Åsa Bonnard, Cecilia Engmér Berglin, Josephine Wincent, Per Olof Eriksson, Eva Westman, Maria Feychting, Hanna Mogensen
IMPORTANCE: Cholesteatoma in the middle ear is not regarded as a hereditary disease, but case reports of familial clustering exist in the literature, as well as observed familial cases in the clinical work. However, the knowledge regarding cholesteatoma as a hereditary disease is lacking in the literature. OBJECTIVE: To assess the risk of cholesteatoma in individuals with a first-degree relative surgically treated for the same disease. DESIGN, SETTING, AND PARTICIPANTS: In this nested case-control study in the Swedish population between 1987 and 2018 of first-time cholesteatoma surgery identified from the Swedish National Patient Register, 2 controls per case were randomly selected from the population register through incidence density sampling, and all first-degree relatives for cases and controls were identified...
March 16, 2023: JAMA Otolaryngology—Head & Neck Surgery