Hassan Dana, Ghanbar Mahmoodi Chalbatani, Habibollah Mahmoodzadeh, Rezvan Karimloo, Omid Rezaiean, Amirreza Moradzadeh, Narges Mehmandoost, Fateme Moazzen, Ali Mazraeh, Vahid Marmari, Mohammad Ebrahimi, Mohammad Menati Rashno, Saeid Jan Abadi, Elahe Gharagouzlo
One of the most important advances in biology has been the discovery that siRNA (small interfering RNA) is able to regulate the expression of genes, by a phenomenon known as RNAi (RNA interference). The discovery of RNAi, first in plants and Caenorhabditis elegans and later in mammalian cells, led to the emergence of a transformative view in biomedical research. siRNA has gained attention as a potential therapeutic reagent due to its ability to inhibit specific genes in many genetic diseases. siRNAs can be used as tools to study single gene function both in vivo and in-vitro and are an attractive new class of therapeutics, especially against undruggable targets for the treatment of cancer and other diseases...
June 2017: International Journal of Biomedical Science: IJBS