journal
https://read.qxmd.com/read/38392350/comparative-study-of-lesions-obtained-through-radiofrequency-between-the-irrigated-ablation-catheter-with-a-flexible-tip-and-the-non-irrigated-catheter-in-ex-vivo-porcine-hearts
#1
JOURNAL ARTICLE
Francesco Vitali, Martina De Raffele, Michele Malagù, Cristina Balla, Giorgia Azzolini, Federico Gibiino, Alberto Boccadoro, Marco Micillo, Matteo Bertini
BACKGROUND: At the same conditions of delivered power and contact force, open-irrigated radiofrequency ablation catheters are believed to create deeper lesions, while non-irrigated ones produce shallower lesions. This ex vivo study aims to directly compare the lesion dimensions and characteristics of an irrigated ablation catheter with a flexible tip and a non-irrigated solid-tip catheter. METHODS: Radiofrequency lesions were induced on porcine myocardial slabs using both open-tip irrigated and non-irrigated standard 4 mm catheters at three power settings (20 W, 30 W, and 40 W), maintaining a fixed contact force of 10 gr...
February 19, 2024: Biology
https://read.qxmd.com/read/38392349/dietary-patterns-and-fertility
#2
REVIEW
Martina Cristodoro, Enrica Zambella, Ilaria Fietta, Annalisa Inversetti, Nicoletta Di Simone
Diet has a key role in the reproductive axis both in males and females. This review aims to analyze the impacts of different dietary patterns on fertility. It appears that the Mediterranean diet has a predominantly protective role against infertility, while the Western diet seems to be a risk factor for infertility. Moreover, we focus attention also on dietary patterns in different countries of the World (Middle Eastern diet, Asian diet). In particular, when analyzing single nutrients, a diet rich in saturated fatty acids, cholesterol, animal proteins, and carbohydrates with high glycemic index is highly associated with male and female infertility...
February 19, 2024: Biology
https://read.qxmd.com/read/38392348/the-reign-of-follistatin-in-tumors-and-their-microenvironment-implications-for-drug-resistance
#3
REVIEW
Jennifer Sosa, Akinsola Oyelakin, Satrajit Sinha
Follistatin (FST) is a potent neutralizer of the transforming growth factor-β superfamily and is associated with normal cellular programs and various hallmarks of cancer, such as proliferation, migration, angiogenesis, and immune evasion. The aberrant expression of FST by solid tumors is a well-documented observation, yet how FST influences tumor progression and therapy response remains unclear. The recent surge in omics data has revealed new insights into the molecular foundation underpinning tumor heterogeneity and its microenvironment, offering novel precision medicine-based opportunities to combat cancer...
February 19, 2024: Biology
https://read.qxmd.com/read/38392347/diet-diversity-of-the-fluviatile-masu-salmon-oncorhynchus-masou-brevoort-1856-revealed-via-gastrointestinal-environmental-dna-metabarcoding-and-morphological-identification-of-contents
#4
JOURNAL ARTICLE
Lijuan Li, Xuwang Yin, Qianruo Wan, Dilina Rusitanmu, Jie Han
Masu salmon, Oncorhynchus masou (Brevoort 1856), a commercially important fish species endemic to the North Pacific Ocean, attained national second-level protected animal status in China in 2021. Despite this recognition, knowledge about the trophic ecology of this fish remains limited. This study investigated the diet diversity of fluviatile Masu salmon in the Mijiang River, China, utilizing the gastrointestinal tract environmental DNA (GITeDNA) metabarcoding and morphological identification. The results revealed a diverse prey composition, ranging from terrestrial and aquatic invertebrates to small fishes...
February 18, 2024: Biology
https://read.qxmd.com/read/38392346/ectopic-expression-of-a-wheat-r2r3-type-myb-gene-in-transgenic-tobacco-enhances-osmotic-stress-tolerance-via-maintaining-ros-balance-and-improving-root-system-architecture
#5
JOURNAL ARTICLE
Omar Azab, Walid Ben Romdhane, Salah El-Hendawy, Abdelhalim Ghazy, Adel M Zakri, Ahmed M Abd-ElGawad, Abdullah Al-Doss
Water scarcity is a critical cause of plant yield loss and decreased quality. Manipulation of root system architecture to minimize the impact of water scarcity stresses may greatly contribute towards an improved distribution of roots in the soil and enhanced water and nutrient uptake abilities. In this study, we explored the potential of TaMYB20 gene, a wheat gene belonging to the R2R3-MYB transcription factor family, to improve root system architecture in transgenic tobacco plants. The full-length TaMYB20 gene was isolated from Triticum aestivum ...
February 18, 2024: Biology
https://read.qxmd.com/read/38392345/exogenous-trehalose-improves-growth-glycogen-and-poly-3-hydroxybutyrate-phb-contents-in-photoautotrophically-grown-arthrospira-platensis-under-nitrogen-deprivation
#6
JOURNAL ARTICLE
Nat-Anong Mudtham, Authen Promariya, Chanchanok Duangsri, Cherdsak Maneeruttanarungroj, Suchanit Ngamkala, Nattaphong Akrimajirachoote, Sorawit Powtongsook, Tiina A Salminen, Wuttinun Raksajit
Glycogen and poly-3-hydroxybutyrate (PHB) are excellent biopolymer products from cyanobacteria. In this study, we demonstrate that nitrogen metabolism is positively influenced by the exogenous application of trehalose (Tre) in Arthrospira platensis under nitrogen-deprived (-N) conditions. Cells were cultivated photoautotrophically for 5 days under -N conditions, with or without the addition of exogenous Tre. The results revealed that biomass and chlorophyll- a content of A. platensis experienced enhancement with the addition of 0...
February 18, 2024: Biology
https://read.qxmd.com/read/38392344/the-role-of-bcl11-transcription-factors-in-neurodevelopmental-disorders
#7
REVIEW
Franziska Anna Seigfried, Stefan Britsch
Neurodevelopmental disorders (NDDs) comprise a diverse group of diseases, including developmental delay, autism spectrum disorder (ASD), intellectual disability (ID), and attention-deficit/hyperactivity disorder (ADHD). NDDs are caused by aberrant brain development due to genetic and environmental factors. To establish specific and curative therapeutic approaches, it is indispensable to gain precise mechanistic insight into the cellular and molecular pathogenesis of NDDs. Mutations of BCL11A and BCL11B , two closely related, ultra-conserved zinc-finger transcription factors, were recently reported to be associated with NDDs, including developmental delay, ASD, and ID, as well as morphogenic defects such as cerebellar hypoplasia...
February 17, 2024: Biology
https://read.qxmd.com/read/38392343/poxipred-an-artificial-intelligence-based-method-for-the-prediction-of-potential-antigens-and-epitopes-to-accelerate-vaccine-development-efforts-against-poxviruses
#8
JOURNAL ARTICLE
Gustavo Sganzerla Martinez, Mansi Dutt, David J Kelvin, Anuj Kumar
Poxviridae is a family of large, complex, enveloped, and double-stranded DNA viruses. The members of this family are ubiquitous and well known to cause contagious diseases in humans and other types of animals as well. Taxonomically, the poxviridae family is classified into two subfamilies, namely Chordopoxvirinae (affecting vertebrates) and Entomopoxvirinae (affecting insects). The members of the Chordopoxvirinae subfamily are further divided into 18 genera based on the genome architecture and evolutionary relationship...
February 17, 2024: Biology
https://read.qxmd.com/read/38392342/the-comparative-effect-of-occupational-and-musical-enrichment-on-fecal-glucocorticoid-metabolite-levels-in-a-captive-colony-of-stumptail-macaques-macaca-arctoides
#9
JOURNAL ARTICLE
Lilian Mayagoitia-Novales, Ana Lilia Cerda-Molina, María Andrea Martín-Guerrero, Emmanuel Muñoz-Zamudio, Gema R Estudillo-Mendoza, Javier I Borráz-León
Environmental enrichment improves captive animal welfare by reducing stress-related behaviors. Previous studies in a captive colony of stumptail macaques ( Macaca arctoides ) reported a reduction of aggression, coprophilia, and stereotypic behaviors after an occupational enrichment program; however, the effect on stress hormones such as glucocorticoids has not been investigated yet. The goal of this study was to compare the effect of sex, age, and social rank on changes in fecal glucocorticoid metabolites (fGCM) after applying two kinds of enrichments (occupational vs...
February 17, 2024: Biology
https://read.qxmd.com/read/38392341/differences-of-pine-wood-nematode-bursaphelenchus-xylophilus-developmental-stages-under-high-osmotic-pressure-stress
#10
JOURNAL ARTICLE
Shuting Wang, Qiaoli Chen, Feng Wang
Under ion imbalance, water deficiency, and salt stress, the osmotic pressure of the tree sap increases, and pine wood nematodes ( Bursaphelenchus xylophilus , PWN) parasitizing in the trees may be subjected to high-osmotic-pressure stress. KCl, L-malic acid, sucrose, and glycerol solutions were used as osmolytes to explore the highest osmotic concentration that PWN can tolerate. Survival analysis showed that when the treatment concentration exceeded 90%, only a few nematodes in the glycerol group survived under 6 h treatment, and most of the survivors were third-stage dispersal juveniles (DJ3)...
February 16, 2024: Biology
https://read.qxmd.com/read/38392340/insights-into-the-roles-of-epigenetic-modifications-in-ferroptosis
#11
REVIEW
Jinghua Kong, Hao Lyu, Qian Ouyang, Hao Shi, Rui Zhang, Shuai Xiao, Dong Guo, Qi Zhang, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang
Ferroptosis is a non-apoptotic mode of cell death driven by membrane lipid peroxidation and is characterized by elevated intracellular levels of Fe2+ , ROS, and lipid peroxidation. Studies have shown that ferroptosis is related to the development of multiple diseases, such as cancer, neurodegenerative diseases, and acute myeloid leukemia. Ferroptosis plays a dual role in the occurrence and development of these diseases. Ferroptosis mainly involves iron metabolism, ROS, and lipid metabolism. Various mechanisms, including epigenetic regulation, have been reported to be deeply involved in ferroptosis...
February 15, 2024: Biology
https://read.qxmd.com/read/38392339/the-diversity-of-wolbachia-across-the-turtle-ants-formicidae-cephalotes-spp
#12
JOURNAL ARTICLE
Corey Reese, Leland C Graber, Manuela O Ramalho, Corrie S Moreau
Wolbachia is a widespread and well-known bacterium that can induce a wide range of changes within its host. Ants specifically harbor a great deal of Wolbachia diversity and are useful systems to study endosymbiosis. The turtle ants ( Cephalotes ) are a widespread group of tropical ants that rely on gut microbes to support their herbivorous diet for their survival, yet little is known of the extent of this diversity. Therefore, studying their endosymbionts and categorizing the diversity of bacteria within Cephalotes hosts could help to delimit species and identify new strains and can help lead to a further understanding of how the microbiome leads to survival and speciation in the wild...
February 13, 2024: Biology
https://read.qxmd.com/read/38392338/structural-and-functional-insights-into-crf-peptides-and-their-receptors
#13
REVIEW
Minos-Timotheos Matsoukas, Vasilis Panagiotopoulos, Vlasios Karageorgos, George P Chrousos, Maria Venihaki, George Liapakis
Corticotropin-releasing factor or hormone (CRF or CRH) and the urocortins regulate a plethora of physiological functions and are involved in many pathophysiological processes. CRF and urocortins belong to the family of CRF peptides (CRF family), which includes sauvagine, urotensin, and many synthetic peptide and non-peptide CRF analogs. Several of the CRF analogs have shown considerable therapeutic potential in the treatment of various diseases. The CRF peptide family act by interacting with two types of plasma membrane proteins, type 1 (CRF1 R) and type 2 (CRF2 R), which belong to subfamily B1 of the family B G-protein-coupled receptors (GPCRs)...
February 13, 2024: Biology
https://read.qxmd.com/read/38392337/-helenus-and-ajax-two-groups-of-non-autonomous-ltr-retrotransposons-represent-a-new-type-of-small-rna-gene-derived-mobile-elements
#14
JOURNAL ARTICLE
Kenji K Kojima
Terminal repeat retrotransposons in miniature (TRIMs) are short non-autonomous long terminal repeat (LTR) retrotransposons found from various eukaryotes. Cassandra is a unique TRIM lineage which contains a 5S rRNA-derived sequence in its LTRs. Here, two new groups of TRIMs, designated Helenus and Ajax, are reported based on bioinformatics analysis and the usage of Repbase. Helenus is found from fungi, animals, and plants, and its LTRs contain a tRNA-like sequence. It includes two LTRs and between them, a primer-binding site (PBS) and polypurine tract (PPT) exist...
February 13, 2024: Biology
https://read.qxmd.com/read/38392336/central-autonomic-mechanisms-involved-in-the-control-of-laryngeal-activity-and-vocalization
#15
REVIEW
Marta González-García, Laura Carrillo-Franco, Carmen Morales-Luque, Marc Stefan Dawid-Milner, Manuel Víctor López-González
In humans, speech is a complex process that requires the coordinated involvement of various components of the phonatory system, which are monitored by the central nervous system. The larynx in particular plays a crucial role, as it enables the vocal folds to meet and converts the exhaled air from our lungs into audible sounds. Voice production requires precise and sustained exhalation, which generates an air pressure/flow that creates the pressure in the glottis required for voice production. Voluntary vocal production begins in the laryngeal motor cortex (LMC), a structure found in all mammals, although the specific location in the cortex varies in humans...
February 13, 2024: Biology
https://read.qxmd.com/read/38392335/case-report-emerging-losses-of-managed-honey-bee-colonies
#16
Zachary S Lamas, Yanping Chen, Jay D Evans
United States commercial beekeepers prepare honey bee colonies for almond pollination in California each year in late January to early February. This represents the largest managed pollination event in the world and involves more than half of all U.S. honey bee colonies. In winter 2023, numerous colonies in Florida, which were graded as suitable for almonds (larger than ten frames of bees), dwindled suddenly or altogether died within several weeks, just prior to movement for almonds. The timing of these losses and the resulting morbidity caused severe economic harm to affected operations...
February 13, 2024: Biology
https://read.qxmd.com/read/38392334/dawn-of-the-delphinidans-new-remains-of-kentriodon-from-the-lower-miocene-of-italy-shed-light-on-the-early-radiation-of-the-most-diverse-extant-cetacean-clade
#17
JOURNAL ARTICLE
Francesco Nobile, Alberto Collareta, Vittore Perenzin, Eliana Fornaciari, Luca Giusberti, Giovanni Bianucci
Nowadays, the infraorder Delphinida (oceanic dolphins and kin) represents the most diverse extant clade of Cetacea, with delphinids alone accounting for more than 40% of the total number of living cetacean species. As for other cetacean groups, the Early Miocene represents a key interval for the evolutionary history of Delphinida, as it was during this time span that the delphinidans became broadly distributed worldwide, first and foremost with the widespread genus Kentriodon and closely related forms. Here, we report on a new odontocete find from Burdigalian (20...
February 11, 2024: Biology
https://read.qxmd.com/read/38392333/effect-of-cb1-receptor-deficiency-on-mitochondrial-quality-control-pathways-in-gastrocnemius-muscle
#18
JOURNAL ARTICLE
Rosalba Senese, Giuseppe Petito, Elena Silvestri, Maria Ventriglia, Nicola Mosca, Nicoletta Potenza, Aniello Russo, Francesco Manfrevola, Gilda Cobellis, Teresa Chioccarelli, Veronica Porreca, Vincenza Grazia Mele, Rosanna Chianese, Pieter de Lange, Giulia Ricci, Federica Cioffi, Antonia Lanni
This study aims to explore the complex role of cannabinoid type 1 receptor (CB1) signaling in the gastrocnemius muscle, assessing physiological processes in both CB1+/+ and CB1-/- mice. The primary focus is to enhance our understanding of how CB1 contributes to mitochondrial homeostasis. At the tissue level, CB1-/- mice exhibit a substantial miRNA-related alteration in muscle fiber composition, characterized by an enrichment of oxidative fibers. CB1 absence induces a significant increase in the oxidative capacity of muscle, supported by elevated in-gel activity of Complex I and Complex IV of the mitochondrial respiratory chain...
February 11, 2024: Biology
https://read.qxmd.com/read/38392332/rho-kinase-inhibition-of-active-force-and-passive-tension-in-airway-smooth-muscle-a-strategy-for-treating-airway-hyperresponsiveness-in-asthma
#19
REVIEW
Yuto Yasuda, Lu Wang, Pasquale Chitano, Chun Y Seow
Rho-kinase inhibitors have been identified as a class of potential drugs for treating asthma because of their ability to reduce airway inflammation and active force in airway smooth muscle (ASM). Past research has revealed that, besides the effect on the ASM's force generation, rho-kinase (ROCK) also regulates actin filament formation and filament network architecture and integrity, thus affecting ASM's cytoskeletal stiffness. The present review is not a comprehensive examination of the roles played by ROCK in regulating ASM function but is specifically focused on passive tension, which is partially determined by the cytoskeletal stiffness of ASM...
February 11, 2024: Biology
https://read.qxmd.com/read/38392331/exploring-the-climatic-niche-evolution-of-the-genus-falco-aves-falconidae-in-europe
#20
JOURNAL ARTICLE
Simona Mariana Popescu, Cristian Tigae, Aurelian Dobrițescu, Dragoș Mihail Ștefănescu
By integrating species distribution modeling techniques, phylogenetic comparative methods, and climatic data, we analyzed how European falcon climatic niches have changed over evolutionary time in order to understand their tempo and mode of evolution and gain phylogenetic insights related to the ecological context of falcon evolution. For this purpose, we tested the relative contributions of niche conservatism, convergent evolution, and divergent evolution in the evolutionary history of this group of species in Europe...
February 11, 2024: Biology
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