...
2023: Journal of Stem Cells & Regenerative Medicine