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Journal of Neonatal-perinatal Medicine

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https://read.qxmd.com/read/30741698/glucose-6-phosphate-dehydrogenase-deficiency-incidence-in-a-hispanic-population
#1
C Cantú-Reyna, J Santos-Guzmán, H Cruz-Camino, D L Vazquez Cantu, J J Góngora-Cortéz, A Gutiérrez-Castillo
Glucose-6-phosphate dehydrogenase deficiency (D-G6PD) is a common erythroenzymopathy that needs to be addressed as an important public health issue. Proper population monitoring is needed to anticipate clinical complications. A joint venture between Genomi-k (a Mexican company focused on newborn screening) and several university researchers conducted a retrospetive study for D-G6PD based on 156,152 newborn screening reports belonging to the Mexican population comprising a period of 10 years. We identified 540 male newborns affected with this deficiency, representing an incidence of 6...
February 4, 2019: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30741697/stress-during-pregnancy-affected-neonatal-outcomes-and-changed-cortisol-and-leptin-levels-both-in-mothers-and-newborns
#2
S Rabiepoor, M Abedi, E Saboory, H R Khalkhali
BACKGROUND: The present study aimed to determine the effect of perceived stress during pregnancy on neonatal outcomes and cortisol and leptin levels in mothers and their newborns. METHODS: This longitudinal study was carried out on 110 pregnant women in Miandoab city, Iran. Mothers, who had singleton pregnancies and gestational age of 24 to 28 weeks, were included in the study. The participants were asked to fill out Cohen's Perceived Stress Scale (PSS). The mothers were then tracked in gestational ages of 28-32 weeks, 32-36 weeks, and the time of delivery...
February 4, 2019: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30741696/anthropometric-measures-as-biomarkers-of-neurodevelopmental-outcomes-of-newborns-with-moderate-to-severe-hypoxic-ischemic-encephalopathy
#3
P Sg, A Kadam, S Kadam, U Vaidya, P Kumar, I Bhagat, A Pandit, N Chouthai
BACKGROUND: Perinatal asphyxia is a prominent cause of neonatal mortality in the developing world. Growth in head circumference is associated with improved neurodevelopment. Previous studies found a positive correlation between additional dietary supplementation and growth in head circumference among newborns with perinatal brain injury. This study aims to evaluate the association between anthropometric parameters and developmental outcomes in newborns with hypoxic ischemic encephalopathy (HIE)...
February 4, 2019: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30714976/pulmonary-mechanics-measurements-by-respiratory-inductive-plethysmography-and-esophageal-manometry-methodology-for-infants-on-non-invasive-respiratory-support
#4
E M Sivieri, M R Wolfson, S Abbasi
BACKGROUND: Infants are commonly supported with non-invasive ventilation (NIV) such as nasal CPAP and high flow nasal cannula (HFNC). These modes utilize a nasal/oral interface precluding use of a traditional airway flow sensor, such as a pneumotachometer (PNT), needed for pulmonary mechanics (PM) measurements. Respiratory Inductive Plethysmography (RIP), when properly calibrated, records tidal volume non-invasively from chest wall movements. Our aim was to integrate RIP into an existing neonatal pulmonary function testing system to measure PM in infants on NIV and to compare measurements of dynamic lung compliance (CL) and resistance (RL) using RIP with those obtained using a PNT...
January 28, 2019: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30714975/the-influence-of-time-of-birth-and-seasonal-variations-on-weight-loss-in-breastfeeding-neonates
#5
M T K Zia, S Golombek, L Lemon, S Nitkowski Keever, U Paudel
BACKGROUND: Breastfeeding (BF) neonates generally lose weight after birth. Neonatal factors like gestational age, birth weight and mode of delivery can affect the neonatal weight loss after birth. Similarly, maternal age, parity and illness may contribute to newborn weight loss. However, influence of the time of birth and season on changes in weight is not well elucidated. OBJECTIVE: The aim of this study is to determine the effect of birth time and the seasonal variations on weight loss in BF newborns...
January 28, 2019: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30614810/narcotics-and-sedatives-use-in-the-mechanical-ventilation-in-preterm-infants-predictors-and-outcome
#6
J M Toye, J Yang, K Sankaran
BACKGROUND: Mechanical ventilation (MV) causes discomfort but whether it causes pain remains controversial. Around the world neonatal intensive care units (NICU) often utilize narcotics and/or sedatives during MV of vulnerable infants yet the association with adverse neonatal outcomes has not been adequately addressed. OBJECTIVE: Test for associations between the use of narcotics/sedatives during MV and mortality/morbidity in preterm infants in a large infant cohort in Canada...
December 31, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30584173/predictors-of-drug-use-during-pregnancy-the-relative-effects-of-socioeconomic-demographic-and-mental-health-risk-factors
#7
R A Brown, H Dakkak, J Gilliland, J A Seabrook
BACKGROUND: With limited Canadian research on predictors of drug use during pregnancy, the primary objective was to assess the relative effects of socioeconomic, demographic, and mental health risk factors associated with drug use during pregnancy. Predictors of an Apgar score <  7 and fetal macrosomia were examined as secondary outcomes. METHODS: This retrospective cohort study consisted of 25,734 pregnant women from Southwestern Ontario. Data were prospectively obtained from perinatal and neonatal databases at a tertiary hospital in London, Ontario...
December 21, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30562908/intranasal-midazolam-and-fentanyl-for-procedural-sedation-and-analgesia-in-infants-in-the-neonatal-intensive-care-unit
#8
L C Ku, C Simmons, P B Smith, R G Greenberg, K Fisher, C D Hornik, C Michael Cotten, R N Goldberg, M Bidegain
BACKGROUND: The intranasal route is a minimally invasive method for rapidly delivering midazolam and fentanyl to provide short-term analgesia and sedation in infants. However, intranasal use of midazolam and fentanyl is not labeled for infants and safety data are sparse. The objective of this study is to evaluate the safety of intranasal midazolam and intranasal fentanyl in infants admitted to the Neonatal Intensive Care Unit (NICU). METHODS: We retrospectively identified all infants receiving intranasal midazolam or fentanyl in the NICU from 2009 to 2015...
December 11, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30530977/central-diabetes-insipidus-a-rare-complication-of-ivh-in-a-very-low-birth-weight-preterm-infant
#9
P Thakore, A E Dunbar, E B Lindsay
A 710 g male infant was born at a referring hospital at a gestational age of 23 weeks and 2 days via vaginal delivery and was transferred to our facility at 14 days of age. His delivery was complicated by the breech presentation with difficult head extraction. The infant's initial course was significant for respiratory distress syndrome, grade III-IV intraventricular hemorrhage (IVH), acute kidney injury, and large PDA. On the day of life 29, a gradual increase in serum sodium level refractory to increasing total fluid volume was noted...
December 1, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30412507/impact-of-red-blood-cell-transfusions-on-intestinal-barrier-function-in-preterm-infants
#10
O O Ajayi, N L Davis, B Saleem, S Kapoor, A C Okogbule-Wonodi, R M Viscardi, Sripriya Sundararajan
OBJECTIVE: To determine the relationships of red blood cell (RBC) transfusion and enteral feeding to changes in intestinal permeability (IP) measured by the relative intestinal uptake of lactulose (La) and rhamnose (Rh) in preterm infants <33 wk gestation. DESIGN/METHODS: Infants 240-326wk gestation received La/Rh solution enterally on study days 1, 8 and 15.Urinary La/Rh ratio was measured by HPLC. Hematocrit preceding transfusion, total RBC transfusion volume, volume/kg, and feeding status during each study interval (birth-d1; d1-d8, and d8-d15) were determined...
November 8, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30400108/the-severity-and-associated-comorbidities-of-retinopathy-of-prematurity-among-micro-premature-infants-with-birth-weights-less-than-750-grams
#11
K Beck, R Young, S Read, H Harper, J Desireddi, C A Harper
OBJECTIVES: To evaluate the characteristics and comorbidities associated with ROP in micro-premature infants and their results. METHODS: This is a retrospective chart review involving multiple intensive care units in Central Texas from 2011 to 2016. Infants were included if birth weight (BW) was≤750 g with confirmed ROP by the International Classification of Retinopathy of Prematurity (ICROP). Neonates were examined and treated with laser ablation or intravitreal ranibizumab (IVR) with subsequent laser treatment, guided by fluorescein angiography, if met treatment criteria defined as type 1 ROP by the Early Treatment of Retinopathy of Prematurity standards...
October 30, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30373964/neonatologists-less-frequently-discuss-long-term-complications-a-simulation-based-study-of-prenatal-consults-beyond-the-threshold-of-viability
#12
J D Humphrey, J L Hagan, G K Suresh, N C Sundgren
BACKGROUND: Guidelines exist for counseling expectant families of infants at periviable gestational ages (22-25 weeks), but it is much more common for neonatologists to counsel families at gestational ages beyond the threshold of viability when several aspects of these guidelines do not apply. We aimed to develop an understanding of what information is shared with mothers at risk of preterm delivery beyond periviability and to evaluate communication skills of our participants. METHODS: We developed a checklist of elements to include in counseling based on a comprehensive literature review...
October 23, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30373963/enteral-fish-oil-supplementation-in-the-resolution-of-parenteral-nutrition-associated-cholestasis
#13
A Thavamani, M J Mhanna, S Groh-Wargo, R Gulati, P S Shekhawat
OBJECTIVE: To analyze safety, tolerance and efficacy of enteral omega-3 fatty acids (FAs) in the resolution of Parenteral Nutrition Associated Cholestasis (PNAC) and postnatal growth among preterm neonates. STUDY DESIGN: This is a single center retrospective case-control study of all neonates born less than 32 weeks of gestation and developed PNAC (Direct bilirubin >2 mg/dl). Infants who received enteral omega-3 FAs supplementation (1 g/Kg/d) served as cases and were compared with gestational age, gender and direct bilirubin level matched controls that did not receive enteral omega-3 FAs supplementation...
October 22, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30347623/enteral-feeding-in-duct-dependent-congenital-heart-disease
#14
T G Day, D Dionisio, D Zannino, C Brizard, M Mh Cheung
BACKGROUND: Infants with duct-dependent congenital heart lesions are treated with a prostaglandin E1 infusion. We aimed to describe the feeding strategies used at our institution in such infants, and to describe the incidence of necrotising enterocolitis (NEC) in this patient group, investigating whether enteral feeding is associated with a higher risk. METHODS: Patients diagnosed with hypoplastic left heart syndrome, coarctation of the aorta, pulmonary atresia, or transposition of the great arteries born over a defined period were identified...
October 19, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30347622/the-association-between-ab-blood-group-and-neonatal-disease
#15
K E McMahon, O Habeeb, G M Bautista, S Levin, P J DeChristopher, L A Glynn, W Jeske, J K Muraskas
BACKGROUND: Numerous studies have examined the association between ABO blood groups and adult disease states, but very few have studied the neonatal population. The objective of this study was to determine the relationship between AB blood group and the occurrence of common neonatal disorders such as neutropenia at birth, sepsis, respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), and patent ductus arteriosus (PDA) compared to all other blood groups...
October 19, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30320598/regional-analgesia-in-neonates-undergoing-thoracoabdominal-surgeries-a-pilot-study
#16
Ajay P Singh, S Lakshminrusimha, M E Thompson
OBJECTIVE: The primary aim of this pilot study was to assess feasibility and to evaluate if peri-operative pain management with regional analgesia resulted in decreased use of narcotic medication and earlier return to preoperative respiratory/nutritional status. STUDY DESIGN: Cases were defined as infants who received regional analgesia as part of their perioperative anesthetic management. Controls were matched for surgical procedures without regional analgesia...
October 10, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30149481/features-of-serial-cranial-ultrasound-detected-neuropathology-in-very-preterm-infants
#17
A Petrova, M Karatas, R Mehta
BACKGROUND: The purpose of this study was to identify the pattern and factors associated with changes in cranial ultrasound (CUS) -detected findings in infants born at or less than 28 weeks of gestation. METHODS: We compared readings of CUS performed at the end of the first week of life and at 4-5 weeks of age. Alteration of CUS findings was classified as: (i) unchanged, if no deviation was detected (Group 1); (ii) worsening, if there were new findings (Group 2); and (iii) improvement, if there was normalization or reduction in severity (Group 3)...
August 23, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30149480/evaluation-of-vancomycin-target-trough-attainment-with-published-dosing-regimens-in-the-neonatal-intensive-care-unit-population
#18
E Chung, T Abraham, N N Saad, A Gad
BACKGROUND: Study aims to evaluate whether vancomycin dosing from published dosing algorithms correlate with the attainment of target troughs of 10 to 20 mg/L. METHODS: NICU patients who received minimum three doses of vancomycin and had a trough level met inclusion criteria. Dosing information was retrospectively evaluated to determine which published dosing regimen was followed. Dosing algorithms used were matched to NeoFax/Harriet Lane, renal-function directed dosing, and weight-directed dosing, in which the latter two can be found in Pediatric and Neonatal Lexi-Drugs...
August 23, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30149478/neonatal-cholelithiasis-in-down-syndrome-is-hypothyroidism-involved-a-case-report
#19
F Ricci, S Stagi, F Messa, M de Martino
We report a 3-month-old male with Down syndrome (DS), prolonged jaundice and poor weight gain, that showed biliary lithiasis and undiagnosed congenital hypothyroidism (CH).CH should be considered in DS, especially in presence of gastrointestinal symptoms or malformations. Clinicians should be aware of the increased risk of gallstones in hypothyroid children with DS, even in neonatal age.
August 23, 2018: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/30149467/retrospective-case-control-study-of-necrotizing-enterocolitis-and-packed-red-blood-cell-transfusions-in-very-low-birth-weight-infants
#20
C S Crabtree, M Pakvasa, P G Radmacher, D H Adamkin
OBJECTIVE: The study objective was to explore the relationship between necrotizing enterocolitis (NEC) and packed red blood cell (pRBC) transfusion in very low birth weight (VLBW) neonates (<1500 g). STUDY DESIGN: A six-year retrospective chart review of VLBW infants with NEC (Bell's Stage > II) and a pRBC transfusion within 48 hours of diagnosis. Prenatal data, postnatal course, transfusion history, and NEC outcomes were reviewed. The transfusion associated necrotizing enterocolitis (TANEC) cases were matched with controls (1:2) who were transfused but did not develop NEC as to proximity of birth date, gestational age, and receipt of transfusion...
August 23, 2018: Journal of Neonatal-perinatal Medicine
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