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Hedy S Wald
No abstract text is available yet for this article.
March 18, 2019: JAMA Neurology
#2
Omid Beiki, Paolo Frumento, Matteo Bottai, Ali Manouchehrinia, Jan Hillert
Importance: Clinicians' experience and findings from recent natural history studies suggest that multiple sclerosis (MS) may now be running a more slowly progressing course than before. Objective: To investigate whether the risk of reaching MS disability milestones has changed over the last decade in Sweden. Design, Setting, and Participants: A nationwide population-based retrospective cohort study. By April 2017, 12 512 patients with available information on demographics, MS phenotype, and date of MS onset and diagnosis were registered in the Swedish MS Registry of which 7331 patients with at least 2 recorded Expanded Disability Status Scale scores (EDSS) and diagnosed between January 1995 and December 2010 were included...
March 18, 2019: JAMA Neurology
#3
(no author information available yet)
No abstract text is available yet for this article.
March 18, 2019: JAMA Neurology
#4
(no author information available yet)
No abstract text is available yet for this article.
March 18, 2019: JAMA Neurology
#5
S Andrew Josephson
No abstract text is available yet for this article.
March 18, 2019: JAMA Neurology
#6
Michael G Heckman, Rebecca R Brennan, Catherine Labbé, Alexandra I Soto, Shunsuke Koga, Michael A DeTure, Melissa E Murray, Ronald C Petersen, Bradley F Boeve, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Rosa Rademakers, Dennis W Dickson, Owen A Ross
Importance: The association between the microtubule-associated protein tau (MAPT) H1 haplotype and the risk of progressive supranuclear palsy (PSP) has been well documented. However, the specific H1 subhaplotypes that drive the association have not been evaluated in large studies, nor have they been studied in relation to neuropathologic severity of disease. Objective: To comprehensively evaluate the associations of MAPT haplotypes with the risk of PSP and the severity of tau pathology using a large series of neuropathologically confirmed PSP cases...
March 18, 2019: JAMA Neurology
#7
Marian Galovic, Irene Baudracco, Evan Wright-Goff, Galo Pillajo, Parashkev Nachev, Britta Wandschneider, Friedrich Woermann, Pamela Thompson, Sallie Baxendale, Andrew W McEvoy, Mark Nowell, Matteo Mancini, Sjoerd B Vos, Gavin P Winston, Rachel Sparks, Ferran Prados, Anna Miserocchi, Jane de Tisi, Louis André Van Graan, Roman Rodionov, Chengyuan Wu, Mahdi Alizadeh, Lauren Kozlowski, Ashwini D Sharan, Lohith G Kini, Kathryn A Davis, Brian Litt, Sebastien Ourselin, Solomon L Moshé, Josemir W A Sander, Wolfgang Löscher, John S Duncan, Matthias J Koepp
Importance: A functional area associated with the piriform cortex, termed area tempestas, has been implicated in animal studies as having a crucial role in modulating seizures, but similar evidence is limited in humans. Objective: To assess whether removal of the piriform cortex is associated with postoperative seizure freedom in patients with temporal lobe epilepsy (TLE) as a proof-of-concept for the relevance of this area in human TLE. Design, Setting, and Participants: This cohort study used voxel-based morphometry and volumetry to assess differences in structural magnetic resonance imaging (MRI) scans in consecutive patients with TLE who underwent epilepsy surgery in a single center from January 1, 2005, through December 31, 2013...
March 11, 2019: JAMA Neurology
#8
Emily A Largent, Jason Karlawish
No abstract text is available yet for this article.
March 11, 2019: JAMA Neurology
#9
Daniel Ciccarone
No abstract text is available yet for this article.
March 11, 2019: JAMA Neurology
#10
Vilakshan Alambyan, Ciro Ramos-Estebanez
No abstract text is available yet for this article.
March 11, 2019: JAMA Neurology
#11
David A Roshal, James P Dunn, Duo Xu
No abstract text is available yet for this article.
March 11, 2019: JAMA Neurology
#12
Shuko Joseph, Cunyi Wang, Kate Bushby, Michaela Guglieri, Iain Horrocks, Volker Straub, S Faisal Ahmed, Sze Choong Wong
Importance: Based on studies with relatively small sample size, fragility fractures are commonly reported in glucocorticoid (GC)-treated boys with Duchenne muscular dystrophy (DMD). Objective: To determine the fracture burden and growth impairment in a large contemporary cohort of boys with DMD in the United Kingdom and in relation to GC regimen. Design, Setting, and Participants: A retrospective review of fracture morbidity and growth from 832 boys with DMD in the UK NorthStar database (2006-2015), which systematically captures information from 23 participating centers...
March 11, 2019: JAMA Neurology
#13
Matthew P Pase, Alexa S Beiser, Jayandra J Himali, Claudia L Satizabal, Hugo J Aparicio, Charles DeCarli, Geneviève Chêne, Carole Dufouil, Sudha Seshadri
Importance: Blood-based biomarkers have the potential to improve the identification of persons with the greatest dementia risk for inclusion in dementia prevention trials through low-cost and minimally invasive screening. Objective: To investigate the use of plasma total tau as a blood biomarker for dementia and related endophenotypes. Design, Setting, and Participants: This prospective cohort study used data from the US community-based Framingham Heart Study with replication in the Memento study, a multicenter cohort of persons with mild cognitive impairment or subjective cognitive complaints recruited from memory clinics across France...
March 4, 2019: JAMA Neurology
#14
Breton M Asken
No abstract text is available yet for this article.
March 4, 2019: JAMA Neurology
#15
Anderson Alexsander Rodrigues Teixeira, Lucas Fernandes Ferreira, Roberto da Justa Pires Neto
No abstract text is available yet for this article.
March 4, 2019: JAMA Neurology
#16
Ahmed Z Obeidat
No abstract text is available yet for this article.
March 4, 2019: JAMA Neurology
#17
Nitin Tandon, Brian A Tong, Elliott R Friedman, Jessica A Johnson, Gretchen Von Allmen, Melissa S Thomas, Omotola A Hope, Giridhar P Kalamangalam, Jeremy D Slater, Stephen A Thompson
Importance: A major change has occurred in the evaluation of epilepsy with the availability of robotic stereoelectroencephalography (SEEG) for seizure localization. However, the comparative morbidity and outcomes of this minimally invasive procedure relative to traditional subdural electrode (SDE) implantation are unknown. Objective: To perform a comparative analysis of the relative efficacy, procedural morbidity, and epilepsy outcomes consequent to SEEG and SDE in similar patient populations and performed by a single surgeon at 1 center...
March 4, 2019: JAMA Neurology
#18
Roos M van der Vuurst de Vries, Rogier Q Hintzen
No abstract text is available yet for this article.
March 4, 2019: JAMA Neurology
#19
Jonathan D Santoro, Tanuja Chitnis
No abstract text is available yet for this article.
February 25, 2019: JAMA Neurology
#20
(no author information available yet)
No abstract text is available yet for this article.
February 25, 2019: JAMA Neurology
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