Bisan El Dakkak, Jalal Taneera, Waseem El-Huneidi, Eman Abu-Gharbieh, Rifat Hamoudi, Mohammad H Semreen, Nelson C Soares, Eman Y Abu-Rish, Mahmoud Y Alkawareek, Alaaldin M Alkilany, Yasser Bustanji
Apoptosis, programmed cell death pathway, is a vital physiological mechanism that ensures cellular homeostasis and overall cellular well-being. In the context of cancer, where evasion of apoptosis is a hallmark, the overexpression of anti-apoptotic proteins like Bcl2, Bcl-XL, and Mcl-1 has been documented. Consequently, these proteins have emerged as promising targets for therapeutic interventions. The BCL-2 protein family is central to apoptosis and plays a significant importance in determining cellular fate serving as a critical determinant in this biological process...
April 9, 2024: Biomolecules & Therapeutics