journal
https://read.qxmd.com/read/36971051/characteristics-and-prognosis-of-rrdlbcl-with-tp53-mutations-and-a-high-risk-subgroup-represented-by-the-co-mutations-of-ddx3x-tp53
#1
JOURNAL ARTICLE
Fan Gao, Kai Hu, Peihao Zheng, Hui Shi, Xiaoyan Ke
BACKGROUND: TP53 mutations have a prognostic significance in relapsed and refractory diffuse large B-cell lymphoma (rrDLBCL) patients, and their treatment still faces a great challenge. This study aimed to evaluate the prognosis of patients with TP53 mutations (TP53mut) in the context of CAR-T therapy (Chimeric antigen receptor T-cell therapy) as well as explore the heterogeneity in their cohort and identify the possible risk factors. METHODS: A retrospective study was conducted to investigate the clinical characteristics of rrDLBCL patients with TP53 mutations and their prognostic factors, receiving CAR-T therapy...
March 27, 2023: Cancer Medicine
https://read.qxmd.com/read/36971049/incidence-and-prognostic-impact-of-her2-positivity-loss-after-dual-her2-directed-neoadjuvant-therapy-for-her2-breast-cancer
#2
JOURNAL ARTICLE
Alexis LeVee, Kellie Spector, Brigid Larkin, Felipe Dezem, Jasmine Plummer, Farnaz Dadmanesh, Sujata Patil, Heather L McArthur
BACKGROUND: Loss of HER2 "positivity" can occur in patients with residual disease after neoadjuvant treatment, but the incidence of HER2-positivity loss after neoadjuvant dual HER2-targeted treatment plus chemotherapy, the current standard-of-care for most early stage HER2-positive breast cancers, is not well described. Previous studies that report the HER2 discordance rate after neoadjuvant treatment also do not include the novel HER2-low category. In this retrospective study, we determine the incidence and prognostic impact of HER2-positivity loss, including the evolution to HER2-low disease, after neoadjuvant dual HER2-targeted therapy with chemotherapy...
March 27, 2023: Cancer Medicine
https://read.qxmd.com/read/36971046/clinical-and-pathological-features-analysis-of-invasive-breast-cancer-with-microcalcification
#3
JOURNAL ARTICLE
Yao Tian, Lu Zhao, Zhengwei Gui, Shiyang Liu, Chenguang Liu, Tianyao Yu, Lin Zhang
PURPOSE: Microcalcification (MC) is a valuable diagnostic indicator to detect invasive breast cancer (IBC). This study aimed to determine the clinicopathological features of IBC with MC and detect biomarkers related to the potential mechanism of the MC formation in IBC. METHODS: Data from 364 patients with IBC were collected for the clinical characteristic analysis. The analysis of clinical data helped us to establish a predictive model of axillary node metastasis (ANM) before surgery...
March 27, 2023: Cancer Medicine
https://read.qxmd.com/read/36971044/development-and-external-validation-of-nomograms-for-predicting-individual-survival-in-patients-with-ovarian-clear-cell-carcinoma
#4
JOURNAL ARTICLE
Xiaoshi Liu, Huaiwu Lu, Ying Zhou, Xiaoran Long, Qing Li, Guanglei Zhuang, Xia Yin, Wen Di
PURPOSE: Ovarian clear cell carcinoma (OCCC) is a distinct and highly malignant subtype of ovarian cancer with high individual heterogeneity in survival that requires specific prognostic predictive tools. Thus, this study aimed to construct and validate nomograms for predicting individual survival in OCCC patients. METHODS: In total, 91 patients with OCCC who were diagnosed and treated at Renji Hospital between 2010 and 2020 were extracted as the training cohort, then 86 patients from the First Affiliated Hospital of USTC were used as the external validation cohort...
March 27, 2023: Cancer Medicine
https://read.qxmd.com/read/36970969/prevalence-severity-and-predictors-of-symptom-burden-among-adolescents-and-young-adults-with-cancer
#5
JOURNAL ARTICLE
Sumit Gupta, Qing Li, Paul C Nathan, Norma D'Agostino, Nancy N Baxter, Colleen Fox, Karine Chalifour, Natalie Coburn, Rinku Sutradhar
BACKGROUND: Symptom burden in adolescents and young adults (AYA) with cancer is poorly characterized but impacts quality of life. METHODS: All Ontario, Canada AYA aged 15-29 years at diagnosis between 2010 and 2018 were linked to population-based healthcare databases, including to Edmonton Symptom Assessment System-revised (ESAS) scores, an 11-point scale routinely obtained at the time of cancer-related outpatient visits and collected provincially. Multistate models estimated mean duration of symptom severity states [none (0) vs...
March 27, 2023: Cancer Medicine
https://read.qxmd.com/read/36965102/utilising-alternative-cystoscopic-schedules-to-minimise-cost-and-patient-burden-after-trimodality-therapy-for-muscle-invasive-bladder-cancer
#6
JOURNAL ARTICLE
Rahul Krishnatry, Priyamvada Maitre, Anuj Kumar, Tejshri Telkhade, Ganesh Bakshi, Gagan Prakash, Mahendra Pal, Amit Joshi, Santosh Menon, Vedang Murthy
BACKGROUND: To assess urinary symptoms and urine cytology as screening tools for cystoscopic detection of local recurrence after bladder-preserving trimodality treatment (TMT). METHODS: Patients with muscle-invasive bladder cancer receiving definitive TMT follow-up three monthly for 2 years, six monthly for the next 3 years and then yearly, with a clinical review, urine cytology and cystoscopy at each visit (triple assessment, TA). Grade 2+ cystitis/haematuria absent/present was scored 0/1, and urine cytology reported negative/suspicious or positive was scored 0/1, respectively...
March 25, 2023: Cancer Medicine
https://read.qxmd.com/read/36965095/evaluation-of-diagnostic-efficacy-of-nrp-1-cd304-in-hematological-diseases
#7
JOURNAL ARTICLE
Yi-Jun Liu, Xiao-Hui Li, Yi-Ling Song, Yi-Chen Zhou, Rong-Zeng Cai, Pei-Dong Chi
BACKGROUND: Previous studies had explored the diagnostic or prognostic value of NRP-1/CD304 in blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute myeloid leukemia (AML), and B-cell acute lymphoblastic leukemia (B-ALL), whereas the expression and application value of NRP-1/CD304 in other common hematological diseases have not been reported. METHODS: Bone marrow samples from 297 newly diagnosed patients with various hematological diseases were collected to detect the expression of NRP-1/CD304 by flow cytometry (FCM)...
March 25, 2023: Cancer Medicine
https://read.qxmd.com/read/36965094/psychological-distress-is-involved-in-crci-in-breast-cancer-survivors-via-mediating-cytokine-levels
#8
JOURNAL ARTICLE
Lulian Pang, Wen Li, Senbang Yao, Yanyan Jing, Xiangxiang Yin, Huaidong Cheng
BACKGROUND: Cancer-related cognitive impairment (CRCI) is a frequent consequence in breast cancer survivors after chemotherapy and lowers their quality of life (QOL). Psychological distress is frequently experienced by breast cancer survivors. There are currently few studies investigating the role of psychological distress in the genesis of CRCI. METHODS: In total, 122 breast cancer survivors after standard chemotherapy within a year were recruited and assessed using the Psychological Distress Thermometer (DT)...
March 25, 2023: Cancer Medicine
https://read.qxmd.com/read/36965092/the-predictive-value-of-pd-l1-expression-in-patients-with-advanced-hepatocellular-carcinoma-treated-with-pd-1-pd-l1-inhibitors-a-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
Yao Yang, Dongbo Chen, Bigeng Zhao, Liying Ren, Rui Huang, Bo Feng, Hongsong Chen
BACKGROUND AND AIM: Programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors have transformed the treatment landscape of advanced hepatocellular carcinoma (HCC), but consistent responses are not observed in all patients, and prognostic biomarkers to guide treatment decisions are lacking. We aimed to evaluate the predictive value of PD-L1 expression in advanced HCC patients treated with PD-1/PD-L1 inhibitors. METHODS: A comprehensive search of PubMed, Embase, Web of Science, and the Cochrane Library was conducted...
March 25, 2023: Cancer Medicine
https://read.qxmd.com/read/36965085/early-effect-of-bivalent-human-papillomavirus-vaccination-on-cytology-outcomes-in-cervical-samples-among-young-women-in-the-netherlands
#10
JOURNAL ARTICLE
Tessa M Schurink-van 't Klooster, Albert G Siebers, Joske Hoes, Folkert J van Kemenade, Johannes Berkhof, Johannes A Bogaards, Hester E de Melker
BACKGROUND: The first HPV-vaccine eligible cohorts in the Netherlands will enter the cervical screening program in 2023. However, a substantial number of young women already have had a cervical sample taken before entry into the regular screening program. This study was initiated to explore early effects of HPV vaccination on detection of cytological abnormalities in cervical samples of women younger than the screening age. METHODS: Results of cervical samples were obtained from the Dutch National Pathology Databank (PALGA) and were linked to the women's HPV vaccination status from the national vaccination registry (Praeventis) (N = 42,171)...
March 25, 2023: Cancer Medicine
https://read.qxmd.com/read/36965083/the-screening-of-compounds-regulating-pd-l1-transcriptional-activity-in-a-cell-functional-high-throughput-manner
#11
JOURNAL ARTICLE
Lanxin Zhang, Hexin Li, Jingchao Liu, Gaoyuan Sun, Xiaokun Tang, Siyuan Xu, Lili Zhang, Wei Zhang, Bin Ai
Immune checkpoints are protein molecules expressed on the immune cell membrane, which regulate the immune system to kill tumor cells. As an essential immune checkpoint, overexpressed PD-1 on tumor cells could inhibit T-cell activation after being bonded to PD-1. Due to this inhibitory effect, T-cell proliferation and cytokine secretion are suppressed, leading to immune escape of tumor cells. Here, we established a high-throughput method based on cell function screening technology to screen drugs regulating PD-L1 expression in tumor cells at the transcriptional level...
March 25, 2023: Cancer Medicine
https://read.qxmd.com/read/36952461/effectiveness-and-safety-of-immune-checkpoint-inhibitor-monotherapy-in-advanced-upper-tract-urothelial-carcinoma-a-multicenter-retrospective-real-world-study
#12
JOURNAL ARTICLE
Ruopeng Su, Zeyu Chen, Daoping Hong, Shuai Jiang, Yichu Yuan, Xingyun Cai, Hailong Hu, Changde Fu, Zhiyang Huang, Zhenyu Wang, Bing Zheng, Jian Huang, Zaoyu Wang, Yige Bao, Ming Cai, Jianming Guo, Minfeng Chen, Qiang Wei, Jiwei Huang, Wei Xue
INTRODUCTION: The effectiveness and safety of immune checkpoint inhibitor (ICI) monotherapy in advanced upper tract urothelial carcinoma (UTUC) is less reported. METHODS: In total, 106 consecutive advanced UTUC patients receiving ICI monotherapy were collected from nine high volume centers. Clinical outcomes were analyzed according to multiple parameters (e.g., treatment line, metastatic sites). Objective response rate (ORR), overall survival (OS) and progression-free survival (PFS) were captured after ICI initiation...
March 23, 2023: Cancer Medicine
https://read.qxmd.com/read/36952458/nucleoporin-107-is-a-prognostic-biomarker-in-hepatocellular-carcinoma-associated-with-immune-infiltration
#13
JOURNAL ARTICLE
Ju-Sen Nong, Xin Zhou, Jun-Qi Liu, Jian-Zhu Luo, Jia-Mi Huang, Hai-Xiang Xie, Ke-Jian Yang, Jing Wang, Xin-Ping Ye, Tao Peng
OBJECTIVE: To assess the diagnostic value and clinical significance of nucleoporin 107 (NUP107) in hepatocellular carcinoma (HCC), and explore the possible mechanisms. METHODS: The transcriptomic and clinical data of HCC patients were retrieved from The Cancer Genome Atlas (TCGA) and GEO databases. Tissue specimens were collected from HCC patients in the Guangxi area. According to the expression levels and prognostic characteristics of NUP107, ROC curves and nomogram models were constructed using the R package...
March 23, 2023: Cancer Medicine
https://read.qxmd.com/read/36952439/lymphovascular-or-perineural-invasion-is-associated-with-lymph-node-metastasis-and-survival-outcomes-in-patients-with-gastric-cancer
#14
JOURNAL ARTICLE
Fengxiang Zhang, Huaxian Chen, Dandong Luo, Zhizhong Xiong, Xianzhe Li, Shi Yin, Longyang Jin, Shi Chen, Junsheng Peng, Lei Lian
BACKGROUND: Lymphovascular invasion (LVI) and perineural invasion (PNI) are associated with poorer prognosis in several human malignancies, but their significance in gastric cancer (GC) remains to be clearly defined. Our study aimed to investigate the prognostic value of LVI/PNI in patients with curative resected GC. METHODS: Records of 1488 patients with stage I--III GC and 3327 patients with stage I-III colorectal cancer (CRC) were reviewed retrospectively, and difference in the incidence of LVI/PNI between GC and CRC was compared...
March 23, 2023: Cancer Medicine
https://read.qxmd.com/read/36952375/survival-and-prognostic-factors-of-early-stage-non-small-cell-lung-cancer-in-central-and-eastern-europe-a-prospective-cohort-study
#15
JOURNAL ARTICLE
Mahdi Sheikh, Shama Virani, Hilary A Robbins, Lenka Foretova, Ivana Holcatova, Vladimir Janout, Jolanta Lissowska, Marie Navratilova, Anush Mukeriya, Miodrag Ognjanovic, Beata Swiatkowska, David Zaridze, Paul Brennan
BACKGROUND: Although early diagnosis and surgical resection of the tumor have been shown to be the most important predictors of lung cancer survival, long-term survival for surgically-resected early-stage lung cancer remains poor. AIMS: In this prospective study we aimed to investigate the survival and prognostic factors of surgically-resected early-stage non-small cell lung cancer (NSCLC) in Central and Eastern Europe. METHODS: We recruited 2052 patients with stage I-IIIA NSCLC from 9 centers in Russia, Poland, Serbia, Czech Republic, and Romania, between 2007-2016 and followed them annually through 2020...
March 23, 2023: Cancer Medicine
https://read.qxmd.com/read/36952359/differences-in-clinical-characteristics-and-prognosis-between-breast-neuroendocrine-carcinoma-and-breast-invasive-ductal-carcinoma-a-multicentre-population-based-study-from-china
#16
JOURNAL ARTICLE
Ding-Yuan Wang, Shuo-Feng Li, Song-Lin Gao, Peng Yuan, Bai-Lin Zhang
AIM: We constructed a multicentre cohort in China to analyse the differences in clinical characteristics, treatment strategies and prognoses between breast neuroendocrine carcinoma (NEC) and invasive ductal carcinoma (IDC) of the breast. METHODS: All patients with early-stage breast cancer who attended three hospitals in Beijing from 2000 to 2018 were included in the study. We used propensity score matching to make a 1:3 match between NEC and IDC. RESULTS: After propensity score matching, 153 patients with IDC and 51 patients with NEC were analysed...
March 23, 2023: Cancer Medicine
https://read.qxmd.com/read/36952352/neuroendocrine-neoplasm-of-the-gallbladder-clinical-features-surgical-efficacy-and-prognosis
#17
JOURNAL ARTICLE
Xin Wu, Binglu Li, Tao Hong, Wei Liu, Xiaodong He, Chaoji Zheng
BACKGROUND: Neuroendocrine neoplasm (NEN) of the gallbladder is rare. It is usually asymptomatic and occurs in older adults. Its clinicopathological characteristics remain controversial, and the diagnosis and treatment strategies are usually based on models of adenocarcinoma. The present study aimed to investigate the clinical characteristics and prognosis of gallbladder NEN. METHODS: The data of patients with gallbladder NEN admitted to Peking Union Medical College Hospital was reviewed, and a database was established for retrospective analysis...
March 23, 2023: Cancer Medicine
https://read.qxmd.com/read/36951656/impact-of-age-antiretroviral-therapy-and-cancer-on-epigenetic-aging-in-people-living-with-hiv
#18
JOURNAL ARTICLE
Yulan Qing, Ricky Chan, Pingfu Fu, Jennifer Cullen, Alexander Miron, Jeffrey M Jacobson, John Pink, Stanton L Gerson
BACKGROUND: Premature aging has been identified as a global risk factor for cancer. Causes of premature aging are multifactorial, including inflammation, infection, chronic stress, and lifestyle factors. METHOD: We evaluated whether premature aging in people living with HIV (PLWH) was associated with antiretroviral therapy (ART) or the diagnosis of cancer. We used well-established DNA methylation patterns to assess premature aging, using Horvath et al., in individuals with HIV located in Cleveland, Ohio and compared these to standardized datasets of US historical blood samples...
March 23, 2023: Cancer Medicine
https://read.qxmd.com/read/36951655/mobilization-of-hematopoietic-stem-cells-with-lenograstim-in-multiple-myeloma-patients-prospective-multicenter-observational-study-kmm122
#19
JOURNAL ARTICLE
Eun Hee Jung, Ja Min Byun, Dong-Yeop Shin, Young Rok Do, Jae-Cheol Jo, Sang Min Lee, Sung-Soo Yoon
BACKGROUND: Current guidelines recommend using filgrastim or tbo-filgrastim to mobilize hematopoietic progenitor cells in an autologous setting. However, previous studies have suggested other forms of granulocyte colony-stimulating factor (G-CSF) are equally efficacious, possibly with fewer leukaphereses required. Thus, we prospectively studied the efficacy of lenograstim, a glycosylated recombinant form of G-CSF, in multiple myeloma (MM) patients. METHODS: From November 2011 to January 2020, 98 MM patients undergoing autologous stem cell transplant (ASCT) from five academic centers in Korea were enrolled...
March 23, 2023: Cancer Medicine
https://read.qxmd.com/read/36951654/efficacy-and-toxicity-profile-of-first-line-treatment-for-extensive-stage-small-cell-lung-cancer-a-bayesian-network-meta-analysis
#20
JOURNAL ARTICLE
Guo Lin, Zhuoran Yao, Kai Kang, Hui Wang, Ren Luo, You Lu
BACKGROUND: The efficacy and toxicity profiles for extensive-stage small cell lung cancer (ES-SCLC) are unclear. We aimed to address this gap through a Bayesian network meta-analysis. METHODS: We performed network analysis from randomized controlled trials comparing these treatments: PD-(L)1 inhibitor, CTLA-4 inhibitor, CXCR inhibitor, PARP inhibitor, CDK inhibitor, chemotherapy, and their combinations. Pooled estimations of progression-free survival, overall survival, objective response rate, and toxicity (systematic and specific) were conducted within the Bayesian framework...
March 23, 2023: Cancer Medicine
journal
journal
44165
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.