journal
https://read.qxmd.com/read/38062905/diagnosis-testing-treatment-and-outcomes-among-patients-with-advanced-non-small-cell-lung-cancer-in-the-united-states
#21
JOURNAL ARTICLE
Mo Yang, Joanna P MacEwan, Sai Sriteja Boppudi, Monica R McClain, Richard M O'Hara, Paul K Paik
INTRODUCTION: Characteristics of patients in clinical trials may differ from those of real-world patients. Our objective was to describe biomarker testing and outcomes among patients with advanced non-small cell lung cancer (aNSCLC) in a real-world setting. METHODS: This retrospective cohort study included patients ≥18 years old, diagnosed with stage IIIB/C or IV NSCLC, and in the TEMPUS oncology dataset from January 1, 2012, to December 31, 2020. Patient characteristics associated with biomarker testing were evaluated in patients with positive biomarkers using univariate logistic regression models...
December 7, 2023: Cancer Medicine
https://read.qxmd.com/read/38062888/beyond-the-horizon-neutrophils-leading-the-way-in-the-evolution-of-immunotherapy
#22
REVIEW
Sanjana Rajgopal, Kosuke Nakano, Leah M Cook
Cancer is a complex and dynamic disease, initiated by a multitude of intrinsic mutations and progressed with the assistance of the tissue microenvironment, encompassed by stromal cells including immune cell infiltration. The novel finding that tumors can evade anti-cancer immune functions shaped the field of immunotherapy, which has been a revolutionary approach for the treatment of cancers. However, the development of predominantly T cell-targeted immunotherapy approaches, such as immune checkpoint inhibition, also brought about an accumulation of evidence demonstrating other immune cell drivers of tumor progression, such as innate immune cells and notably, neutrophils...
December 7, 2023: Cancer Medicine
https://read.qxmd.com/read/38059559/adjuvant-chemotherapy-combined-with-immunotherapy-in-patients-with-cholangiocarcinoma-after-radical-resection
#23
JOURNAL ARTICLE
Xiao-Hui Li, En-Liang Zhou, Chong-Yu Zhao, Bo-Kang Cui, Xiao-Yuan Dong, Hang Du, Xiao-Jun Lin
BACKGROUND: The malignancy of cholangiocarcinoma is highly pronounced, and it exhibits a propensity for recurrence and metastasis even in the presence of standard chemotherapy. The efficacy of adjuvant chemotherapy combined with immunotherapy in patients with resected cholangiocarcinoma needs to be substantiated. METHODS: Data from 101 patients with cholangiocarcinoma treated at the Sun Yat-sen University Cancer Center between 2015 and 2020 were studied. RESULTS: After propensity score matching, there were no significant differences in baseline characteristics between patients in the combined adjuvant chemotherapy and immunotherapy group (AC + IM group) and the adjuvant chemotherapy alone group (AC group) (all p > 0...
December 7, 2023: Cancer Medicine
https://read.qxmd.com/read/38059408/components-of-the-tumor-immune-microenvironment-based-on-m-ihc-correlate-with-prognosis-and-subtype-of-triple-negative-breast-cancer
#24
JOURNAL ARTICLE
Luyi Lin, Haiming Li, Xin Wang, Zezhou Wang, Guanhua Su, Jiayin Zhou, Shiyun Sun, Xiaowen Ma, Yan Chen, Chao You, Yajia Gu
BACKGROUND AND AIM: The spatial distribution and interactions of cells in the tumor immune microenvironment (TIME) might be related to the different responses of triple-negative breast cancer (TNBC) to immunomodulators. The potential of multiplex IHC (m-IHC) in evaluating the TIME has been reported, but the efficacy is insufficient. We aimed to research whether m-IHC results could be used to reflect the TIME, and thus to predict prognosis and complement the TNBC subtyping system. METHODS: The clinical, imaging, and prognosis data for 86 TNBC patients were retrospectively reviewed...
December 7, 2023: Cancer Medicine
https://read.qxmd.com/read/38054365/associations-of-circulating-immunomarkers-with-the-efficacy-of-immunotherapy-for-primary-hepatic-carcinoma
#25
JOURNAL ARTICLE
Sha Liu, Wentao Xu, Hang Shu, Ying Dai, Yingying Du, Yunmei Liu, Lei Huang, Guoping Sun
BACKGROUND: Peripheral blood immunomarkers are associated with prognosis in patients with solid tumors receiving chemotherapy or immunotherapy. In this study, the associations of circulating neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR), as well as their dynamic changes were investigated in relation to the efficacy of immunotherapy in patients with primary liver cancer. METHODS: Comparisons were made between NLR, MLR, and PLR among individuals exhibiting disease control (defined as the best response of partial response [PR] or stable disease [SD]) and those with progressive disease (PD)...
December 6, 2023: Cancer Medicine
https://read.qxmd.com/read/38054208/evaluation-of-cardiotoxicity-of-anthracycline-containing-chemotherapy-regimens-in-patients-with-bone-and-soft-tissue-sarcomas-a-study-of-the-fda-adverse-event-reporting-system-joint-single-center-real-world-experience
#26
JOURNAL ARTICLE
Zeming Mo, Yaotiao Deng, Yiwen Bao, Jie Liu, Yu Jiang
OBJECTIVES: To assess the occurrence of cardiotoxicity in patients with tumors receiving anthracycline-based chemotherapy, especially for sarcomas. METHODS: This study summarized the types and frequency of adverse events (AEs) for three anthracyclines from the FDA adverse event reporting system (FAERS) database. FAERS data from January 2004 to June 2022 were collected and analyzed. Disproportionality analyses, logistic regression, and descriptive analysis were used to compare the differences in cardiac disorders...
December 6, 2023: Cancer Medicine
https://read.qxmd.com/read/38053512/longitudinal-dynamics-of-gut-microbiota-in-the-pathogenesis-of-acute-graft-versus-host-disease
#27
JOURNAL ARTICLE
Ling Qi, Jie Peng, Xianbao Huang, Ting Zhou, Genmei Tan, Fei Li
AIM: The gut microbiota has been reported to be associated with acute graft-versus-host disease (aGvHD) in hematopoietic stem cell transplantation (HSCT). Dynamic surveillance of the microbiota is required to understand the detailed pathogenesis involved in the process of aGvHD. METHODS: Fecal samples were collected prospectively at four timepoints, including pre-HSCT (T1), graft infusion (T2), neutrophil engraftment (T3), and 30 days after transplantation (T4)...
December 6, 2023: Cancer Medicine
https://read.qxmd.com/read/38050871/the-genomic-and-immune-landscapes-of-gastric-cancer-and-their-correlations-with-her2-amplification-and-pd-l1-expression
#28
JOURNAL ARTICLE
Xiaoqian Jing, Zhiping Luo, Jiayan Wu, Feng Ye, Jianfang Li, Zijia Song, Yaqi Zhang, Minmin Shi, Huaibo Sun, Yi Fang, Yimei Jiang, Xiaopin Ji
BACKGROUND: Anti-PD1/PD-L1 antibody plus human epidermal growth factor receptor 2 (HER2) antibody and chemotherapy have become the new first-line therapy for HER2 overexpression-positive advanced gastric cancers (GC), suggesting that HER2 and PD-L1 play a vital role in guiding systemic treatment for patients with GC. This study aimed to depict the genomic and immune landscapes of Chinese patients with GC and investigate their correlations with HER2 amplification and PD-L1 expression. PATIENTS AND METHODS: Next-generation targeted sequencing and PD-L1 immunohistochemistry were performed on tumor samples from 735 patients with pathologically diagnosed GC...
December 5, 2023: Cancer Medicine
https://read.qxmd.com/read/38037839/hs-10352-in-hormone-receptor-positive-her2-negative-advanced-breast-cancer-a-phase-1-dose-escalation-trial
#29
JOURNAL ARTICLE
Quchang Ouyang, Ying Wang, Jian Zhang, Qiong Wu, Hongying Wei, Chuan Li, Xiaoling Qian, Xichun Hu
BACKGROUND: Approximately 40% of patients with hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer (ABC) exhibit PIK3CA mutations. AIMS: This study aims to evaluate the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of HS-10352, a selective PI3Kα inhibitor, in this patient population. MATERIALS AND METHODS: Conducted as a phase 1 dose-escalation trial, HS-10352 was administered orally once-daily (QD) at dose levels of 2, 4, 6, and 8 mg...
December 1, 2023: Cancer Medicine
https://read.qxmd.com/read/38037808/regional-outcome-disparities-in-german-head-and-neck-cancer-patients-shorter-survival-in-eastern-germany
#30
JOURNAL ARTICLE
Julius M Vahl, Gabriele Nagel, Tsima Abou Kors, Matthias Brand, Adrian von Witzleben, Michael Sonntag, Ayla Grages, Marie N Theodoraki, Jens Greve, Michael Denkinger, Dhayana Dallmeier, Christian Idel, Stephan Stilgenbauer, Thomas K Hoffmann, Simon Laban
INTRODUCTION: Demographics are important prognostic factors in malignant diseases. A nationwide analysis concerning the prognostic impact of demographics in head and neck cancer (HNC) patients (HNCP) has not been performed previously. METHODS: A retrospective analysis of data from the Center for Cancer Registry Data (ZfKD) and the Federal Statistical Office (Destatis) between 2002 and 2017 was performed. A total of 212'920 HNCP were included. Incidence, tumor stage, age development, sex distribution, age-, residence-, and diagnosis-time-specific survival were examined...
December 1, 2023: Cancer Medicine
https://read.qxmd.com/read/38037752/novel-immunotherapeutic-options-for-bcg-unresponsive-high-risk-non-muscle-invasive-bladder-cancer
#31
REVIEW
Zein Alabdin Hannouneh, Amjad Hijazi, Alaa Aldeen Alsaleem, Siwan Hami, Nina Kheyrbek, Fadi Tanous, Karam Khaddour, Abdulfattah Abbas, Zuheir Alshehabi
BACKGROUND: High-risk non-muscle-invasive bladder cancer (HR-NMIBC) presents a challenge to many physicians due to its ability to resist Bacillus Calmette-Guérin (BCG) intravesical therapy and the substantial rate of progression into muscle-invasive bladder cancer (MIBC). Patients who are BCG-unresponsive have worse prognosis and thus require further management including radical cystectomy (RC), which significantly impacts quality of life. Moreover, the ongoing worldwide shortage of BCG warrants the need for policies that prioritize drug use and utilize alternative treatment strategies...
December 1, 2023: Cancer Medicine
https://read.qxmd.com/read/38037736/gene-silencing-of-helicobacter-pylori-through-newly-designed-sirna-convenes-the-treatment-of-gastric-cancer
#32
JOURNAL ARTICLE
Mahjerin Nasrin Reza, Shahin Mahmud, Nadim Ferdous, Ishtiaque Ahammad, Mohammad Uzzal Hossain, Md Al Amin, A K M Mohiuddin
BACKGROUND: Helicobacter pylori is a gastric pathogen that is responsible for causing chronic inflammation and increasing the risk of gastric cancer development. It is capable of persisting for decades in the harsh gastric environment because of the inability of the host to eradicate the infection. Several treatment strategies have been developed against this bacterium using different antibiotics. But the effectiveness of treating H. pylori has significantly decreased due to widespread antibiotic resistance, including an increased risk of gastric cancer...
December 1, 2023: Cancer Medicine
https://read.qxmd.com/read/38037545/anti-inflammatory-mechanisms-in-cancer-research-characterization-of-a-distinct-m2-like-macrophage-model-derived-from-the-thp-1-cell-line
#33
JOURNAL ARTICLE
Katharina M Scheurlen, Dylan L Snook, Andrew B Littlefield, Joan B George, Mary A Parks, Robert J Beal, Anne MacLeod, Daniel W Riggs, Jeremy T Gaskins, Julia Chariker, Eric C Rouchka, Susan Galandiuk
AIMS: Macrophages play an essential role in cancer development. Tumor-associated macrophages (TAMs) have predominantly M2-like attributes that are associated with tumor progression and poor patient survival. Numerous methods have been reported for differentiating and polarizing macrophages in vitro, but there is no standardized and validated model for creating TAMs. Primary cells show varying cytokine responses depending on their origin and functional studies utilizing these cells may lack generalization and validity...
November 30, 2023: Cancer Medicine
https://read.qxmd.com/read/38033095/apatinib-added-when-nsclc-patients-get-slow-progression-with-egfr-tki-a-prospective-single-arm-study
#34
JOURNAL ARTICLE
Minghui Liu, Xin Li, Hongbing Zhang, Fan Ren, Jinghao Liu, Yongwen Li, Ming Dong, Honglin Zhao, Song Xu, Hongyu Liu, Jun Chen
BACKGROUND: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) acquired resistance was an inevitably events in NSCLC treatment. AIMS: Intending to overcome the acquired resistance of EGFR-TKI. MATERIALS & METHODS: A clinical trial was, we enrolled 12 patients who were slowly progressing on first-generation EGFR-TKI, and added apatinib when the patients got slow progression. RESULTS: Seven patients were included in the efficacy analysis...
November 30, 2023: Cancer Medicine
https://read.qxmd.com/read/38032013/high-intensity-focused-ultrasound-ablation-combined-with-systemic-therapy-for-unresectable-colorectal-cancer-liver-metastasis-a-propensity-score-matched-analysis
#35
JOURNAL ARTICLE
Fei Tang, Qin Zhong, Tingting Ni, Yingbo Xue, Jing Wu, Rong Deng, Qi Zhang, Yan Li, Xuanlu He, Zhenzhou Yang, Yu Zhang
OBJECTIVE: Unresectable colorectal cancer liver metastasis (CRLM) remains a challenging obstacle that often prevents curative treatment. In this study, we retrospectively analyzed the efficacy and safety of high-intensity focused ultrasound (HIFU) as a local adjuvant therapy for systemic chemotherapy for patients with unresectable CRLM. HIFU is a noninvasive method previously demonstrated as efficacious for various solid malignancies. METHODS: Propensity score matching was used for the combination therapy group (HIFU group, n = 59) and the observation group receiving systemic therapy only (No-HIFU group, n = 59)...
November 30, 2023: Cancer Medicine
https://read.qxmd.com/read/38018376/updated-systematic-review-of-the-effects-of-exercise-on-understudied-health-outcomes-in-cancer-survivors
#36
REVIEW
Kathleen M Sturgeon, Dieuwertje E Kok, Ian R Kleckner, Kristin A Guertin, Jessica McNeil, Traci L Parry, Diane K Ehlers, Andrew Hamilton, Kathryn Schmitz, Kristin L Campbell, Kerri Winters-Stone
INTRODUCTION: The American College of Sports Medicine provided guidelines for exercise prescriptions in cancer survivors for specific cancer- and treatment-related health outcomes. However, there was insufficient evidence to generate exercise prescriptions for 10 health outcomes of cancer treatment. We sought to update the state of evidence. METHODS: We conducted a systematic review of these 10 understudied health outcomes (bone health, sleep, cardiovascular function, chemotherapy-induced peripheral neuropathy (CIPN), cognitive function, falls and balance, nausea, pain, sexual function, and treatment tolerance) and provided an update of evidence...
November 29, 2023: Cancer Medicine
https://read.qxmd.com/read/38018346/neutrophil-extracellular-traps-in-relationship-to-efficacy-of-systemic-therapy-for-metastatic-renal-cell-carcinoma
#37
JOURNAL ARTICLE
Ruiyang Xie, Bingqing Shang, Hongzhe Shi, Xingang Bi, Yan Song, Wang Qu, Hongsong Bai, Linjun Hu, Jie Wu, Honglei Cui, Gan Du, Lei Guo, Shan Zheng, Jianming Ying, Changling Li, Jianhui Ma, Aiping Zhou, Jianzhong Shou
BACKGROUND: The efficacy of systemic therapy regimens, such as immune checkpoint inhibitors and tyrosine kinase inhibitors (IO-TKI) and targeted therapy, for metastatic clear cell renal cell carcinoma (ccRCC) remains unpredictable due to the lack of effective biomarkers. Neutrophil extracellular trap (NET) plays an important role in promoting ccRCC. This study explores the NET predictive value of the efficacy in metastatic ccRCC. METHODS: In this retrospective study, patients with metastatic ccRCC who received targeted drugs and IO-TKI were included...
November 28, 2023: Cancer Medicine
https://read.qxmd.com/read/38018321/allogeneic-hematopoietic-stem-cell-transplantation-for-b-cell-lymphoma-in-taiwan
#38
JOURNAL ARTICLE
Chun-Hui Lee, Tzu-Chien Lin, Ming Yao, Liang-Tsai Hsiao, Bor-Sheng Ko, Chia-Jen Liu, Tsai-Yun Chen
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered for patients with high-risk B-cell lymphoma and relapsed or refractory disease. This study aimed to analyze the long-term follow-up data of patients who underwent allo-HSCT in Taiwan. This was a retrospective observational study using data from the Taiwan Society of Blood and Marrow Transplantation database. A total of 105 patients who underwent allo-HSCT because of high-risk, relapsed, or refractory disease between 2010 and 2019 were included...
November 28, 2023: Cancer Medicine
https://read.qxmd.com/read/38018291/the-value-of-atad3a-as-a-potential-biomarker-for-bladder-cancer
#39
JOURNAL ARTICLE
Zhenghong Liu, Li Sun, Bin Zheng, Heng Wang, Xiaowen Qin, Pu Zhang, Qijun Wo, Haichang Li, Yixuan Mou, Dahong Zhang, Shuai Wang
BACKGROUND: Bladder cancer (BCa) is a highly malignant tumor, and if left untreated, it can develop severe hematuria and tumor metastasis, thereby endangering the patient's life. The purpose of this paper was to detect the expression of ATAD3A in BCa and research the relationship between ATAD3A and pathological features of bladder cancer and the prognosis of patients. METHODS: First, the expression of ATAD3A in BCa and normal bladder tissues was analyzed based on the UALCAN and Oncomine public databases...
November 28, 2023: Cancer Medicine
https://read.qxmd.com/read/38014709/wavelet-scattering-networks-in-deep-learning-for-discovering-protein-markers-in-a-cohort-of-swedish-rectal-cancer-patients
#40
JOURNAL ARTICLE
Tuan D Pham, Xiao-Feng Sun
BACKGROUND: Cancer biomarkers play a pivotal role in the diagnosis, prognosis, and treatment response prediction of the disease. In this study, we analyzed the expression levels of RhoB and DNp73 proteins in rectal cancer, as captured in immunohistochemical images, to predict the 5-year survival time of two patient groups: one with preoperative radiotherapy and one without. METHODS: The utilization of deep convolutional neural networks in medical research, particularly in clinical cancer studies, has been gaining substantial attention...
November 28, 2023: Cancer Medicine
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