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JAMA Internal Medicine

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https://read.qxmd.com/read/31305876/prevalence-of-inappropriateness-of-parenteral-vitamin-b12-administration-in-ontario-canada
#1
William K Silverstein, Yulia Lin, Christoffer Dharma, Ruth Croxford, Craig C Earle, Matthew C Cheung
No abstract text is available yet for this article.
July 15, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31305875/association-of-mirabegron-with-the-risk-of-arrhythmia-in-adult-patients-66-years-or-older-a-population-based-cohort-study
#2
Mina Tadrous, Rano Matta, Simon Greaves, Sender Herschorn, Muhammad M Mamdani, David N Juurlink, Tara Gomes
No abstract text is available yet for this article.
July 15, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31305874/nabiximols-for-the-treatment-of-cannabis-dependence-a-randomized-clinical-trial
#3
Nicholas Lintzeris, Anjali Bhardwaj, Llewellyn Mills, Adrian Dunlop, Jan Copeland, Iain McGregor, Raimondo Bruno, Jessica Gugusheff, Nghi Phung, Mark Montebello, Therese Chan, Adrienne Kirby, Michelle Hall, Meryem Jefferies, Jennifer Luksza, Marian Shanahan, Richard Kevin, David Allsop
Importance: There are no effective medications for treating dependence on cannabis. Objective: To examine the safety and efficacy of nabiximols in the treatment of patients with cannabis dependence. Design, Setting, and Participants: This parallel double-blind randomized clinical trial comparing nabiximols with placebo in a 12-week, multisite outpatient study recruited participants from February 3, 2016, to June 14, 2017, at 4 outpatient specialist alcohol and drug treatment services in New South Wales, Australia...
July 15, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31305872/applying-the-guidelines-for-primary-hyperparathyroidism-the-path-not-taken
#4
Kelly Wentworth, Dolores Shoback
No abstract text is available yet for this article.
July 15, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31305866/the-ketogenic-diet-for-obesity-and-diabetes-enthusiasm-outpaces-evidence
#5
Shivam Joshi, Robert J Ostfeld, Michelle McMacken
No abstract text is available yet for this article.
July 15, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31305864/diagnosis-and-management-of-primary-hyperparathyroidism-across-the-veterans-affairs-health-care-system
#6
Elizabeth A Alore, James W Suliburk, David J Ramsey, Nader N Massarweh, Courtney J Balentine, Hardeep Singh, Samir S Awad, Konstantinos I Makris
Importance: Untreated primary hyperparathyroidism impairs quality of life and incurs substantial costs. Parathyroidectomy is a low-risk, high-success, definitive intervention. Objectives: To determine the appropriateness of diagnostic evaluation for primary hyperparathyroidism in patients with hypercalcemia and the use of parathyroidectomy for the treatment of primary hyperparathyroidism across the Veterans Affairs (VA) health care system. Design, Setting, and Participants: A retrospective cohort study of veterans with hypercalcemia and primary hyperparathyroidism was conducted from January 1, 2000, through September 30, 2015, using the VA Corporate Data Warehouse, a national electronic health record-based repository...
July 15, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31305860/association-between-electronic-cigarette-use-and-smoking-reduction-in-france
#7
Ramchandar Gomajee, Fabienne El-Khoury, Marcel Goldberg, Marie Zins, Cédric Lemogne, Emmanuel Wiernik, Emeline Lequy-Flahault, Lucile Romanello, Isabelle Kousignian, Maria Melchior
Importance: The electronic cigarette (EC) has become popular among smokers who wish to reduce their tobacco use levels or quit smoking, but its effectiveness as a cessation aid is uncertain. Objective: To examine the association of regular EC use with the number of cigarettes smoked per day, smoking cessation among current smokers, and smoking relapse among former smokers. Design, Setting, and Participants: The CONSTANCES (Consultants des Centres d'Examens de Santé) cohort study, based in France, began recruiting participants January 6, 2012, and is currently ongoing...
July 15, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31305859/arrhythmogenic-syncope-in-a-soldier-first-responder-reveals-channelopathy-last-response-for-the-first-responder
#8
Caroline E Murphy, Colin M Kenny, Emilio Fentanes
No abstract text is available yet for this article.
July 15, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31282933/clinical-trial-evidence-for-the-real-world
#9
Joseph S Ross, Ken Covinsky
No abstract text is available yet for this article.
July 8, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31282928/preclinical-alzheimer-disease-early-diagnosis-or-overdiagnosis
#10
Kenneth M Langa, James F Burke
No abstract text is available yet for this article.
July 8, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31282924/representativeness-of-randomized-clinical-trial-cohorts-in-end-stage-kidney-disease-a-meta-analysis
#11
Brendan Smyth, Anna Haber, Konlawij Trongtrakul, Carmel Hawley, Vlado Perkovic, Mark Woodward, Meg Jardine
Importance: Systematic differences between patients included in randomized clinical trials (RCTs) and the general patient population may influence the generalizability of RCT findings. Comprehensive national registries of patients with end-stage kidney disease who are undergoing dialysis provide a unique opportunity to compare trial and real-world patient cohorts. Objective: To determine if participants in large, multicenter dialysis trials were similar to the general population undergoing dialysis in terms of age, comorbidities, and mortality rate...
July 8, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31282923/financial-implications-of-12-month-dispensing-of-oral-contraceptive-pills-in-the-veterans-affairs-health-care-system
#12
Colleen P Judge-Golden, Kenneth J Smith, Maria K Mor, Sonya Borrero
Importance: The Veterans Affairs (VA) health care system is the largest integrated health care system in the United States. Like most US health plans, the VA currently stipulates a 3-month maximum dispensing limit for all medications, including oral contraceptive pills (OCPs). However, 12-month OCP dispensing has been shown to improve continuation of use, decrease coverage gaps, and reduce unintended pregnancy in other practice settings. Objective: To estimate the financial and reproductive health implications for the VA of implementing a 12-month OCP dispensing option, with the goal of informing policy change...
July 8, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31282922/association-between-industry-payments-to-physicians-and-gabapentinoid-prescribing
#13
Taeho Greg Rhee, Joseph S Ross
No abstract text is available yet for this article.
July 8, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31282921/effectiveness-of-a-bundled-intervention-including-adjunctive-corticosteroids-on-outcomes-of-hospitalized-patients-with-community-acquired-pneumonia-a-stepped-wedge-randomized-clinical-trial
#14
Melanie Lloyd, Amalia Karahalios, Edward Janus, Elizabeth H Skinner, Terry Haines, Anurika De Silva, Stephanie Lowe, Melina Shackell, Soe Ko, Lucy Desmond, Harin Karunajeewa
Importance: Community-acquired pneumonia remains a leading cause of hospitalization, mortality, and health care costs worldwide. Randomized clinical trials support the use of adjunctive corticosteroids, early progressive mobilization, antibiotic switching rules, and dietary interventions in improving outcomes. However, it is uncertain whether implementing these interventions will translate into effectiveness under routine health care conditions. Objective: To evaluate the effectiveness of a bundle of evidence-supported treatments under conditions of routine care in a representative population hospitalized for community-acquired pneumonia...
July 8, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31282920/assessment-of-self-reported-prognostic-expectations-of-people-undergoing-dialysis-united-states-renal-data-system-study-of-treatment-preferences-ustate
#15
Ann M O'Hare, Manjula Kurella Tamura, Danielle C Lavallee, Elizabeth K Vig, Janelle S Taylor, Yoshio N Hall, Ronit Katz, J Randall Curtis, Ruth A Engelberg
Importance: Prognostic understanding can shape patients' treatment goals and preferences. Patients undergoing dialysis in the United States have limited life expectancy and may receive end-of-life care directed at life extension. Little is known about their prognostic expectations. Objective: To understand the prognostic expectations of patients undergoing dialysis and how these relate to care planning, goals, and preferences. Design, Setting, and Participants: Cross-sectional survey study of 996 eligible patients treated with regular dialysis at 31 nonprofit dialysis facilities in 2 metropolitan areas (Seattle, Washington, and Nashville, Tennessee) between April 2015 and October 2018...
July 8, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31282919/expanding-access-to-short-acting-hormonal-contraceptive-methods-in-the-united-states
#16
Daniel Grossman
No abstract text is available yet for this article.
July 8, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31282918/association-of-biologic-prescribing-for-inflammatory-bowel-disease-with-industry-payments-to-physicians
#17
Rishad Khan, Cameron M Nugent, Michael A Scaffidi, Nikko Gimpaya, Samir C Grover
No abstract text is available yet for this article.
July 8, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31282917/industry-payments-and-physician-prescribing
#18
Robert Steinbrook
No abstract text is available yet for this article.
July 8, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31260069/trial-protocol-and-data-sharing-statement-missing-from-supplements
#19
(no author information available yet)
No abstract text is available yet for this article.
July 1, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/31260066/association-of-radioactive-iodine-treatment-with-cancer-mortality-in-patients-with-hyperthyroidism
#20
Cari M Kitahara, Amy Berrington de Gonzalez, Andre Bouville, Aaron B Brill, Michele M Doody, Dunstana R Melo, Steven L Simon, Julie A Sosa, Mark Tulchinsky, Daphnée Villoing, Dale L Preston
Importance: Radioactive iodine (RAI) has been used extensively to treat hyperthyroidism since the 1940s. Although widely considered a safe and effective therapy, RAI has been associated with elevated risks of total and site-specific cancer death among patients with hypothyroidism. Objective: To determine whether greater organ- or tissue-absorbed doses from RAI treatment are associated with overall and site-specific cancer mortality in patients with hyperthyroidism...
July 1, 2019: JAMA Internal Medicine
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