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Pierre Seners, Wagih Ben Hassen, Bertrand Lapergue, Caroline Arquizan, Mirjam R Heldner, Hilde Henon, Claire Perrin, Davide Strambo, Jean-Philippe Cottier, Denis Sablot, Isabelle Girard Buttaz, Ruben Tamazyan, Cécile Preterre, Pierre Agius, Nadia Laksiri, Laura Mechtouff, Yannick Béjot, Duc-Long Duong, François Mounier-Vehier, Gioia Mione, Charlotte Rosso, Ludovic Lucas, Jérémie Papassin, Andreea Aignatoaie, Aude Triquenot, Emmanuel Carrera, Philippe Niclot, Alexandre Obadia, Aïcha Lyoubi, Pierre Garnier, Nicolae Crainic, Valérie Wolff, Clément Tracol, Frédéric Philippeau, Chantal Lamy, Sébastien Soize, Jean-Claude Baron, Guillaume Turc
Importance: The best reperfusion strategy in patients with acute minor stroke and large vessel occlusion (LVO) is unknown. Accurately predicting early neurological deterioration of presumed ischemic origin (ENDi) following intravenous thrombolysis (IVT) in this population may help to select candidates for immediate transfer for additional thrombectomy. Objective: To develop and validate an easily applicable predictive score of ENDi following IVT in patients with minor stroke and LVO...
January 11, 2021: JAMA Neurology
#2
Alexis Moscoso, Michel J Grothe, Nicholas J Ashton, Thomas K Karikari, Juan Lantero Rodríguez, Anniina Snellman, Marc Suárez-Calvet, Kaj Blennow, Henrik Zetterberg, Michael Schöll
Importance: Plasma phosphorylated tau at threonine 181 (p-tau181) has been proposed as an easily accessible biomarker for the detection of Alzheimer disease (AD) pathology, but its ability to monitor disease progression in AD remains unclear. Objective: To study the potential of longitudinal plasma p-tau181 measures for assessing neurodegeneration progression and cognitive decline in AD in comparison to plasma neurofilament light chain (NfL), a disease-nonspecific marker of neuronal injury...
January 11, 2021: JAMA Neurology
#3
Daniele Mandia, Natalia Shor, Jean-François Benoist, Yann Nadjar
Importance: Vitamin-responsive inherited diseases are among the rare genetic disorders with a specific pharmacological treatment. Many of these conditions have a prominent neurological phenotype that is mainly reported in children. Being rare and often strikingly different in adult-onset forms, they are still poorly known in the medical fields specific to adults. Observation: This article reviews all articles reporting cases of patients with a genetically confirmed inherited vitamin-responsive neurological disease and neurological onset after the age of 10 years...
January 11, 2021: JAMA Neurology
#4
Emily A Largent, Anna Wexler, Jason Karlawish
No abstract text is available yet for this article.
January 4, 2021: JAMA Neurology
#5
Ermelinda De Meo, Emilio Portaccio, Antonio Giorgio, Luis Ruano, Benedetta Goretti, Claudia Niccolai, Francesco Patti, Clara Grazia Chisari, Paolo Gallo, Paola Grossi, Angelo Ghezzi, Marco Roscio, Flavia Mattioli, Chiara Stampatori, Marta Simone, Rosa Gemma Viterbo, Raffaello Bonacchi, Maria A Rocca, Nicola De Stefano, Massimo Filippi, Maria Pia Amato
Importance: Cognitive impairment is a common and disabling feature of multiple sclerosis (MS), but a precise characterization of cognitive phenotypes in patients with MS is lacking. Objectives: To identify cognitive phenotypes in a clinical cohort of patients with MS and to characterize their clinical and magnetic resonance imaging (MRI) features. Design, Setting, and Participants: This multicenter cross-sectional study consecutively screened clinically stable patients with MS and healthy control individuals at 8 MS centers in Italy from January 1, 2010, to October 31, 2019...
January 4, 2021: JAMA Neurology
#6
Linda D'Antona, Melida Andrea Jaime Merchan, Anna Vassiliou, Laurence Dale Watkins, Indran Davagnanam, Ahmed Kassem Toma, Manjit Singh Matharu
Importance: Spontaneous intracranial hypotension (SIH) is a highly disabling but often misdiagnosed disorder. The best management options for patients with SIH are still uncertain. Objective: To provide an objective summary of the available evidence on the clinical presentation, investigations findings, and treatment outcomes for SIH. Data Sources: Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline-compliant systematic review and meta-analysis of the literature on SIH...
January 4, 2021: JAMA Neurology
#7
Rafid Mustafa, Bryan J Neth, Derek Stitt
No abstract text is available yet for this article.
December 28, 2020: JAMA Neurology
#8
Jillian M Berkman, Joseph A Rosenthal, Altaf Saadi
No abstract text is available yet for this article.
December 28, 2020: JAMA Neurology
#9
Linda R van Dillen, Vanessa M Lanier, Karen Steger-May, Michael Wallendorf, Barbara J Norton, Jesse M Civello, Sylvia L Czuppon, Sara J Francois, Kristen Roles, Catherine E Lang
Importance: Chronic low back pain (LBP) is the most prevalent chronic pain in adults, and there is no optimal nonpharmacologic management. Exercise is recommended, but no specific exercise-based treatment has been found to be most effective. Objective: To determine whether an exercise-based treatment of person-specific motor skill training (MST) in performance of functional activities is more effective in improving function than strength and flexibility exercise (SFE) immediately, 6 months, and 12 months following treatment...
December 28, 2020: JAMA Neurology
#10
Roopa Rajan, Achal K Srivastava, Reghu Anandapadmanabhan, Arti Saini, Ashish Upadhyay, Anu Gupta, Venugopalan Y Vishnu, Awadh K Pandit, Deepti Vibha, Mamta B Singh, Rohit Bhatia, Vinay Goyal, Sada Nand Dwivedi, Padma Srivastava, Kameshwar Prasad
Importance: There is an unmet need for safe and efficacious treatments for upper-extremity dystonic tremor (DT). To date, only uncontrolled retrospective case series have reported the effect of botulinum neurotoxin (BoNT) injections on upper-extremity DT. Objective: To assess the effect of BoNT injections on tremor in patients with upper-extremity DT. Design, Setting, and Participants: In this placebo-controlled, parallel-group randomized clinical trial, 30 adult patients with upper-extremity DT treated at a movement disorder clinic in a tertiary care university hospital were randomized in a 1:1 ratio to BoNT or saline injection, 0...
December 21, 2020: JAMA Neurology
#11
Elizabeth A Thiele, E Martina Bebin, Hari Bhathal, Floor E Jansen, Katarzyna Kotulska, John A Lawson, Finbar J O'Callaghan, Michael Wong, Farhad Sahebkar, Daniel Checketts, Volker Knappertz
Importance: Efficacy of cannabidiol has been demonstrated in seizures associated with Lennox-Gastaut and Dravet syndromes but appears not yet to have been established in conditions with primarily focal seizures, such as tuberous sclerosis complex (TSC). Objective: To evaluate efficacy and safety of 25-mg/kg/day and 50-mg/kg/day cannabidiol dosages vs placebo against seizures associated with TSC. Design, Setting, and Participants: This double-blind, placebo-controlled randomized clinical trial (GWPCARE6) enrolled patients between April 6, 2016, and October 4, 2018; follow-up was completed on February 15, 2019...
December 21, 2020: JAMA Neurology
#12
Mao Liu, Jing Zhang, Min Zhang
No abstract text is available yet for this article.
December 21, 2020: JAMA Neurology
#13
Katherine L Possin, Elena Tsoy, Charles C Windon
No abstract text is available yet for this article.
December 21, 2020: JAMA Neurology
#14
(no author information available yet)
No abstract text is available yet for this article.
December 21, 2020: JAMA Neurology
#15
Tanya Simuni, Brian Fiske, Kalpana Merchant, Christopher S Coffey, Elizabeth Klingner, Chelsea Caspell-Garcia, David-Erick Lafontant, Helen Matthews, Richard K Wyse, Patrik Brundin, David K Simon, Michael Schwarzschild, David Weiner, Jaime Adams, Charles Venuto, Ted M Dawson, Liana Baker, Melissa Kostrzebski, Tina Ward, Gary Rafaloff
Importance: There is a critical need for careful and independent validation of reported symptomatic efficacy and dopaminergic biomarker changes induced by nilotinib in Parkinson disease (PD). Objectives: To assess safety and tolerability of nilotinib in participants with moderately advanced PD. Secondary and exploratory objectives were to assess its affect on PD disability, pharmacokinetics, cerebrospinal fluid (CSF) penetration, and biomarkers. Design, Setting, and Participants: This was a 6-month, multicenter, randomized parallel-group, double-blind, placebo-controlled trial...
December 14, 2020: JAMA Neurology
#16
Massimo Filippi, Paolo Preziosa, Frederik Barkhof, Declan T Chard, Nicola De Stefano, Robert J Fox, Claudio Gasperini, Ludwig Kappos, Xavier Montalban, Bastiaan Moraal, Daniel S Reich, Àlex Rovira, Ahmed T Toosy, Anthony Traboulsee, Brian G Weinshenker, Burcu Zeydan, Brenda L Banwell, Maria A Rocca
Importance: Although magnetic resonance imaging (MRI) is useful for monitoring disease dissemination in space and over time and excluding multiple sclerosis (MS) mimics, there has been less application of MRI to progressive MS, including diagnosing primary progressive (PP) MS and identifying patients with relapsing-remitting (RR) MS who are at risk of developing secondary progressive (SP) MS. This review addresses clinical application of MRI for both diagnosis and prognosis of progressive MS...
December 14, 2020: JAMA Neurology
#17
Benzi M Kluger, Cynthia W Garvan, Robert G Holloway
No abstract text is available yet for this article.
December 7, 2020: JAMA Neurology
#18
Sebastiaan M Bossers, Stephan A Loer, Frank W Bloemers, Dennis Den Hartog, Esther M M Van Lieshout, Nico Hoogerwerf, Joukje van der Naalt, Anthony R Absalom, Saskia M Peerdeman, Lothar A Schwarte, Christa Boer, Patrick Schober
Importance: The development and expansion of intracranial hematoma are associated with adverse outcomes. Use of tranexamic acid might limit intracranial hematoma formation, but its association with outcomes of severe traumatic brain injury (TBI) is unclear. Objective: To assess whether prehospital administration of tranexamic acid is associated with mortality and functional outcomes in a group of patients with severe TBI. Design, Setting, and Participants: This multicenter cohort study is an analysis of prospectively collected observational data from the Brain Injury: Prehospital Registry of Outcome, Treatments and Epidemiology of Cerebral Trauma (BRAIN-PROTECT) study in the Netherlands...
December 7, 2020: JAMA Neurology
#19
Erik S Musiek, John C Morris
No abstract text is available yet for this article.
November 30, 2020: JAMA Neurology
#20
Carl V Hill
No abstract text is available yet for this article.
November 30, 2020: JAMA Neurology
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