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JAMA Ophthalmology

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https://read.qxmd.com/read/30763441/comparison-of-biphasic-vs-static-oxygen-saturation-targets-among-infants-with-retinopathy-of-prematurity
#1
Ankita Shukla, Christine Sonnie, Sarah Worley, Amit Sharma, Dawn Howard, Jon Moore, Ricardo J Rodriguez, George Hoppe, Jonathan E Sears
Importance: The Surfactant, Positive Pressure, and Pulse Oximetry Randomized Trial (SUPPORT) demonstrated that static low oxygen saturation decreased retinopathy of prematurity (ROP) but increased mortality compared with static high oxygen saturation cohorts. Objective: To compare outcomes of a biphasic oxygen protocol with static targets recommended by SUPPORT. Design, Setting, and Participants: Retrospective cohort study comparing biphasic vs static standards 41 months prior to and 42 months after a change from biphasic to static SUPPORT standards at a level III neonatal intensive care unit (Fairview Hospital, Cleveland, Ohio)...
February 14, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30763438/retinal-hemorrhages-in-a-patient-with-petechiae
#2
Iris Zhuang, Isha Gupta, Christina Y Weng
No abstract text is available yet for this article.
February 14, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30763437/tailored-vs-static-oxygen-saturation-targets-to-prevent-retinopathy-of-prematurity
#3
Ann Hellström, Anna-Lena Hård, Lois E H Smith
No abstract text is available yet for this article.
February 14, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30763435/multiple-errors-in-article-and-supplement
#4
(no author information available yet)
No abstract text is available yet for this article.
February 14, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30763432/self-perception-in-children-aged-3-to-7-years-with-amblyopia-and-its-association-with-deficits-in-vision-and-fine-motor-skills
#5
Eileen E Birch, Yolanda S Castañeda, Christina S Cheng-Patel, Sarah E Morale, Krista R Kelly, Cynthia L Beauchamp, Ann Webber
Importance: Deficits in fine motor skills and slow reading speed have been reported in school-aged children and adults with amblyopia. These deficits were correlated with lower self-perception of athletic and cognitive competence. Although perceived competence and social acceptance are key determinants of developing self-perception in young children, the association of amblyopia with self-perception and the association of altered self-perception with fine motor skills to date have not been reported for young children aged 3 to 7 years...
February 14, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30763431/the-argument-for-sterile-loading-of-all-intravitreal-injections-and-the-benefit-of-replicated-results
#6
Brian L VanderBeek
No abstract text is available yet for this article.
February 14, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30763416/ocular-surface-squamous-neoplasia-hiding-in-primary-acquired-melanosis
#7
Yan Zhang, Sander Dubovy, Carol L Karp
No abstract text is available yet for this article.
February 14, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30730553/looking-at-the-lamina-more-than-meets-the-eye
#8
Rachel L Anderson, Hiroshi Ishikawa, Joel S Schuman
No abstract text is available yet for this article.
February 7, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30730544/two-year-incidence-of-retinal-intervention-in-patients-with-minimal-or-no-diabetic-retinopathy-on-telemedicine-screening
#9
Bobeck S Modjtahedi, Christos Theophanous, Stephan Chiu, Tiffany Q Luong, Natasha Nguyen, Donald S Fong
Importance: Most patients with diabetes have little or no retinopathy on initial examination. Tracking the long-term outcomes of these patients may increase our understanding of how to best provide follow-up treatment. Objective: To assess how many patients with minimal or no retinopathy require retinal intervention within 2 years of retinal evaluation. Design, Setting, and Participants: This retrospective cohort study assessed patients who underwent screening for diabetic retinopathy within a telemedicine program at Kaiser Permanente Southern California and had minimal or no retinopathy on fundus photographs...
February 7, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30730543/the-case-for-extended-screening-intervals-for-people-with-diabetes-and-no-or-minimal-retinopathy-at-baseline
#10
Peter van Wijngaarden, Stuart Keel, Peter H Scanlon
No abstract text is available yet for this article.
February 7, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30730541/immune-response-and-intraocular-inflammation-in-patients-with-leber-hereditary-optic-neuropathy-treated-with-intravitreal-injection-of-recombinant-adeno-associated-virus-2-carrying-the-nd4-gene-a-secondary-analysis-of-a-phase-1-2-clinical-trial
#11
Céline Bouquet, Catherine Vignal Clermont, Anne Galy, Serge Fitoussi, Laure Blouin, Marion R Munk, Sonia Valero, Sandrine Meunier, Barrett Katz, José Alain Sahel, Nitza Thomasson
Importance: Intravitreal gene therapy is regarded as generally safe with limited mild adverse events, but its systemic effects remain to be investigated. Objective: To examine the association between immune response and intraocular inflammation after ocular gene therapy with recombinant adeno-associated virus 2 carrying the ND4 gene (rAAV2/2-ND4). Design, Setting, and Participants: This secondary analysis of an open-label, dose-escalation phase 1/2 randomized clinical trial of rAAV2/2-ND4 included data from February 13, 2014 (first patient visit), to March 30, 2017 (last patient visit at week 96), the first 2 years after injection...
February 7, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30730538/understanding-ocular-inflammation-in-eyes-treated-with-intravitreal-gene-therapy
#12
Jacque L Duncan
No abstract text is available yet for this article.
February 7, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30730536/sudden-fixed-swirl-circles-in-the-vision-of-a-young-healthy-woman
#13
Giuseppe Casalino, Vasuki Sivagnanavel, Carlos Pavesio
No abstract text is available yet for this article.
February 7, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30730530/association-between-lamina-cribrosa-defects-and-progressive-retinal-nerve-fiber-layer-loss-in-glaucoma
#14
Sasan Moghimi, Linda M Zangwill, Patricia Isabel C Manalastas, Min Hee Suh, Rafaella C Penteado, Huiyuan Hou, Kyle Hasenstab, Elham Ghahari, Christopher Bowd, Robert N Weinreb
Importance: Certain features of the lamina cribrosa may be associated with increased risk of glaucoma progression. Objectives: To compare the rates of retinal nerve fiber layer (RNFL) thinning in patients with open-angle glaucoma with or without lamina cribrosa (LC) defects and to evaluate factors associated with the rate of glaucoma progression in eyes with LC defects. Design, Setting, and Participants: This longitudinal cohort study designed in September 2017 and conducted at a tertiary glaucoma center in California included 51 eyes of 43 patients with LC defects and 83 eyes of 68 patients without LC defects followed up for a mean (SD) of 3...
February 7, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30703203/association-of-intravitreal-anti-vascular-endothelial-growth-factor-therapy-with-risk-of-stroke-myocardial-infarction-and-death-in-patients-with-exudative-age-related-macular-degeneration
#15
Lauren A Dalvin, Matthew R Starr, Jackson E AbouChehade, Gena M Damento, Maria Garcia, Saumya M Shah, David O Hodge, Irene Meissner, Sophie J Bakri, Raymond Iezzi
Importance: Current studies assessing the risk of stroke, myocardial infarction (MI), and death in patients undergoing intravitreal anti-vascular endothelial growth factor (VEGF) therapy are inconclusive. To our knowledge, no population-based studies have been performed to examine these potential risks. Objective: To examine whether patients with exudative age-related macular degeneration (AMD) receiving intravitreal anti-VEGF injections have a higher incidence of MI, stroke, or death compared with control populations...
January 31, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30703202/estimates-of-the-percentage-of-us-adults-with-diabetes-who-could-be-screened-for-diabetic-retinopathy-in-primary-care-settings
#16
Diane M Gibson
Importance: Prior studies found that screening for diabetic retinopathy (DR) in primary care settings using telemedicine increased screening rates among individuals with diabetes. This finding has led to interest in expanding the use of primary care-based screening for DR. Objective: To estimate the percentages of US adults with diabetes and high-risk US adults with diabetes who have regular contact with primary care physicians and therefore could potentially receive timely screening for DR in primary care settings...
January 31, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30703199/optic-nerve-head-edema-in-a-healthy-man-in-his-20s
#17
Talisa E de Carlo, Sarwar Zahid, Peter W MacIntosh
No abstract text is available yet for this article.
January 31, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30703197/predictors-of-spectacle-wear-and-reasons-for-nonwear-in-students-randomized-to-ready-made-or-custom-made-spectacles-results-of-secondary-objectives-from-a-randomized-noninferiority-trial
#18
Priya Morjaria, Jennifer Evans, Clare Gilbert
Importance: Visual impairment from uncorrected refractive errors affects 12.8 million children globally. Spectacle correction is simple and cost-effective; however, low adherence to spectacle wear, which can occur in all income settings, limits visual potential. Objective: To investigate predictors of spectacle wear and reasons for nonwear in students randomized to ready-made or custom-made spectacles. Design, Setting, and Participants: In planned secondary objectives of a noninferiority randomized clinical trial, students aged 11 to 15 years who fulfilled eligibility criteria, which included improvement in vision with correction by at least 2 lines in the better eye, were recruited from government schools in Bangalore, India...
January 31, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30703194/establishing-prescribing-guidelines-in-school-based-eye-health-programs-in-children-aged-11-to-15-years-the-conundrum-of-cost-vs-benefit
#19
Vivian Manh
No abstract text is available yet for this article.
January 31, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30676635/factors-associated-with-visual-acuity-and-central-subfield-thickness-changes-when-treating-diabetic-macular-edema-with-anti-vascular-endothelial-growth-factor-therapy-an-exploratory-analysis-of-the-protocol-t-randomized-clinical-trial
#20
Susan B Bressler, Isoken Odia, Maureen G Maguire, Dilsher S Dhoot, Adam R Glassman, Lee M Jampol, Dennis M Marcus, Sharon D Solomon, Jennifer K Sun
Importance: Identifying the factors that are associated with the magnitude of treatment benefits from anti-vascular endothelial growth factor (anti-VEGF) therapy for diabetic macular edema (DME) may help refine treatment expectations. Objective: To identify the baseline factors that are associated with vision and anatomic outcomes when managing DME with anti-VEGF and determine if there are interactions between factors and the agent administered. Design, Setting, and Participants: This post hoc analysis of data from the Diabetic Retinopathy Clinical Research Network multicenter randomized clinical trial , Protocol T, was conducted between December 2016 and December 2017...
January 24, 2019: JAMA Ophthalmology
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