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JOURNAL ARTICLE
Naomi Kouri, Isabelle Frankenhauser, Zhongwei Peng, Sydney A Labuzan, Baayla D C Boon, Christina M Moloney, Cyril Pottier, Daniel P Wickland, Kelsey Caetano-Anolles, Nick Corriveau-Lecavalier, Jessica F Tranovich, Ashley C Wood, Kelly M Hinkle, Sarah J Lincoln, A J Spychalla, Matthew L Senjem, Scott A Przybelski, Erica Engelberg-Cook, Christopher G Schwarz, Rain S Kwan, Elizabeth R Lesser, Julia E Crook, Rickey E Carter, Owen A Ross, Christian Lachner, Nilüfer Ertekin-Taner, Tanis J Ferman, Julie A Fields, Mary M Machulda, Vijay K Ramanan, Aivi T Nguyen, R Ross Reichard, David T Jones, Jonathan Graff-Radford, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jack, Kejal Kantarci, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Dennis W Dickson, Val J Lowe, Prashanthi Vemuri, Melissa E Murray
IMPORTANCE: Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay along a continuum hypothesized to associate with tangle distribution and are relevant for understanding glial activation considerations in therapeutic advancement. OBJECTIVES: To examine clinicopathologic and neuroimaging characteristics of disease heterogeneity in AD along a quantitative continuum using the corticolimbic index (CLix) to account for individuality of spatially distributed tangles found at autopsy...
April 15, 2024: JAMA Neurology
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JOURNAL ARTICLE
Murva Asad, Arpan R Mehta, Dermot Mallon
No abstract text is available yet for this article.
April 15, 2024: JAMA Neurology
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JOURNAL ARTICLE
Frederick Thomas Gibson
No abstract text is available yet for this article.
April 15, 2024: JAMA Neurology
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JOURNAL ARTICLE
James E Siegler, Luciano A Sposato, Shadi Yaghi
No abstract text is available yet for this article.
April 8, 2024: JAMA Neurology
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JOURNAL ARTICLE
Matthew Pease, Adi Mittal, Sara Merkaj, David O Okonkwo, Jorge A Gonzalez-Martinez, Jonathan Elmer, Wen-Shyong Liou, Valeria Pingue, Flora M Hammond, Sergiu Abramovici, James Castellano, Niravkumar Barot
IMPORTANCE: Guidelines recommend seizure prophylaxis for early posttraumatic seizures (PTS) after severe traumatic brain injury (TBI). Use of antiseizure medications for early seizure prophylaxis after mild or moderate TBI remains controversial. OBJECTIVE: To determine the association between seizure prophylaxis and risk reduction for early PTS in mild and moderate TBI. DATA SOURCES: PubMed, Google Scholar, and Web of Science (January 1, 1991, to April 18, 2023) were systematically searched...
April 8, 2024: JAMA Neurology
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JOURNAL ARTICLE
Sara Habib, Haroon Butt, Shira R Goldenholz, Chi Yuan Chang, Daniel M Goldenholz
No abstract text is available yet for this article.
April 8, 2024: JAMA Neurology
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JOURNAL ARTICLE
Jeffrey Cummings, Krista Lanctot, George Grossberg, Clive Ballard
IMPORTANCE: Neuropsychiatric syndromes (NPSs) are common in neurodegenerative disorders (NDDs); compromise the quality of life of patients and their care partners; and are associated with faster disease progression, earlier need for nursing home care, and poorer quality of life. Advances in translational pharmacology, clinical trial design and conduct, and understanding of the pathobiology of NDDs are bringing new therapies to clinical care. OBSERVATIONS: Consensus definitions have evolved for psychosis, agitation, apathy, depression, and disinhibition in NDDs...
April 1, 2024: JAMA Neurology
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JOURNAL ARTICLE
Matthew Spotnitz, Cameron D Ekanayake, Anna Ostropolets, Guy M McKhann, Hyunmi Choi, Ruth Ottman, Alfred I Neugut, George Hripcsak, Karthik Natarajan, Brett E Youngerman
IMPORTANCE: Interdisciplinary practice parameters recommend that patients with drug-resistant epilepsy (DRE) undergo comprehensive neurodiagnostic evaluation, including presurgical assessment. Reporting from specialized centers suggests long delays to referral and underuse of surgery; however, longitudinal data are limited to characterize neurodiagnostic evaluation among patients with DRE in more diverse US settings and populations. OBJECTIVE: To examine the rate and factors associated with neurodiagnostic studies and comprehensive evaluation among patients with DRE within 3 US cohorts...
April 1, 2024: JAMA Neurology
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JOURNAL ARTICLE
Yufei Chen, Cuibai Wei
No abstract text is available yet for this article.
April 1, 2024: JAMA Neurology
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JOURNAL ARTICLE
Charles DeCarli, Pauline Maillard, Matthew P Pase, Alexa S Beiser, Daniel Kojis, Claudia L Satizabal, Jayandra J Himali, Hugo J Aparicio, Evan Fletcher, Sudha Seshadri
IMPORTANCE: Human brain development and maintenance is under both genetic and environmental influences that likely affect later-life dementia risk. OBJECTIVE: To examine environmental influences by testing whether time-dependent secular differences occurred in cranial and brain volumes and cortical thickness over birth decades spanning 1930 to 1970. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used data from the community-based Framingham Heart Study cohort for participants born in the decades 1930 to 1970...
March 25, 2024: JAMA Neurology
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JOURNAL ARTICLE
Sebastian Küchlin, Gabriele Ihorst, Sven P Heinrich, Pablo Márquez Neila, Philipp Albrecht, Martin J Hug, Wolf A Lagrèze
No abstract text is available yet for this article.
March 25, 2024: JAMA Neurology
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JOURNAL ARTICLE
Guillaume Jouvenot, Guilhem Courbon, Mathilde Lefort, Fabien Rollot, Romain Casey, Emmanuelle Le Page, Laure Michel, Gilles Edan, Jérome de Seze, Laurent Kremer, Kevin Bigaut, Sandra Vukusic, Guillaume Mathey, Jonathan Ciron, Aurélie Ruet, Elisabeth Maillart, Pierre Labauge, Hélène Zephir, Caroline Papeix, Gilles Defer, Christine Lebrun-Frenay, Thibault Moreau, David Axel Laplaud, Eric Berger, Bruno Stankoff, Pierre Clavelou, Eric Thouvenot, Olivier Heinzlef, Jean Pelletier, Abdullatif Al-Khedr, Olivier Casez, Bertrand Bourre, Philippe Cabre, Abir Wahab, Laurent Magy, Jean-Philippe Camdessanché, Ines Doghri, Solène Moulin, Haifa Ben-Nasr, Céline Labeyrie, Karolina Hankiewicz, Jean-Philippe Neau, Corinne Pottier, Chantal Nifle, Nicolas Collongues, Anne Kerbrat
IMPORTANCE: A recent randomized clinical trial concluded that discontinuing medium-efficacy therapy might be a reasonable option for older patients with nonactive multiple sclerosis (MS), but there is a lack of data on discontinuing high-efficacy therapy (HET). In younger patients, the discontinuation of natalizumab and fingolimod is associated with a risk of rebound of disease activity. OBJECTIVE: To determine whether discontinuing HET in patients 50 years and older with nonactive MS is associated with an increased risk of relapse compared with continuing HET...
March 25, 2024: JAMA Neurology
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JOURNAL ARTICLE
Patricia Pozo-Rosich, David Dolezil, Koen Paemeleire, Adam Stepien, Philipp Stude, Josefin Snellman, Michal Arkuszewski, Tracy Stites, Shannon Ritter, Cristina Lopez Lopez, Jeff Maca, Matias Ferraris, Raquel Gil-Gouveia
IMPORTANCE: Patients with migraine often cycle through multiple nonspecific preventive medications due to poor tolerability and/or inadequate efficacy leading to low adherence and increased disease burden. OBJECTIVE: To compare the efficacy, tolerability, patient adherence, and patient satisfaction between erenumab and nonspecific oral migraine preventive medications (OMPMs) in patients with episodic migraine (EM) who had previously failed 1 or 2 preventive treatments...
March 25, 2024: JAMA Neurology
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JOURNAL ARTICLE
Prashanthi Vemuri
No abstract text is available yet for this article.
March 25, 2024: JAMA Neurology
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JOURNAL ARTICLE
He Li, Zhizong Lai, Wei Tang
No abstract text is available yet for this article.
March 25, 2024: JAMA Neurology
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JOURNAL ARTICLE
Cathy Meng Fei Li, Matthew McShane, John Alexander Fraser
No abstract text is available yet for this article.
March 18, 2024: JAMA Neurology
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JOURNAL ARTICLE
S Andrew Josephson
No abstract text is available yet for this article.
March 18, 2024: JAMA Neurology
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JOURNAL ARTICLE
Dina Battino, Torbjörn Tomson, Erminio Bonizzoni, John Craig, Emilio Perucca, Anne Sabers, Sanjeev Thomas, Silje Alvestad, Piero Perucca, Frank Vajda
IMPORTANCE: Women with epilepsy (WWE) require treatment with antiseizure medications (ASMs) during pregnancy, which may be associated with an increased risk of major congenital malformations (MCMs) in their offspring. OBJECTIVE: To investigate the prevalence of MCMs after prenatal exposure to 8 commonly used ASM monotherapies and changes in MCM prevalence over time. DESIGN, SETTING, AND PARTICIPANTS: This was a prospective, observational, longitudinal cohort study conducted from June 1999 to October 2022...
March 18, 2024: JAMA Neurology
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JOURNAL ARTICLE
Mark J Kelly, Eleanor Grant, Andrew G Murchison, Sophie Binks, Sudarshini Ramanathan, Sophia Michael, Adam E Handel, Lahiru Handunnetthi, Christopher E Uy, John N Soltys, Divyanshu Dubey, Gregory S Day, A Sebastian Lopez-Chiriboga, Eoin P Flanagan, Fintan Sheerin, Sarosh R Irani
IMPORTANCE: Rapid and accurate diagnosis of autoimmune encephalitis encourages prompt initiation of immunotherapy toward improved patient outcomes. However, clinical features alone may not sufficiently narrow the differential diagnosis, and awaiting autoantibody results can delay immunotherapy. OBJECTIVE: To identify simple magnetic resonance imaging (MRI) characteristics that accurately distinguish 2 common forms of autoimmune encephalitis, LGI1- and CASPR2-antibody encephalitis (LGI1/CASPR2-Ab-E), from 2 major differential diagnoses, viral encephalitis (VE) and Creutzfeldt-Jakob disease (CJD)...
March 18, 2024: JAMA Neurology
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JOURNAL ARTICLE
Yang Su, Minjin Wang
No abstract text is available yet for this article.
March 18, 2024: JAMA Neurology
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