journal
https://read.qxmd.com/read/38808361/genetically-redirected-hbv-specific-t-cells-target-hbsag-positive-hepatocytes-and-primary-lesions-in-hbv-associated-hcc
#1
JOURNAL ARTICLE
Xueshuai Wan, Karin Wisskirchen, Tao Jin, Lu Yang, Xiaorui Wang, Xiang'an Wu, Fang Liu, Yu Wu, Christy Ma, Yong Pang, Qi Li, Ke Zhang, Ulrike Protzer, Shunda Du
BACKGROUND AND AIMS: HBV-DNA integration in HBV-related hepatocellular carcinoma (HBV-HCC) can be targeted by HBV-specific T cells. SCG101 is an autologous, HBV-specific T-cell product expressing a T-cell receptor (TCR) after lentiviral transduction recognizing the envelope-derived peptide (S20-28) on HLA-A2. We here validated its safety and efficacy preclinically and applied it in an HBV-related HCC patient (NCT05339321). METHODS: GMP-grade manufactured cells were assessed for off-target reactivity and functionality against hepatoma cells...
May 29, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38768964/equivalent-prevalence-and-progression-of-chronic-kidney-disease-in-nafld-and-masld
#2
JOURNAL ARTICLE
Hiroyuki Suzuki, Tsubasa Tsutsumi, Machiko Kawaguchi, Keisuke Amano, Takumi Kawaguchi
No abstract text is available yet for this article.
May 20, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38768963/reply-to-correspondence-prognosis-of-biopsy-confirmed-masld-a-sub-analysis-of-the-clione-study
#3
JOURNAL ARTICLE
Eileen Laurel Yoon, Dae Won Jun
No abstract text is available yet for this article.
May 20, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38768962/reply-to-unlocking-the-future-machine-learning-sheds-light-on-prognostication-for-early-stage-hepatocellular-carcinoma
#4
JOURNAL ARTICLE
Chun-Ting Ho, Elise Chia-Hui Tan, Chien-Wei Su
No abstract text is available yet for this article.
May 20, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38768961/correspondence-on-editorial-regarding-unveiling-etiology-specific-blood-biomarkers-in-hepatocellular-carcinoma-a-gateway-to-personalized-medicine
#5
JOURNAL ARTICLE
Su Bin Lim, Hyo Jung Cho
No abstract text is available yet for this article.
May 20, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38768960/mafld-is-a-ubiquitous-latent-cofactor-in-viral-and-alcoholic-related-hepatocellular-carcinoma
#6
EDITORIAL
Toru Nakamura, Masahito Nakano, Tsubasa Tsutsumi, Keisuke Amano, Takumi Kawaguchi
No abstract text is available yet for this article.
May 20, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38755017/correspondence-on-letter-regarding-liver-sinusoidal-endothelial-cell-an-important-yet-often-overlooked-player-in-the-liver-fibrosis
#7
JOURNAL ARTICLE
Jiaorong Qu, Le Wang, Xiaojiaoyang Li
No abstract text is available yet for this article.
May 17, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38741238/novel-role-of-mhc-class-ii-transactivator-in-hepatitis-b-virus-replication-and-viral-counteraction
#8
JOURNAL ARTICLE
Mehrangiz Dezhbord, Seong Ho Kim, Soree Park, Da Rae Lee, Nayeon Kim, Juhee Won, Ah Ram Lee, Dong-Sik Kim, Kyun-Hwan Kim
BACKGROUND/AIMS: The major histocompatibility class II (MHC II) transactivator, known as CIITA, is induced by Interferon gamma (IFN-γ) and plays a well-established role in regulating the expression of class II MHC molecules in antigen-presenting cells. METHODS: Primary human hepatocytes (PHH) were isolated via therapeutic hepatectomy from two donors who tested negative for hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV)...
May 14, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38741237/core-protein-inhibitors-opportunities-and-challenges-at-the-forefront-of-hepatitis-b-cure
#9
EDITORIAL
Hae Lim Lee, Jeong Won Jang
No abstract text is available yet for this article.
May 14, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38741236/unveiling-etiology-specific-blood-biomarkers-in-hepatocellular-carcinoma-a-gateway-to-personalized-medicine
#10
EDITORIAL
Joseph C Ahn, Ju Dong Yang
No abstract text is available yet for this article.
May 14, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38726505/extrahepatic-malignancies-and-antiviral-drugs-for-chronic-hepatitis-b-a-nationwide-cohort-study
#11
JOURNAL ARTICLE
Moon Haeng Hur, Dong Hyeon Lee, Jeong-Hoon Lee, Mi-Sook Kim, Jeayeon Park, Hyunjae Shin, Sung Won Chung, Hee Jin Cho, Min Kyung Park, Heejoon Jang, Yun Bin Lee, Su Jong Yu, Sang Hyub Lee, Yong Jin Jung, Yoon Jun Kim, Jung-Hwan Yoon
BACKGROUND/AIMS: Chronic hepatitis B (CHB) is related to an increased risk of extrahepatic malignancy (EHM), and antiviral treatment is associated with an incidence of EHM comparable to controls. We compared the risks of EHM and intrahepatic malignancy (IHM) between entecavir (ETV) and tenofovir disoproxil fumarate (TDF) treatment. METHODS: Using data from the National Health Insurance Service of Korea, this nationwide cohort study included treatment-naïve CHB patients who initiated ETV (n=24,287) or TDF (n=29,199) therapy between 2012 and 2014...
May 10, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38726504/macrophage-atg16l1-expression-suppresses-mash-progression-by-promoting-lipophagy
#12
JOURNAL ARTICLE
Qi Wang, Qingfa Bu, Zibo Xu, Yuan Liang, Jinren Zhou, Yufeng Pan, Haoming Zhou, Ling Lu
BACKGROUND/AIMS: metabolic dysfunction-associated steatohepatitis (MASH) is an unmet clinical challenge due to the rapid increased occurrence but lacking approved drugs. Autophagy-related protein 16-like 1 (ATG16L1) plays an important role in the process of autophagy, which is indispensable for proper biogenesis of the autophagosome, but its role in modulating macrophage-related inflammation and metabolism during MASH has not been documented. Here, we aimed to elucidate the role of ATG16L1 in the progression of MASH...
May 10, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38726503/changing-from-nafld-to-masld-cumulative-incidence-of-gallstones-between-patients-with-nafld-and-those-with-masld-in-asia
#13
JOURNAL ARTICLE
Shuhei Fukunaga, Tomoyuki Nakane, Michita Mukasa, Hidetoshi Takedatsu, Takumi Kawaguchi
No abstract text is available yet for this article.
May 10, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38726502/unlocking-the-role-of-liver-sinusoidal-endothelial-cells-key-players-in-liver-fibrosis
#14
EDITORIAL
Yasuko Iwakiri
No abstract text is available yet for this article.
May 10, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38711390/evolutionary-changes-in-metabolic-dysfunction-associated-steatotic-liver-disease-and-the-risk-of-hepatocellular-carcinoma-a-nationwide-cohort-study
#15
JOURNAL ARTICLE
Seogsong Jeong, Yun Hwan Oh, Joseph C Ahn, Seulggie Choi, Sun Jae Park, Hye Jun Kim, Gyeongsil Lee, Joung Sik Son, Heejoon Jang, Dong Hyeon Lee, Meng Sha, Lei Chen, Won Kim, Sang Min Park
BACKGROUND/AIMS: To determine the association between evolutionary changes in metabolic dysfunction-associated steatotic liver disease (MASLD) status and the risk of hepatocellular carcinoma (HCC) in a nationwide population-based cohort. METHODS: Information on study participants were derived from the Korea National Health Insurance Service database. The study population consisted of 5,080,410 participants who underwent two consecutive biennial health screenings between 2009 and 2012...
May 7, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38711304/atezolizumab-and-bevacizumab-for-hepatocellular-carcinoma-how-to-approach-salvage-therapy-for-non-responders
#16
EDITORIAL
Naoshi Nishida
No abstract text is available yet for this article.
May 7, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38711303/unlocking-the-future-machine-learning-sheds-light-on-prognostication-for-early-stage-hepatocellular-carcinoma
#17
EDITORIAL
Junlong Dai, Jimmy Che-To Lai, Grace Lai-Hung Wong, Terry Cheuk-Fung Yip
No abstract text is available yet for this article.
May 7, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38697652/complement-proteins-and-liver-diseases-a-response-to-the-correspondence
#18
JOURNAL ARTICLE
Mohammad Saeid Rezaee-Zavareh, Naomy Kim, Ju Dong Yang
No abstract text is available yet for this article.
May 2, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38685664/functional-cure-of-chb-encounters-resmetirom
#19
JOURNAL ARTICLE
Nai-Bin Yang, Wai-Kay Seto, Ming-Hua Zheng
No abstract text is available yet for this article.
April 30, 2024: Clinical and Molecular Hepatology
https://read.qxmd.com/read/38665034/unmet-needs-in-the-post-daa-era-the-risk-and-molecular-mechanisms-of-hepatocellular-carcinoma-after-hcv-eradication
#20
REVIEW
Chung-Feng Huang, Manar Hijaze Awad, Meital Gal-Tanamy, Ming-Lung Yu
Hepatitis C virus (HCV) is one of the major etiologies of hepatocellular carcinoma with approximately 30% of HCC being due to HCV infection worldwide. HCV eradication by antivirals greatly reduces the risk of HCC; nevertheless, HCC remains to occur in CHC patients who have achieved a sustained virological response (SVR). The proportion of post-SVR HCC among newly diagnosed HCC patients is increasing in the DAA era and might be due to preexisting inflammatory and fibrotic liver background, immune dysregulation between host and virus interaction, as well as host epigenetic scar, genetic predispositions and alternations...
April 26, 2024: Clinical and Molecular Hepatology
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