journal
https://read.qxmd.com/read/38528825/phase-1-trial-of-the-safety-pharmacokinetics-and-antiviral-activity-of-edp-514-in-untreated-viremic-chronic-hepatitis-b-patients
#1
JOURNAL ARTICLE
Man-Fung Yuen, Wan-Long Chuang, Cheng-Yuan Peng, Wen-Juei Jeng, Wei-Wen Su, Ting-Tsung Chang, Chi-Yi Chen, Yao-Chun Hsu, Guy De La Rosa, Alaa Ahmad, Ed Luo, Annie L Conery
BACKGROUND & AIMS: Oral EDP-514 is a potent core protein inhibitor of hepatitis B virus (HBV) replication, which produced a >4-log viral load reduction in HBV-infected chimeric mice with human liver cells. This study evaluated the safety, pharmacokinetics (PK), and antiviral activity of three doses of EDP-514 in treatment naïve viremic patients with HBeAg-positive or -negative chronic HBV infection. METHODS: Patients with HBsAg detectable at screening and at least 6 months previously were eligible...
March 26, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38503552/both-liver-parenchymal-and-non-parenchymal-cells-express-jcad-proteins-under-various-circumstances
#2
JOURNAL ARTICLE
Li Xie, Li Zhang, Hui Chen, Yong-Yu Yang, Jian Wu
No abstract text is available yet for this article.
March 20, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38499439/reply-to-evaluation-of-the-histological-scoring-systems-of-autoimmune-hepatitis-a-significant-step-towards-the-optimization-of-clinical-diagnosis
#3
JOURNAL ARTICLE
Haeryoung Kim, Sook-Hyang Jeong
No abstract text is available yet for this article.
March 19, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38486508/multiomics-profiling-of-buffy-coat-and-plasma-unveils-etiology-specific-signatures-in-hepatocellular-carcinoma
#4
JOURNAL ARTICLE
Jiwon Hong, Jung Woo Eun, Geum Ok Baek, Jae Youn Cheong, Seryoung Park, Soon Sun Kim, Hyo Jung Cho, Su Bin Lim
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide. Despite identification of several biomarkers for HCC diagnosis, challenges such as low sensitivity and intratumoral heterogeneity have impeded early detection, highlighting the need for etiology-specific blood biomarkers. METHODS: We generated whole-transcriptome sequencing (WTS) and targeted proteome data from buffy coat and plasma samples from HCC patients. By integrating etiological information on viral infection, we investigated the etiology-specific gene expression landscape at the blood level...
March 15, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38468561/sorafenib-vs-lenvatinib-in-advanced-hepatocellular-carcinoma-after-atezolizumab-bevacizumab-failure-a-real-world-study
#5
JOURNAL ARTICLE
Young Eun Chon, Dong Yun Kim, Mina Kim, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Yeonjung Ha, Joo Ho Lee, Kwan Sik Lee, Beodeul Kang, Jung Sun Kim, Hong Jae Chon, Do Young Kim
BACKGROUND: Atezolizumab plus bevacizumab (ATE+BEV) therapy has become the recommended first-line therapy for patients with unresectable hepatocellular carcinoma (HCC) because of favorable treatment responses. However, there is a lack of data on sequential regimens after ATE+BEV treatment failure. We aimed to investigate the clinical outcomes of patients with advanced HCC who received subsequent systemic therapy for disease progression after ATE+BEV. METHODS: This multicenter, retrospective study included patients who started second-line systemic treatment with sorafenib or lenvatinib after HCC progressed on ATE+BEV between August 2019 and December 2022...
March 12, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38454802/jcad-a-new-potential-therapeutic-target-in-cholestatic-liver-disease
#6
EDITORIAL
Byoung Kuk Jang
No abstract text is available yet for this article.
March 8, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38447533/linvencovir-paving-the-way-for-functional-cure-in-hepatitis-b
#7
EDITORIAL
Jiwon Yang, Jonggi Choi
No abstract text is available yet for this article.
March 6, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38447532/examining-the-therapeutic-landscape-of-beta-blockers-in-portal-hypertension
#8
JOURNAL ARTICLE
Anna Brujats, Càndid Villanueva
No abstract text is available yet for this article.
March 6, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38447531/changing-from-nafld-to-masld-prevalence-and-progression-of-ascvd-risk-are-similar-between-nafld-and-masld-in-asia
#9
JOURNAL ARTICLE
Hiroyuki Suzuki, Tsubasa Tsutsumi, Machiko Kawaguchi, Keisuke Amano, Takumi Kawaguchi
No abstract text is available yet for this article.
March 6, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38439190/correspondence-on-letter-regarding-toward-hepatitis-c-virus-elimination-using-artificial-intelligence
#10
JOURNAL ARTICLE
Ming-Ying Lu, Ming-Lung Yu
No abstract text is available yet for this article.
March 5, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38439189/clinical-impact-of-five-cardiometabolic-risk-factors-in-malsd-insights-into-regional-and-ethnic-differences
#11
EDITORIAL
Joo Hyun Oh, Dae Won Jun
No abstract text is available yet for this article.
March 5, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38414375/liver-sinusoidal-endothelial-cell-an-important-yet-often-overlooked-player-in-the-liver-fibrosis
#12
REVIEW
Jiaorong Qu, Le Wang, Yufei Li, Xiaojiaoyang Li
Liver sinusoidal endothelial cells (LSECs) are liver-specific endothelial cells with the highest permeability than other mammalian endothelial cells, characterized by the presence of fenestrae on their surface, the absence of diaphragms and lack of basement membrane. Located at the interface between blood and other liver cell types, LSECs mediate the exchange of substances between the blood and the Disse space, playing a crucial role in maintaining substance circulation and homeostasis of multicellular communication...
February 28, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38414374/-exploring-the-prognostic-value-of-ultra-low-pass-whole-genome-sequencing-of-circulating-tumor-dna-in-hepatocellular-carcinoma
#13
EDITORIAL
Ji Eun Han, Hyo Jung Cho
No abstract text is available yet for this article.
February 28, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38390704/correspondence-on-editorial-regarding-identification-of-signature-gene-set-as-highly-accurate-determination-of-masld-progression
#14
JOURNAL ARTICLE
Sungju Jung, Sumin Yoon, Jong Hoon Park, Yeon-Su Lee, Kyung Hyun Yoo
No abstract text is available yet for this article.
February 23, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38390703/toward-hepatitis-c-virus-elimination-using-artificial-intelligence
#15
EDITORIAL
Moon Haeng Hur, Jeong-Hoon Lee
No abstract text is available yet for this article.
February 23, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38390702/evaluation-of-the-histological-scoring-systems-of-autoimmune-hepatitis-aih-a-significant-step-towards-the-optimization-of-clinical-diagnosis
#16
EDITORIAL
Atsumasa Komori
No abstract text is available yet for this article.
February 23, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38385197/enhancing-off-nucleos-t-ide-analogue-outcome-predictions-in-chronic-hepatitis-b-with-time-varying-hbcrag
#17
EDITORIAL
Chen-Te Huang, Tai-Chung Tseng
No abstract text is available yet for this article.
February 22, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38385196/starting-the-journey-understanding-the-roles-of-complement-proteins-in-liver-diseases-through-mendelian-randomization
#18
EDITORIAL
Mohammad Saeid Rezaee-Zavareh, Naomy Kim, Ju Dong Yang
No abstract text is available yet for this article.
February 22, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38382919/letter-cardiovascular-risk-of-tdf-or-taf-in-patients-with-chronic-hepatitis-b-more-questions-than-an-answer-author-s-reply
#19
JOURNAL ARTICLE
Hyeyeon Hong, Jonggi Choi
No abstract text is available yet for this article.
February 21, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38373421/in-response-to-steatotic-liver-disease-know-your-enemies
#20
JOURNAL ARTICLE
Michael Le, Linda Henry, Mindie H Nguyen
No abstract text is available yet for this article.
February 19, 2024: Clinical and Molecular Hepatology
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