journal

JAMA Internal Medicine

journal
https://read.qxmd.com/read/31930361/association-of-ticagrelor-vs-clopidogrel-with-major-adverse-coronary-events-in-patients-with-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention
#1
Ricky D Turgeon, Sheri L Koshman, Erik Youngson, Bryan Har, Stephen B Wilton, Matthew T James, Michelle M Graham
Importance: Guidelines currently recommend ticagrelor over clopidogrel for patients with acute coronary syndrome (ACS) based on randomized clinical trial data in which ticagrelor reduced major adverse coronary events (MACE) vs clopidogrel but increased bleeding and dyspnea. Objective: To compare the risk of MACE with ticagrelor vs clopidogrel in patients with ACS treated with percutaneous coronary intervention (PCI), to compare major bleeding and dyspnea, and to evaluate the association between P2Y12 inhibitor adherence and MACE...
January 13, 2020: JAMA Internal Medicine
https://read.qxmd.com/read/31930360/effectiveness-of-combined-behavioral-and-drug-therapy-for-overactive-bladder-symptoms-in-men-a-randomized-clinical-trial
#2
Kathryn L Burgio, Stephen R Kraus, Theodore M Johnson, Alayne D Markland, Camille P Vaughan, Peng Li, David T Redden, Patricia S Goode
Importance: First-line behavioral and drug therapies for overactive bladder (OAB) symptoms in men are effective but not usually curative. Objective: To determine whether combining behavioral and drug therapies improves outcomes compared with each therapy alone for OAB in men and to compare 3 sequences for implementing combined therapy. Design, Setting, and Participants: In this 3-site, 2-stage, 3-arm randomized clinical trial, participants were randomized to 6 weeks of behavioral therapy alone, drug therapy alone, or combined therapy followed by step-up to 6 weeks of combined therapy for all groups...
January 13, 2020: JAMA Internal Medicine
https://read.qxmd.com/read/31930357/assessment-of-cardiovascular-diagnostic-tests-and-procedures-offered-in-executive-screening-programs-at-top-ranked-cardiology-hospitals
#3
Alan Ge, David L Brown
No abstract text is available yet for this article.
January 13, 2020: JAMA Internal Medicine
https://read.qxmd.com/read/31930356/first-physical-reprised
#4
Rita F Redberg, Mitchell H Katz
No abstract text is available yet for this article.
January 13, 2020: JAMA Internal Medicine
https://read.qxmd.com/read/31930348/wide-qrs-complex-tachycardia-in-an-apparently-healthy-man
#5
Daniel Liauw, Anthony Dang, Laszlo Littmann
No abstract text is available yet for this article.
January 13, 2020: JAMA Internal Medicine
https://read.qxmd.com/read/31904844/unnecessary-bimanual-pelvic-examinations-and-papanicolaou-testing-in-adolescents-and-young-women-learning-how-to-unlearn
#6
Melissa A Simon
No abstract text is available yet for this article.
January 6, 2020: JAMA Internal Medicine
https://read.qxmd.com/read/31904796/professional-dissonance-and-burnout-in-primary-care-a-qualitative-study
#7
Sumit D Agarwal, Erika Pabo, Ronen Rozenblum, Karen M Sherritt
Importance: Burnout negatively affects physician health, productivity, and patient care. Its prevalence is high among physicians, especially those in primary care, yet few qualitative studies of burnout have been performed that engage frontline primary care practitioners (PCPs) for their perspectives. Objective: To identify factors contributing to burnout and low professional fulfillment, as well as potential solutions, by eliciting the views of PCPs. Design, Setting, and Participants: For this qualitative study, focus group discussions and interviews were conducted between February 1 and April 30, 2018, among 26 PCPs (physicians, nurse practitioners, and physician assistants) at a US academic medical center with a network of 15 primary care clinics...
January 6, 2020: JAMA Internal Medicine
https://read.qxmd.com/read/31904769/primary-care-practitioners-perspectives-on-burnout-and-what-to-do-about-it
#8
Richard W Grant, Lara Goitein
No abstract text is available yet for this article.
January 6, 2020: JAMA Internal Medicine
https://read.qxmd.com/read/31904768/prevalence-of-potentially-unnecessary-bimanual-pelvic-examinations-and-papanicolaou-tests-among-adolescent-girls-and-young-women-aged-15-20-years-in-the-united-states
#9
Jin Qin, Mona Saraiya, Gladys Martinez, George F Sawaya
Importance: Pelvic examination is no longer recommended for asymptomatic, nonpregnant women and may cause harms such as false-positive test results, overdiagnosis, anxiety, and unnecessary costs. The bimanual pelvic examination (BPE) is an invasive and controversial examination component. Cervical cancer screening is not recommended for women younger than 21 years. Objectives: To estimate prevalence of potentially unnecessary BPE and Papanicolaou (Pap) tests performed among adolescent girls and women younger than 21 years (hereinafter referred to as young women) in the United States and to identify factors associated with receiving these examinations...
January 6, 2020: JAMA Internal Medicine
https://read.qxmd.com/read/31886844/association-between-automotive-assembly-plant-closures-and-opioid-overdose-mortality-in-the-united-states-a-difference-in-differences-analysis
#10
Atheendar S Venkataramani, Elizabeth F Bair, Rourke L O'Brien, Alexander C Tsai
Importance: Fading economic opportunity has been hypothesized to be an important factor associated with the US opioid overdose crisis. Automotive assembly plant closures are culturally significant events that substantially erode local economic opportunities. Objective: To estimate the extent to which automotive assembly plant closures were associated with increasing opioid overdose mortality rates among working-age adults. Design, Setting, and Participants: A county-level difference-in-differences study was conducted among adults aged 18 to 65 years in 112 manufacturing counties located in 30 commuting zones (primarily in the US South and Midwest) with at least 1 operational automotive assembly plant as of 1999...
December 30, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31886829/getting-serious-about-opioid-regulation
#11
William K Hubbard
No abstract text is available yet for this article.
December 30, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31886827/hospital-transfer-rates-among-us-nursing-home-residents-with-advanced-illness-before-and-after-initiatives-to-reduce-hospitalizations
#12
Ellen P McCarthy, Jessica A Ogarek, Lacey Loomer, Pedro L Gozalo, Vincent Mor, Mary Beth Hamel, Susan L Mitchell
Importance: Hospital transfers among nursing home residents in the United States who have been diagnosed with advanced illnesses and have limited life expectancy are often burdensome, costly, and of little clinical benefit. National initiatives, introduced since 2012, have focused on reducing such hospitalizations, but little is known about the consequences of these initiatives in this population. Objective: To investigate the change in hospital transfer rates among nursing home residents with advanced illnesses, such as dementia, congestive heart failure (CHF), and chronic obstructive pulmonary disease (COPD), from 2011 to 2017-before and after the introduction of national initiatives to reduce hospitalizations...
December 30, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31886824/association-between-exposure-to-pyrethroid-insecticides-and-risk-of-all-cause-and-cause-specific-mortality-in-the-general-us-adult-population
#13
Wei Bao, Buyun Liu, Derek W Simonsen, Hans-Joachim Lehmler
Importance: Widespread exposure to pyrethroid insecticides has been reported among the general population in the United States and worldwide. However, little is known about the association of pyrethroid exposure with long-term health outcomes in adults. Objective: To examine the association of pyrethroid exposure with all-cause and cause-specific mortality among adults in the United States. Design, Setting, and Participants: The nationally representative cohort included 2116 adults aged 20 years and older who participated in the US National Health and Nutrition Examination Survey conducted from 1999 to 2002 and provided urine samples for pyrethroid metabolite measurements...
December 30, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31886823/pyrethroid-insecticides-time-for-a-closer-look
#14
Steven D Stellman, Jeanne Mager Stellman
No abstract text is available yet for this article.
December 30, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31886822/evaluation-of-the-extended-release-long-acting-opioid-prescribing-risk-evaluation-and-mitigation-strategy-program-by-the-us-food-and-drug-administration-a-review
#15
James Heyward, Lily Olson, Joshua M Sharfstein, Elizabeth A Stuart, Peter Lurie, G Caleb Alexander
Importance: Extended-release/long-acting (ER/LA) opioids have caused substantial morbidity and mortality in the United States, yet little is known about the efforts of the US Food and Drug Administration (FDA) and drug manufacturers to reduce adverse outcomes associated with inappropriate prescribing or use. This review of 9739 pages of FDA documents obtained through a Freedom of Information Act request aimed to investigate whether the FDA and ER/LA manufacturers were able to assess the effectiveness of the ER/LA Risk Evaluation and Mitigation Strategy (REMS) program by evaluating manufacturer REMS assessments and FDA oversight of these assessments...
December 30, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31860020/bridging-the-gap-between-where-the-quality-metric-ends-and-real-life-begins-a-trusting-relationship
#16
Jennifer E DeVoe
No abstract text is available yet for this article.
December 20, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31860015/mortality-trends-for-veterans-hospitalized-with-heart-failure-and-pneumonia-using-claims-based-vs-clinical-risk-adjustment-variables
#17
Gabriella C Silva, Lan Jiang, Roee Gutman, Wen-Chih Wu, Vincent Mor, Michael J Fine, Nancy R Kressin, Amal N Trivedi
Importance: Prior studies have reported declines in mortality for patients admitted to Veterans Health Administration (VA) and non-VA hospitals using claims-based risk adjustment. These apparent mortality reductions may be influenced by changes in coding practices. Objective: To compare trends in the VA for 30-day mortality following hospitalization for heart failure (HF) and pneumonia using claims-based and clinical risk-adjustment models. Design, Setting, and Participants: This observational time-trend study analyzed admissions to a VA Medical Center with a principal diagnosis of HF, pneumonia, or sepsis/respiratory failure (RF) with a secondary diagnosis of pneumonia...
December 20, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31860012/getting-better-at-measuring-hospital-mortality
#18
Mark R Chassin
No abstract text is available yet for this article.
December 20, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31860011/outcomes-before-and-after-the-recall-of-a-heart-failure-pacemaker
#19
Jay Sengupta, Katelyn Storey, Susan Casey, Lena Trager, Melissa Buescher, Mark Horning, Charles Gornick, Raed Abdelhadi, Chuen Tang, Suzanne Brill, Laura Ashbach, Robert G Hauser
Importance: Timely and complete disclosure of medical device defects is necessary to manage patient care safely and effectively. Objectives: To determine if the manufacturer's recommendations following the recall of a medical device were timely and complete, the follow-up information and data provided to patients and physicians were adequate for managing patient care, and the actions taken by the US Food and Drug Administration (FDA) regarding the recall were appropriate...
December 20, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31860008/long-term-outcome-of-implantable-cardioverter-defibrillator-lead-failure
#20
Gustav Arnar Davidsson, Gudlaug M Jonsdottir, Hjortur Oddsson, Sigrun H Lund, David O Arnar
No abstract text is available yet for this article.
December 20, 2019: JAMA Internal Medicine
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