journal
https://read.qxmd.com/read/38872370/trefoil-factor-1-suppresses-stemness-and-enhances-chemosensitivity-of-pancreatic-cancer
#21
JOURNAL ARTICLE
Junpei Yamaguchi, Toshio Kokuryo, Yukihiro Yokoyama, Shunsuke Oishi, Masaki Sunagawa, Takashi Mizuno, Shunsuke Onoe, Nobuyuki Watanabe, Atsushi Ogura, Tomoki Ebata
BACKGROUND AND AIMS: Pancreatic cancer is one of the most lethal malignancies, partly due to resistance to conventional chemotherapy. The chemoresistance of malignant tumors is associated with epithelial-mesenchymal transition (EMT) and the stemness of cancer cells. The aim of this study is to investigate the availability and functional mechanisms of trefoil factor family 1 (TFF1), a tumor-suppressive protein in pancreatic carcinogenesis, to treat pancreatic cancer. METHODS: To investigate the role of endogenous TFF1 in human and mice, specimens of human pancreatic cancer and genetically engineered mouse model of pancreatic cancer (KPC/TFF1KO; Pdx1-Cre/LSL-KRASG12D /LSL-p53R172H /TFF1-/- ) were analyzed by immunohistochemistry (IHC)...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38872364/fertility-preservation-in-male-adolescents-with-cancer-2011-2020-a-retrospective-study-in-china
#22
JOURNAL ARTICLE
Shasha Liu, Qiling Wang, Wenbing Zhu, Zhou Zhang, Wenhao Tang, Huiqiang Sheng, Jigao Yang, Yushan Li, Xiaowei Liang, Tianqing Meng, Zhiqiang Wang, Faxi Lin, Hao Dong, Xiaojin He, Xianglong Jiang, Shanjun Dai, Aiping Zhang, Chunying Song, Zuowen Liang, Feng Zhang, Xiaojun Wang, Peiyu Liang, Guihua Gong, Xiaohong Huai, Yanyun Wang, Fuping Li, Xinzong Zhang
BACKGROUND: According to the studies, more than 80% of pediatric patients with cancer can achieve a survival rate greater than 5 years; however, long-term chemotherapy and/or radiation therapy may seriously affect their reproductive ability. Fertility preservation in adolescents with cancer in China was initiated late, and related research is lacking. Analyze data to understand the current situation and implement measures to improve current practices. METHODS: From 2011 to 2020, data on 275 male adolescents with cancer whose age ranged from 0 to 19 years old were collected from 16 human sperm banks for this retrospective study...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38872360/renal-cell-carcinoma-and-risk-of-second-primary-cancer-a-danish-nationwide-cohort-study
#23
JOURNAL ARTICLE
Maria B Bengtsen, Dóra K Farkas, Henrik T Sørensen, Mette Nørgaard
AIM: To examine the risk of second primary cancer in patients with incident renal cell carcinoma (RCC). METHODS: We identified all patients diagnosed with incident RCC during 1995-2019, using population-based Danish medical registries. Patients were followed from the date of RCC diagnosis until any second primary cancer diagnosis, death, emigration, or December 31, 2019, whichever came first. We computed the absolute risk, standardized incidence ratio (SIR), and excess absolute risk of second primary cancer, with 95% confidence intervals (CIs), among patients with RCC compared to the general population...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38864483/integrated-whole-exome-and-bulk-transcriptome-sequencing-delineates-the-dynamic-evolution-from-preneoplasia-to-invasive-lung-adenocarcinoma-featured-with-ground-glass-nodules
#24
JOURNAL ARTICLE
Dong Zhou, Yan-Qi Li, Quan-Xing Liu, Xu-Feng Deng, Liang Chen, Man-Yuan Li, Jiao Zhang, Xiao Lu, Hong Zheng, Ji-Gang Dai
OBJECTIVE: The genomic and molecular ecology involved in the stepwise continuum progression of lung adenocarcinoma (LUAD) from adenocarcinoma in situ (AIS) to minimally invasive adenocarcinoma (MIA) and subsequent invasive adenocarcinoma (IAC) remains unclear and requires further elucidation. We aimed to characterize gene mutations and expression landscapes, and explore the association between differentially expressed genes (DEGs) and significantly mutated genes (SMGs) during the dynamic evolution from AIS to IAC...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38864480/long-non-coding-rna-as-potential-diagnostic-markers-for-acute-myeloid-leukemia-a-systematic-review-and-meta-analysis
#25
JOURNAL ARTICLE
Yenealem Solomon, Ayenew Berhan, Andargachew Almaw, Tamirat Ersino, Shewaneh Damtie, Teklehaimanot Kiros, Alemie Fentie, Ermias Sisay Chanie, Anteneh Mengist Dessie, Ermiyas Alemayehu
BACKGROUND: Acute myeloid leukemia (AML) is aggressive type of hematological malignancy. Its poses challenges in early diagnosis, necessitating the identification of an effective biomarker. This study aims to assess the diagnostic accuracy of long noncoding RNAs (lncRNA) in the diagnosis of AML through a meta-analysis. The study is registered on the PROSPERO website with the number 493518. METHOD: A literature search was conducted in the PubMed, Embase, Hinari, and the Scopus databases to identify relevant studies...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38864479/mir-34a-promotes-the-immunosuppressive-function-of-multiple-myeloma-associated-macrophages-by-dampening-the-tlr-9-signaling
#26
JOURNAL ARTICLE
Rui Zhang, Disi Zhang, Yilan Luo, Yunyan Sun, Ci Duan, Jiapeng Yang, Jia Wei, Xianshi Li, Yanqi Lu, Xun Lai
BACKGROUND: Promising outcomes have been observed in multiple myeloma (MM) with the use of immunotherapies, specifically chimeric antigen receptor T (CAR-T) cell therapy. However, a portion of MM patients do not respond to CAR-T therapy, and the reasons for this lack of response remain unclear. The objective of this study was to investigate the impact of miR-34a on the immunosuppressive polarization of macrophages obtained from MM patients. METHODS: The levels of miR-34a and TLR9 (Toll-like receptor 9) were examined in macrophages obtained from both healthy individuals and patients with MM...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38864477/prevalence-and-prognosis-of-hypoxia-inducible-factor-2%C3%AE-hif-2%C3%AE-pathway-gene-mutations-across-advanced-solid-tumors
#27
JOURNAL ARTICLE
Wenjun Zhong, Jiemin Ma, Cai Chen, E J Dettman, Razvan Cristescu, Girish S Naik, Fan Jin, Changxia Shao
INTRODUCTION: Hypoxia-inducible factor-2α (HIF-2α) modulates the hypoxic response pathway in tumors; however, mutations in pathways (including SDHA, SDHB, SDHC, SDHD, FH, and VHL genes) that are suspected to activate HIF-2α are poorly understood, with limited understanding of the prevalence and clinical prognosis. METHODS: This retrospective observational study used a de-identified nationwide (US-based) clinico-genomic database (CGDB) across 15 available tumor types...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38864475/cervical-cancer-specific-long-non-coding-rna-landscape-reveals-the-favorable-prognosis-predictive-performance-of-an-ion-channel-related-signature-model
#28
JOURNAL ARTICLE
Bochang Wang, Wei Wang, Wenhao Zhou, Yujie Zhao, Wenxin Liu
BACKGROUND: Ion channels play an important role in tumorigenesis and progression of cervical cancer. Multiple long non-coding RNA genes are widely involved in ion channel-related signaling regulation. However, the association and potential clinical application of lncRNAs in the prognosis of cervical cancer are still poorly explored. METHODS: Thirteen patients with cervical cancer were enrolled in current study. Whole transcriptome (involving both mRNAs and lncRNAs) sequencing was performed on fresh tumor and adjacent normal tissues that were surgically resected from patients...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38864474/advances-in-research-on-factors-affecting-chimeric-antigen-receptor-t-cell-efficacy
#29
REVIEW
Delian Zhou, Xiaojian Zhu, Yi Xiao
Chimeric antigen receptor T-cell (CAR-T) therapy is becoming an effective technique for the treatment of patients with relapsed/refractory hematologic malignancies. After analyzing patients with tumor progression and sustained remission after CAR-T cell therapy, many factors were found to be associated with the efficacy of CAR-T therapy. This paper reviews the factors affecting the effect of CAR-T such as tumor characteristics, tumor microenvironment and immune function of patients, CAR-T cell structure, construction method and in vivo expansion values, lymphodepletion chemotherapy, and previous treatment, and provides a preliminary outlook on the corresponding therapeutic strategies...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38864473/a-clinical-radiomic-pathomic-model-for-prognosis-prediction-in-patients-with-hepatocellular-carcinoma-after-radical-resection
#30
JOURNAL ARTICLE
Qu Xie, Zeyin Zhao, Yanzhen Yang, Xiaohong Wang, Wei Wu, Haitao Jiang, Weiyuan Hao, Ruizi Peng, Cong Luo
PURPOSE: Radical surgery, the first-line treatment for patients with hepatocellular cancer (HCC), faces the dilemma of high early recurrence rates and the inability to predict effectively. We aim to develop and validate a multimodal model combining clinical, radiomics, and pathomics features to predict the risk of early recurrence. MATERIALS AND METHODS: We recruited HCC patients who underwent radical surgery and collected their preoperative clinical information, enhanced computed tomography (CT) images, and whole slide images (WSI) of hematoxylin and eosin (H & E) stained biopsy sections...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38859698/identification-of-psmd11-as-a-novel-cuproptosis-and-immune-related-prognostic-biomarker-promoting-lung-adenocarcinoma-progression
#31
JOURNAL ARTICLE
Qiumin Huang, Ran Tian, Jinxi Yu, Wei Du
BACKGROUND: Due to the unfavorable prognosis associated with lung adenocarcinoma (LUAD), the development of targeted therapies and immunotherapies is essential. Cuproptosis, an emerging form of regulated cell death, is implicated in mitochondrial metabolism and is induced by copper ions. This study aimed to explore the prognostic value of cuproptosis- and immune-related genes (CIRGs) in LUAD. METHODS: We used The Cancer Genome Atlas database to develop a prognostic prediction model for LUAD patients based on eight CIRGs...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38859692/favorable-outcome-of-neoadjuvant-endocrine-treatment-than-surgery-first-in-female-hr-positive-her2-negative-breast-cancer-patients-a-ncdb-analysis-2010-2016
#32
JOURNAL ARTICLE
Peng Xu, Wen Luo, Jingjing Hu, Xiaobin Ma, Qian Hao, Wentao Hui, Zhangjian Zhou, Shuai Lin, Meng Wang, Hao Wu, Zhijun Dai, Huafeng Kang
PURPOSE: To assess the efficacy of neoadjuvant endocrine therapy in female HR-positive/HER2-negative breast cancer patients. DATA AND METHODS: We identified female patients aged ≥18 years with cT1-4N0-XM0, HR(+), and HER2(-) breast cancer from the National Cancer Database. The patients who underwent surgery first were categorized as "surgery-first," while those who received NET before surgery were classified as "NET." Propensity score-matching, Cox proportional-hazard model, variance inflation factors, and interaction analysis were employed to estimate the correlation between NET and survival outcomes...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38859683/tumor-treating-fields-for-newly-diagnosed-high-grade-glioma-based-on-the-criteria-of-2021-who-cns5-a-retrospective-analysis-of-chinese-patients-in-a-single-center
#33
JOURNAL ARTICLE
Li Zhang, Yanming Ren, Youheng Peng, Yong Luo, Yanhui Liu, Xiang Wang, Yuan Yang, Lei Liu, Ping Ai, Xiaoyan Yang, Yanchu Li, Qing Mao, Feng Wang
BACKGROUND AND OBJECTIVE: High-grade glioma (HGG) is known to be characterized by a high degree of malignancy and a worse prognosis. The classical treatment is safe resection supplemented by radiotherapy and chemotherapy. Tumor treating fields (TTFields), an emerging physiotherapeutic modality that targets malignant solid tumors using medium-frequency, low-intensity, alternating electric fields to interfere with cell division, have been used for the treatment of new diagnosis of glioblastoma, however, their administration in HGG requires further clinical evidence...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38855831/prognosis-of-unresected-versus-resected-early-stage-pulmonary-carcinoid-tumors-%C3%A2-3%C3%A2-cm-in-size-a-population-based-study
#34
COMPARATIVE STUDY
Xiongfei Li, Fanfan Fan, Xuewang Jia, Lingqi Yang, Jinling He, Quanying Tang, Weibo Cao, Ji Che, Song Xu
PURPOSE: The observation-based prognosis, rather than resection, for small carcinoid tumors is still unclear. This lack of clarity has important implications for counseling elderly patients or patients for whom surgical resection poses a high risk. This study compared the outcomes of observation and surgical resection in patients with pulmonary carcinoid (PC) tumors ≤3 cm in size without metastasis. METHODS: Data of patients with PC tumors with ≤3 cm in diameter and without lymph node and distant metastases were retrieved from Surveillance, Epidemiology, and End Results (SEER) registry...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38850125/predictive-factors-for-peripheral-blood-stem-cell-mobilization-in-multiple-myeloma-in-the-era-of-novel-therapies-a-single-center-experience
#35
JOURNAL ARTICLE
Xiao He, Duanfeng Jiang, Liang Zhao, Shuping Chen, Yan Zhu, Qun He, Yanjuan He
OBJECTIVE: Multiple myeloma (MM) is the leading indication of autologous hematopoietic stem cell transplantation. The aim of this study was to determine the incidence of mobilization failure and characterize the risk factors associated with poor mobilization (PM) of MM patients in novel therapies era. METHODS: We conducted a retrospective study of 211 MM patients who received their first peripheral blood stem cells (PBSC) mobilization at our single center...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38850123/survival-outcome-and-predictors-of-who-grade-2-and-3-insular-gliomas-a-classification-based-on-the-tumor-spread
#36
JOURNAL ARTICLE
Bowen Xue, Zonggang Hou, Zhenghai Deng, Shengjun Sun, Chuanhao Zhang, Yuesong Pan, Yazhuo Zhang, Zhenye Li, Jian Xie
OBJECTIVE: The study aimed to identify if clinical features and survival outcomes of insular glioma patients are associated with our classification based on the tumor spread. METHODS: Our study included 283 consecutive patients diagnosed with histological grade 2 and 3 insular gliomas. A new classification was proposed, and tumors restricted to the paralimbic system were defined as type 1. When tumors invaded the limbic system (referred to as the hippocampus and its surrounding structures in this study) simultaneously, they were defined as type 2...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38847519/explainable-machine-learning-predicts-survival-of-retroperitoneal-liposarcoma-a-study-based-on-the-seer-database-and-external-validation-in-china
#37
JOURNAL ARTICLE
Maoyu Wang, Zhizhou Li, Shuxiong Zeng, Ziwei Wang, Yidie Ying, Wei He, Zhensheng Zhang, Huiqing Wang, Chuanliang Xu
OBJECTIVE: We have developed explainable machine learning models to predict the overall survival (OS) of retroperitoneal liposarcoma (RLPS) patients. This approach aims to enhance the explainability and transparency of our modeling results. METHODS: We collected clinicopathological information of RLPS patients from The Surveillance, Epidemiology, and End Results (SEER) database and allocated them into training and validation sets with a 7:3 ratio. Simultaneously, we obtained an external validation cohort from The First Affiliated Hospital of Naval Medical University (Shanghai, China)...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38847087/predictive-capacity-of-immune-related-adverse-events-and-cytokine-profiling-in-neoadjuvant-immune-checkpoint-inhibitor-trials-for-head-and-neck-squamous-cell-carcinoma
#38
JOURNAL ARTICLE
Angela E Alnemri, Sruti Tekumalla, Annie E Moroco, Ioannis Vathiotis, Madalina Tuluc, Stacey Gargano, Tingting Zhan, David M Cognetti, Joseph M Curry, Athanassios Argiris, Alban Linnenbach, Andrew P South, Larry A Harshyne, Jennifer M Johnson, Adam J Luginbuhl
OBJECTIVES: Certain low-level immune-related adverse events (irAEs) have been associated with survival benefits in patients with various solid tumors on immune checkpoint inhibitors (ICIs). We aimed to investigate the association between irAEs and response to neoadjuvant ICIs in patients with head and neck squamous cell carcinoma (HNSCC) and to identify differences in circulating cytokine levels based on irAE status. METHODS: This was a retrospective cohort study including three neoadjuvant clinical trials from July 2017 to January 2022: NCT03238365 (nivolumab ± tadalafil), NCT03854032 (nivolumab ± BMS986205), NCT03618654 (durvalumab ± metformin)...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38847084/the-clinical-molecular-and-therapeutic-implications-of-time-from-primary-diagnosis-to-brain-metastasis-in-lung-and-breast-cancer-patients
#39
JOURNAL ARTICLE
Haitao Ge, Kaibin Zhu, Qian Sun, Huan Wang, Hui Liu, Jinyi Ge, Chunyang Liu, Peng Liang, Zhonghua Lv, Hongbo Bao
PURPOSE: Lung cancer (LC) and breast cancer (BC) are the most common causes of brain metastases (BMs). Time from primary diagnosis to BM (TPDBM) refers to the time interval between initial LC or BC diagnosis and development of BM. This research aims to identify clinical, molecular, and therapeutic risk factors associated with shorter TPDBM. METHODS: We retrospectively reviewed all diagnosed LC and BC patients with BM at Harbin Medical University Cancer Hospital from 2016 to 2020...
June 2024: Cancer Medicine
https://read.qxmd.com/read/38845529/myc-rearrangement-redefines-the-stratification-of-high-risk-multiple-myeloma
#40
JOURNAL ARTICLE
Xianghong Jin, Hui Li, Dingding Zhang, Shuangjiao Liu, Yuhang Song, Fujing Zhang, Ziping Li, Junling Zhuang
BACKGROUND: Myc rearrangement (Myc-R) is a controversial factor linked to adverse outcomes in newly diagnosed multiple myeloma (NDMM). AIMS: This study aimed to evaluate the impact of Myc-R on the prognosis of NDMM patients and its role in risk stratification compared with traditional high-risk cytogenetic abnormalities (HRCAs). MATERIALS & METHODS: A total of 417 NDMM patients enrolled from May 2009 to September 2022 were included. Fluorescence in situ hybridization (FISH) was used to detect Myc-R and other Myc abnormalities (Myc-OA)...
June 2024: Cancer Medicine
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