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JAMA Psychiatry

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https://read.qxmd.com/read/31090881/association-between-incident-exposure-to-benzodiazepines-in-early-pregnancy-and-risk-of-spontaneous-abortion
#1
Odile Sheehy, Jin-Ping Zhao, Anick Bérard
Importance: Benzodiazepine use in early pregnancy is associated with spontaneous abortion (SA). However, to date, the association between specific benzodiazepine agent exposure and the risk of SA has not been examined. Objective: To quantify the risk of SA associated with gestational benzodiazepine incident use by drug class, duration of action, and specific benzodiazepine agent. Design, Setting, and Participants: This nested case-control study within the Quebec Pregnancy Cohort, Montreal, Quebec, Canada, includes all pregnancies covered by the Quebec Prescription Drug Insurance Plan from January 1, 1998, through December 31, 2015...
May 15, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31090878/treatment-considerations-in-severe-mental-illness-caring-for-the-whole-patient
#2
Martha C Ward, Benjamin G Druss
No abstract text is available yet for this article.
May 15, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31090873/introducing-jama-network-insights
#3
Dost Öngür
No abstract text is available yet for this article.
May 15, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31066892/biomarker-guided-anti-inflammatory-therapies-from-promise-to-reality-check
#4
Michael Berk, Adam J Walker, Andrew A Nierenberg
No abstract text is available yet for this article.
May 8, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31066887/efficacy-of-adjunctive-infliximab-vs-placebo-in-the-treatment-of-adults-with-bipolar-i-ii-depression-a-randomized-clinical-trial
#5
Roger S McIntyre, Mehala Subramaniapillai, Yena Lee, Zihang Pan, Nicole E Carmona, Margarita Shekotikhina, Joshua D Rosenblat, Elisa Brietzke, Joanna K Soczynska, Victoria E Cosgrove, Shefali Miller, Eileen Grace Fischer, Nicole E Kramer, Kiley Dunlap, Trisha Suppes, Rodrigo B Mansur
Importance: To our knowledge, no study has previously evaluated whether individuals with bipolar depression enriched a priori on the basis of biochemical and/or phenotypic immuno-inflammatory activation would differentially respond to an anti-inflammatory agent for the treatment of depressive symptoms. Objective: To assess the antidepressant efficacy of adjunctive infliximab, a monoclonal antibody targeting tumor necrosis factor, in adults with bipolar I and bipolar II depression and inflammatory conditions...
May 8, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31066881/buprenorphine-treatment-divide-by-race-ethnicity-and-payment
#6
Pooja A Lagisetty, Ryan Ross, Amy Bohnert, Michael Clay, Donovan T Maust
No abstract text is available yet for this article.
May 8, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31066876/anhedonia-reduction-and-the-association-between-left-ventral-striatal-reward-response-and-6-month-improvement-in-life-satisfaction-among-young-adults
#7
Kristen L Eckstrand, Erika E Forbes, Michele A Bertocci, Henry W Chase, Tsafrir Greenberg, Jeanette Lockovich, Ricki Stiffler, Haris A Aslam, Simona Graur, Genna Bebko, Mary L Phillips
Importance: Anhedonia is a symptom of multiple psychiatric conditions in young adults that is associated with poorer mental health and psychosocial function and abnormal ventral striatum reward processing. Aberrant function of neural reward circuitry is well documented in anhedonia and other psychiatric disorders. Longitudinal studies to identify potential biomarkers associated with a reduction in anhedonia are necessary for the development of novel treatment targets. Objective: To identify neural reward-processing factors associated with improved psychiatric symptoms and psychosocial function in a naturalistic, observational context...
May 8, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31066874/missing-affiliations
#8
(no author information available yet)
No abstract text is available yet for this article.
May 8, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31042292/typographical-error-in-discussion
#9
(no author information available yet)
No abstract text is available yet for this article.
May 1, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31042280/assessment-of-striatal-dopamine-transporter-binding-in-individuals-with-major-depressive-disorder-in-vivo-positron-emission-tomography-and-postmortem-evidence
#10
Diego A Pizzagalli, Sabina Berretta, Dustin Wooten, Franziska Goer, Kanoelani T Pilobello, Poornima Kumar, Laura Murray, Miranda Beltzer, Anne Boyer-Boiteau, Nathanial Alpert, Georges El Fakhri, Naguib Mechawar, Gordana Vitaliano, Gustavo Turecki, Marc Normandin
Importance: Major depressive disorder (MDD) might involve dopamine (DA) reductions. The DA transporter (DAT) regulates DA clearance and neurotransmission and is sensitive to DA levels, with preclinical studies (including those involving inescapable stressors) showing that DAT density decreases when DA signaling is reduced. Despite preclinical data, evidence of reduced DAT in MDD is inconclusive. Objective: Using a highly selective DAT positron emission tomography (PET) tracer ([11C] altropane), DAT availability was probed in individuals with MDD who were not taking medication...
May 1, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31042274/rigorous-trial-design-is-essential-to-understand-the-role-of-opioid-receptors-in-ketamine-s-antidepressant-effect
#11
Boris D Heifets, Nolan R Williams, Brandon S Bentzley, Alan F Schatzberg
No abstract text is available yet for this article.
May 1, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31042271/association-of-maternal-neurodevelopmental-risk-alleles-with-early-life-exposures
#12
Beate Leppert, Alexandra Havdahl, Lucy Riglin, Hannah J Jones, Jie Zheng, George Davey Smith, Kate Tilling, Anita Thapar, Ted Reichborn-Kjennerud, Evie Stergiakouli
Importance: Early-life exposures, such as prenatal maternal lifestyle, illnesses, nutritional deficiencies, toxin levels, and adverse birth events, have long been considered potential risk factors for neurodevelopmental disorders in offspring. However, maternal genetic factors could be confounding the association between early-life exposures and neurodevelopmental outcomes in offspring, which makes inferring a causal relationship problematic. Objective: To test whether maternal polygenic risk scores (PRSs) for neurodevelopmental disorders were associated with early-life exposures previously linked to the disorders...
May 1, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31042270/rigorous-trial-design-is-essential-to-understand-the-role-of-opioid-receptors-in-ketamine-s-antidepressant-effect-reply
#13
John H Krystal, Gihyun Yoon, Ismene L Petrakis
No abstract text is available yet for this article.
May 1, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31017639/efficacy-of-integrated-exposure-therapy-vs-integrated-coping-skills-therapy-for-comorbid-posttraumatic-stress-disorder-and-alcohol-use-disorder-a-randomized-clinical-trial
#14
Sonya B Norman, Ryan Trim, Moira Haller, Brittany C Davis, Ursula S Myers, Peter J Colvonen, Erika Blanes, Robert Lyons, Emma Y Siegel, Abigail C Angkaw, Gregory J Norman, Tina Mayes
Importance: Co-occurrence of posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) is common and associated with psychiatric and functional problems. Understanding whether exposure therapy is tolerable and efficacious for treating PTSD and AUD is critical to ensure that best practice treatments are available. Objective: To compare the efficacy of integrated (ie, targeting both PTSD and alcohol use) prolonged exposure (I-PE) therapy with present-centered integrated coping skills (I-CS) therapy, a more commonly available treatment, in reducing PTSD symptoms and alcohol use...
April 24, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31017638/the-two-cultures-of-computational-psychiatry
#15
Daniel Bennett, Steven M Silverstein, Yael Niv
No abstract text is available yet for this article.
April 24, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31017632/association-of-exposure-to-infections-in-childhood-with-risk-of-eating-disorders-in-adolescent-girls
#16
Lauren Breithaupt, Ole Köhler-Forsberg, Janne Tidselbak Larsen, Michael E Benros, Laura Marie Thornton, Cynthia M Bulik, Liselotte Petersen
Importance: Infections are recognized as playing a critical role in the risk of psychiatric disorders and suicidal behavior; however, few studies have evaluated the risk of eating disorders. Objective: To evaluate the association of hospitalization for infections and treatment with anti-infective agents with the risk of an eating disorder diagnosis. Design, Setting, and Participants: A nationwide, population-based, prospective cohort study of 525 643 girls born from January 1, 1989, to December 31, 2006, and followed up until December 31, 2012, was conducted using individual-level data drawn from Danish longitudinal registers...
April 24, 2019: JAMA Psychiatry
https://read.qxmd.com/read/31017627/trends-in-treatment-and-spending-for-patients-receiving-outpatient-treatment-of-depression-in-the-united-states-1998-2015
#17
Jason M Hockenberry, Peter Joski, Courtney Yarbrough, Benjamin G Druss
Context: After marked increases from 1987 to 1997, trends in depression treatment in the United States increased modestly from 1998 to 2007. However, multiple policy changes that expanded insurance coverage for mental health conditions may have shifted these trends again since 2007. Objective: To examine national trends in outpatient treatment of depression from 1998 to 2015, with particular focus on 2007 to 2015. Design, Setting, and Participants: This analysis of the use of health services and spending for treatment of depression in the United States assessed data from the 1998 (n = 22 953), 2007 (n = 29 370), and 2015 (n = 33 893) Medical Expenditure Panel Surveys (MEPSs)...
April 24, 2019: JAMA Psychiatry
https://read.qxmd.com/read/30994881/combining-pharmacological-and-nonpharmacological-interventions-in-network-meta-analysis-in-psychiatry
#18
Cinzia Del Giovane, Samuele Cortese, Andrea Cipriani
No abstract text is available yet for this article.
April 17, 2019: JAMA Psychiatry
https://read.qxmd.com/read/30994877/effectiveness-and-acceptability-of-cognitive-behavior-therapy-delivery-formats-in-adults-with-depression-a-network-meta-analysis
#19
Pim Cuijpers, Hisashi Noma, Eirini Karyotaki, Andrea Cipriani, Toshi A Furukawa
Importance: Cognitive behavior therapy (CBT) has been shown to be effective in the treatment of acute depression. However, whether CBT can be effectively delivered in individual, group, telephone-administered, guided self-help, and unguided self-help formats remains unclear. Objective: To examine the most effective delivery format for CBT via a network meta-analysis. Data Sources: A database updated yearly from PubMed, PsycINFO, Embase, and the Cochrane Library...
April 17, 2019: JAMA Psychiatry
https://read.qxmd.com/read/30994872/association-of-rare-copy-number-variants-with-risk-of-depression
#20
Kimberley Marie Kendall, Elliott Rees, Matthew Bracher-Smith, Sophie Legge, Lucy Riglin, Stanley Zammit, Michael Conlon O'Donovan, Michael John Owen, Ian Jones, George Kirov, James Tynan Rhys Walters
Importance: The role of large, rare copy number variants (CNVs) in neuropsychiatric disorders is well established, but their association with common psychiatric disorders, such as depression, remains unclear. Objective: To examine the association of a group of 53 CNVs associated with neurodevelopmental disorders and burden of rare CNVs with risk of depression. Design, Setting, and Participants: This case-control study used data from the UK Biobank study sample, which comprised 502 534 individuals living in the United Kingdom...
April 17, 2019: JAMA Psychiatry
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