Jose Vinoth Raja Antony Samy, Nirubama Kumar, Sengottuvelu Singaravel, Rajapandiyan Krishnamoorthy, Mohammad A Alshuniaber, Mansour K Gatasheh, Amalan Venkatesan, Vijayakumar Natesan, Sung-Jin Kim
In the modern era, chronic kidney failure due to diabetes has spread across the globe. Prunetin (PRU), a component of herbal medicines, has a broad variety of pharmacological activities; these may help to slow the onset of diabetic kidney disease. The anti-nephropathic effects of PRU have not yet been reported. The present study explored the potential nephroprotective actions of PRU in diabetic rats. For 28 days, nephropathic rats were given oral doses of PRU (20, 40, and 80 mg/kg). Body weight, blood urea, creatinine, total protein, lipid profile, liver marker enzymes, carbohydrate metabolic enzymes, C-reactive protein, antioxidants, lipid peroxidative indicators, and the expression of insulin receptor substrate 1 (IRS-1) and glucose transporter 2 (GLUT-2) mRNA genes were all examined...
November 1, 2023: Biomolecules & Therapeutics