Felix Neuhaus, Sonja Lieber, Veronika Shinkevich, Anna Mary Steitz, Hartmann Raifer, Kathrin Roth, Florian Finkernagel, Thomas Worzfeld, Andreas Burchert, Corinna Keber, Andrea Nist, Thorsten Stiewe, Silke Reinartz, Vanessa M Beutgen, Johannes Graumann, Kim Pauck, Holger Garn, Matthias Gaida, Rolf Müller, Magdalena Huber
BACKGROUND: IL-17A and TNF synergistically promote inflammation and tumorigenesis. Their interplay and impact on ovarian carcinoma (OC) progression are, however, poorly understood. We addressed this question focusing on mesothelial cells, whose interaction with tumor cells is known to play a pivotal role in transcoelomic metastasis formation. METHODS: Flow-cytometry and immunohistochemistry experiments were employed to identify cellular sources of IL-17A and TNF...
April 2024: Clinical and Translational Medicine