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Advanced Biomedical Research

Parvin Mahzouni, Mitra Shavakhi
Background: Glioblastoma (GBM) is the most malignant brain tumor with a poor prognosis that can be very difficult to cure, and the current treatment options have no optimal outcomes. Hence, it is essential to find new treatment modalities. Histologically, this tumor has high microvascular density that makes it desirable for vascular target agent drugs. Prostate-specific membrane antigen (PSMA) is a novel antigen with unique features that expresses in the vascular endothelium of some malignant tumors...
2019: Advanced Biomedical Research
Babak Alikiaii, Mohammad Azad Majedi, Seyed Taghi Hashemi, Maryam Kiani
Background: Constipation is an intestinal syndrome that can be created alone or in the context of another disease in patients admitted to intensive care units (ICUs). Given the role of sennosides in increasing the transfer rate of materials from the large intestine, we aimed to compare the effect of senalin with bisacodyl on the treatment of constipation in patients admitted to ICUs. Materials and Methods: In this randomized, double-blind study, 70 patients admitted to the ICU were divided into two groups...
2019: Advanced Biomedical Research
Seyed Ziyae Aldin Samsamshariat, Fariba Sakhaei, Leila Salehizadeh, Mahtab Keshvari, Sedigheh Asgary
Background: Resistin is peptides that signal the functional status of adipose tissue to the brain and other target organs. It causes insulin resistance and affects the vascular endothelial dysfunction. However, the function and relation between resistin in endothelin-1 (ET-1), which leads to the endothelial dysfunction in humans are enigmatic. Materials and Methods: In a cross-sectional study of 76 participants (38 metabolic syndrome patients and 38 healthy participants), biochemical and clinical parameters, including lipid profile, fasting glucose, resistin, ET-1, C-reactive protein (CRP), flow-mediated dilation (FMD), and hypertension were determined and compared between the two groups...
2019: Advanced Biomedical Research
Seyed Abolfazl Hosseininasab Nodoushan, Amin Nabavi
Helicobacter pylori is one of the most common human pathogens that can cause gastrointestinal (GI) disorders, including simple gastritis, gastric ulcer, and malignant gastritis. In some cases, such as immunodeficiency and underlying diseases, it can be problematic as opportunistic infections. Diabetes mellitus (type 2) (T2DM) is one of the H. pylori underlying diseases. Since GI problems are observed in diabetic patients, it is necessary to treat H. pylori infection. In this review, we aimed to evaluate the possible relationship between H...
2019: Advanced Biomedical Research
Esmaeil Chahardahmasumi, Rezvan Salehidoost, Massoud Amini, Ashraf Aminorroaya, Hassan Rezvanian, Ali Kachooei, Bijan Iraj, Masoud Nazem, Mohsen Kolahdoozan
Background: The complications in thyroid surgery have been reported variable in literature. The aim of this study was to evaluate the early and late (3 months after surgery) complication rates of thyroidectomy in a cohort of patients undergoing thyroid surgery at two hospitals of Isfahan University of Medical Science, Iran. Materials and Methods: This study included 204 patients who candidates for thyroidectomy presenting at Medical Educational Centers of Al-Zahra and Kashani hospitals in Isfahan between March 2016 and March 2017...
2019: Advanced Biomedical Research
Yasaman Sadeghi, Meghdad Sedaghat, Mohammad Azad Majedi, Bahram Pakzad, Amir Ghaderi, Ahmad Raeisi
Background: To date, there is no standard approach to manage and to improve central sleep apnea (CSA). The most applicable therapeutic approaches are positive airway pressure therapy (PAP), bi-level PAP therapy (BIPAP), supplemental O2 and servo ventilation, or a combination of two approaches. Given the high prevalence of heart disease (HF) and/or concomitants of other diseases and opioid use worldwide; it seemingly requires evaluation of patients' conditions in response to each abovementioned approach to select the most effective approach...
2019: Advanced Biomedical Research
Amir-Mohammad Armanian, Behzad Barekatain, Fatemeh Sohrabi, Nima Salehimehr, Marjan Mansourian
Background: Different morbidity conditions are globally reported from different nations for premature infants. The aim of this study was to identify the relative frequency of some of the most important complications of prematurity in a population of about 1000 of very low birth weight (VLBW; i.e., infants with weight of <1500 g) premature infants in our city and publish the results of the project at the level of the urban community of Isfahan in order to use it for further decisions...
2019: Advanced Biomedical Research
Sanaz Ramezany Yasuj, Mona Nourhashemi, Saghar Keshavarzi, Majid Motaghinejad, Manijeh Motevalian
Background: Duloxetine is used for treating depression and anxiety. The current study evaluated the effects of duloxetine against methamphetamine withdrawal-induced anxiety, depression, and motor disturbances and methamphetamine use-induced cognitive impairments. Materials and Methods: Ninety-six adult male rats were used for two independent experiments. Each experiment consisted of Groups 1 and 2 which received normal saline (0.2 ml/rat) and methamphetamine (10 mg/kg) respectively, Groups 3, 4, and 5 received both methamphetamine and duloxetine at doses of 5, 10, and 15 mg/kg, respectively...
2019: Advanced Biomedical Research
Mehdi Ghaderian, Mohammad Reza Sabri
Coarctation of aorta (CoA) is a congenital heart disease that can lead to heart failure during infancy and neonatal period. Several treatments have been proposed for this disease, including surgery and balloon angioplasty. The experiences of using stents in small infants or neonatal patients are very low. In this article, we report a 3 months old age infant who after balloon angioplasty, his CoA symptoms had return and stenting of CoA was performed for him.
2019: Advanced Biomedical Research
Yasaman Sadeghi, Pouya Tabatabaei Irani, Laleh Rafiee, Mohamadhasan Tajadini, Shaghayegh Haghjooy Javanmard
Background: The kB family of nuclear factor (NF-κB) is a series of transcription factors that plays a key role in regulation of immunity, cell growth, and apoptosis and is considered as the main downstream component of epidermal growth factor receptor for which there are evidence of excessive activity in most cases of glioblastoma multiform (GBM). Thus, the current information has gained evidence on NF-κBIA tumor suppressor role in GMB. SNP rs1957106 was diagnosed as a new polymorphism which affected the expression of NF-κBI and causes activation of NF-κB in GBM patients...
2019: Advanced Biomedical Research
Mohammadreza Zarei, Homayoun Tabesh, Hossein Fazeli, Akram Aarabi
Background: The aim of this study was to investigate the effect of the incise drape (ID) on surgical wound bacterial contamination during lumbar spine surgical procedures in treatment group (with ID) and control group (without ID). Materials and Methods: The present study was conducted on 88 patients who were a candidate for lumbar spine surgery. The patients were randomly assigned to one of the two groups, treatment and control. The ID was only used in the treatment group...
2019: Advanced Biomedical Research
Mohammad Azad Majedi, Shahab Sarlak, Yasaman Sadeghi, Behzad Ahsan
Background: Epidural anesthesia (EA) today has been used extensively in surgical procedures and the management of pain associated with midwifery and chronic pain. This type of anesthesia can be done in different technical, physiological, and pharmacological ways. The aim of this study was to compare the effects of thoracic EA with general anesthesia (GA) on hemodynamic changes and its complications in patients underwent laparoscopic colonoscopy. Materials and Methods: This clinical trial study was conducted on 80 patients undergoing laparoscopic cholecystectomy with EA or GA based on inclusion and exclusion criteria...
2019: Advanced Biomedical Research
Neda Mansouri, Kobra Nasrollahi, Hamidreza Shetabi
Background: This study aimed to compare the effects of preoperative administration of midazolam and dexmedetomidine on cognitive dysfunction prevention after cataract surgery. Materials and Methods: This research was a double-blind controlled clinical trial. In this study, 150 candidates for cataract surgery under general anesthesia, over 65 years, and similar to American Society of Anesthesiologists I and II characteristics were selected as the sample and randomly assigned to three groups...
2019: Advanced Biomedical Research
Hajar Naji Esfahani, Laleh Rafiee, Shaghayegh Haghjooy Javanmard
Background: Fluvoxamine, a well-known selective serotonin reuptake inhibitor, is used for the management of mental disorders and various types of chronic pain. In our previous study, we found the inhibitory effect of fluvoxamine on inflammatory mediator's expression. In the line of the indicated study, we sought to evaluate the effect of fluvoxamine on the expression of some inflammatory mediators such as cyclooxygenase-2 (COX-2). Materials and Methods: An in vitro model system of lipopolysaccharide-stimulated human U937 macrophages was used...
2019: Advanced Biomedical Research
Shiva Roshankhah, Cyrus Jalili, Mohammad Reza Salahshoor
Background: Diabetes can increase the generation of free radicals and can be harmfully effective in spermatogenesis. Crocin is a carotenoid and is accountable for the red color of saffron. Crocin has shown numerous pharmacological actions such as antioxidant roles and radical scavenging. The aim of this study was to determine the effects of crocin on sperm parameters and the diameter of seminiferous tubules in diabetic rats. Materials and Methods: In this experimental study, diabetic rats were induced by Streptozotocin (STZ) (60 mg/kg)...
2019: Advanced Biomedical Research
Masoud Keikha, Mohsen Karbalaei
No abstract text is available yet for this article.
2019: Advanced Biomedical Research
Mehrbud Vakhshuury, Alireza Khoshdel
Background: Assessing the relation between dietary habits and functional gastrointestinal disorders (FGIDs) is less investigated among military personnel. In this study, we aimed to evaluate the association of certain eating patterns and FGIDs in Iranian army men. Materials and Methods: This cross-sectional study was performed on 600 army personnel working in Kerman ground forces military station number 05, Iran. Participants were asked to define their weekly breakfast consumption, lunch intake time, and chewing efficiency...
2019: Advanced Biomedical Research
Chinnambedu Ravichandran Swathirajan, Marimuthu Ragavan Rameshkumar, Sunil Suhas Solomon, Ramachandran Vignesh, Pachamuthu Balakrishnan
No abstract text is available yet for this article.
2019: Advanced Biomedical Research
Mahtab Zargham, Narjes Saberi, Mohammad Hatef Khorrami, Mehrdad Mohamadi, Kia Nourimahdavi, Mohammad Hosein Izadpanahi
Background: The aim was to study the effectiveness and safety of a modified technique that employs a four-arm polypropylene (PP) mesh (NAZCA-TC) to treat pelvic organ prolapse (POP) and concurrent stress urinary incontinence (SUI) simultaneously. Materials and Methods: This prospective follow-up study was conducted on fifty SUI women with concurrent high-grade (greater than Stage 2) anterior vaginal wall and/or uterine prolapse who were referred to Al-Zahra and Noor Hospitals in Isfahan and underwent surgery using the NAZCA-TC, Promedon, Argantina kit...
2018: Advanced Biomedical Research
Azar Danesh Shahraki, Azam Zafarbakhsh, Amirreza Farhadian Dehkordi
Sickle cell disease (SCD) is a hereditary blood disorder that can increase complications during pregnancy and in turn negatively influence pregnancy outcomes. In addition to patients with SCD are at a high risk of been infected with hepatitis C infection. Furthermore in this study, we reported the clinical status of a pregnant woman with SCD who had hepatitis C virus infection.
2018: Advanced Biomedical Research
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