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Kristine L Rae Olmsted, Michael Bartoszek, Sean Mulvaney, Brian McLean, Ali Turabi, Ryan Young, Eugene Kim, Russ Vandermaas-Peeler, Jessica Kelley Morgan, Octav Constantinescu, Shawn Kane, Cuong Nguyen, Shawn Hirsch, Breda Munoz, Dennis Wallace, Julie Croxford, James H Lynch, Ronald White, Bradford B Walters
Importance: This is the first multisite, randomized clinical trial of stellate ganglion block (SGB) outcomes on posttraumatic stress disorder (PTSD) symptoms. Objective: To determine whether paired SGB treatments at 0 and 2 weeks would result in improvement in mean Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) total symptom severity scores from baseline to 8 weeks. Design, Setting, and Participants: This multisite, blinded, sham-procedure, randomized clinical trial used a 2:1 SGB:sham ratio and was conducted from May 2016 through March 2018 in 3 US Army Interdisciplinary Pain Management Centers...
November 6, 2019: JAMA Psychiatry
#2
Stephanie Winkelbeiner, Philipp Homan
No abstract text is available yet for this article.
November 6, 2019: JAMA Psychiatry
#3
Christoph U Correll, John M Kane
No abstract text is available yet for this article.
November 6, 2019: JAMA Psychiatry
#4
Denise E Wilfley, W Stewart Agras, Ellen E Fitzsimmons-Craft, Cara Bohon, Dawn M Eichen, R Robinson Welch, Booil Jo, Ramesh Raghavan, Enola K Proctor, G Terence Wilson
Importance: Progress has been made in establishing evidence-based treatments for psychiatric disorders, but these are not often delivered in routine settings. A scalable solution for training clinicians in evidence-based treatments is needed. Objective: To compare 2 methods of training college (university) counseling center therapists to treat psychiatric disorders using interpersonal psychotherapy. The hypothesis was that the train-the-trainer condition would demonstrate superior implementation outcomes vs the expert condition...
November 6, 2019: JAMA Psychiatry
#5
Sunjae Bae
No abstract text is available yet for this article.
November 6, 2019: JAMA Psychiatry
#6
Dennis van der Meer, Ida E Sønderby, Tobias Kaufmann, G Bragi Walters, Abdel Abdellaoui, David Ames, Katrin Amunts, Micael Andersson, Nicola J Armstrong, Manon Bernard, Nicholas B Blackburn, John Blangero, Dorret I Boomsma, Henry Brodaty, Rachel M Brouwer, Robin Bülow, Wiepke Cahn, Vince D Calhoun, Svenja Caspers, Gianpiero L Cavalleri, Christopher R K Ching, Sven Cichon, Simone Ciufolini, Aiden Corvin, Benedicto Crespo-Facorro, Joanne E Curran, Shareefa Dalvie, Paola Dazzan, Eco J C de Geus, Greig I de Zubicaray, Sonja M C de Zwarte, Norman Delanty, Anouk den Braber, Sylvane Desrivieres, Marta Di Forti, Joanne L Doherty, Gary Donohoe, Stefan Ehrlich, Else Eising, Thomas Espeseth, Simon E Fisher, Tormod Fladby, Oleksandr Frei, Vincent Frouin, Masaki Fukunaga, Thomas Gareau, David C Glahn, Hans J Grabe, Nynke A Groenewold, Ómar Gústafsson, Jan Haavik, Asta K Haberg, Ryota Hashimoto, Jayne Y Hehir-Kwa, Derrek P Hibar, Manon H J Hillegers, Per Hoffmann, Laurena Holleran, Jouke-Jan Hottenga, Hilleke E Hulshoff Pol, Masashi Ikeda, Sébastien Jacquemont, Neda Jahanshad, Christiane Jockwitz, Stefan Johansson, Erik G Jönsson, Masataka Kikuchi, Emma E M Knowles, John B Kwok, Stephanie Le Hellard, David E J Linden, Jingyu Liu, Arvid Lundervold, Astri J Lundervold, Nicholas G Martin, Karen A Mather, Samuel R Mathias, Katie L McMahon, Allan F McRae, Sarah E Medland, Torgeir Moberget, Clara Moreau, Derek W Morris, Thomas W Mühleisen, Robin M Murray, Jan E Nordvik, Lars Nyberg, Loes M Olde Loohuis, Roel A Ophoff, Michael J Owen, Tomas Paus, Zdenka Pausova, Juan M Peralta, Bruce Pike, Carlos Prieto, Erin Burke Quinlan, Céline S Reinbold, Tiago Reis Marques, James J H Rucker, Perminder S Sachdev, Sigrid B Sando, Peter R Schofield, Andrew J Schork, Gunter Schumann, Jean Shin, Elena Shumskaya, Ana I Silva, Sanjay M Sisodiya, Vidar M Steen, Dan J Stein, Lachlan T Strike, Christian K Tamnes, Alexander Teumer, Anbupalam Thalamuthu, Diana Tordesillas-Gutiérrez, Anne Uhlmann, Magnús Ö Úlfarsson, Dennis van 't Ent, Marianne B M van den Bree, Evangelos Vassos, Wei Wen, Katharina Wittfeld, Margaret J Wright, Tetyana Zayats, Anders M Dale, Srdjan Djurovic, Ingrid Agartz, Lars T Westlye, Hreinn Stefánsson, Kári Stefánsson, Paul M Thompson, Ole A Andreassen
Importance: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. Objective: To determine the association of the 15q11...
October 30, 2019: JAMA Psychiatry
#7
Robert A McCutcheon, Tiago Reis Marques, Oliver D Howes
Importance: Schizophrenia is a common, severe mental illness that most clinicians will encounter regularly during their practice. This report provides an overview of the clinical characteristics, epidemiology, genetics, neuroscience, and psychopharmacology of schizophrenia to provide a basis to understand the disorder and its treatment. This educational review is integrated with a clinical case to highlight how recent research findings can inform clinical understanding. Observations: The first theme considered is the role of early-life environmental and genetic risk factors in altering neurodevelopmental trajectories to predispose an individual to the disorder and leading to the development of prodromal symptoms...
October 30, 2019: JAMA Psychiatry
#8
Yuelong Ji, Romuladus E Azuine, Yan Zhang, Wenpin Hou, Xiumei Hong, Guoying Wang, Anne Riley, Colleen Pearson, Barry Zuckerman, Xiaobin Wang
Importance: Prior studies have raised concern about maternal acetaminophen use during pregnancy and increased risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in their children; however, most studies have relied on maternal self-report. Objective: To examine the prospective associations between cord plasma acetaminophen metabolites and physician-diagnosed ADHD, ASD, both ADHD and ASD, and developmental disabilities (DDs) in childhood...
October 30, 2019: JAMA Psychiatry
#9
Delfina Janiri, Dominik A Moser, Gaelle E Doucet, Maxwell J Luber, Alexander Rasgon, Won Hee Lee, James W Murrough, Gabriele Sani, Simon B Eickhoff, Sophia Frangou
Importance: Major depressive disorder, bipolar disorder, posttraumatic stress disorder, and anxiety disorders are highly comorbid and have shared clinical features. It is not yet known whether their clinical overlap is reflected at the neurobiological level. Objective: To detect transdiagnostic convergence in abnormalities in task-related brain activation. Data Source: Task-related functional magnetic resonance imaging articles published in PubMed, Web of Science, and Google Scholar during the last decade comparing control individuals with patients with mood, posttraumatic stress, and anxiety disorders were examined...
October 30, 2019: JAMA Psychiatry
#10
Robert A McCutcheon, Tiago Reis Marques, Oliver D Howes
No abstract text is available yet for this article.
October 30, 2019: JAMA Psychiatry
#11
Richard G Frank
No abstract text is available yet for this article.
October 23, 2019: JAMA Psychiatry
#12
Christian Hakulinen, Roger T Webb, Carsten B Pedersen, Esben Agerbo, Pearl L H Mok
Importance: Evidence linking parental socioeconomic position and offspring's schizophrenia risk has been inconsistent, and how risk is associated with parental socioeconomic mobility has not been investigated. Objective: To elucidate the association between parental income level and income mobility during childhood and subsequent schizophrenia risk. Design, Setting, and Participants: National cohort study of all persons born in Denmark from January 1, 1980, to December 31, 2000, who were followed up from their 15th birthday until schizophrenia diagnosis, emigration, death, or December 31, 2016, whichever came first...
October 23, 2019: JAMA Psychiatry
#13
Matthew L MacDonald, Megan Garver, Jason Newman, Zhe Sun, Joseph Kannarkat, Ryan Salisbury, Jill Glausier, Ying Ding, David A Lewis, Nathan Yates, Robert A Sweet
Importance: Findings from unbiased genetic studies have consistently implicated synaptic protein networks in schizophrenia, but the molecular pathologic features within these networks and their contribution to the synaptic and circuit deficits thought to underlie disease symptoms remain unknown. Objective: To determine whether protein levels are altered within synapses from the primary auditory cortex (A1) of individuals with schizophrenia and, if so, whether these differences are restricted to the synapse or occur throughout the gray matter...
October 23, 2019: JAMA Psychiatry
#14
Jaimie L Gradus, Anthony J Rosellini, Erzsébet Horváth-Puhó, Amy E Street, Isaac Galatzer-Levy, Tammy Jiang, Timothy L Lash, Henrik T Sørensen
Importance: Suicide is a public health problem, with multiple causes that are poorly understood. The increased focus on combining health care data with machine-learning approaches in psychiatry may help advance the understanding of suicide risk. Objective: To examine sex-specific risk profiles for death from suicide using machine-learning methods and data from the population of Denmark. Design, Setting, and Participants: A case-cohort study nested within 8 national Danish health and social registries was conducted from January 1, 1995, through December 31, 2015...
October 23, 2019: JAMA Psychiatry
#15
Seena Fazel, Lauren O'Reilly
No abstract text is available yet for this article.
October 23, 2019: JAMA Psychiatry
#16
Myrna M Weissman, Jyotishman Pathak, Ardesheer Talati
No abstract text is available yet for this article.
October 23, 2019: JAMA Psychiatry
#17
Rasmi M Tith, Gilles Paradis, Brian J Potter, Nancy Low, Jessica Healy-Profitós, Siyi He, Nathalie Auger
Importance: Bulimia nervosa is associated with short-term cardiovascular complications in women, but its long-term consequences on cardiovascular health are unknown. Objective: To study the association of bulimia nervosa with the long-term risk of cardiovascular disease and mortality in women. Design, Setting, and Participants: In this longitudinal cohort study, 416 709 women hospitalized in Quebec, Canada, including women hospitalized for bulimia nervosa and those for pregnancy-related events as a comparison group, were followed up for 12 years from 2006 to 2018 to identify incidences of cardiovascular disease and death...
October 16, 2019: JAMA Psychiatry
#18
(no author information available yet)
No abstract text is available yet for this article.
October 16, 2019: JAMA Psychiatry
#19
Benjamin P Chapman, Alison Huang, Kelly Peters, Elizabeth Horner, Jennifer Manly, David A Bennett, Susan Lapham
Importance: Personality phenotype has been associated with subsequent dementia in studies of older adults. However, neuropathologic changes often precede cognitive symptoms by many years and may affect personality itself. Therefore, it is unclear whether supposed dementia-prone personality profiles (high neuroticism and low conscientiousness) are true risk factors or merely reflections of preexisting disease. Objectives: To examine whether personality during adolescence-a time when preclinical dementia pathology is unlikely to be present-confers risk of dementia in later life and to test whether associations could be accounted for by health factors in adolescence or differed across socioeconomic status (SES)...
October 16, 2019: JAMA Psychiatry
#20
Leandro da Costa Lane Valiengo, Stephan Goerigk, Pedro Caldana Gordon, Frank Padberg, Mauricio Henriques Serpa, Stephanie Koebe, Leonardo Afonso Dos Santos, Roger Alberto Marcos Lovera, Juliana Barbosa de Carvalho, Martinus van de Bilt, Acioly L T Lacerda, Helio Elkis, Wagner Farid Gattaz, Andre R Brunoni
Importance: Negative symptoms represent a substantial burden in schizophrenia. Although preliminary studies have suggested that transcranial direct current stimulation (tDCS) is effective for some clusters of symptoms, the clinical benefits for negative symptoms are unclear. Objective: To determine the efficacy and safety of tDCS vs sham as an add-on treatment for patients with schizophrenia and predominant negative symptoms. Design, Setting, and Participants: The double-blind Schizophrenia Treatment With Electric Transcranial Stimulation (STARTS) randomized clinical trial was conducted from September 2014 to March 2018 in 2 outpatient clinics in the state of São Paulo, Brazil...
October 16, 2019: JAMA Psychiatry
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