Michael P Milham, Joshua Vogelstein, Ting Xu
No abstract text is available yet for this article.
January 13, 2021: JAMA Psychiatry
Benjamin I Perry, Jan Stochl, Rachel Upthegrove, Stan Zammit, Nick Wareham, Claudia Langenberg, Eleanor Winpenny, David Dunger, Peter B Jones, Golam M Khandaker
Importance: Cardiometabolic disorders often occur concomitantly with psychosis and depression, contribute to high mortality rates, and are detectable from the onset of the psychiatric disorders. However, it is unclear whether longitudinal trends in cardiometabolic traits from childhood are associated with risks for adult psychosis and depression. Objective: To examine whether specific developmental trajectories of fasting insulin (FI) levels and body mass index (BMI) from early childhood were longitudinally associated with psychosis and depression in young adults...
January 13, 2021: JAMA Psychiatry
Esben Agerbo, Betina B Trabjerg, Anders D Børglum, Andrew J Schork, Bjarni J Vilhjálmsson, Carsten B Pedersen, Christian Hakulinen, Clara Albiñana, David M Hougaard, Jakob Grove, John J McGrath, Jonas Bybjerg-Grauholm, Ole Mors, Oleguer Plana-Ripoll, Thomas Werge, Naomi R Wray, Preben Bo Mortensen, Katherine L Musliner
Importance: Combining information on polygenic risk scores (PRSs) with other known risk factors could potentially improve the identification of risk of depression in the general population. However, to our knowledge, no study has estimated the association of PRS with the absolute risk of depression, and few have examined combinations of the PRS and other important risk factors, including parental history of psychiatric disorders and socioeconomic status (SES), in the identification of depression risk...
January 13, 2021: JAMA Psychiatry
Ángel García de la Garza, Carlos Blanco, Mark Olfson, Melanie M Wall
Importance: Because more than one-third of people making nonfatal suicide attempts do not receive mental health treatment, it is essential to extend suicide attempt risk factors beyond high-risk clinical populations to the general adult population. Objective: To identify future suicide attempt risk factors in the general population using a data-driven machine learning approach including more than 2500 questions from a large, nationally representative survey of US adults...
January 6, 2021: JAMA Psychiatry
Thomas R Kosten, Ismene L Petrakis
No abstract text is available yet for this article.
December 30, 2020: JAMA Psychiatry
Qingyu Zhao, Edith V Sullivan, Nicolas Honnorat, Ehsan Adeli, Simon Podhajsky, Michael D De Bellis, James Voyvodic, Kate B Nooner, Fiona C Baker, Ian M Colrain, Susan F Tapert, Sandra A Brown, Wesley K Thompson, Bonnie J Nagel, Duncan B Clark, Adolf Pfefferbaum, Kilian M Pohl
Importance: Maturation of white matter fiber systems subserves cognitive, behavioral, emotional, and motor development during adolescence. Hazardous drinking during this active neurodevelopmental period may alter the trajectory of white matter microstructural development, potentially increasing risk for developing alcohol-related dysfunction and alcohol use disorder in adulthood. Objective: To identify disrupted adolescent microstructural brain development linked to drinking onset and to assess whether the disruption is more pronounced in younger rather than older adolescents...
December 30, 2020: JAMA Psychiatry
(no author information available yet)
No abstract text is available yet for this article.
December 30, 2020: JAMA Psychiatry
Pia Jeppesen, Rasmus Trap Wolf, Sabrina M Nielsen, Robin Christensen, Kerstin Jessica Plessen, Niels Bilenberg, Per Hove Thomsen, Mikael Thastum, Simon-Peter Neumer, Louise Berg Puggaard, Mette Maria Agner Pedersen, Anne Katrine Pagsberg, Wendy K Silverman, Christoph U Correll
Importance: Behavioral therapy and cognitive-behavioral therapy (CBT) programs targeting a single class of problems have not been widely implemented. The population of youths with common mental health problems is markedly undertreated. Objective: To determine the effectiveness of a new transdiagnostic CBT program (Mind My Mind [MMM]) compared with management as usual (MAU) in youths with emotional and behavioral problems below the threshold for referral to mental health care...
December 23, 2020: JAMA Psychiatry
Hanke Heun-Johnson, Michael Menchine, Sarah Axeen, Khristina Lung, Ilene Claudius, Tyler Wright, Seth A Seabury
Importance: Racial/ethnic disparities in health care use and clinical outcomes for behavioral health disorders, including psychosis, are well documented, but less is known about these disparities during the period leading up to first-episode psychosis (FEP). Objective: To describe the racial/ethnic disparities in behavioral health care use and prescription drug use of children and young adults before the diagnosis of FEP. Design, Setting, and Participants: An observational cohort study was conducted using medical and prescription drug claims from January 1, 2007, to September 30, 2015, obtained from Optum's deidentified Clinformatics Data Mart Database, a commercial claims database augmented with race/ethnicity and socioeconomic variables...
December 23, 2020: JAMA Psychiatry
Peter J Uhlhaas, Patrick D McGorry, Stephen J Wood
No abstract text is available yet for this article.
December 16, 2020: JAMA Psychiatry
Ying-Yeh Chen, Sun Yu, Ya-Hui Hu, Chung-Yi Li, Fanny Artaud, Laure Carcaillon-Bentata, Alexis Elbaz, Pei-Chen Lee
Importance: Parkinson disease (PD) is an increasingly common neurodegenerative disorder in many aging societies. Although comorbidities with mental disorders are common in PD, whether PD is associated with an increased risk of suicide is unclear. Objective: To use a large national representative PD cohort to compare the risk of suicide in patients with PD and control participants and identify potential risk factors. Design, Setting, and Participants: This nationwide population-based cohort study used linked data from Taiwan's National Health Insurance data set and Taiwan Death Registry between January 2002 and December 2016...
December 16, 2020: JAMA Psychiatry
Michael Johnathan Charles Bray, Nicholas Omid Daneshvari, Indu Radhakrishnan, Janel Cubbage, Michael Eagle, Pamela Southall, Paul Sasha Nestadt
No abstract text is available yet for this article.
December 16, 2020: JAMA Psychiatry
Nicola Warren, Steve Kisely, Dan Siskind
No abstract text is available yet for this article.
December 15, 2020: JAMA Psychiatry
Marica Leone, Ralf Kuja-Halkola, Amy Leval, Brian M D'Onofrio, Henrik Larsson, Paul Lichtenstein, Sarah E Bergen
Importance: Early-onset depression has been linked to poor health outcomes. However, it is unclear the extent to which this disorder is associated with specific diseases and premature death and whether these associations remain after controlling for psychiatric comorbidity. Objective: To quantify the association of youth depression with subsequent diagnoses of numerous somatic diseases and mortality. Design, Setting, and Participants: A population-based cohort study was conducted using Swedish national registers containing data on all individuals born in Sweden between 1982 and 1996...
December 9, 2020: JAMA Psychiatry
Nora D Volkow, Joshua A Gordon, Michelle P Freund
No abstract text is available yet for this article.
December 9, 2020: JAMA Psychiatry
Sergi Papiol, Andrea Schmitt, Isabel Maurus, Moritz J Rossner, Thomas G Schulze, Peter Falkai
No abstract text is available yet for this article.
December 9, 2020: JAMA Psychiatry
Lindsay D Oliver, Iska Moxon-Emre, Meng-Chuan Lai, Laura Grennan, Aristotle N Voineskos, Stephanie H Ameis
Importance: Schizophrenia spectrum disorders (SSDs) and autism spectrum disorder (ASD) both feature social cognitive deficits; however, these disorders historically have been examined separately using a range of tests and subdomain focus and at different time points in the life span. Moving beyond diagnostic categories and characterizing social cognitive deficits can enhance understanding of shared pathways across these disorders. Objective: To investigate how deficits in social cognitive domains diverge or overlap between SSDs and ASD based on the extant literature...
December 8, 2020: JAMA Psychiatry
Joseph Friedman, Leo Beletsky, David L Schriger
No abstract text is available yet for this article.
December 3, 2020: JAMA Psychiatry
Niamh Mullins, Hailiang Huang
No abstract text is available yet for this article.
December 2, 2020: JAMA Psychiatry
Hui-Juan Li, Chen Zhang, Li Hui, Dong-Sheng Zhou, Yi Li, Chu-Yi Zhang, Chuang Wang, Lu Wang, Wenqiang Li, Yongfeng Yang, Na Qu, Jinsong Tang, Ying He, Jun Zhou, Zihao Yang, Xingxing Li, Jun Cai, Lu Yang, Jun Chen, Weixing Fan, Wei Tang, Wenxin Tang, Qiu-Fang Jia, Weiqing Liu, Chuanjun Zhuo, Xueqin Song, Fang Liu, Yan Bai, Bao-Liang Zhong, Shu-Fang Zhang, Jing Chen, Bin Xia, Luxian Lv, Zhongchun Liu, Shaohua Hu, Xiao-Yan Li, Jie-Wei Liu, Xin Cai, Yong-Gang Yao, Yuyanan Zhang, Hao Yan, Suhua Chang, Jing-Ping Zhao, Wei-Hua Yue, Xiong-Jian Luo, Xiaogang Chen, Xiao Xiao, Yiru Fang, Ming Li
Importance: The genetic basis of bipolar disorder (BD) in Han Chinese individuals is not fully understood. Objective: To explore the genetic basis of BD in the Han Chinese population. Design, Setting, and Participants: A genome-wide association study (GWAS), followed by independent replication, was conducted to identify BD risk loci in Han Chinese individuals. Individuals with BD were diagnosed based on DSM-IV criteria and had no history of schizophrenia, mental retardation, or substance dependence; individuals without any personal or family history of mental illnesses, including BD, were included as control participants...
December 2, 2020: JAMA Psychiatry
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