Vincent Labbé, Damien Contou, Nicholas Heming, Bruno Megarbane, Keyvan Razazi, Florence Boissier, Hafid Ait-Oufella, Matthieu Turpin, Serge Carreira, Alexandre Robert, Mehran Monchi, Bertrand Souweine, Sebastien Preau, Denis Doyen, Emmanuel Vivier, Noémie Zucman, Martin Dres, Mohamed Fejjal, Elise Noel-Savina, Marwa Bachir, Karim Jaffal, Jean-François Timsit, Santiago Alberto Picos, Eric Mariotte, Nihal Martis, William Juguet, Giovanna Melica, Paul Rondeau, Etienne Audureau, Armand Mekontso Dessap
IMPORTANCE: Given the high risk of thrombosis and anticoagulation-related bleeding in patients with hypoxemic COVID-19 pneumonia, identifying the lowest effective dose of anticoagulation therapy for these patients is imperative. OBJECTIVES: To determine whether therapeutic anticoagulation (TA) or high-dose prophylactic anticoagulation (HD-PA) decreases mortality and/or disease duration compared with standard-dose prophylactic anticoagulation (SD-PA), and whether TA outperforms HD-PA; and to compare the net clinical outcomes among the 3 strategies...
March 22, 2023: JAMA Internal Medicine