Helena Estevão-Pereira, Catarina Guimarães-Teixeira, Bianca C T Flores, Filipa Moreira-Silva, Nuno Tiago Tavares, Rita Guimarães, Isaac Braga, Joaquina Maurício, Rui Henrique, Carmen Jerónimo, João Lobo
BACKGROUND: Testicular germ cell tumors remain the most frequent solid malignancies in young males. Despite excellent prognosis, the fact that only 60% of patients at diagnosis have elevated serum tumor markers (dependent on stage and histology) and the poor quality of life of patients who develop resistance to chemotherapy cannot be neglected. Consequently, it is mandatory to bring out novel biomarkers. OBJECTIVES: The main goal was to evaluate EZH2 and EHMT2/G9a immunoexpression in a well-characterized patients' cohort of primary and metastatic testicular germ cell tumors, seeking associations with clinicopathological features and discovering differential immunoexpression patterns among specific subtypes...
February 21, 2024: Andrology