Angela Genge, Jesse M Cedarbaum, Jeremy Shefner, Adriano Chio, Ammar Al-Chalabi, Philip Van Damme, Chris McDermott, Jonathan Glass, James Berry, Ruben P A van Eijk, Christina Fournier, Julian Grosskreutz, Jinsy Andrews, Vanessa Bertone, Tommy M Bunte, Mathias Couillard, Cathy Cummings, Gale Kittle, John Polzer, Kristiana Salmon, Corey Straub, Leonard H van den Berg
The Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) was developed more than 25 years ago as an instrument to monitor functional change over time in patients with ALS. It has since been revised and extended to meet the needs of high data quality in ALS trials (ALSFRS-R), however a full re-validation of the scale was not completed. Despite this, the scale has remained a primary outcome measure in clinical trials. We convened a group of clinical trialists to discuss and explore opportunities to improve the scale and propose alternative measures...
February 23, 2024: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration