journal
Journals Journal of Central Nervous Sys...

Journal of Central Nervous System Disease

https://read.qxmd.com/read/38487717/awake-craniotomies-in-south-america-advancements-challenges-and-future-prospects
#1
JOURNAL ARTICLE
Hareesha R Bharadwaj, Wireko A Awuah, Favour T Adebusoye, Joecelyn K Tan, Syed H Ali, Niels Pacheco-Barrios, Marios Papadakis
BACKGROUND: Awake craniotomy has emerged as an advanced surgical technique, characterized by keeping the patient awake during brain surgery. In South America, awake craniotomies have grained traction in neurosurgical practices across various medical centres and hospitals, with notable practitioners contributing to its growth and refinement in the region. PURPOSE: This study aims to explore the integration and impact of awake craniotomies in South American neurosurgical practices. The focus is on understanding the benefits, challenges, and potential transformative effects of the procedure in the region...
2024: Journal of Central Nervous System Disease
https://read.qxmd.com/read/38449707/advances-in-epileptic-network-findings-of-hypothalamic-hamartomas
#2
REVIEW
Di Wang, Di Lu, Mingtai Zhang, Anqi Dai, Guangyuan Jin, Qiao Wang, Yuyang Zhang, Philippe Kahane
Hypothalamic hamartomas (HHs) are congenital developmental malformations located in the hypothalamus. They are associated with a characteristic clinical manifestation known as gelastic seizures (GS). However, the traditional understanding of HHs has been limited, resulting in insufficient treatment options and high recurrence rates of seizures after surgery. This is consistent with the network hypothesis of focal epilepsy that the epileptogenic zone is not only limited to HH but may also involve the distant cerebral cortex external to the HH mass...
2024: Journal of Central Nervous System Disease
https://read.qxmd.com/read/38312734/advances-in-the-long-term-treatment-of-neuromyelitis-optica-spectrum-disorder
#3
REVIEW
Monique Anderson, Michael Levy
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune neuroinflammatory disorder with a prevalence of 1-5/100,000 globally, characterized by attacks of the central nervous system including but not limited to optic neuritis, transverse myelitis and brainstem lesions, including area postrema lesions. These autoimmune attacks can lead to irreversible damage if left untreated, therefore strategies have been developed to prevent relapses. Initial off-label treatments have achieved variable levels of success in relapse prevention, but improved relapse prevention and quality of life remain a goal in the field...
2024: Journal of Central Nervous System Disease
https://read.qxmd.com/read/38188227/sex-hormone-therapy-in-multiple-sclerosis-a-systematic-review-of-randomized-clinical-trials
#4
REVIEW
Monir Shayestehfar, Mehri Salari, Shahedeh Karimi, Massoud Vosough, Amirhossein Memari, Seyed Massood Nabavi
BACKGROUND: In spite of the observed immunomodulatory properties of different sex hormones on Multiple Sclerosis (MS) in different investigations, to date, there has been no study to systematically review the documents to add more powerful data to the field. OBJECTIVES: Therefore, in this paper we aim to systematically review clinical and randomized controlled trials (RCT) assessing the effect of sex hormone therapies on individuals with MS. DESIGN: A comprehensive search of electronic databases including PubMed, EMBASE, and Scopus was conducted...
2024: Journal of Central Nervous System Disease
https://read.qxmd.com/read/38025402/post-coronavirus-disease-2019-functional-impairments-limitations-and-restrictions-a-prospective-cohort-study-based-on-the-international-classification-of-functioning-disability-and-health
#5
JOURNAL ARTICLE
Isabella Polo Monteiro, Pablo Andrei Appelt, Angélica Taciana Sisconetto, Kelly Savana Minaré Baldo Sucupira, Rodrigo Bazan, Gustavo José Luvizutto, Luciane Aparecida Pascucci Sande de Souza
BACKGROUND: Current knowledge regarding coronavirus disease 2019 (COVID-19) is constantly evolving, and the long-term functional impairments, limitations, and restrictions have not yet been well established. OBJECTIVE: to evaluate the impact of post-COVID condition on the human functioning through the International Classification of Functioning, Disability and Health (ICF) classification. METHODS: This is a prospective cohort study with 53 individuals with post-COVID condition at 3 time points: 0 to 3 (baseline), 3 to 6, and 6-12 months (follow-up)...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/38025401/perception-of-verticality-in-the-post-covid-19-condition-correlates-to-infection-severity
#6
JOURNAL ARTICLE
Bruno Henrique de Souza Fonseca, Pedro Henrique Sousa de Andrade, Maria Eduarda Salum Aveiro Henrique, Jussara Almeida de Oliveira Baggio, Rodrigo Bazan, Luciane Aparecida Pascucci Sande de Souza, Gustavo José Luvizutto
BACKGROUND: SARS-CoV-2 infection affects multiple systems, including musculoskeletal, neurological, and respiratory systems. Changes associated with physical inactivity due to prolonged hospitalization can affect the functional capacity of individuals with long coronavirus disease 2019 (COVID-19) or post-COVID-19 condition and may cause changes in some postural control functions, such as verticality. OBJECTIVES: This study aimed to evaluate the perception of verticality in individuals with long COVID...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/37942276/cerebellar-pathology-in-multiple-sclerosis-and-experimental-autoimmune-encephalomyelitis-current-status-and-future-directions
#7
REVIEW
Dain L Maxwell, Jacqueline M Orian
Recent decades have witnessed significant progress in understanding mechanisms driving neurodegeneration and disease progression in multiple sclerosis (MS), but with a focus on the cerebrum. In contrast, there have been limited studies of cerebellar disease, despite the common occurrence of cerebellar symptoms in this disorder. These rare studies, however, highlight the early cerebellar involvement in disease development and an association between the early occurrence of cerebellar lesions and risk of worse prognosis...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/37900908/functional-mri-and-diffusion-tensor-imaging-in-migraine-a-review-of-migraine-functional-and-white-matter-microstructural-changes
#8
REVIEW
Brendon C Chou, Alexander Lerner, Giuseppe Barisano, Daniel Phung, Wilson Xu, Soniya N Pinto, Nasim Sheikh-Bahaei
Migraine is a complex and heterogenous disorder whose disease mechanisms remain disputed. This narrative review summarizes functional MRI (fMRI) and diffusion tensor imaging (DTI) findings and interprets their association with migraine symptoms and subtype to support and expand our current understanding of migraine pathophysiology. Our PubMed search evaluated and included fMRI and DTI studies involving comparisons between migraineurs vs healthy controls, migraineurs with vs without aura, and episodic vs chronic migraineurs...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/37876767/clinical-diagnostic-and-radiographic-features-of-primary-spinal-atypical-teratoid-rhabdoid-tumors-tumor-in-a-pediatric-patient-a-case-report-and-review-of-the-literature
#9
Hashim Syed, Nahom Teferi, Alec Hanson, Meron Challa, Kathryn Eschbacher, Patrick Hitchon
Atypical teratoid rhabdoid tumors (ATRTs) are rare embryonal tumors comprising 1-2% of all pediatric CNS neoplasms. Spinal ATRTs are even more uncommon, accounting for 2% of all reported ATRT cases. Despite their rarity, ATRTs affect young children disproportionately and are characterized by a high malignant potential due to a heterogeneous cellular composition and inactivating mutations in the SMARCB1 (90%) and SMARCA4 (10%) genes. A 15-month-old female presented with a 2-week history of decreased lower extremity movement and new-onset need for assistance with ambulation...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/37868934/the-evolution-of-antiseizure-medication-therapy-selection-in-adults-is-artificial-intelligence-assisted-antiseizure-medication-selection-ready-for-prime-time
#10
REVIEW
Charlene L Gunasekera, Joseph I Sirven, Anteneh M Feyissa
Antiseizure medications (ASMs) are the mainstay of symptomatic epilepsy treatment. The primary goal of pharmacotherapy with ASMs in epilepsy is to achieve complete seizure remission while minimizing therapy-related adverse events. Over the years, more ASMs have been introduced, with approximately 30 now in everyday use. With such a wide variety, much guidance is needed in choosing ASMs for initial therapy, subsequent replacement monotherapy, or adjunctive therapy. The specific ASMs are typically tailored by the patient's related factors, including epilepsy syndrome, age, sex, comorbidities, and ASM characteristics, including the spectrum of efficacy, pharmacokinetic properties, safety, and tolerability...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/37692459/lidocaine-as-a-potential-therapeutic-option-for-super-refractory-status-epilepticus-a-case-report
#11
Mayu Sugata, Hiroshi Kataoka, Yuto Uchihara, Daisuke Shimada, Kazuaki Atagi, Michitaka Nakamura, Makoto Hara, Makoto Kawahara, Kazuma Sugie
New-onset refractory status epilepticus (NORSE) is a rare and devastating condition and the prognosis is often poor, with half to two-thirds of survivors experiencing drug-resistant epilepsy, residual cognitive impairment, or functional disability, and the mortality rate is 16% to 27% for adults. We describe a patient with cryptogenic NORSE and favorable recovery from drug-resistant super-refractory SE after the use of intravenous lidocaine. The patient experienced fever and presented with refractory generalized tonic-clonic seizures...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/37621670/nerve-ultrasound-reference-values-in-children-and-adolescents-echogenicity-and-influence-of-anthropometric-factors-including-hand-volume
#12
JOURNAL ARTICLE
Ifirae Yusuf, Hannah Mork, Bernhard Erdlenbruch, Peter Dieter Schellinger, Jörg Philipps
BACKGROUND: Nerve cross-sectional area (CSA) reference values in high-resolution ultrasound for children and adolescents are influenced by demographic and anthropometric factors such as age, height and weight. OBJECTIVES: The influence of hand volume as an additional morphometric factor was evaluated and nerve echogenicity was analyzed in a prospective cross-sectional study. METHODS: CSA were measured in 30 healthy children and adolescents from 2 to 17 years in the median, ulnar, radial, tibial, peroneal and sural nerves...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/37600237/influence-of-natalizumab-on-resting-state-connectivity-in-patients-with-multiple-sclerosis
#13
JOURNAL ARTICLE
Diogo G Corrêa, Eelco van Duinkerken, João Gabriel D Farinhas, Valéria C Pereira, Emerson L Gasparetto, Soniza V Alves-Leon, Fernanda Cristina R Lopes
BACKGROUND: Changes in brain connectivity occur in patients with multiple sclerosis (MS), even in patients under disease-modifying therapies. Using magnetic resonance imaging (MRI) to asses patients treated with disease-modifying therapies, such as natalizumab, can elucidate the mechanisms involved in clinical deterioration in MS. OBJECTIVES: To evaluate differences in resting-state functional connectivity among MS patients treated with natalizumab, MS patients not treated with natalizumab, and controls...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/37600236/the-impact-of-interaction-between-verteporfin-and-yes-associated-protein-1-transcriptional-coactivator-with-pdz-binding-motif-tea-domain-pathway-on-the-progression-of-isocitrate-dehydrogenase-wild-type-glioblastoma
#14
REVIEW
Mahmoud Osama, Muhammed Amir Essibayi, Mona Osama, Ismail A Ibrahim, Mostafa Nasr Mostafa, Murat Şakir Ekşi
Verteporfin and 5-ALA are used for visualizing malignant tissue components in different body tumors and as photodynamic therapy in treating isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM). Additionally, verteporfin interferes with Yes-associated protein 1 (YAP)/Transcriptional coactivator with PDZ-binding motif - TEA domain (TAZ-TEAD) pathway, thus inhibiting the downstream effect of these oncogenes and reducing the malignant properties of GBM. Animal studies have shown verteporfin to be successful in increasing survival rates, which have led to the conduction of phase 1 and 2 clinical trials to further investigate its efficacy in treating GBM...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/37581177/disseminated-aspergillosis-in-a-patient-with-neurosarcoidosis-persistent-contrast-enhancement-in-cns-despite-prolonged-antifungal-treatment-a-case-report
#15
Lakshman Arcot Jayagopal, Afsaneh Shirani, Kelly Cawcutt, Jie Chen, Ana Yuil-Valdes, Rana Zabad
A 56-year-old Caucasian man was diagnosed with definite neurosarcoidosis after he presented with progressive bilateral lower extremity weakness and dysesthesia. He was started on a combination immunosuppressant regimen of dexamethasone, methotrexate and infliximab. Two months into treatment with immunosuppressants, he developed devastating disseminated aspergillosis which clinically stabilized with aggressive antifungal treatment however had a protracted radiological course despite prolonged anti-fungal treatment for over two years...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/37346291/neurological-phenotypes-of-irf2bpl-gene-variants-a-report-of-four-novel-variants
#16
JOURNAL ARTICLE
Dafne Dain Gandelman Horovitz, Maria Angelica de Faria Domingues de Lima, Lais de Carvalho Pires, Abelardo de Queiroz Campos Araujo, Fernando Regla Vargas
IRF2BPL gene variants have recently been associated to developmental disability and epilepsy in children and movement disorders in adults. So far, only few cases have been reported; here we present four novel cases identified by exome sequencing, while investigating developmental delay, adult-onset cerebellar ataxia or regression.
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/37077432/structural-mri-in-migraine-a-review-of-migraine-vascular-and-structural-changes-in-brain-parenchyma
#17
REVIEW
Wilson J Xu, Giuseppe Barisano, Daniel Phung, Brendon Chou, Soniya N Pinto, Alexander Lerner, Nasim Sheikh-Bahaei
Migraine is a complex and common disorder that affects patients around the world. Despite recent advances in this field, the exact pathophysiology of migraine is still not completely understood. Structural MRI sequences have revealed a variety of changes to brain parenchyma associated with migraine, including white matter lesions, volume changes, and iron deposition. This Review highlights different structural imaging findings in various types of migraine and their relationship to migraine characteristics and subtypes in order to improve our understanding of migraine, its pathophysiologic mechanisms, and how to better diagnose and treat it...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/37008248/myelin-oligodendrocyte-glycoprotein-antibody-associated-disease-and-covid-19-a-systematic-review
#18
REVIEW
Omid Mirmosayyeb, Elham Moases Ghaffary, Mohammad S Dehghan, Hamed Ghoshouni, Sara Bagherieh, Mahdi Barzegar, Vahid Shaygannejad
BACKGROUND: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an uncommon neurological disease affecting the central nervous system (CNS). Numerous neurological disorders, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), acute transverse myelitis (ATM), and MOGAD, have been reported following the COVID-19 infection during the current COVID-19 pandemic. On the other hand, it has been suggested that patients with MOGAD may be at greater risk for infection (particularly in the current pandemic)...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/36949932/radiation-therapy-for-pineal-parenchymal-tumor-of-intermediate-differentiation-a-case-series-and-literature-review
#19
JOURNAL ARTICLE
Cassie Liu, Joseph Carmicheal, Michael J Baine, Chi Zhang
Pineal parenchymal tumor of intermediate differentiation (PPTID) is a rare, primary tumor of the pineal gland. Due to its rarity, there is no consensus on optimal therapeutic strategies or standard characterization of the tumor's behavior. Here, we report 2 new cases of PPTID and an extensive review of the literature involving the use and extent of radiation therapy. Patient 1 is a 54-year-old male who presented with PPTID and drop metastases in the spinal cord, received cranial spinal irradiation (CSI), and experienced recurrence 3...
2023: Journal of Central Nervous System Disease
https://read.qxmd.com/read/36909831/hippocampal-vulnerability-to-hyperhomocysteinemia-worsens-pathological-outcomes-of-mild-traumatic-brain-injury-in-rats
#20
JOURNAL ARTICLE
Flaubert Tchantchou, Ru-Ching Hsia, Adam Puche, Gary Fiskum
BACKGROUND: Mild traumatic brain injury (mTBI) generally resolves within weeks. However, 15-30% of patients present persistent pathological and neurobehavioral sequelae that negatively affect their quality of life. Hyperhomocysteinemia (HHCY) is a neurotoxic condition derived from homocysteine accumulation above 15 μM. HHCY can occur in diverse stressful situations, including those sustained by U.S. active-duty service members on the battlefield or during routine combat practice...
2023: Journal of Central Nervous System Disease
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