Mohana Karlekar, Khaldoun Almhanna, Dana Guyer
Colorectal (CRC) and anal (AC) cancer, both lower gastrointestinal (GI) cancers vary in their presentation and treatment. Overall, the incidence of CRC has decreased. However, the incidence of CRCs in younger adults has increased over the last 5 years. The incidence of ACs too has increased. Women are disproportionally impacted by AC which is frequently associated with human papilloma virus (HPV). Patients diagnosed with both cancers often experience multiple symptoms including pain, constipation, nausea, and vomiting...
September 20, 2023: Annals of Palliative Medicine
Emily Keit, Shing Fung Lee, Melissa Woodward, Agata Rembielak, Kevin Shiue, Isacco Desideri, Eva Oldenburger, Maya Bienz, Dirk Rades, Marilena Theodorou, Mervin B Agyeman, Joel Yarney, John Michael Bryant, Hsiang-Hsuan Michael Yu, Charles B Simone, Peter Hoskin, Peter A S Johnstone
BACKGROUND: Improvements in radiation delivery and systemic therapies have resulted in few remaining indications for palliative whole brain radiation therapy (WBRT). Most centers preferentially use stereotactic radiotherapy (SRT) and reserve WBRT for those with >15 lesions, leptomeningeal presentation, rapidly progressive disease, or limited estimated survival. Despite regional differences among preferred dose, fractionation, and treatment technique, we predict survival post-WBRT will remain poor-indicating appropriate application of WBRT in this era of SRT and improved systemic therapies...
September 20, 2023: Annals of Palliative Medicine
Katsuya Cho, Hirotaka Saikawa, Tatsuya Hashimoto, Hiroshi Katagiri, Yoshihiro Owada, Kazuhiro Yakuwa, Itaru Fujimura, Yu Utsumi, Masachika Akiyama, Hiromi Nagashima, Fumiaki Takahashi, Makoto Maemondo
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) has a significant impact on the therapeutic efficacy of chemotherapy and patients' quality of life. The aim of this study was to assess the preventive effect of lafutidine on CIPN. METHODS: Patients were randomly assigned (1:1) to carboplatin and paclitaxel chemotherapy with lafutidine 10 mg twice daily (lafutidine group) or without lafutidine (control group). Peripheral neuropathy in both groups was assessed with the Common Terminology Criteria for Adverse Events (CTCAE) version 5...
September 18, 2023: Annals of Palliative Medicine
Lily Kuo, Saatchi Kuwelker, Eugenia Tsai
BACKGROUND AND OBJECTIVE: Cancer immunotherapy has firmly established itself as a pillar of cancer care due to its advantages over traditional anti-tumor therapy but also carries limitations due to potential for severe adverse reactions. This review highlights the current understanding and management of patients with autoimmune and viral hepatitis immune in the setting of immune checkpoint inhibitor (ICI) therapy. METHODS: A literature search was conducted on PubMed, Scopus, Google Scholar SEER*Stat databases (from inception to December 2022) using search terms: "immune checkpoint inhibitor", "autoimmune hepatitis", "viral hepatitis", "HBV pathogenesis", "HCV pathogenesis", "HBV reactivation", "HCV reactivation", "cancer immunotherapy", "immune related adverse events", "immune related hepatitis"...
September 13, 2023: Annals of Palliative Medicine
Ting-Han Chiu, Hsiang-Shun Shih, Seng-Feng Jeng
Pharyngocutaneous fistula is a serious complication after head and neck reconstruction and concurrent chemoradiotherapy, yet no consensus or practical protocols regarding the surgical timing and specific procedures could be found in the current literature. The authors aimed to review their clinical experience in surgical management and develop an algorithmic approach accordingly. A retrospective review of all hypopharyngeal cancer patients who developed pharyngocutaneous fistula during 2017 to 2021 at our hospital was conducted...
September 7, 2023: Annals of Palliative Medicine
Peter A S Johnstone, Charles B Simone
No abstract text is available yet for this article.
September 4, 2023: Annals of Palliative Medicine
Patsy Yates
No abstract text is available yet for this article.
August 28, 2023: Annals of Palliative Medicine
Karlotta Schloesser, Anja Bergmann, Yvonne Eisenmann, Berenike Pauli, Anne Pralong, Martin Hellmich, Max Oberste, Stefanie Hamacher, Armin Tuchscherer, Konrad F Frank, Winfried Randerath, Simon Herkenrath, Andreas von Leupoldt, Alexander Niecke, Steffen T Simon
BACKGROUND: Episodic breathlessness is often accompanied by panic. A vicious cycle of breathlessnesspanic-breathlessness leads to emergencies with severe breathlessness and/or fear of dying. However, the interaction between episodic breathlessness and panic is poorly understood. Thus, the aim is a better understanding of the interaction between panic and episodic breathlessness to develop appropriate support for patients suffering from this symptom. METHODS: Patients suffering from episodic breathlessness due to life-limiting diseases answered questions on the characteristics of episodic breathlessness and panic-spectrum psychopathology, including underlying mechanisms...
August 25, 2023: Annals of Palliative Medicine
Jennifer Corcoran, Benzi M Kluger
BACKGROUND AND OBJECTIVE: Prognostication is the process of predicting a patient's likely outcome from their medical condition, and consists of determining both how well and how long a patient may live. There are few disease-specific prognostic tools to estimate a patient's individualized prognosis in terms of symptom burden and mortality. Here we summarize relevant literature on prognosis in four progressive neurologic diseases-dementia, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis-as well as on best practices on communicating prognosis with patients and care partners...
August 24, 2023: Annals of Palliative Medicine
Jaya Amaram-Davila, Patricia Bramati, Laura Gammon, Tarun Mallipeddi, Olivia Jastrzemski, Matthew D Clark, Joseph Arthur, Akhila Reddy, Eduardo Bruera
BACKGROUND: ; 2 ; 3 ; 4 ; 5 The CAGE-AID questionnaire (Cut-down, Annoyed, Guilty, Eye-opener scale Adapted to Include Drugs) is used to screen patients for substance use disorder and nonmedical opioid use (NMOU). Major pain guidelines encourage using such screening tools for all patients including cancer patients before initiating opioids. We present two cases where the CAGE-AID results did not accurately identify the risk for NMOU. CASE DESCRIPTION: Patient 1 is a male in his 60s with metastatic prostate cancer was admitted for uncontrolled pain...
August 22, 2023: Annals of Palliative Medicine
Emily Zametkin, Dana Guyer, Yael Tarshish, Kinan Bash, Khaldoun Almhanna
The use of total parenteral nutrition (TPN) in patients with gastrointestinal cancers is a wellestablished practice, yet there is substantial variability in its use across institutions. Decision-making around the initiation of TPN is complex. An interdisciplinary team can help identify patient factors and clinical situations that influence whether a patient is likely to benefit from parenteral nutrition. We present the case of a woman with a gastrointestinal cancer who benefited from the initiation of TPN as a bridge therapy to further cancer treatment...
August 21, 2023: Annals of Palliative Medicine
Irma N Hashmi, Hannah M Lee, Joel P Wedd, Richard K Sterling, Teri E Dulong-Rae, J Brian Cassel, John W Cyrus, James J Fletcher, Danielle M Noreika
BACKGROUND AND OBJECTIVE: Hepatocellular carcinoma (HCC) remains a leading cause of cancerrelated deaths, and case numbers continue to rise in the United States. HCC carries a poor prognosis, and management requires a multidisciplinary approach. This narrative review aims to identify opportunities for further integration of palliative care (PC) in HCC care. Given the high symptom burden faced by patients with HCC, early PC consultation can be beneficial for patients. METHODS: A search of PubMed was conducted from inception of the database to March 1, 2023...
August 21, 2023: Annals of Palliative Medicine
Cal Cates, Kerry Jordan, Niki Munk, Rory Farrand, Ann Blair Kennedy, Hunter Groninger
BACKGROUND AND OBJECTIVE: Patients living with serious illness are often eligible for palliative care and experience physical symptoms including pain or dyspnea and psychological distress that negatively impacts health-related quality of life and other outcomes. Such patients often benefit from massage therapy to reduce symptom burden and improve quality of life when such treatment is available. At present, no synthesis or review exists exploring massage therapy specifically provided with palliative care patient populations...
August 11, 2023: Annals of Palliative Medicine
Anish Narayanan, Andres Garza-Berlanga, Jorge Lopera
BACKGROUND: It is estimated that 35-40% of hepatocellular carcinoma (HCC) patients present with multiple nodules at the time of diagnosis. Treating multifocal disease is difficult given patient population heterogeneity. Multiple interventional radiological (IR) options, including ablation, transarterial chemoembolization (TACE), and transarterial radioembolization (TARE), are available, each with its own merits and limitations. Our aim is to explore the current state of the literature to identify where each of these options is best applied to multifocal HCC management...
August 9, 2023: Annals of Palliative Medicine
Alessandro Cianfoni, Alice Venier, Joshua Adam Hirsch
No abstract text is available yet for this article.
August 9, 2023: Annals of Palliative Medicine
Alvin Ka Nok Liu, Shilo Lefresne
BACKGROUND: Pancreatic cancer is often incurable and can be associated with significant pain and abdominal symptoms. This study aims to characterize the symptomatic burden of patients with pancreatic cancer receiving palliative radiotherapy and the corresponding symptomatic and radiographic responses. METHODS: Patients with pancreatic adenocarcinoma referred to BC Cancer for palliative radiation from 2006 to 2013 were retrospectively reviewed. Logistic regression and Cox proportional hazards model were used to evaluate variables predictive of symptomatic response and survival respectively...
August 7, 2023: Annals of Palliative Medicine
M Judy Lubas, Patricia Mae G Santos, Divya Yerramilli, Charles B Simone
Given its sharp dose fall off and ability to spare healthy surrounding tissue, proton beam therapy (PBT) has traditionally been used to treat various types of malignancies in the definitive setting, with strong, empirical data supporting its utility and safety. In the palliative setting, however, photon therapy has generally remained the standard of care in radiation treatment delivery due to lower cost, and greater availability. However, recent data suggest that the use of PBT may provide benefit in terms of symptom management and disease control in patients with locally advanced or recurrent disease who do not qualify for definitive therapy or with metastatic disease...
August 4, 2023: Annals of Palliative Medicine
Gudrun Kreye
BACKGROUND: Home care visits are crucial for individuals with palliative care (PC) needs, as they allow them to stay in the comfort of their own homes for as long as possible or to pass away surrounded by loved ones. These visits also provide PC teams with the opportunity to understand the patient as a whole person, replete with their own individual stories and needs. One aspect that can be particularly significant in a patient's life is their relationship with animals and pets. So far, there are no case reports on patients living with a deer at home...
August 1, 2023: Annals of Palliative Medicine
Michael Pennock, Jonathan Klein, Michael Lock
BACKGROUND AND OBJECTIVE: Primary and metastatic liver cancer presents heterogeneously. New radiotherapy techniques have reduced toxicity concerns, leading to increased use of liver radiotherapy. This review synthesizes available evidence and offers recommendations for palliative radiotherapy for liver cancer. METHODS: PubMed, Ovid Medline, Embase, Cochrane Central, and Web of Science were searched from from inception to December 28th, 2022. Articles reporting local control (LC), survival, toxicity, symptom control, and response after stereotactic body radiotherapy (SBRT), partial-liver, or whole-liver radiotherapy (WLRT) techniques were reviewed...
July 31, 2023: Annals of Palliative Medicine
James W Snider, Nina A Mayr, Charles B Simone
No abstract text is available yet for this article.
July 31, 2023: Annals of Palliative Medicine
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