journal
https://read.qxmd.com/read/38048122/trends-in-traumatic-brain-injury-mortality-in-the-us
#1
JOURNAL ARTICLE
Noor F Shaik, Connor A Law, Holly Elser, Andrea L C Schneider
No abstract text is available yet for this article.
December 4, 2023: JAMA Neurology
https://read.qxmd.com/read/38048096/plasma-biomarker-strategy-for-selecting-patients-with-alzheimer-disease-for-antiamyloid-immunotherapies
#2
JOURNAL ARTICLE
Niklas Mattsson-Carlgren, Lyduine E Collij, Erik Stomrud, Alexa Pichet Binette, Rik Ossenkoppele, Ruben Smith, Linda Karlsson, Juan Lantero-Rodriguez, Anniina Snellman, Olof Strandberg, Sebastian Palmqvist, Nicholas J Ashton, Kaj Blennow, Shorena Janelidze, Oskar Hansson
IMPORTANCE: Antiamyloid immunotherapies against Alzheimer disease (AD) are emerging. Scalable, cost-effective tools will be needed to identify amyloid β (Aβ)-positive patients without an advanced stage of tau pathology who are most likely to benefit from these therapies. Blood-based biomarkers might reduce the need to use cerebrospinal fluid (CSF) or positron emission tomography (PET) for this. OBJECTIVE: To evaluate plasma biomarkers for identifying Aβ positivity and stage of tau accumulation...
December 4, 2023: JAMA Neurology
https://read.qxmd.com/read/38048091/mirror-hand-movements-caused-by-a-deletion-of-the-dcc-gene
#3
JOURNAL ARTICLE
Lotte Kleinendorst, Mieke M van Haelst
No abstract text is available yet for this article.
December 4, 2023: JAMA Neurology
https://read.qxmd.com/read/38048087/neuronally-derived-extracellular-vesicle-%C3%AE-synuclein-as-a-serum-biomarker-for-individuals-at-risk-of-developing-parkinson-disease
#4
JOURNAL ARTICLE
Shijun Yan, Cheng Jiang, Annette Janzen, Thomas R Barber, Aline Seger, Michael Sommerauer, Jason J Davis, Kenneth Marek, Michele T Hu, Wolfgang H Oertel, George K Tofaris
IMPORTANCE: Nonmotor symptoms of Parkinson disease (PD) often predate the movement disorder by decades. Currently, there is no blood biomarker to define this prodromal phase. OBJECTIVE: To investigate whether α-synuclein in neuronally derived serum-extracellular vesicles identifies individuals at risk of developing PD and related dementia. DESIGN, SETTING, AND PARTICIPANTS: This retrospective, cross-sectional multicenter study of serum samples included the Oxford Discovery, Marburg, Cologne, and Parkinson's Progression Markers Initiative cohorts...
December 4, 2023: JAMA Neurology
https://read.qxmd.com/read/38010712/multiple-sclerosis-progression-and-relapse-activity-in-children
#5
JOURNAL ARTICLE
Pietro Iaffaldano, Emilio Portaccio, Giuseppe Lucisano, Marta Simone, Alessia Manni, Tommaso Guerra, Damiano Paolicelli, Matteo Betti, Ermelinda De Meo, Luisa Pastò, Lorenzo Razzolini, Maria A Rocca, Laura Ferrè, Vincenzo Brescia Morra, Francesco Patti, Mauro Zaffaroni, Claudio Gasperini, Giovanna De Luca, Diana Ferraro, Franco Granella, Carlo Pozzilli, Silvia Romano, Paolo Gallo, Roberto Bergamaschi, Maria Gabriella Coniglio, Giacomo Lus, Marika Vianello, Paola Banfi, Alessandra Lugaresi, Rocco Totaro, Daniele Spitaleri, Eleonora Cocco, Franco Di Palma, Davide Maimone, Paola Valentino, Valentina Torri Clerici, Alessandra Protti, Giorgia Teresa Maniscalco, Giuseppe Salemi, Ilaria Pesci, Umberto Aguglia, Vito Lepore, Massimo Filippi, Maria Trojano, Maria Pia Amato
IMPORTANCE: Although up to 20% of patients with multiple sclerosis (MS) experience onset before 18 years of age, it has been suggested that people with pediatric-onset MS (POMS) are protected against disability because of greater capacity for repair. OBJECTIVE: To assess the incidence of and factors associated with progression independent of relapse activity (PIRA) and relapse-associated worsening (RAW) in POMS compared with typical adult-onset MS (AOMS) and late-onset MS (LOMS)...
November 27, 2023: JAMA Neurology
https://read.qxmd.com/read/38010709/when-pregnancy-becomes-an-inclusion-criterion-in-neuroscience-research
#6
JOURNAL ARTICLE
Amanda Tieu-Mi Huynh, Paula Emanuela Voinescu, Esther Bui
No abstract text is available yet for this article.
November 27, 2023: JAMA Neurology
https://read.qxmd.com/read/38010701/a-young-woman-with-hypertonia-severe-scoliosis-and-encephalopathy
#7
JOURNAL ARTICLE
Lei Hua, Yang Zhao, Yong-Shen Han
No abstract text is available yet for this article.
November 27, 2023: JAMA Neurology
https://read.qxmd.com/read/38010691/alberta-stroke-program-early-computed-tomography-score-infarct-core-volume-and-endovascular-therapy-outcomes-in-patients-with-large-infarct-a-secondary-analysis-of-the-angel-aspect-trial
#8
JOURNAL ARTICLE
Dapeng Sun, Xu Guo, Thanh N Nguyen, Yuesong Pan, Gaoting Ma, Xu Tong, Raynald, Mengxing Wang, Ning Ma, Feng Gao, Dapeng Mo, Xiaochuan Huo, Zhongrong Miao
IMPORTANCE: Endovascular therapy (EVT) demonstrated better outcomes compared with medical management in recent randomized clinical trials (RCTs) of patients with large infarct. OBJECTIVE: To compare outcomes of EVT vs medical management across different strata of the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and infarct core volume in patients with large infarct. DESIGN, SETTING, AND PARTICIPANTS: This prespecified secondary analysis of subgroups of the Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients With a Large Infarct Core (ANGEL-ASPECT) RCT included patients from 46 stroke centers across China between October 2, 2020, and May 18, 2022...
November 27, 2023: JAMA Neurology
https://read.qxmd.com/read/38010690/potential-medicare-and-medicaid-savings-on-anti-cd20-therapy-for-multiple-sclerosis
#9
JOURNAL ARTICLE
John Kim, Aaron S Kesselheim, Riley Bove, Jerry Avorn, Benjamin N Rome
No abstract text is available yet for this article.
November 27, 2023: JAMA Neurology
https://read.qxmd.com/read/37983058/behavioral-outcomes-and-neurodevelopmental-disorders-among-children-of-women-with-epilepsy
#10
JOURNAL ARTICLE
Morris J Cohen, Kimford J Meador, David W Loring, Abigail G Matthews, Carrie Brown, Chelsea P Robalino, Angela K Birnbaum, Paula E Voinescu, Laura A Kalayjian, Elizabeth E Gerard, Evan R Gedzelman, Julie Hanna, Jennifer Cavitt, Maria C Sam, Jacqueline A French, Sean T Hwang, Alison M Pack, Page B Pennell
IMPORTANCE: The association of fetal exposure to antiseizure medications (ASMs) with outcomes in childhood are not well delineated. OBJECTIVE: To examine the association of fetal ASM exposure with subsequent adaptive, behavioral or emotional, and neurodevelopmental disorder outcomes at 2, 3, and 4.5 years of age. DESIGN, SETTING, AND PARTICIPANTS: The Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) study is a prospective, observational cohort study conducted at 20 epilepsy centers in the US...
November 20, 2023: JAMA Neurology
https://read.qxmd.com/read/37983053/comparative-efficacy-of-disease-modifying-treatments-for-relapsing-multiple-sclerosis-variations-in-real-world-experience-reply
#11
JOURNAL ARTICLE
Izanne Roos, Tomas Kalincik
No abstract text is available yet for this article.
November 20, 2023: JAMA Neurology
https://read.qxmd.com/read/37983046/holding-onto-our-hats-a-hmong-medical-student-s-reflection
#12
JOURNAL ARTICLE
Viangkaeo Lee
No abstract text is available yet for this article.
November 20, 2023: JAMA Neurology
https://read.qxmd.com/read/37983040/reversible-cortical-and-basal-ganglia-lesions-in-late-onset-methylmalonic-aciduria
#13
JOURNAL ARTICLE
Xujun Chu, Haotian Yan, Meng Yu
No abstract text is available yet for this article.
November 20, 2023: JAMA Neurology
https://read.qxmd.com/read/37983039/comparative-efficacy-of-disease-modifying-treatments-for-relapsing-multiple-sclerosis-variations-in-real-world-experience
#14
JOURNAL ARTICLE
Andrew B Wolf, Enrique Alvarez, John R Corboy
No abstract text is available yet for this article.
November 20, 2023: JAMA Neurology
https://read.qxmd.com/read/37983023/streamlining-prior-authorization-to-improve-care
#15
JOURNAL ARTICLE
Neil A Busis, Babar Khokhar, Brian C Callaghan
No abstract text is available yet for this article.
November 20, 2023: JAMA Neurology
https://read.qxmd.com/read/37955923/patient-and-family-outcomes-of-community-neurologist-palliative-education-and-telehealth-support-in-parkinson-disease
#16
JOURNAL ARTICLE
Benzi M Kluger, Maya Katz, Nicholas B Galifianakis, Steven Z Pantilat, Joshua M Hauser, Ryan Khan, Cari Friedman, Christina L Vaughan, Yuika Goto, S Judith Long, Christine S Martin, Megan Dini, R Brett McQueen, Laura Palmer, Diane Fairclough, Lauren C Seeberger, Stefan H Sillau, Jean S Kutner
IMPORTANCE: Parkinson disease and related disorders (PDRD) are the fastest growing neurodegenerative illness in terms of prevalence and mortality. As evidence builds to support palliative care (PC) for PDRD, studies are needed to guide implementation. OBJECTIVE: To determine whether PC training for neurologists and remote access to a PC team improves outcomes in patients with PDRD in community settings. DESIGN, SETTING, AND PARTICIPANTS: This pragmatic, stepped-wedge comparative effectiveness trial enrolled and observed participants from 19 community neurology practices supported by PC teams at 2 academic centers from March 8, 2017, to December 31, 2020...
November 13, 2023: JAMA Neurology
https://read.qxmd.com/read/37955917/risk-of-suicidal-ideation-and-behavior-in-individuals-with-parkinson-disease-a-systematic-review-and-meta-analysis
#17
JOURNAL ARTICLE
Aaron Shengting Mai, Yinxia Chao, Bin Xiao, Zhidong Zhou, Jung Hahn Yong, Ainsley Ryan Yan Bin Lee, Eng-King Tan
IMPORTANCE: Suicide risk may be increased in patients with Parkinson disease (PD), a common neurodegenerative condition. Mood disorders, especially depression, are prevalent in patients with PD who report suicidality. OBJECTIVE: To address inconsistent results from studies of suicidal ideation and behavior in patients with PD. DATA SOURCES: The study team searched MEDLINE and Embase from inception to June 14, 2023, and further screened the bibliographies of relevant studies to ensure a comprehensive search...
November 13, 2023: JAMA Neurology
https://read.qxmd.com/read/37955912/multimodal-neuroimaging-reveals-and-guides-treatment-of-a-middle-cerebral-artery-web
#18
JOURNAL ARTICLE
Meng Zuo, Wei Chen, Zhenhua Zhou
No abstract text is available yet for this article.
November 13, 2023: JAMA Neurology
https://read.qxmd.com/read/37955904/error-in-figure-2b
#19
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 13, 2023: JAMA Neurology
https://read.qxmd.com/read/37930705/apoe-genotype-and-alzheimer-disease-risk-across-age-sex-and-population-ancestry
#20
JOURNAL ARTICLE
Michael E Belloy, Shea J Andrews, Yann Le Guen, Michael Cuccaro, Lindsay A Farrer, Valerio Napolioni, Michael D Greicius
IMPORTANCE: Apolipoprotein E (APOE)*2 and APOE*4 are, respectively, the strongest protective and risk-increasing, common genetic variants for late-onset Alzheimer disease (AD), making APOE status highly relevant toward clinical trial design and AD research broadly. The associations of APOE genotypes with AD are modulated by age, sex, race and ethnicity, and ancestry, but these associations remain unclear, particularly among racial and ethnic groups understudied in the AD and genetics research fields...
November 6, 2023: JAMA Neurology
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