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Journals Journal of Stem Cell Research ...

Journal of Stem Cell Research & Therapy

https://read.qxmd.com/read/25405071/lost-in-translation-regulation-of-abcg2-expression-in-human-embryonic-stem-cells
#21
JOURNAL ARTICLE
Raji Padmanabhan, Kevin G Chen, Michael M Gottesman
The expression and function of the ATP-binding cassette (ABC) transporter ABCG2 have been studied for two decades in both adult and cancer stem cells. However, this important ABC transporter has not been well characterized in human embryonic stem cells (hESCs). Studies designed to understand the role of ABCG2 in hESCs are still in their initial stages. Several recent reports on expression patterns of the ABCG2 gene in hESCs contain contradictory results at both the mRNA and protein levels. In this review, we provide possible explanations for these discrepancies in ABCG2 expression patterns...
March 17, 2014: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/26203401/unconventional-neurogenic-niches-and-neurogenesis-modulation-by-vitamins
#22
JOURNAL ARTICLE
Karina Oyarce, Ernesto R Bongarzone, Francisco Nualart
Although the generation of new neurons occurs in adult mammals, it has been classically described in two defined regions of the brain denominated neurogenic niches: the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus. In these regions, neural stem cells give rise to new neurons and glia, which functionally integrate into the existing circuits under physiological conditions. However, accumulating evidence indicates the presence of neurogenic potential in other brain regions, from which multipotent precursors can be isolated and differentiated in vitro ...
March 2014: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/25068075/mr-imaging-of-stem-cell-transplants-in-arthritic-joints
#23
JOURNAL ARTICLE
Heike E Daldrup-Link, Hossein Nejadnik
About 43 million individuals in the US currently suffer from disabilities due to arthritis. Cartilage defects are the major source of pain in the affected joints. Current treatments, whilst alleviating some of the clinical symptoms, prove insufficient to cure the underlying irreversible cartilage loss. Stem cells represent a unique source for restoration of cartilage defects. Pre-clinical and clinical trials are currently pursued to investigate the potential of various types of stem cells and stem cell derived chondrocytes to repair arthritic joints...
February 7, 2014: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/24900946/nk-cells-and-mscs-possible-implications-for-msc-therapy-in-renal-transplantation
#24
JOURNAL ARTICLE
Marlies Ej Reinders, Martin J Hoogduijn
No abstract text is available yet for this article.
February 7, 2014: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/24883232/duplication-of-tbk1-stimulates-autophagy-in-ipsc-derived-retinal-cells-from-a-patient-with-normal-tension-glaucoma
#25
JOURNAL ARTICLE
Budd A Tucker, Frances Solivan-Timpe, Ben R Roos, Kristin R Anfinson, Alan L Robin, Luke A Wiley, Robert F Mullins, John H Fingert
Duplication of theTBK1 gene causes normal tension glaucoma (NTG); however the mechanism by which this copy number variation leads to retinal ganglion cell death is poorly understood. The ability to use skin-derived induced pluripotent stem cells (iPSCs) to investigate the function or dysfunction of a mutant gene product in inaccessible tissues such as the retina now provides us with the ability to interrogate disease pathophysiology in vitro. iPSCs were generated from dermal fibroblasts obtained from a patient with TBK1-associated NTG, via viral transduction of the transcription factors OCT4, SOX2, KLF4, and c-MYC...
January 25, 2014: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/25599002/application-of-umbilical-cord-blood-derived-stem-cells-in-diseases-of-the-nervous-system
#26
JOURNAL ARTICLE
Bhagelu R Achyut, Nadimpalli Ravi S Varma, Ali S Arbab
Umbilical cord blood (UCB) derived multipotent stem cells are capable of giving rise hematopoietic, epithelial, endothelial and neural progenitor cells. Thus suggested to significantly improve graft-versus-host disease and represent the distinctive therapeutic option for several malignant and non-malignant diseases. Recent advances in strategies to isolate, expand and shorten the timing of UCB stem cells engraftment have tremendously improved the efficacy of transplantations. Nervous system has limited regenerative potential in disease conditions such as cancer, neurodegeneration, stroke, and several neural injuries...
2014: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/24729944/human-allogeneic-bone-marrow-and-adipose-tissue-derived-mesenchymal-stromal-cells-induce-cd8-cytotoxic-t-cell-reactivity
#27
JOURNAL ARTICLE
Marieke Roemeling-van Rhijn, Marlies E Reinders, Marcella Franquesa, Anja U Engela, Sander S Korevaar, Helene Roelofs, Paul G Genever, Jan Nm Ijzermans, Michiel Gh Betjes, Carla C Baan, Willem Weimar, Martin J Hoogduijn
INTRODUCTION: For clinical applications, Mesenchymal Stromal Cells (MSC) can be isolated from bone marrow and adipose tissue of autologous or allogeneic origin. Allogeneic cell usage has advantages but may harbor the risk of sensitization against foreign HLA. Therefore, we evaluated whether bone marrow and adipose tissue-derived MSC are capable of inducing HLA-specific alloreactivity. METHODS: MSC were isolated from healthy human Bone Marrow (BM-MSC) and adipose tissue (ASC) donors...
December 12, 2013: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/24672744/human-bone-marrow-and-adipose-tissue-derived-mesenchymal-stromal-cells-are-immunosuppressive-in-vitro-and-in-a-humanized-allograft-rejection-model
#28
JOURNAL ARTICLE
Marieke Roemeling-van Rhijn, Meriem Khairoun, Sander S Korevaar, Ellen Lievers, Danielle G Leuning, Jan Nm Ijzermans, Michiel Gh Betjes, Paul G Genever, Cees van Kooten, Hans Jw de Fijter, Ton J Rabelink, Carla C Baan, Willem Weimar, Helene Roelofs, Martin J Hoogduijn, Marlies E Reinders
BACKGROUND: Recent studies with bone marrow (BM)-derived Mesenchymal Stromal Cells (MSC) in transplant recipients demonstrate that treatment with MSC is safe and clinically feasible. While BM is currently the preferred source of MSC, adipose tissue is emerging as an alternative. To develop efficient therapies, there is a need for preclinical efficacy studies in transplantation. We used a unique humanized transplantation model to study the in vivo immunosuppressive effect of human BM-MSC and adipose tissue-derived MSC (ASC)...
November 25, 2013: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/25197614/ex-vivo-expansion-of-human-adult-pancreatic-cells-with-properties-of-distributed-stem-cells-by-suppression-of-asymmetric-cell-kinetics
#29
JOURNAL ARTICLE
Jf Paré, Jl Sherley
Transplantation therapy for type I diabetes (T1D) might be improved if pancreatic stem cells were readily available for investigation. Unlike macroscopic islets, pancreatic tissue stem cells could more easily access the retroperitoneal pancreatic environment and thereby might achieve more effective pancreatic regeneration. Unfortunately, whether the adult pancreas actually contains renewing stem cells continues as a controversial issue in diabetes research. We evaluated a new method developed in our lab for expanding renewing distributed stem cells (DSCs) from adult tissues as a means to provide more evidence for adult pancreatic stem cells, and potentially advance their availability for future clinical investigation...
September 2013: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/24383045/identification-of-hematopoietic-stem-cell-engraftment-genes-in-gene-therapy-studies
#30
JOURNAL ARTICLE
John M Powers, Grant D Trobridge
Hematopoietic stem cell (HSC) therapy using replication-incompetent retroviral vectors is a promising approach to provide life-long correction for genetic defects. HSC gene therapy clinical studies have resulted in functional cures for several diseases, but in some studies clonal expansion or leukemia has occurred. This is due to the dyregulation of endogenous host gene expression from vector provirus insertional mutagenesis. Insertional mutagenesis screens using replicating retroviruses have been used extensively to identify genes that influence oncogenesis...
September 1, 2013: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/25045589/safeguarding-stem-cell-based-regenerative-therapy-against-iatrogenic-cancerogenesis-transgenic-expression-of-dnase1-dnase1l3-dnase2-dffb-controlled-by-pola1-promoter-in-proliferating-and-directed-differentiation-resisting-human-autologous-pluripotent-induced
#31
JOURNAL ARTICLE
Marek Malecki, Christine LaVanne, Dominique Alhambra, Chaitanya Dodivenaka, Sarah Nagel, Raf Malecki
INTRODUCTION: The worst possible complication of using stem cells for regenerative therapy is iatrogenic cancerogenesis. The ultimate goal of our work is to develop a self-triggering feedback mechanism aimed at causing death of all stem cells, which resist directed differentiation, keep proliferating, and can grow into tumors. SPECIFIC AIM: The specific aim was threefold: (1) to genetically engineer the DNA constructs for the human, recombinant DNASE1, DNASE1L3, DNASE2, DFFB controlled by POLA promoter; (2) to bioengineer anti-SSEA-4 antibody guided vectors delivering transgenes to human undifferentiated and proliferating pluripotent stem cells; (3) to cause death of proliferating and directed differentiation resisting stem cells by transgenic expression of the human recombinant the DNases (hrDNases)...
July 22, 2013: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/24307973/human-umbilical-cord-blood-for-transplantation-therapy-in-myocardial-infarction
#32
JOURNAL ARTICLE
Sandra A Acosta, Nick Franzese, Meaghan Staples, Nathan L Weinbren, Monica Babilonia, Jason Patel, Neil Merchant, Alejandra Jacotte Simancas, Adam Slakter, Mathew Caputo, Milan Patel, Giorgio Franyuti, Max H Franzblau, Lyanne Suarez, Chiara Gonzales-Portillo, Theo Diamandis, Kazutaka Shinozuka, Naoki Tajiri, Paul R Sanberg, Yuji Kaneko, Leslie W Miller, Cesar V Borlongan
Cell-based therapy is a promising therapy for myocardial infarction. Endogenous repair of the heart muscle after myocardial infarction is a challenge because adult cardiomyocytes have a limited capacity to proliferate and replace damaged cells. Pre-clinical and clinical evidence has shown that cell based therapy may promote revascularization and replacement of damaged myocytes after myocardial infarction. Adult stem cells can be harvested from different sources including bone marrow, skeletal myoblast, and human umbilical cord blood cells...
July 1, 2013: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/23956947/improved-targeting-and-enhanced-retention-of-the-human-autologous-fibroblast-derived-induced-pluripotent-stem-cells-to-the-sarcomeres-of-the-infarcted-myocardium-with-the-aid-of-the-bioengineered-heterospecific-tetravalent-antibodies
#33
JOURNAL ARTICLE
Marek Malecki
Clinical trials, to regenerate the human heart injured by myocardial infarction, involve the delivery of stem cells to the site of the injury. However, only a small fraction of the introduced stem cells are detected at the site of the injury, merely two weeks after this therapeutic intervention. This significantly hampers the effectiveness of the stem cell therapy. To resolve the aforementioned problem, we genetically and molecularly bioengineered heterospecific, tetravalent antibodies (htAbs), which have both exquisite specificity and high affinity towards human, pluripotent, stem cells through the htAbs' domains binding SSEA-4, SSEA-3, TRA-1-60, and TRA-1-81, as well as towards the injured cardiac muscle through the htAbs' domains binding human cardiac myosin, α-actinin, actin, and titin...
May 6, 2013: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/23885309/what-is-a-master-regulator
#34
JOURNAL ARTICLE
Sunny Sun-Kin Chan, Michael Kyba
No abstract text is available yet for this article.
May 4, 2013: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/25383240/a-perspective-on-the-potential-of-human-ips-cell-based-therapies-for-muscular-dystrophies-advancements-so-far-and-hurdles-to-overcome
#35
JOURNAL ARTICLE
Radbod Darabi, Rita C R Perlingeiro
No abstract text is available yet for this article.
May 2, 2013: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/24077523/stem-cells-for-neurovascular-repair-in-stroke
#36
JOURNAL ARTICLE
Kazutaka Shinozuka, Travis Dailey, Naoki Tajiri, Hiroto Ishikawa, Dae Won Kim, Mibel Pabon, Sandra Acosta, Yuji Kaneko, Cesar V Borlongan
Stem cells exert therapeutic effects against ischemic stroke via transplantation of exogenous stem cells or stimulation of endogenous stem cells within the neurogenic niches of subventricular zone and subgranular zone, or recruited from the bone marrow through peripheral circulation. In this paper, we review the different sources of stem cells that have been tested in animal models of stroke. In addition, we discuss specific mechanisms of action, in particular neurovascular repair by endothelial progenitor cells, as key translational research for advancing the clinical applications of stem cells for ischemic stroke...
May 1, 2013: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/23772337/tra-1-60-ssea-4-pou5f1-sox2-nanog-clones-of-pluripotent-stem-cells-in-the-embryonal-carcinomas-of-the-testes
#37
JOURNAL ARTICLE
Marek Malecki, Xenia Tombokan, Mark Anderson, Raf Malecki, Michael Beauchaine
INTRODUCTION: Cancer of the testes is currently the most frequent neoplasm and a leading cause of morbidity in men 15-35 years of age. Its incidence is increasing. Embryonal carcinoma is its most malignant form, which either may be resistant or may develop resistance to therapies, which results in relapses. Cancer stem cells are hypothesized to be drivers of these phenomena. SPECIFIC AIM: The specific aim of this work was identification and isolation of spectra of single, living cancer stem cells, which were acquired directly from the patients' biopsies, followed by testing of their pluripotency...
April 2, 2013: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/23565347/cancer-stem-cells-in-colorectal-cancer-genetic-and-epigenetic-changes
#38
JOURNAL ARTICLE
Sanchita Roy, Adhip P N Majumdar
Colorectal cancer (CRC), an age-related disease, is the third most common cancer in the world. Although sporadic CRC, that affects 80-85% of CRC patients, is a multi-step process initiated by APC gene mutation, it is becoming increasingly evident that a small sub-population of cells termed cancer stem/stem-like cells (CSCs/CSLCs) plays critical roles in the progression of this malignancy specially the recurrence and drug resistance. The current review will summarize genetic and epigenetic changes observed at different stages in the progression of sporadic CRC...
December 17, 2012: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/24319631/systems-and-network-pharmacology-approaches-to-cancer-stem-cells-research-and-therapy
#39
JOURNAL ARTICLE
Irfana Muqbil, Ginny W Bao, Rkya El-Kharraj, Minjel Shah, Ramzi M Mohammad, Fazlul H Sarkar, Asfar S Azmi
The cancer stem cell (CSC) hypothesis is increasingly being accepted as a model to explain for the functional heterogeneity that is commonly observed in solid tumors. According to this hypothesis, there exists a hierarchical organization of cells within the tumor, in which a differential subpopulation of stem-like cells is responsible for sustaining and recurrence of tumor growth. CSCs have been shown to exist in a variety of solid tumors especially those with known resistant phenotypes such as breast, prostate and pancreatic adenocarcinoma (PDAC)...
December 16, 2012: Journal of Stem Cell Research & Therapy
https://read.qxmd.com/read/24524010/molecular-regulation-of-muscle-satellite-cell-self-renewal
#40
JOURNAL ARTICLE
Norio Motohashi, Atsushi Asakura
No abstract text is available yet for this article.
November 2012: Journal of Stem Cell Research & Therapy
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