journal
https://read.qxmd.com/read/38436139/metastasis-associated-protein-1-participates-in-regulating-luminal-acidification-of-the-epididymis-via-repressing-estrogen-receptor-alpha-transcription
#21
JOURNAL ARTICLE
Pang Cheng, Jinhua Wei, Bo Liu, Ya Zhao, Binfang Ma, Xiao Feng, Mingxiang Xiong, Jie Zhao, Changhong Shi, Zhen Li
BACKGROUND: As a component of the nucleosome remodeling and deacetylating (NuRD) complex, metastasis-associated protein 1 (MTA1) has been reported to be abundant in male reproductive system and might participate in spermatogenesis and sperm maturation, whereas the precise functional role of MTA1 in these processes is still undetermined. OBJECTIVE: To investigate the effect and potential function of MTA1 in male fertility. MATERIALS AND METHODS: Mta1 knockout mice (Mta1-/- ) were employed to detect their reproductive phenotype...
March 4, 2024: Andrology
https://read.qxmd.com/read/38436127/the-association-of-socioeconomic-status-with-semen-parameters-in-a-cohort-of-men-in-the-united-states
#22
JOURNAL ARTICLE
Jad Badreddine, Nicholas Sellke, Stephen Rhodes, Nannan Thirumavalavan, Ramy Abou Ghayda
BACKGROUND: Socioeconomic differences are present within the population of men who experience infertility and seek treatment. OBJECTIVE: To study the association of socioeconomic status with semen parameters in a group of men using mail-in semen analyses. MATERIALS AND METHODS: The records of 11,134 men that used mail-in semen analyses from a fertility company were identified. Their demographic information, semen parameters, and ZIP codes were collected...
March 4, 2024: Andrology
https://read.qxmd.com/read/38436126/the-neurological-decline-and-psychological-factors-caused-by-coronavirus-disease-2019-may-be-predictors-of-erectile-dysfunction
#23
JOURNAL ARTICLE
Yukuai Ma, Tianle Zhu, Peng Yang, Rui Gao, Lanhui Shen, Pan Gao, Jingjing Gao, Xi Liu, Hui Jiang, Xiansheng Zhang
BACKGROUND: Since the outbreak of coronavirus disease 2019, it has had a serious impact on people's physical and mental health. However, in our clinical work, we have found that the erectile function of coronavirus disease 2019 patients with neurological decline was often seriously affected. OBJECTIVES: To further explore the relationship between erectile dysfunction and neurological dysfunction caused by coronavirus disease 2019. MATERIALS AND METHODS: We conducted a survey from August 2022 to February 2023 at the First Affiliated Hospital of Anhui Medical University and the Third People's Hospital of Linyi City...
March 4, 2024: Andrology
https://read.qxmd.com/read/38421140/a-detection-model-of-testis-derived-circular-rnas-in-serum-for-predicting-testicular-sperm-retrieval-rate-in-non-obstructive-azoospermia-patients
#24
JOURNAL ARTICLE
Mo-Qi Lv, Yan-Qi Yang, Yi-Xin Li, Liang Zhou, Pan Ge, Rui-Fang Sun, Jian Zhang, Jun-Cheng Gao, Liu-Qing Qu, Qi-Ya Jing, Pin-Cheng Li, Yu-Jia Yan, Hai-Xu Wang, He-Cheng Li, Dang-Xia Zhou
BACKGROUND: Microdissection testicular sperm extraction is an effective method to retrieve sperm from non-obstructive azoospermia patients. However, its successful rate is less than 50%. OBJECTIVES: To identify the predictive value of circular RNAs in serum for sperm retrieval rate in non-obstructive azoospermia patients. MATERIALS AND METHODS: 180 non-obstructive azoospermia patients were recruited in this study, including 84 individuals with successful sperm retrieval and 96 individuals with failed sperm retrieval...
February 29, 2024: Andrology
https://read.qxmd.com/read/38421134/evaluating-the-impact-of-pre-diagnostic-use-of-statins-and-testosterone-replacement-therapy-on-mortality-outcomes-in-older-men-with-hormone-related-cancers-surveillance-epidemiology-and-end-results-medicare-2007-2015
#25
JOURNAL ARTICLE
Maryam R Hussain, Omer Abdelgadir, Efstathia Polychronopoulou, Konstantinos K Tsilidis, Laith Alzweri, Alejandro Villasante-Tezanos, Jacques Baillargeon, Steven Canfield, Yong-Fang Kuo, David S Lopez
BACKGROUND: The link between the pre-diagnostic use of statins and testosterone replacement therapy and their impact on hormone-related cancers, prostate cancer, colorectal cancer, and male breast cancer survival remains a topic of controversy. Further, there is a knowledge gap concerning the joint effects of statins and testosterone replacement therapy on hormone-related cancer survival outcomes. OBJECTIVE: To examine the independent and joint effects of pre-diagnostic use of statins and testosterone replacement therapy on the risk of all-cause and cause-specific mortality among older men diagnosed with hormone-related cancers, including prostate cancer, colorectal cancer, and male breast cancer...
February 29, 2024: Andrology
https://read.qxmd.com/read/38421114/real-life-users-of-hormonal-or-thermal-male-contraception-an-analysis-of-female-partners-motivation-experience-and-satisfaction
#26
JOURNAL ARTICLE
Clothilde Laurent, Roger Mieusset, Jean-Claude Soufir, Jeanne Perrin
BACKGROUND: Two male contraceptive methods that inhibit spermatogenesis currently exist: thermal male contraception and hormonal male contraception. Only five studies have been conducted on the acceptability of these methods among men; among women, only the hypothetical acceptability of such a male contraceptive approach as the sole contraception method used by a couple has been evaluated. OBJECTIVES: To evaluate the motivation, experience, and satisfaction of female partners in couples using hormonal male contraception or thermal male contraception as the sole contraception...
February 29, 2024: Andrology
https://read.qxmd.com/read/38396220/transgenerational-effects-of-paternal-exposures-the-role-of-germline-de-novo-mutations
#27
REVIEW
Hojat Dehghanbanadaki, Masaya Jimbo, Kiarad Fendereski, Jason Kunisaki, Joshua J Horns, Joemy M Ramsay, Kelli X Gross, Alexander W Pastuszak, James M Hotaling
Germline de novo mutations (DNMs) refer to spontaneous mutations arising during gametogenesis, resulting in genetic changes within germ cells that are subsequently transmitted to the next generation. While the impact of maternal exposures on germline DNMs has been extensively studied, more recent studies have begun to highlight the increasing importance of the effects of paternal factors. In this review, we have summarized the existing literature on how various exposures experienced by fathers affect the germline DNM burden in their spermatozoa, as well as their consequences for semen analysis parameters, pregnancy outcomes, and offspring health...
February 23, 2024: Andrology
https://read.qxmd.com/read/38385883/whole-exome-sequencing-identifies-adgb-as-a-novel-causative-gene-for-male-infertility-in-humans-from-motility-to-fertilization
#28
JOURNAL ARTICLE
Yang Gao, Liting Liu, Shixiong Tian, Chunyu Liu, Mingrong Lv, Huan Wu, Dongdong Tang, Bing Song, Qunshan Shen, Yuping Xu, Ping Zhou, Zhaolian Wei, Feng Zhang, Yunxia Cao, Xiaojin He
OBJECTIVES: In male mice, adgb-knockout has been reported to cause male infertility with spermatogenesis defects involving flagella and acrosome. However, this remains unclear for humans. MATERIALS AND METHODS: Sequencing studies were conducted in a research hospital on samples from three unrelated infertile men with severe asthenoteratozoospermia from Han Chinese families. Data were collected through rigorous in silico analysis. Sanger sequencing were performed to identify pathogenic mutations...
February 22, 2024: Andrology
https://read.qxmd.com/read/38380739/ehmt2-g9a-and-ezh2-epimarkers-in-testicular-germ-cell-tumors
#29
JOURNAL ARTICLE
Helena Estevão-Pereira, Catarina Guimarães-Teixeira, Bianca C T Flores, Filipa Moreira-Silva, Nuno Tiago Tavares, Rita Guimarães, Isaac Braga, Joaquina Maurício, Rui Henrique, Carmen Jerónimo, João Lobo
BACKGROUND: Testicular germ cell tumors remain the most frequent solid malignancies in young males. Despite excellent prognosis, the fact that only 60% of patients at diagnosis have elevated serum tumor markers (dependent on stage and histology) and the poor quality of life of patients who develop resistance to chemotherapy cannot be neglected. Consequently, it is mandatory to bring out novel biomarkers. OBJECTIVES: The main goal was to evaluate EZH2 and EHMT2/G9a immunoexpression in a well-characterized patients' cohort of primary and metastatic testicular germ cell tumors, seeking associations with clinicopathological features and discovering differential immunoexpression patterns among specific subtypes...
February 21, 2024: Andrology
https://read.qxmd.com/read/38376008/serum-total-testosterone-is-associated-with-phosphate-and-calcium-excretion-in-response-to-oral-phosphate-loading-in-healthy-middle-aged-males
#30
JOURNAL ARTICLE
Jaya K Sharma, Mandy E Turner, Amanda S Paynter, Patrick A Norman, Christine A White, Emilie C Ward, Michael A Adams, Rachel M Holden
Androgen receptors are expressed in the kidney and serum testosterone is negatively associated with serum phosphate in males, suggesting a role of testosterone in renal phosphate handling. In this cross-sectional study, we examined the association of serum total and free testosterone with acute phosphate and calcium excretion in males in response to an oral phosphate challenge. Thirty-five healthy adult males with normal baseline testosterone levels consumed a 500 mg phosphorus drink and the urinary excretion of minerals, as well as levels of relevant circulating parameters, were assessed at baseline and hourly for 4 h...
February 20, 2024: Andrology
https://read.qxmd.com/read/38375999/testicular-biopsies-in-men-with-testicular-microlithiasis-and-additional-risk-factors-for-cancer-a-case-series
#31
JOURNAL ARTICLE
Rasmus Hassing Frandsen, Emil Durukan, Elena von Rohden, Christian Fuglesang S Jensen, Andreas Key Milan Thamsborg, Nessn Azawi, Mikkel Fode
BACKGROUND: Testicular microlithiasis is the presence of small calcifications in the testicular parenchyma. The association between testicular microlithiasis and germ cell neoplasia in situ, a precursor to testicular cancer, is still unclear. OBJECTIVES: To determine the incidence of germ cell neoplasia in situ in men with testicular microlithiasis and evaluate the indication for testicular biopsy according to risk factors in the form of male infertility/reduced semen quality, testicular atrophy, and history of cryptorchidism...
February 20, 2024: Andrology
https://read.qxmd.com/read/38345602/is-varicocoelectomy-indicated-in-infertile-men-with-isolated-teratozoospermia-a-systematic-review-and-meta-analysis
#32
REVIEW
Murat Dursun, Hüseyin Beşiroğlu, Reşat Aydın, Turgay Kaçan, Ahmet Halil Sevinç, Ateş Kadıoğlu
BACKGROUND: Clinical palpable varicocoeles in conjunction with isolated teratozoospermia are rarely observed. Therefore, the effects of varicocoelectomy on sperm morphology are not clear. The aim of this meta-analysis is to compile studies that assess the effectiveness of varicocoelectomy in isolated teratozoospermia to reach a more consistent and reliable conclusion. MATERIAL-METHODS: The present meta-analysis was registered to PROSPERO (CRD42023467933). We utilized the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline to report the outcomes...
February 12, 2024: Andrology
https://read.qxmd.com/read/38334037/the-paternal-role-in-pregnancy-loss
#33
REVIEW
Wade Muncey, Michael Scott, Ruth B Lathi, Michael L Eisenberg
In this comprehensive review, the intricate relationship between paternal factors and pregnancy loss is examined. While pregnancy loss has historically been predominantly attributed to maternal factors, recent research underscores the significant contribution of the male partner. The review delves into various aspects of paternal influence, including paternal age, health, chromosome abnormalities, Y chromosome deletions, and sperm DNA fragmentation. Notably, advanced paternal age is found to be associated with an increased risk of recurrent pregnancy loss, shedding light on the importance of understanding the impact of aging on male fertility...
February 9, 2024: Andrology
https://read.qxmd.com/read/38288910/the-association-between-ambient-temperature-and-semen-quality-in-a-northern-peninsular-province-china
#34
JOURNAL ARTICLE
Li Wang, Yinan Qu, Wenkai Han, Meng Cai, Wei Ma, Qi Zhao, Zi-Jiang Chen
BACKGROUND: Extreme ambient temperature has been linked to decline in males' semen quality. Although the temperature-semen quality association has been examined in certain cities of South China, how the effect size of the extreme temperature may lag over critical windows in spermatogenesis and whether the strength of association may vary in North China have yet been adequately explored. OBJECTIVES: To quantify the association between air temperature and semen quality, and identify critical exposure windows in a Northern Peninsular Province, China...
January 30, 2024: Andrology
https://read.qxmd.com/read/38273709/3-hydroxy-3-methylglutaryl-coa-synthase-2-facilitates-erectile-dysfunction-via-inhibiting-autophagy-by-enhancing-the-mammalian-target-of-rapamycin-pathway-in-type-1-diabetic-mellitus-rats
#35
JOURNAL ARTICLE
Zhiqiang Dai, Yang Zeng, Xiao Tan, Tao Zhou, Xiong Li, Qingfu Deng
BACKGROUND: The relationship between erectile dysfunction (ED) and type 1 diabetes mellitus (T1DM) is currently a hot topic of medical research. It has been reported that autophagy plays a crucial role in causing erectile dysfunction in T1DM. Recent research has shown that mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) is strongly linked to the development of T1DM. However, the specific mechanism by which it regulates the erectile function is not yet fully understood...
January 25, 2024: Andrology
https://read.qxmd.com/read/38233215/cost-effectiveness-of-testosterone-treatment-utilising-individual-patient-data-from-randomised-controlled-trials-in-men-with-low-testosterone-levels
#36
JOURNAL ARTICLE
Rodolfo Hernández, Nipun Lakshitha de Silva, Jemma Hudson, Moira Cruickshank, Richard Quinton, Paul Manson, Waljit S Dhillo, Siladitya Bhattacharya, Miriam Brazzelli, Channa N Jayasena
BACKGROUND: Testosterone is safe and highly effective in men with organic hypogonadism, but worldwide testosterone prescribing has recently shifted towards middle-aged and older men, mostly with low testosterone related to age, diabetes and obesity, for whom there is less established evidence of clinical safety and benefit. The value of testosterone treatment in middle-aged and older men with low testosterone is yet to be determined. We therefore evaluated the cost-effectiveness of testosterone treatment in such men with low testosterone compared with no treatment...
January 17, 2024: Andrology
https://read.qxmd.com/read/38231194/a-global-perspective-characteristics-of-infertility-related-randomized-clinical-trials
#37
JOURNAL ARTICLE
Yu Xi, Ya-Lei Cao, Li-Yuan Tao, Song-Zhan Gao, Zi-Run Jin, Jian-Xing Cheng, Hui Jiang, Zhe Zhang
BACKGROUND: Infertility is a prevalent global condition, and emerging reproductive technologies may enhance its evaluation and treatment. Understanding the current features of randomized clinical trials in infertility is crucial for improving study design and ensuring the translation of results for patient benefits. OBJECTIVES: To investigate the primary characteristics of randomized clinical trials related to infertility and areas where require improvement. MATERIALS AND METHODS: We conducted a search on the International Clinical Trials Registry platform for eligible infertility trials between 2003 and 2022...
January 17, 2024: Andrology
https://read.qxmd.com/read/38231174/heme-induced-corpus-cavernosum-relaxation-and-its-implications-for-priapism-in-sickle-cell-disease-a-mechanistic-insight
#38
JOURNAL ARTICLE
Dalila Andrade Pereira, Danillo Andrade Pereira, Tammyris Helena Rebecchi Silveira, Fabiano Beraldi Calmasini, Arthur L Burnett, Fernando Ferreira Costa, Fábio Henrique Silva
BACKGROUND: Patients with sickle cell disease (SCD) experience intravascular hemolysis, leading to elevated plasma heme levels. This phenomenon has been associated with increased priapism in men with SCD. The heme group can be metabolized by heme oxygenase (HO), generating carbon monoxide (CO), which is known to promote smooth muscle relaxation via soluble guanylyl cyclase (sGC)-cyclic guanosine monophosphate (cGMP). However, the effects of heme on the relaxation responses of corpus cavernosum (CC) have not been investigated...
January 17, 2024: Andrology
https://read.qxmd.com/read/38230991/repetitive-transcranial-magnetic-stimulation-via-the-hippocampal-brain-derived-neurotrophic-factor-tyrosine-kinase-receptor-b-pathway-to-affect-sexual-behavior-and-neuroplasticity-in-rapid-ejaculation-rats
#39
JOURNAL ARTICLE
Qiushi Liu, Ming Wang, Weinan Wang, Shaoyu Yue, Tommaso B Jannini, Emmanuele A Jannini, Hui Jiang, Xiansheng Zhang
BACKGROUND: Premature ejaculation (PE) is the most prevalent sexual dysfunction among men. Eejaculation involves a complex nervous mechanism in which the ejaculatory centers play a key role in modulating sperm emission. Although treatment possibilities span from psychotherapy to pharmacological approaches, results show inconsistent efficacy. In this context, the emergence of repetitive transcranial magnetic stimulation (rTMS) as a non-invasive neuromodulatory approach represents a compelling avenue for potential therapeutic exploration...
January 17, 2024: Andrology
https://read.qxmd.com/read/38228861/novel-variations-in-tent5d-lead-to-teratozoospermia-in-infertile-patients
#40
JOURNAL ARTICLE
Ying-Teng Zhang, Gan Shen, Liang-Chai Zhuo, Xue Yang, Su-Yan Wang, Tie-Chao Ruan, Chuan Jiang, Xiang Wang, Yan Wang, Yi-Hong Yang, Ying Shen
PURPOSE: Teratozoospermia is the main pathogenic factor of male infertility. However, the genetic etiology of teratozoospermia is largely unknown. This study aims to clarify the relationship between novel variations in TENT5D and teratozoospermia in infertile patients. MATERIALS AND METHODS: Two infertile patients were enrolled. Routine semen analysis of patients and normal controls was conducted with the WHO guidelines. Whole-exome sequencing (WES) was conducted to identify pathogenic variants in the two patients...
January 16, 2024: Andrology
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