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Dermatology and Therapy

Alisha Bhanot, Alyson Huntley, Matthew J Ridd
Atopic dermatitis/eczema is a chronic inflammatory skin condition, and emollients are the first-line treatment. Despite their widespread use, there is uncertainty about the frequency and type of adverse events associated with different emollients. We conducted a restricted review of published data on adverse events associated with emollient use in eczema. Medline (Ovid) was searched from inception (1946) to June 2018. All types of studies, with the exception of reviews, were included. Eligibility was assessed using a two-stage screening process against inclusion and exclusion criteria...
February 15, 2019: Dermatology and Therapy
Alan Menter, Richard Warren
No abstract text is available yet for this article.
February 15, 2019: Dermatology and Therapy
Zoe D Draelos, Steven R Feldman, Brian Berman, Melissa Olivadoti, Debra Sierka, Anna M Tallman, Michael A Zielinski, William C Ports, Sheryl Baldwin
Atopic dermatitis (AD) is a common inflammatory skin disease that is accompanied by increased sensitivity to itch-provoking and pain-provoking stimuli. Patients with AD experience skin pain before initiation of therapy and have also reported painful application site reactions in clinical trials of emollients and prescription topical therapies, including topical corticosteroids (TCSs), topical calcineurin inhibitors (TCIs), and a topical phosphodiesterase 4 (PDE4) inhibitor. To compare the sensory tolerability of prescription topical therapies for AD, a comprehensive literature search and analysis of published clinical trials was conducted...
January 24, 2019: Dermatology and Therapy
Marie-Therese Leccia, Celeste Lebbe, Jean-Paul Claudel, Mridvika Narda, Nicole Basset-Seguin
Chronic exposure to solar radiation is associated with an increased incidence of skin cancer worldwide and more specifically with non-melanoma skin cancers and actinic keratosis. At the cellular level DNA damage is the main event following ultraviolet (UV) exposure. The kind of lesions produced depends on the wavelength and the energy profile of the radiation, with different photoproducts being formed as a result. Although endogenous DNA repair mechanisms are somewhat effective in repairing DNA, some DNA damage persists and can accumulate with chronic exposure...
January 23, 2019: Dermatology and Therapy
Robert S English, James M Barazesh
INTRODUCTION: Standardized scalp massages (SSMs) improve hair thickness in nonbalding men, but their effects on androgenic alopecia (AGA) have not yet been evaluated. The objective of this study was to investigate the effect of SSMs on self-assessed AGA sufferers (SAGASs). METHODS: Between October 2016 and October 2017, 1899 SAGASs searching online for hair loss treatments beyond AGA management drugs accessed literature explaining SSMs as a potential therapy for AGA, then watched a demonstration video detailing twice-daily, 20-min SSMs segmented by three rotational scalp regions using hand-generated presses, pinches, and stretches...
January 22, 2019: Dermatology and Therapy
Bruce E Strober, Joelle M van der Walt, April W Armstrong, Marc Bourcier, Andre V E Carvalho, Edgardo Chouela, Arnon D Cohen, Claudia de la Cruz, Charles N Ellis, Andrew Y Finlay, Alice B Gottlieb, Johann E Gudjonsson, Lars Iversen, C Elise Kleyn, Craig L Leonardi, Charles W Lynde, Caitriona Ryan, Colin T Theng, Fernando Valenzuela, Ronald Vender, Jashin J Wu, Helen S Young, Alexa B Kimball
Engaging global key opinion leaders, the International Psoriasis Council (IPC) held a day-long roundtable discussion with the primary purpose to discuss the treatment goals of psoriasis patients and worldwide barriers to optimal care. Setting clear expectations might ultimately encourage undertreated psoriasis patients to seek care in an era in which great gains in therapeutic efficacy have been achieved. Here, we discuss the option for early treatment of all categories of psoriasis to alleviate disease impact while emphasizing the need for more focused attention for psoriasis patients with mild and moderate forms of this autoimmune disease...
December 21, 2018: Dermatology and Therapy
Hind M Almohanna, Azhar A Ahmed, John P Tsatalis, Antonella Tosti
People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Micronutrients are major elements in the normal hair follicle cycle, playing a role in cellular turnover, a frequent occurrence in the matrix cells in the follicle bulb that are rapidly dividing...
December 13, 2018: Dermatology and Therapy
David E Castillo, Sonali Nanda, Jonette E Keri
Acne vulgaris is the most common dermatological disorder worldwide. It is a multifactorial disease that involves increased sebum production, hyperkeratinization of the pilosebaceous unit, Propionibacterium acnes (Cutibacterium acnes) colonization, and inflammation. The human skin microbiome hosts a wide variety of microorganisms, including bacteria, viruses, and fungi. A delicate balance of these microorganisms is essential for the barrier function of the skin. Propionibacterium acnes represents nearly 90% of the human skin microbiome of healthy adults...
December 11, 2018: Dermatology and Therapy
Evelyn Yu-Xin Tay, Yee-Leng Teoh, Matthew Sze-Wei Yeo
Basal cell carcinoma (BCC) is the most commonly diagnosed malignancy in humans, and as such it poses a significant healthcare burden. The majority of BCC cases are amenable to cure by surgical extirpation. However, until recently there have been no good treatment options for a significant minority of advanced BCC cases, including locally advanced BCC and metastatic BCC. The introduction of a novel class of drugs, the Hedgehog pathway inhibitors, into clinical practice has ushered in a new treatment algorithm for the treatment of difficult BCC cases...
December 11, 2018: Dermatology and Therapy
Martina Kerscher, Arti Tania Nurrisyanti, Christine Eiben-Nielson, Susanne Hartmann, Judith Lambert-Baumann
INTRODUCTION: Combined cosmetic treatments are becoming increasingly popular. The objective of this clinical evaluation was to assess the long-term safety and efficacy of combining microfocused ultrasound with visualization (MFU-V) treatment with a calcium hydroxylapatite (CaHA) dermal filler to tighten skin at the submental region and contour the jawline. METHODS: Women with loss of contour and skin laxity in the lower face received MFU-V treatment. If subjects did not respond satisfactorily after 12 weeks, they received CaHA to the jawline...
December 8, 2018: Dermatology and Therapy
Ewelina Kosior, Adam Reich
INTRODUCTION: Erysipelas and bacterial cellulitis are two of the most common infectious skin diseases. They are usually caused by the β-hemolytic group of Streptococcus, and less frequently by other bacteria. The objective of the study was to assess the factors affecting the length of stay of patients admitted to hospital with erysipelas or bacterial cellulitis. METHODS: The study was based on the retrospective analysis of medical records of patients diagnosed with erysipelas or bacterial cellulitis...
December 7, 2018: Dermatology and Therapy
Frank Eertmans, Bart Rossel, Lidia Serrano, Elisabeth Rivera, Els Adriaens
INTRODUCTION: Silicones (e.g., dimethicone) are effective and safe alternatives to insecticides for the treatment of head lice. However, silicones are lipophilic substances and do not only leave the hair greasy but they are also difficult to wash out. We have evaluated the efficacy and safety of a potential solution to this problem: an aqueous dispersion of a novel silylated polyol that has the same mode of action as dimethicone (suffocation) without its negative impact on hair characteristics...
November 30, 2018: Dermatology and Therapy
Philip R Cohen
Scrotal rejuvenation encompasses not only the functional quality but also the aesthetic appearance of the scrotum. It includes medical therapy and procedural interventions to improve scrotal conditions that require morphologic restoration and/or aesthetic alteration. Rejuvenation of the scrotum may be appropriate for aging-related and non-aging-related changes concerning the hair (alopecia and hypertrichosis), the morphology (laxity and wrinkles), and/or the vascularity (angiokeratoma) of the scrotum. Angiokeratomas-typically small, asymptomatic, purple papules-may occur on the scrotum...
November 26, 2018: Dermatology and Therapy
Gil Yosipovitch, Adam Reich, Martin Steinhoff, Anke Beselin, Toby Kent, Martin Dossenbach, Lovisa Berggren, Carsten Henneges, Thomas Luger
INTRODUCTION: We evaluated baseline itch and its impact on the efficacy of ixekizumab (IXE) in clearing psoriasis and improving quality-of-life measures, and we explored the relationship between itch and psoriatic skin improvement. METHODS: Data were analyzed from two double-blind, randomized, controlled phase III studies (UNCOVER-2/3) comparing etanercept (ETN), IXE, and placebo (PBO) in patients with moderate-to-severe plaque psoriasis. Long-term analysis included UNCOVER-3 data from week 0 to week 156...
December 2018: Dermatology and Therapy
Shinichi Imafuku, Taizo Matsuki, Akiko Mizukami, Yasushi Goto, Sabrina de Souza, Céline Jégou, Veronique Bianco, Dominique Rosillon, Chie Ito, Desmond Curran, Katsiaryna Holl
INTRODUCTION: The aim of this study is to describe the disease burden and costs of herpes zoster (HZ) in the general adult Japanese population or patients with immunocompromised (IC) conditions or chronic disorders. METHODS: A retrospective cohort study of individuals aged 18-74 years was conducted using January 2005 to December 2014 records from the Japan Medical Data Center claims database. Twenty-eight IC conditions and chronic disorders were defined by diagnosis codes and/or procedures/treatments...
November 19, 2018: Dermatology and Therapy
Lina Saeed, Isabelle M Sanchez, Nina C Botto, Charles N Ellis, Erik J Stratman, Jennifer Thompson, Kanade Shinkai
INTRODUCTION: Communication skills influence the quality of health care and patient experience; both may affect provider reimbursement. There are few opportunities available for practicing physicians to receive direct feedback on communication in patient encounters. The purpose of this simulation-based patient encounter workshop was for dermatologists to practice and obtain feedback on their communication skills. METHODS: In March 2016, dermatologists participated in a workshop with four simulated patient encounters...
November 17, 2018: Dermatology and Therapy
Omar Jiménez-Zarazúa, Andrés Guzmán-Ramírez, Lourdes N Vélez-Ramírez, Jesús A López-García, Leticia Casimiro-Guzmán, Jaime D Mondragón
Pemphigus is a bullous autoimmune disease that affects the skin and mucous membranes. It is very difficult to establish the etiology and the triggering factors that influence reactivations in pemphigus vulgaris (PV). The case of a 33-year-old male with chronic history of intranasal cocaine consumption is presented in this report. We present the clinical case of the patient, followed for a total of 86 weeks, with ten relapses secondary to probable cocaine use. The patient was admitted to the emergency department after presenting polymorphic dermatosis characterized by blisters, vesicles, and excoriations extending from the oral cavity to the thorax, and to the inguinal and genital regions, affecting approximately 35 % of the body surface area with a score of 56 on the Pemphigus Skin Disorder Index...
November 10, 2018: Dermatology and Therapy
Francisco Gómez-García, Juan L Sanz-Cabanillas, Isabel Viguera-Guerra, Beatriz Isla-Tejera, Antonio Vélez-García Nieto, Juan Ruano
INTRODUCTION: Deficiencies in interleukin (IL)-1 receptor (IL-R) antagonist (DIRA) and IL-36R antagonist (DITRA) are rare genetic autoinflammatory diseases related to alterations in antagonists of the IL-1 pathway. IL-1 antagonists may represent therapeutic alternatives. Here, we aim to provide a scoping review of knowledge on use of IL-1-targeting drugs in DIRA and DITRA. METHODS: An a priori protocol was published, and the study was conducted using the methodology described in the Joanna Briggs Institute Reviewer's Manual and the recently published PRISMA Extension for Scoping Review statement...
November 3, 2018: Dermatology and Therapy
Eric L Simpson, Amy S Paller, Mark Boguniewicz, Lawrence F Eichenfield, Steven R Feldman, Jonathan I Silverberg, Sarah L Chamlin, Lee T Zane
INTRODUCTION: The impact of crisaborole ointment, a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis (AD), on quality of life (QoL) was assessed in two identically designed phase 3 studies (AD-301: NCT02118766; AD-302: NCT02118792, both at ). METHODS: In both studies, patients aged ≥ 2 years with mild to moderate AD per the Investigator's Static Global Assessment were randomly assigned 2:1 to receive crisaborole or vehicle twice daily for 28 days...
October 22, 2018: Dermatology and Therapy
Di Yan, Richard Ahn, Stephen Leslie, Wilson Liao
INTRODUCTION: Psoriatic arthritis (PsA) is a chronic, inflammatory arthritis that affects an estimated 30% of patients with psoriasis. PsA is underdiagnosed in primary care and dermatology clinics due to a variety of reasons, including failure of healthcare providers to ask about symptoms, overlap of symptoms and signs with other rheumatologic conditions, and lack of a specific diagnostic test. A delay in PsA diagnosis and treatment, even as short as 6 months, can lead to decreased quality of life, increased joint damage, and worse long-term physical function...
October 20, 2018: Dermatology and Therapy
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