journal
https://read.qxmd.com/read/38148550/current-development-status-of-cytokines-for-cancer-immunotherapy
#21
REVIEW
Kyoung Song
Cytokines influence the overall cancer immune cycle by triggering tumor antigen expression, antigen presenting, immune cell priming and activation, effector immune cell recruitment and infiltration to cancer, and cancer killing in the tumor microenvironment (TME). Therefore, cytokines have been considered potential anti-cancer immunotherapy, and cytokine-based anti-cancer therapies continue to be an active area of research and development in the field of cancer immunotherapy, with ongoing clinical trials exploring new strategies to improve efficacy and safety...
January 1, 2024: Biomolecules & Therapeutics
https://read.qxmd.com/read/38148549/immunological-mechanisms-in-cutaneous-adverse-drug-reactions
#22
REVIEW
Ai-Young Lee
Adverse drug reactions (ADRs) are an inherent aspect of drug use. While approximately 80% of ADRs are predictable, immune system-mediated ADRs, often unpredictable, are a noteworthy subset. Skin-related ADRs, in particular, are frequently unpredictable. However, the wide spectrum of skin manifestations poses a formidable diagnostic challenge. Comprehending the pathomechanisms underlying ADRs is essential for accurate diagnosis and effective management. The skin, being an active immune organ, plays a pivotal role in ADRs, although the precise cutaneous immunological mechanisms remain elusive...
January 1, 2024: Biomolecules & Therapeutics
https://read.qxmd.com/read/38072501/bortezomib-is-toxic-but-induces-neurogenesis-and-inhibits-tubb3-degradation-in-rat-neural-stem-cells
#23
JOURNAL ARTICLE
Seung Yeon Sohn, Thin Thin San, Junhyung Kim, Hyun-Jung Kim
Bortezomib (BTZ) is a proteasome inhibitor used to treat multiple myeloma (MM). However, the induction of peripheral neuropathy is one of the major concerns in using BTZ to treat MM. In the current study, we have explored the effects of BTZ (0.01-5 nM) on rat neural stem cells (NSCs). BTZ (5 nM) induced cell death; however, the percentage of neurons was increased in the presence of mitogens. BTZ reduced the b-cell lymphoma 2 (Bcl-2)/Bcl-2 associated X protein ratio in proliferating NSCs and differentiated cells...
December 11, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37899746/domperidone-exerts-antitumor-activity-in-triple-negative-breast-cancer-cells-by-modulating-reactive-oxygen-species-and-jak-stat3-signaling
#24
JOURNAL ARTICLE
Rajina Shakya, Mi Ran Byun, Sang Hoon Joo, Kyung-Soo Chun, Joon-Seok Choi
The lack of molecular targets hampers the treatment of triple-negative breast cancer (TNBC). In this study, we determined the cytotoxicity of domperidone, a dopamine D2 receptor (DRD2) antagonist in human TNBC BT-549 and CAL-51 cells. Domperidone inhibited cell growth in a dose- and time-dependent manner. The annexin V/propidium iodide staining showed that domperidone induced apoptosis. The domperidone-induced apoptosis was accompanied by the generation of mitochondrial superoxide and the down-regulation of cyclins and CDKs...
November 1, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37899745/licochalcone-d-inhibits-skin-epidermal-cells-transformation-through-the-regulation-of-akt-signaling-pathways
#25
JOURNAL ARTICLE
Sun-Young Hwang, Kwanhwan Wi, Goo Yoon, Cheol-Jung Lee, Soong-In Lee, Jong-Gil Jung, Hyun-Woo Jeong, Jeong-Sang Kim, Chan-Heon Choi, Chang-Su Na, Jung-Hyun Shim, Mee-Hyun Lee
Cell transformation induced by epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) is a critical event in cancer initiation and progression, and understanding the underlying mechanisms is essential for the development of new therapeutic strategies. Licorice extract contains various bioactive compounds, which have been reported to have anticancer and anti-inflammatory effects. This study investigated the cancer preventive efficacy of licochalcone D (LicoD), a chalcone derivative in licorice extract, in EGF and TPA-induced transformed skin keratinocyte cells...
November 1, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37899744/licochalcone-h-targets-egfr-and-akt-to-suppress-the-growth-of-oxaliplatin-sensitive-and-resistant-colorectal-cancer-cells
#26
JOURNAL ARTICLE
Seung-On Lee, Mee-Hyun Lee, Ah-Won Kwak, Jin-Young Lee, Goo Yoon, Sang Hoon Joo, Yung Hyun Choi, Jin Woo Park, Jung-Hyun Shim
Treatment of colorectal cancer (CRC) has always been challenged by the development of resistance. We investigated the antiproliferative activity of licochalcone H (LCH), a regioisomer of licochalcone C derived from the root of Glycyrrhiza inflata, in oxaliplatin (Ox)-sensitive and -resistant CRC cells. LCH significantly inhibited cell viability and colony growth in both Ox-sensitive and Ox-resistant CRC cells. We found that LCH decreased epidermal growth factor receptor (EGFR) and AKT kinase activities and related activating signaling proteins including pEGFR and pAKT...
November 1, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37899743/sex-differences-in-the-preventive-effect-of-cardiovascular-and-metabolic-therapeutics-on-dementia
#27
REVIEW
Sun Ah Choi, Hye Jin Jee, Katrina Joy Bormate, Yeonjae Kim, Yi-Sook Jung
Dementia is a clinical syndrome characterized by progressive impairment of cognitive and functional abilities. As currently applied treatments for dementia can only delay the progression of dementia and cannot fundamentally cure it, much attention is being paid to reducing its incidence by preventing the associated risk factors. Cardiovascular and metabolic diseases are well-known risk factors for dementia, and many studies have attempted to prevent dementia by treating these risk factors. Growing evidence suggests that sex-based factors may play an important role in the pathogenesis of dementia...
November 1, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37818624/aquaporin-3-downregulation-in-vitiligo-keratinocytes-increases-oxidative-stress-of-melanocytes
#28
JOURNAL ARTICLE
Nan-Hyung Kim, Ha Jung Kim, Ai-Young Lee
Oxidative stress-induced melanocyte apoptosis is linked to the immune system and plays a critical role in the pathogenesis of vitiligo. Aquaporin-3 (AQP3), which is downregulated in vitiligo keratinocytes, regulates intracellular H2 O2 accumulation. However, the role of AQP3 in oxidative stress is uncertain in vitiligo. This study investigated the effect of downregulated AQP3 on oxidative stress in vitiligo using lesional and non-lesional skin specimen sets from vitiligo patients and primary cultured adult normal human epidermal keratinocytes, with or without downregulation and overexpression of AQP3 in the presence or absence of H2 O2 treatment...
November 1, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37818618/effect-of-prunetin-on-streptozotocin-induced-diabetic-nephropathy-in-rats-a-biochemical-and-molecular-approach
#29
JOURNAL ARTICLE
Jose Vinoth Raja Antony Samy, Nirubama Kumar, Sengottuvelu Singaravel, Rajapandiyan Krishnamoorthy, Mohammad A Alshuniaber, Mansour K Gatasheh, Amalan Venkatesan, Vijayakumar Natesan, Sung-Jin Kim
In the modern era, chronic kidney failure due to diabetes has spread across the globe. Prunetin (PRU), a component of herbal medicines, has a broad variety of pharmacological activities; these may help to slow the onset of diabetic kidney disease. The anti-nephropathic effects of PRU have not yet been reported. The present study explored the potential nephroprotective actions of PRU in diabetic rats. For 28 days, nephropathic rats were given oral doses of PRU (20, 40, and 80 mg/kg). Body weight, blood urea, creatinine, total protein, lipid profile, liver marker enzymes, carbohydrate metabolic enzymes, C-reactive protein, antioxidants, lipid peroxidative indicators, and the expression of insulin receptor substrate 1 (IRS-1) and glucose transporter 2 (GLUT-2) mRNA genes were all examined...
November 1, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37817377/stimulatory-anticancer-effect-of-resveratrol-mediated-by-g-protein-coupled-estrogen-receptor-in-colorectal-cancer
#30
JOURNAL ARTICLE
Nayun Kim, Junhye Kwon, Ui Sup Shin, Joohee Jung
Colorectal cancer (CRC) is one of the most high-risk cancers; however, it has been suggested that estrogen signaling in CRC could have a protective effect. Therefore, we focused on the function of the G protein-coupled estrogen receptor (GPER) among the estrogen receptors in CRC. In this study, we investigated the therapeutic effect of resveratrol via GPER in CRC (RKO and WiDr) cells, CRC cell-derived xenograft models, and organoids (30T and 33T). Resveratrol significantly suppressed cell viability and proliferation in highly GPER-expressing RKO cells compared to that in low GPER-expressing WiDr cells...
October 11, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37641880/current-status-and-future-trends-of-cold-atmospheric-plasma-as-an-oncotherapy
#31
REVIEW
Xiaofeng Dai, Jiale Wu, Lianghui Lu, Yuyu Chen
Cold atmospheric plasma (CAP), a redox modulation tool, is capable of inhibiting a wide spectrum of cancers and has thus been proposed as an emerging onco-therapy. However, with incremental successes consecutively reported on the anticancer efficacy of CAP, no consensus has been made on the types of tumours sensitive to CAP due to the different intrinsic characteristics of the cells and the heterogeneous design of CAP devices and their parameter configurations. These factors have substantially hindered the clinical use of CAP as an oncotherapy...
September 1, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37562979/aerobic-exercise-ameliorates-muscle-atrophy-induced-by-methylglyoxal-via-increasing-gastrocnemius-and-extensor-digitorum-longus-muscle-sensitivity
#32
JOURNAL ARTICLE
Seong-Min Hong, Eun Yoo Lee, Jinho Park, Jiyoun Kim, Sun Yeou Kim
Muscle atrophy is characterized by the loss of muscle function. Many efforts are being made to prevent muscle atrophy, and exercise is an important alternative. Methylglyoxal is a well-known causative agent of metabolic diseases and diabetic complications. This study aimed to evaluate whether methylglyoxal induces muscle atrophy and to evaluate the ameliorative effect of moderateintensity aerobic exercise in a methylglyoxal-induced muscle atrophy animal model. Each mouse was randomly divided into three groups: control, methylglyoxal-treated, and methylglyoxal-treated within aerobic exercise...
August 11, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37562952/c-reactive-protein-signaling-pathways-in-tumor-progression
#33
JOURNAL ARTICLE
Eun-Sook Kim, Sun Young Kim, Aree Moon
Many cancers arise from sites of chronic inflammation, which creates an inflammatory microenvironment surrounding the tumor. Inflammatory substances secreted by cells in the inflammatory environment can induce the proliferation and survival of cancer cells, thereby promoting cancer metastasis and angiogenesis. Therefore, it is important to identify the role of inflammatory factors in cancer progression. This review summarizes the signaling pathways and roles of C-reactive protein (CRP) in various cancer types, including breast, liver, renal, and pancreatic cancer, and the tumor microenvironment...
August 11, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37558633/diagnostic-role-of-bile-pigment-components-in-biliary-tract-cancer
#34
JOURNAL ARTICLE
Keun Soo Ahn, Koo Jeong Kang, Yong Hoon Kim, Tae-Seok Kim, Kwang Bum Cho, Hye Soon Kim, Won-Ki Baek, Seong-Il Suh, Jin-Yi Han
Bile pigment, bilirubin, and biliverdin concentrations may change as a results of biliary tract cancer (BTC) altering the mechanisms of radical oxidation and heme breakdown. We explored whether changes in bile pigment components could help distinguish BTC from benign biliary illness by evaluating alterations in patients with BTC. We collected bile fluid from 15 patients with a common bile duct stone (CBD group) and 63 individuals with BTC (BTC group). We examined the bile fluid's bilirubin, biliverdin reductase (BVR), heme oxygenase (HO-1), and bacterial taxonomic abundance...
August 10, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37551651/a-novel-role-of-hyaluronic-acid-and-proteoglycan-link-protein-1-hapln1-in-delaying-vascular-endothelial-cell-senescence
#35
JOURNAL ARTICLE
Dan Zhou, Ji Min Jang, Goowon Yang, Hae Chan Ha, Zhicheng Fu, Dae Kyong Kim
Cardiovascular diseases (CVDs) are the most common cardiovascular system disorders. Cellular senescence is a key mechanism associated with dysfunction of aged vascular endothelium. Hyaluronic acid and proteoglycan link protein 1 (HAPLN1) has been known to non-covalently link hyaluronic acid (HA) and proteoglycans (PGs), and forms and stabilizes HAPLN1-containing aggregates as a major component of extracellular matrix. Our previous study showed that serum levels of HAPLN1 decrease with aging. Here, we found that the HAPLN1 gene expression was reduced in senescent human umbilical vein endothelial cells (HUVECs)...
August 8, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37551604/novel-effect-of-hyaluronan-and-proteoglycan-link-protein-1-hapln1-on-hair-follicle-cells-proliferation-and-hair-growth
#36
JOURNAL ARTICLE
Hae Chan Ha, Dan Zhou, Zhicheng Fu, Moon Jung Back, Ji Min Jang, In Chul Shin, Dae Kyong Kim
Hair loss is a common condition that can have a negative impact on an individual's quality of life. The severe side effects and the low efficacy of current hair loss medications create unmet needs in the field of hair loss treatment. Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1), one of the components of the extracellular matrix, has been shown to play a role in maintaining its integrity. HAPLN1 was examined for its ability to impact hair growth with less side effects than existing hair loss treatments...
August 8, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37551139/inhaled-volatile-molecules-responsive-trp-channels-as-non-olfactory-receptors
#37
JOURNAL ARTICLE
Hyungsup Kim, Minwoo Kim, Yongwoo Jang
Generally, odorant molecules are detected by olfactory receptors, which are specialized chemoreceptors expressed in olfactory neurons. Besides odorant molecules, certain volatile molecules can be inhaled through the respiratory tract, often leading to pathophysiological changes in the body. These inhaled molecules mediate cellular signaling through the activation of the Ca2+ -permeable transient receptor potential (TRP) channels in peripheral tissues. This review provides a comprehensive overview of TRP channels that are involved in the detection and response to volatile molecules, including hazardous substances, anesthetics, plant-derived compounds, and pheromones...
August 8, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37524442/the-effect-of-%C3%AE-aminobutyric-acid-intake-on-uvb-induced-skin-damage-in-hairless-mice
#38
JOURNAL ARTICLE
Hairu Zhao, Bomi Park, Min-Jung Kim, Seok-Hyun Hwang, Tae-Jong Kim, Seung-Un Kim, Iksun Kwon, Jae Sung Hwang
The skin, the largest organ in the body, undergoes age-related changes influenced by both intrinsic and extrinsic factors. The primary external factor is photoaging which causes hyperpigmentation, uneven skin surface, deep wrinkles, and markedly enlarged capillaries. In the human dermis, it decreases fibroblast function, resulting in a lack of collagen structure and also decreases keratinocyte function, which compromises the strength of the protective barrier. In this study, we found that treatment with γ-aminobutyric acid (GABA) had no toxicity to skin fibroblasts and GABA enhanced their migration ability, which can accelerate skin wound healing...
August 1, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37503756/association-between-lepr-genotype-and-gut-microbiome-in-healthy-non-obese-korean-adults
#39
JOURNAL ARTICLE
Yoon Jung Cha, In Ae Chang, Eun-Heui Jin, Ji Hye Song, Jang Hee Hong, Jin-Gyu Jung, Jung Sunwoo
The LEPR (leptin receptor) genotype is associated with obesity. Gut microbiome composition differs between obese and nonobese adults. However, the impact of LEPR genotype on gut microbiome composition in humans has not yet been studied. In this study, the association between LEPR single nucleotide polymorphism (rs1173100, rs1137101, and rs790419) and the gut microbiome composition in 65 non-obese Korean adults was investigated. Leptin, triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels were also measured in all participants...
July 28, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37465849/biased-dopamine-d-2-receptors-exhibit-distinct-intracellular-trafficking-properties-and-erk-activation-in-different-subcellular-domains
#40
JOURNAL ARTICLE
Shujie Wang, Lulu Peng, Kyeong-Man Kim
Biased signaling or functional selectivity refers to the ability of an agonist or receptor to selectively activate a subset of transducers such as G protein and arrestin in the case of G protein-coupled receptors (GPCRs). Although signaling through arrestin has been reported from various GPCRs, only a few studies have examined side-by-side how it differs from signaling via G protein. In this study, two signaling pathways were compared using dopamine D2 receptor (D2 R) mutants engineered via the evolutionary tracer method to selectively transduce signals through G protein or arrestin (D2 G and D2 Arr, respectively)...
July 19, 2023: Biomolecules & Therapeutics
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