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Artificial Cells, Nanomedicine, and Biotechnology

Sarah Mousa Asiri, Firdos Alam Khan, Ayhan Bozkurt
In recent years, natural and synthetic polymers have attracted much attention due to their great potentials in medical science. In the present study, we have investigated the effect of chitosan-bulk (Ch-bulk), chitosan nanoparticles (ChNP), chitosan nanoparticles conjugated with glutaraldehyde (ChNP-GA) with an average size of 300-400 nm on human colorectal carcinoma cells (HCT-116) to examine their cytotoxic and anti-cancer abilities. We have evaluated the effects of Ch-bulk, ChNP, ChNP-GA on cancer cells by morphometric and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays respectively...
January 31, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Gang Wang, Jun-Jie Wang, Yu-Zhu Wang, Shi Feng, Gao Jing, Xing-Li Fu
As the most aggressive and malignant glioma, glioblastoma multiforme (GBM) abnormally expresses genes that mediate glycolytic metabolism and tumour cell growth. In this study, we investigated myricetin incorporated nanoliposomes and ascertained their prospect in effectively treating cancer via the employment of the GBM cell line DBTRG-05MG. Notably, the myricetin nanoliposomes (MYR-NLs) displayed potent inhibition of proliferation and significantly regulated the levels of proteins related to both glycolytic metabolism and cell survival...
January 28, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Doga Kavaz, Huzaifa Umar, Shafiu Shehu
Cancer incidence is still increasing due to inadequate responsive treatments. Inertness and biocompatibility of nanoparticles synthesized using plant extracts have shown therapeutic applications and make it to be a good anti-cancer candidates. This study is a recent novel spotlight that synthesized silver nanoparticle from Ficus ingens leaf extract (FILE) and studied its anti-metastatic and anti-bacterial activity. The chemical and surface analysis of the synthesized FILE silver nanoparticles (FILE-AgNPs) was studied using UV-visible, Fourier transform infrared (FTIR), X-ray diffraction (XRD), zeta sizer, atomic force microscopy (AFM) and scanning electron microscopy (SEM)...
January 28, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Jiayi Zhang, Huijuan Wang, Geng Niu, Yongkang Liu, Yanxia Wang, Lirong Zhang, Yanrui Pei, Hongli Zhu, Penggao Dai, Chao Chen
We investigated the allele frequencies of drug absorption, distribution, metabolism and elimination (ADME)-related drug-metabolizing enzymes and transporters (DMET) genes in the Northwestern Han, Tibetan and Uyghur populations and compared the related genes in these three populations with those in eleven 1000 Genome populations. We examined 1936 single nucleotide polymorphisms of 225 DMET genes involved in ADME processes and found 732, 679 and 804 sites were polymorphic in Han, Tibetan and Uyghur. Tibetan differed from Han in only four sites (p < ...
January 28, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Faheem Maqbool, Peter M Moyle, Madeleine S A Tan, Kristofer J Thurecht, James R Falconer
Supercritical fluid (SCF) technology offers a potential green alternative to organic solvent-based methods for drug formulation. Albendazole (ABZ) has promising anticancer activity when formulated to increase its cellular uptake. Herein, a static volume method was used to determine the solubility of ABZ in supercritical carbon dioxide (scCO2 ) for the future development of such ABZ formulations. The solubility of ABZ in scCO2 (250 bar, 37 °C) was approximately 12 mg/100 mL. The extent of dissolution was measured at various time points to determine when saturation solubility occurred, which was demonstrated from 9 h...
January 28, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Seema Saroj, Sadhana J Rajput
The present research was motivated by the dire need to design a targeted and safe Nano-vehicle for delivery of Etoposide (ETE), which would be tolerant of normal cells and exclusively toxic to prostate cancer cells. The folic acid functionalized mesoporous silica nanoparticles (MSNs) constructed by using a facile method acting as a unique selective platform for ETE delivery for effective prostate cancer treatment. FA@MSNs possessed good payload and encouraging in vitro release was obtained for ETE caged inside FA-MSNs compared with ETE-MSNs alone...
January 23, 2019: Artificial Cells, Nanomedicine, and Biotechnology
N L Dlamini, H E Mukaya, R L Van Zyl, N C Jansen van Vuuren, X Y Mbianda
About 40% of the world's population lives in malaria zones where it presents a challenging health problem. Malaria treatment and prevention have been hindered by drug resistance. Bisphosphonates have been found to be active against Trypanosoma cruzi and Plasmodium falciparum that cause Chaga's disease and malaria respectively. However, bisphosphonates have a shortcoming of being rapidly removed from the bloodstream through the kidneys before reaching the target sites due to their low molecular weight. In the current study, increased bisphosphonates' efficacy for malaria treatment was attempted by conjugating bisphosphonates onto carbon nanospheres (CNSs)...
January 16, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Abbas Hajizade, Ali Hatef Salmanian, Jafar Amani, Firouz Ebrahimi, Ayyoob Arpanaei
In the present study, the application of mesoporous silica nanoparticles (MSNPs) loaded with recombinant EspA protein, an immunogen of enterohaemorrhagic E. coli, was investigated in the case of BALB/c mice immunization against the bacterium. MSNPs of 96.9 ± 15.9 nm in diameter were synthesized using template removing method. The immunization of mice was carried out orally and subcutaneously. Significant immune responses to the antigen were observed for the immunized mice when rEspA-loaded MSNPs were administered in both routes in comparison to that of the antigen formulated using a well-known adjuvant, i...
January 14, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Dan Ma, Ping Wang, Qin Fang, Zhengyu Yu, Zhen Zhou, Zhengchang He, Danna Wei, Kunling Yu, Tingting Lu, Yaming Zhang, Jishi Wang
Imatinib (IM) resistance has become a critical problem for the treatment of patients with relapsed chronic myeloid leukaemia (CML), so novel therapies are in need. Various isotypes of protein kinases C (PKCs) are up-regulated in CML and related with BCR-ABL regulating several signalling pathways that are crucial to malignant cellular transformation. However, it is still unknown whether PKC isotypes play crucial roles in IM resistance. Therefore, we herein used a PKC pan-inhibitor staurosporine (St). To protect normal cells from damage, a proper dose of St was used, at which IM-resistant CML cells were selectively killed in combination with IM but normal cells survived...
January 8, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Jun Zhang, Ying Wang, Shan Zhang, Guo-Xing You, Peng-Long Li, Quan Wang, Wei-Li Yu, Tao Hu, Hong Zhou, Lian Zhao
The development of hemoglobin-based oxygen carriers (HBOCs) is a persistent and urgent need in biomedicine. As a potential HBOCs, Dextran-hemoglobin (Dex-bHb) has been developed over the past years. The novel Dex-bHb, whose thiol group of Cys-93(β) was reversibly protected, was produced and the characteristics were evaluated in our previous study. Herein, blood compatibility was characterized in terms of the red blood cell aggregation and hemolysis rate in vitro, and Dex-bHb showed no obvious effects. After intravenous administration of Dex-bHb to golden Syrian hamsters with hemorrhages shock, it showed mean arterial pressure recovery, blood flow increase and the organ protection from serious hemorrhage injury...
January 8, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Guanghua Peng, Xucheng Hou, Wenxi Zhang, Maoyuan Song, Mengya Yin, Jiaxing Wang, Jiajia Li, Yajie Liu, Yuanyuan Zhang, Wenkai Zhou, Xinru Li, Guiling Li
As novel amphiphilic materials, six uncharged alkyl rhamnosides incorporating various alkyl chain and one rhamnose amine quaternary ammonium salt were successfully synthesized in this study. Their amphiphilic properties (HLB and CMC), antimicrobial and anti-biofilm activity against S. aureus and P. aeruginosa were investigated. Differentially regulated proteins and pathways were identified by comparative proteomics research to first give a sight on how alkyl rhamnosides performed the anti-biofilm activity at protein and pathway levels...
January 8, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Xiaowu Hu, Yuke Zhu, Junsheng Wang, Jinshan Tang, Huaixi Yu, Ye Xie, Qirong Dong
Abnormal destruction of the components of the articular extracellular matrix (ECM) such as type II collagen and aggrecan caused by advanced glycation end products (AGEs) has been considered as one of the pathological characteristics of osteoarthritis (OA). Receptor-interacting protein 1 (RIP1), an important serine/threonine kinase, possesses a variety of biological functions including cell proliferation, survival and death. The physiological roles of RIP1 in OA have not been reported before. Here, we found that AGEs increased the expression of RIP1 in human chondrosarcoma cell line SW1353 cells...
January 3, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Hong Tan, Jing Hu, Shan Liu
Nanoparticle albumin-bound paclitaxel (Nab-paclitaxel) offer more efficient paclitaxel delivery into tumor cells with fewer side effects than conventional chemotherapies. However, whether the efficacy of Nab-paclitaxel for non-small cell lung cancer (NSCLC) patients is age-related remains unknown. We performed this meta-analysis to evaluate the anticancer efficacy and safety of Nab-paclitaxel in NSCLC. Hazard ratios (HRs) or rate ratios (RRs) with corresponding 95% confidence intervals (CIs) for outcomes were retrieved...
January 2, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Mahnoosh Abbaszade Dibavar, Masoud Soleimani, Amir Atashi, Neda Rassaei, Shahin Amiri
Acute Promyelocytic Leukemia is one of the most prevalent forms of leukemia which has been treated with arsenic trioxide (ATO) and/or all-trans retinoic acid (ATRA). Although, ATRA and ATO are broadly accessible and administrated, some adverse side effects have been reported recently. Nowadays, microvesicles (MVs) are considered as a potential therapeutic agent. Their capacity to alter the behavior of the cells is one of the most controversial issues. In this study, we investigated apoptotic effects of MVs derived from human bone marrow mesenchymal stem cells (hBM-MSCs) in combination with ATO on NB4 cell line...
January 2, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Shulian Tan, Liangsong Song, Meifang Wang, Wenjie Zhao, Yongguang Yang
OBJECTIVE: Diabetes is a common chronic disease. ARF is a new tumor suppressor, which is one hotspot of cell cycle regulators. The mutation of ARF is absent in nearly 50% of tumors. ARF plays an important role in many physiological processes, such as cell proliferation, cell senescence and cell cycle arrest. However, the molecular mechanism of ARF regulating is not clear at present. Our study aims to explore the mechanism of ARF in diabetes. METHODS: ARF-Tg mice and C57 mice were fasted for 12 hours before the experiment...
January 2, 2019: Artificial Cells, Nanomedicine, and Biotechnology
Hitomi Iwasaki, Kyoko Yokomaku, Moeka Kureishi, Keisuke Igarashi, Ryo Hashimoto, Mitsutomo Kohno, Masayuki Iwazaki, Risa Haruki, Motofusa Akiyama, Kenichi Asai, Yuka Nakamura, Ryosuke Funaki, Yoshitsugu Morita, Teruyuki Komatsu
A core-shell protein cluster comprising hemoglobin and human serum albumins, hemoglobin-albumin cluster (Hb-HSA3 ), was designed and synthesized for use as an artificial O2 carrier and red blood cell (RBC) substitute. For initial preclinical safety evaluation of the Hb-HSA3 solution, we observed blood compatibility in vitro, physiological responses after exchange transfusion into rats and blood circulation lifetime in dogs. Dilution of human whole blood with Hb-HSA3 showed an appropriate decrease in blood cell number, proportional to the mixing volume ratio...
December 25, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Mohammad Kamalabadi-Farahani, Mohammad Vasei, Naser Ahmadbeigi, Somayeh Ebrahimi-Barough, Masoud Soleimani, Reza Roozafzoon
Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer with poor prognosis. Despite the emergence of new and targeted therapies for other types of breast cancer, chemotherapy, surgery and radiotherapy are the only common therapies for TNBC. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), with selective apoptotic properties in tumour cells has been considered as a promising neoadjuvant therapy in some cancers including TNBC. The application of TRAIL in clinic has been prevented due to its short half-life and TRAIL resistance...
December 24, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Yawen Zhang, Yang Lv, Wenliang Ji, Rubing Zhou, Shan Gao, Fang Zhou
In recent years, systemic hypothermia has taken the spotlight for its use in spinal cord injury (SCI) research fields, but detailed molecular mechanisms are still not fully understood. In this study, we use an online-electrochemical system (OECS) to in vivo continuously monitor the ascorbate of the rats' spinal cord. We find that the basal level of ascorbate in rat spinal cord is 1.85 ± 0.88 μmol L-1 (n = 20). It increased immediately after SCI and reached 2.36 ± 0.65 μmol L-1 (164.90% ± 7...
December 11, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Elisa Santovito, José das Neves, Donato Greco, Vito D'Ascanio, Bruno Sarmento, Antonio Francesco Logrieco, Giuseppina Avantaggiato
Rosin acids (RA) from coniferous trees are used in folk medicine for healing various skin infections. Despite the antimicrobial potential of RA, their poor solubility in aqueous media may limit their use. In this work RA-loaded polyethylene glycol-poly(lactic-co-glycolic acid) nanoparticles (RA-NPs) with enhanced antimicrobial properties against foodborne bacterial pathogens were produced. RA-NPs were prepared by solvent displacement technique and characterized for relevant colloidal features by dynamic light scattering, laser Doppler anemometry and transmission electron microscopy...
December 7, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Özge Lalegül-Ülker, Şükran Şeker, Ayşe Eser Elçin, Yaşar Murat Elçin
Repair of volumetric muscle loss (VML) injuries is a complicated endeavour which necessitates the collaborative use of different regenerative approaches and technologies. Herein is proposed the development of fibrin-based microbeads (FMs) alone or as a bone marrow mesenchymal stem cell (MSC) encapsulation matrix for modular muscle engineering. FMs were generated through the ionotropic gelation of alginate and fibrinogen obtained from the platelet-rich plasma of whole blood, and then removing the alginate by citrate treatment...
December 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
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