journal

JAMA Neurology

journal
https://read.qxmd.com/read/31930374/ambroxol-for-the-treatment-of-patients-with-parkinson-disease-with-and-without-glucocerebrosidase-gene-mutations-a-nonrandomized-noncontrolled-trial
#1
Stephen Mullin, Laura Smith, Katherine Lee, Gayle D'Souza, Philip Woodgate, Josh Elflein, Jenny Hällqvist, Marco Toffoli, Adam Streeter, Joanne Hosking, Wendy E Heywood, Rajeshree Khengar, Philip Campbell, Jason Hehir, Sarah Cable, Kevin Mills, Henrik Zetterberg, Patricia Limousin, Vincenzo Libri, Tom Foltynie, Anthony H V Schapira
Importance: Mutations of the glucocerebrosidase gene, GBA1 (OMIM 606463), are the most important risk factor for Parkinson disease (PD). In vitro and in vivo studies have reported that ambroxol increases β-glucocerebrosidase (GCase) enzyme activity and reduces α-synuclein levels. These observations support a potential role for ambroxol therapy in modifying a relevant pathogenetic pathway in PD. Objective: To assess safety, tolerability, cerebrospinal fluid (CSF) penetration, and target engagement of ambroxol therapy with GCase in patients with PD with and without GBA1 mutations...
January 13, 2020: JAMA Neurology
https://read.qxmd.com/read/31930373/overcoming-neurophobia-with-the-help-of-peruvian-talking-bears
#2
Brian Dewar, Gregory S Day, Michel C F Shamy
No abstract text is available yet for this article.
January 13, 2020: JAMA Neurology
https://read.qxmd.com/read/31930364/safety-and-efficacy-of-rimabotulinumtoxinb-for-treatment-of-sialorrhea-in-adults-a-randomized-clinical-trial
#3
Stuart H Isaacson, William Ondo, Carlayne E Jackson, Richard M Trosch, Eric Molho, Fernando Pagan, Mark Lew, Khashayar Dashtipour, Thomas Clinch, Alberto J Espay
Importance: RimabotulinumtoxinB (RIMA) may be preferable as an anti-sialorrhea treatment compared with current oral anticholinergic drugs in people with neurological disorders. Objective: To assess the safety, efficacy, and tolerability of RIMA injections for the treatment of sialorrhea in adults. Design, Setting, and Participants: This randomized, parallel, double-blind, placebo-controlled clinical trial of RIMA 2500 U and 3500 U was conducted from November 14, 2013, to January 23, 2017...
January 13, 2020: JAMA Neurology
https://read.qxmd.com/read/31930362/assessment-of-the-validity-of-the-2helps2b-score-for-inpatient-seizure-risk-prediction
#4
Aaron F Struck, Mohammad Tabaeizadeh Fesharaki, Sarah E Schmitt, Andres Rodriguez Ruiz, Christa B Swisher, Thanujaa Subramaniam, Christian Hernandez, Safa Kaleem, Hiba A Haider, Abbas Fodé Cissé, Monica B Dhakar, Lawrence J Hirsch, Eric S Rosenthal, Sahar F Zafar, Nicholas Gaspard, M Brandon Westover
Importance: Seizure risk stratification is needed to boost inpatient seizure detection and to improve continuous electroencephalogram (cEEG) cost-effectiveness. 2HELPS2B can address this need but requires validation. Objective: To use an independent cohort to validate the 2HELPS2B score and develop a practical guide for its use. Design, Setting, and Participants: This multicenter retrospective medical record review analyzed clinical and EEG data from patients 18 years or older with a clinical indication for cEEG and an EEG duration of 12 hours or longer who were receiving consecutive cEEG at 6 centers from January 2012 to January 2019...
January 13, 2020: JAMA Neurology
https://read.qxmd.com/read/31930354/error-in-results
#5
(no author information available yet)
No abstract text is available yet for this article.
January 13, 2020: JAMA Neurology
https://read.qxmd.com/read/31904807/best-of-jama-neurology-2019-research-that-drives-practice
#6
Hooman Kamel, Dena B Dubal
No abstract text is available yet for this article.
January 6, 2020: JAMA Neurology
https://read.qxmd.com/read/31904795/missing-funding-information-in-funding-support
#7
(no author information available yet)
No abstract text is available yet for this article.
January 6, 2020: JAMA Neurology
https://read.qxmd.com/read/31904767/association-of-neighborhood-level-disadvantage-with-cerebral-and-hippocampal-volume
#8
Jack F V Hunt, William Buckingham, Alice J Kim, Jennifer Oh, Nicholas M Vogt, Erin M Jonaitis, Tenah K Hunt, Megan Zuelsdorff, Ryan Powell, Derek Norton, Robert A Rissman, Sanjay Asthana, Ozioma C Okonkwo, Sterling C Johnson, Amy J H Kind, Barbara B Bendlin
Importance: Identifying risk factors for brain atrophy during the aging process can help direct new preventive approaches for dementia and cognitive decline. The association of neighborhood socioeconomic disadvantage with brain volume in this context is not well known. Objective: To test whether neighborhood-level socioeconomic disadvantage is associated with decreased brain volume in a cognitively unimpaired population enriched for Alzheimer disease risk. Design, Setting, and Participants: This study, conducted from January 6, 2010, to January 17, 2019, at an academic research neuroimaging center, used cross-sectional data on 951 participants from 2 large, ongoing cohort studies of Alzheimer disease (Wisconsin Registry for Alzheimer's Prevention and Wisconsin Alzheimer's Disease Research Center clinical cohort)...
January 6, 2020: JAMA Neurology
https://read.qxmd.com/read/31904765/tau-positron-emission-tomographic-findings-in-a-former-us-football-player-with-pathologically-confirmed-chronic-traumatic-encephalopathy
#9
William G Mantyh, Salvatore Spina, Alex Lee, Leonardo Iaccarino, David Soleimani-Meigooni, Elena Tsoy, Taylor J Mellinger, Harli Grant, Lawren Vandevrede, Renaud La Joie, Orit Lesman-Segev, Stephanie Gaus, Katherine L Possin, Lea T Grinberg, Bruce L Miller, William W Seeley, Gil D Rabinovici
Importance: Biomarkers for chronic traumatic encephalopathy (CTE) are currently lacking. The radiotracer fluorine F 18-labeled (18F)-flortaucipir (FTP) detects tau pathology in Alzheimer disease, and positron emission tomography (PET) with FTP shows elevated binding in individuals at risk for CTE. No study, however, has assessed the correlation between in vivo FTP PET and postmortem tau in CTE. Objective: To assess the regional association between in vivo FTP binding and postmortem tau pathology in a patient with pathologically confirmed CTE...
January 6, 2020: JAMA Neurology
https://read.qxmd.com/read/31904763/association-of-time-since-injury-to-the-first-clinic-visit-with-recovery-following-concussion
#10
Anthony P Kontos, Kendra Jorgensen-Wagers, Alicia M Trbovich, Nathan Ernst, Kouros Emami, Brandon Gillie, Jonathan French, Cyndi Holland, R J Elbin, Michael W Collins
Importance: Recovery after concussion varies, with adolescents taking longer (approximately 30 days) than adults. Many factors have been reported to influence recovery, including preinjury factors, perceptions about recovery, comorbid conditions, and sex. However, 1 factor that may play a role in recovery but has received little attention from researchers is the timeliness of clinical evaluation and care. Objective: To investigate the association of time since injury with initiation of clinical care on recovery time following concussion...
January 6, 2020: JAMA Neurology
https://read.qxmd.com/read/31886870/prognostic-value-of-spreading-depolarizations-in-patients-with-severe-traumatic-brain-injury
#11
Jed A Hartings, Norberto Andaluz, M Ross Bullock, Jason M Hinzman, Bruce Mathern, Clemens Pahl, Ava Puccio, Lori A Shutter, Anthony J Strong, Achala Vagal, J Adam Wilson, Jens P Dreier, Laura B Ngwenya, Brandon Foreman, Laura Pahren, Hester Lingsma, David O Okonkwo
Importance: Advances in treatment of traumatic brain injury are hindered by the inability to monitor pathological mechanisms in individual patients for targeted neuroprotective treatment. Spreading depolarizations, a mechanism of lesion development in animal models, are a novel candidate for clinical monitoring in patients with brain trauma who need surgery. Objective: To test the null hypothesis that spreading depolarizations are not associated with worse neurologic outcomes...
December 30, 2019: JAMA Neurology
https://read.qxmd.com/read/31886839/development-and-validation-of-the-rasch-built-overall-amyotrophic-lateral-sclerosis-disability-scale-roads
#12
Christina N Fournier, Richard Bedlack, Colin Quinn, James Russell, Diane Beckwith, Kathleen H Kaminski, William Tyor, Vicki Hertzberg, Virginia James, Meraida Polak, Jonathan D Glass
Importance: A new outcome measure for overall disability level with improved responsiveness is needed for amyotrophic lateral sclerosis (ALS) clinical trials. Objective: To describe the creation and development of a new self-reported ALS disability scale with improved item targeting and psychometric properties that used a mathematically rigorous Rasch methodology. Design, Setting, and Participants: A preliminary ALS disability questionnaire with 119 questions was created based on literature review, clinical judgement of an expert panel, and patient input...
December 30, 2019: JAMA Neurology
https://read.qxmd.com/read/31886830/the-term-mild-in-mild-traumatic-surgery-and-the-representation-of-outcomes-reply
#13
Lindsay D Nelson, Harvey S Levin, Michael A McCrea
No abstract text is available yet for this article.
December 30, 2019: JAMA Neurology
https://read.qxmd.com/read/31886825/antiepileptic-drug-exposure-in-infants-of-breastfeeding-mothers-with-epilepsy
#14
Angela K Birnbaum, Kimford J Meador, Ashwin Karanam, Carrie Brown, Ryan C May, Elizabeth E Gerard, Evan R Gedzelman, Patricia E Penovich, Laura A Kalayjian, Jennifer Cavitt, Alison M Pack, John W Miller, Zachary N Stowe, Page B Pennell
Importance: There is limited information on infant drug exposure via breastfeeding by mothers who are receiving antiepileptic drug therapy. Objective: To provide direct, objective information on antiepileptic drug exposure through breast milk. Design, Setting, and Participants: This prospective cohort study was conducted between December 2012 to October 2016, with follow-up in children until 6 years of age at 20 sites across the United States...
December 30, 2019: JAMA Neurology
https://read.qxmd.com/read/31886821/the-term-mild-in-mild-traumatic-surgery-and-the-representation-of-outcomes
#15
Jim Andrikopoulos
No abstract text is available yet for this article.
December 30, 2019: JAMA Neurology
https://read.qxmd.com/read/31860019/error-in-results
#16
(no author information available yet)
No abstract text is available yet for this article.
December 20, 2019: JAMA Neurology
https://read.qxmd.com/read/31860018/association-of-cognitive-and-behavioral-features-between-adults-with-tuberous-sclerosis-and-frontotemporal-dementia
#17
Andy J Liu, Adam M Staffaroni, Julio C Rojas-Martinez, Nicholas T Olney, Carolina Alquezar-Burillo, Peter A Ljubenkov, Renaud La Joie, Jamie C Fong, Joanne Taylor, Anna Karydas, Eliana Marisa Ramos, Giovanni Coppola, Adam L Boxer, Gil D Rabinovici, Bruce L Miller, Aimee W Kao
Importance: Individuals with tuberous sclerosis complex can develop a progressive neuropsychiatric syndrome known as tuberous sclerosis-associated neuropsychiatric disorders. Tuberous sclerosis-associated neuropsychiatric disorders symptoms overlap with clinical criteria for frontotemporal dementia, yet the association between the 2 has not been explored. Objective: To investigate the potential association between tuberous sclerosis-associated neuropsychiatric disorders and frontotemporal dementia...
December 20, 2019: JAMA Neurology
https://read.qxmd.com/read/31860013/crmp5-igg-associated-paraneoplastic-myelopathy-with-pd-l1-inhibitor-therapy
#18
Amy Kunchok, Anastasia Zekeridou, Sean Pittock
No abstract text is available yet for this article.
December 20, 2019: JAMA Neurology
https://read.qxmd.com/read/31860007/diagnosis-across-the-spectrum-of-progressive-supranuclear-palsy-and-corticobasal-syndrome
#19
Edwin Jabbari, Negin Holland, Viorica Chelban, P Simon Jones, Ruth Lamb, Charlotte Rawlinson, Tong Guo, Alyssa A Costantini, Manuela M X Tan, Amanda J Heslegrave, Federico Roncaroli, Johannes C Klein, Olaf Ansorge, Kieren S J Allinson, Zane Jaunmuktane, Janice L Holton, Tamas Revesz, Thomas T Warner, Andrew J Lees, Henrik Zetterberg, Lucy L Russell, Martina Bocchetta, Jonathan D Rohrer, Nigel M Williams, Donald G Grosset, David J Burn, Nicola Pavese, Alexander Gerhard, Christopher Kobylecki, P Nigel Leigh, Alistair Church, Michele T M Hu, John Woodside, Henry Houlden, James B Rowe, Huw R Morris
Importance: Atypical parkinsonian syndromes (APS), including progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), may be difficult to distinguish in early stages and are often misdiagnosed as Parkinson disease (PD). The diagnostic criteria for PSP have been updated to encompass a range of clinical subtypes but have not been prospectively studied. Objective: To define the distinguishing features of PSP and CBS subtypes and to assess their usefulness in facilitating early diagnosis and separation from PD...
December 20, 2019: JAMA Neurology
https://read.qxmd.com/read/31860001/association-of-intracranial-atherosclerotic-disease-with-brain-%C3%AE-amyloid-deposition-secondary-analysis-of-the-aric-study
#20
Rebecca F Gottesman, Thomas H Mosley, David S Knopman, Qing Hao, Dean Wong, Lynne E Wagenknecht, Timothy M Hughes, Ye Qiao, Jennifer Dearborn, Bruce A Wasserman
Importance: Intracranial atherosclerotic disease (ICAD) is an important cause of stroke and has also been recently identified as an important risk factor for all-cause dementia, but the mechanism of its association with cognitive performance is not fully understood. Objective: To test the hypothesis that ICAD is associated with cerebral β-amyloid deposition as a marker of Alzheimer disease. Design, Setting, and Participants: This cross-sectional analysis of data collected from August 2011 through November 2014 was a community-based cohort study conducted in 3 US communities...
December 20, 2019: JAMA Neurology
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