Ornina Atieh, Nohad Maria J Azzi, Georges J Lteif, Ninar A Atieh, Nadim Y Germanos, Valérie Grandjean, Zalihe Yarkiner, Zakhia Saliba, Marie-Claude Fadous Khalife, Georges Raad
BACKGROUND: Genetic and environmental factors have been shown to contribute to the development of congenital heart disease (CHD). To date, the focus of scientific articles has primarily centered on genetics and maternal environmental factors, with comparatively less attention given to paternal risk factors. OBJECTIVES: This study aims to investigate the potential association between paternal pre-conceptional physical activity levels (PA), along with paternal peri-conceptional smoking and alcohol consumption, and the risk of CHD in offspring...
April 11, 2024: Andrology
Ida M Heerfordt, Josefine Windfeld-Mathiasen, Kim Peder Dalhoff, Jon Trærup Andersen, Henrik Horwitz
BACKGROUND: A link between androgen use and the risk of cancers, especially prostate and breast cancer, has been suggested. The knowledge about a possible association is limited. OBJECTIVE: The study aimed to investigate cancer incidence rates, particularly those related to prostate and breast cancer, in male androgen users and compare them to a control group. METHODS: We included male androgen users identified through a nationwide anti-doping testing program in Danish fitness centers from 2006 to 2018...
April 11, 2024: Andrology
Jasmine S Lin, Justin M Dubin, Jonathan Aguiar, Robert E Brannigan, Joshua A Halpern
BACKGROUND: Fertility declines with increasing age and physicians often delay childbearing beyond prime reproductive years for the sake of medical training. However, the risks of infertility in male physicians compared to the general population remain poorly studied. OBJECTIVES: To characterize rates of infertility among male physicians and identify barriers in access to fertility care and family building. MATERIALS & METHODS: Between June 2022 and December 2022, male physicians were invited to complete a questionnaire regarding fertility and family building...
April 10, 2024: Andrology
Hailan He, Guancheng Xiao, Xing Hu, Hui Luo, Yunfeng Liao, Biao Qian, Guoxi Zhang, Xiaofeng Zou, Junrong Zou
BACKGROUND: The etiology of chronic prostatitis remains unclear; consequently, this disease is associated with recurrence and ineffective clinical therapy. Therefore, there is an urgent need to investigate the underlying pathogenesis of chronic prostatitis in order to develop more efficacious treatments. OBJECTIVE: The previous study found that knocking out of PEBP4 leads to chronic prostatitis in the male mice. This research aimed to identify the role of PEBP4 in prostatitis, determine the molecular pathogenic mechanisms associated with chronic prostatitis, and provide guidelines for the development of new treatment strategies for chronic prostatitis...
April 9, 2024: Andrology
Simone Cilio, Paolo Capogrosso, Edoardo Pozzi, Federico Belladelli, Christian Corsini, Massimiliano Raffo, Luigi Candela, Giuseppe Fallara, Luca Boeri, Alessia d'Arma, Ciro Imbimbo, Vincenzo Mirone, Francesco Montorsi, Andrea Salonia
BACKGROUND: Phosphodiesterase 5 inhibitors (PDE5is) represent a first-line pharmacological therapy for erectile dysfunction (ED). Men could obtain PDE5is for recreational purposes without any proper medical prescription. OBJECTIVE: We aimed to analyze clinical characteristics of patients who already used any PDE5i for ED without previous formal medical prescription. MATERIALS AND METHODS: Data from 2012 heterosexual, sexually active men seeking first medical help for ED at our outpatient clinic between 2005 and 2022 were analyzed...
April 8, 2024: Andrology
Eisa Mahyari, Katinka A Vigh-Conrad, Clément Daube, Ana C Lima, Jingtao Guo, Douglas T Carrell, James M Hotaling, Kenneth I Aston, Donald F Conrad
BACKGROUND: Single-cell RNA-seq (scRNA-Seq) has been widely adopted to study gene expression of the human testis. Several datasets of scRNA-Seq from human testis have been generated from different groups processed with different informatics pipelines. An integrated atlas of scRNA-Seq expression constructed from multiple donors, developmental ages, and fertility states would be widely useful for the testis research community. OBJECTIVE: To describe the generation and use of the human infertility single-cell testis atlas (HISTA), an interactive web tool for understanding human spermatogenesis through scRNA-Seq analysis...
April 5, 2024: Andrology
David A Skerrett-Byrne, Simone J Stanger, Natalie A Trigg, Amanda L Anderson, Petra Sipilä, Ilana R Bernstein, Tessa Lord, John E Schjenken, Heather C Murray, Nicole M Verrills, Matthew D Dun, Terence Y Pang, Brett Nixon
BACKGROUND: The epididymis has long been of interest owing to its role in promoting the functional maturation of the male germline. More recent evidence has also implicated the epididymis as an important sensory tissue responsible for remodeling of the sperm epigenome, both under physiological conditions and in response to diverse forms of environmental stress. Despite this knowledge, the intricacies of the molecular pathways involved in regulating the adaptation of epididymal tissue to paternal stressors remains to be fully resolved...
April 4, 2024: Andrology
Yusuke Tominaga, Tomoko Kobayashi, Yuko Matsumoto, Takatoshi Moriwake, Yoshitaka Oshima, Misa Okumura, Satoshi Horii, Takuya Sadahira, Satoshi Katayama, Takehiro Iwata, Shingo Nishimura, Kensuke Bekku, Kohei Edamura, Morito Sugimoto, Yasuyuki Kobayashi, Masami Watanabe, Yuzaburo Namba, Yosuke Matsumoto, Mikiya Nakatsuka, Motoo Araki
BACKGROUND: Transgender individuals undergo the gender-affirming hormone therapy (GAHT) to achieve physical changes consistent with their gender identity. Few studies are available on the long-term safety and efficacy of GAHT. OBJECTIVES: To investigate the long-term physical effects and the safety of the testosterone therapy for trans men and to assess the impact of differential hormone dose. MATERIALS AND METHODS: Trans men who initiated GAHT between May 2000 and December 2021 were included in this retrospective analysis...
April 2, 2024: Andrology
Muhammed Arif Ibis, Eda Ureyen Ozdemir, Khaled Obaid, Cagri Akpinar, Batuhan Ozmen, Kaan Aydos, Onder Yaman
BACKGROUND: The question of whether patients are more likely to succeed with testicular sperm intracytoplasmic sperm injection (T-ICSI) after unsuccessful ICSI with ejaculated sperm (Ej-ICSI) remains unknown. OBJECTIVE: The study aimed to identify potential predictors of successful T-ICSI in men with idiopathic infertility and oligozoospermia (sperm concentration < 15 × 106 /mL, non-azoospermic) who had previously experienced unsuccessful Ej-ICSI...
April 2, 2024: Andrology
Daniele Tienforti, Giorgio Felzani, Alfonso Boris Di Pasquale, Arcangelo Barbonetti
BACKGROUND: Phosphodiesterase 5 inhibitors (PDE5i) are the first-line drugs for erectile dysfunction (ED) but differences among available molecules should drive therapy personalization. Choosing one PDE5i over another is a challenge in men with spinal cord injury (SCI), as the evidence of efficacy for each molecule is derived from few studies and comparative "head-to-head" trials are lacking. OBJECTIVE: To assess the efficacy of the different PDE5i for SCI-related ED with a network meta-analysis (NMA) approach...
March 30, 2024: Andrology
Valeria Hasenmajer, Dario De Alcubierre, Davide Ferrari, Marianna Minnetti, Ilaria Bonaventura, Riccardo Pofi, Chiara Simeoli, Alessandra Tomaselli, Francesca Sciarra, Grazia Bottillo, Francesco Angelini, Alessia Cozzolino, Mary Anna Venneri, Emmanuele A Jannini, Daniele Gianfrilli, Rosario Pivonello, Andrea M Isidori
BACKGROUND: Data on sexual function in patients with adrenal insufficiency are scarce and largely controversial. OBJECTIVES: To investigate sexual dysfunction in patients with primary and secondary adrenal insufficiency and the effects of switching to once-daily dual-release hydrocortisone on sexual function in outcome assessors blinded, randomized, multicenter, active comparator clinical trial. MATERIALS AND METHODS: Eighty-nine adrenal insufficiency patients on conventional, multiple daily doses of glucocorticoid replacement, enrolled in the Dual RElease hydrocortisone versus conventionAl glucocorticoid replaceMent in hypocortisolism (DREAM) trial, were randomly assigned to continue their therapy or to switch to an equivalent dose of dual-release hydrocortisone...
March 28, 2024: Andrology
Chenglun Wu, Shengyu Huang, Zhuojie Liu, Yixin Wang, Yuanqiang Zhu, Zhi-Jun Zang
INTRODUCTION: Primary premature ejaculation (PPE) is a common male neurobiological disorder. Currently, there is consensus that the impairment in central serotonin (5-HT) neurotransmission constitutes a key pathogenic factor in PPE. Selective serotonin reuptake inhibitors (SSRIs) serve as the primary pharmacological intervention; however, a comprehensive elucidation of their mechanism of action remains incomplete. Owing to significant individual variability in efficacy, SSRIs exhibit a high discontinuation rate...
March 21, 2024: Andrology
Lisha Yin, Nan Jiang, Tao Li, Youzhi Zhang, Shuiqiao Yuan
BACKGROUND: Telomeres are unique structures situated at the ends of chromosomes. Preserving the structure and function of telomeres is essential for maintaining genomic stability and promoting genetic diversity during male meiosis in mammals. MATERIAL-METHODS: This review compiled recent literature on the function and regulation of telomeres during male meiosis in both mice and humans, and also highlighted the critical roles of telomeres in reproductive biology and medicine...
March 21, 2024: Andrology
Alberto de la Iglesia, Dorte L Egeberg, Daniel Marcu, Guillaume Richer, Brendan J Houston, Omar Ammar, Gülizar Saritas, Emily Delgouffe, Davor Jezek, Csilla Krausz, Ewa Rajpert-De Meyts, Hermann M Behre
No abstract text is available yet for this article.
March 20, 2024: Andrology
Ting-Ting Han, Ji-Hua Huang, Ling-Xiao Li, Xue Liao, Xiang-Qian Meng, Zi-Na Wen, Qian Sun, Jian Ma, Tian-Hua Huang
BACKGROUND: Like the coronavirus disease 2019, the hepatitis B virus is also wreaking havoc worldwide, which has infected over 2 billion people globally. Using an experimental animal model, our previous research observed that the hepatitis B virus genes integrated into human spermatozoa can replicate and express after being transmitted to embryos. However, as of now, this phenomenon has not been confirmed in clinical data from patients. OBJECTIVES: To explore the integration of the hepatitis B virus into patients' sperm genome and its potential clinical risks...
March 20, 2024: Andrology
Tomás Bernardo Costa Moretti, Luís Alberto Magna, Leonardo Oliveira Reis
PURPOSE: Comparing post-radical prostatectomy erectile function rates among different techniques has always been a challenge in urology. This difficulty is due to the heterogeneity of studies, mainly in relation to the type of erectile function classification criteria used. The aim is to apply a new evidence-gathering methodology, called reverse systematic review, to compare erectile function rates among retropubic radical prostatectomy, laparoscopic radical prostatectomy, and robot-assisted radical prostatectomy, considering the diversity of classification criteria...
March 20, 2024: Andrology
Zhao Huangfu, Xinxin Gan, Yiren Yang, Qingyang Pang, Baohua Zhu, Xiao Zhang, Linhui Wang
BACKGROUND: Erectile dysfunction has been associated with leisure sedentary behavior in several epidemiological and observational studies. However, the interpretation of these findings is difficult due to residual confounding or reverse causality. OBJECTIVES: To explore the causal association between leisure sedentary behavior and erectile dysfunction, and to explore the underlying mechanism using Mendelian randomization. MATERIALS AND METHODS: In the present study, publicly available large-scale genome-wide association studies of leisure sedentary behaviors (television watching, computer use, and driving), erectile dysfunction, sex hormones (total testosterone, bioactive testosterone, estradiol, follicle-stimulating hormone, luteinizing hormone, prolactin, and sex hormone binding globulin), biomarkers of endothelial function (C reactive protein, E-selectin, and matrix metalloproteinase 7), and psychiatric symptoms (depression and anxiety) were used to perform two-sample Mendelian randomization analyses...
March 20, 2024: Andrology
Alexandre D Andrade, Priscila G C Almeida, Noemia A P Mariani, Natalia C M Santos, Isabela A Camargo, Poliana V Martini, Helio Kushima, Dingding Ai, Maria Christina W Avellar, Andreas Meinhardt, Christiane Pleuger, Erick J R Silva
BACKGROUND: Region-specific immune environments in the epididymis influence the immune responses to uropathogenic Escherichia coli (UPEC) infection, a relevant cause of epididymitis in men. Toll-like receptors (TLRs) are essential to orchestrate immune responses against bacterial infections. The epididymis displays region-specific inflammatory responses to bacterial-derived TLR agonists, such as lipopolysaccharide (LPS; TLR4 agonist) and lipoteichoic acid (LTA; TLR2/TLR6 agonist), suggesting that TLR-associated signaling pathways could influence the magnitude of inflammatory responses in epididymitis...
March 18, 2024: Andrology
Michael Zitzmann, Jann-Frederik Cremers, Claudia Krallmann, Armin Soave, Sabine Kliesch
BACKGROUND AND OBJECTIVE: The longitudinal efficacy and clinical utility of Testosterone Therapy (TTh) in ameliorating functional hypogonadism (FH) remain contentious, with long-term data being scarce. To address this lacuna, a comprehensive long-term registry study, stratifying patients across a spectrum of hypogonadal etiologies, offers a robust investigative paradigm. MATERIALS AND METHODS: This 9-year registry, encompassing 650 patients (equivalent to 4,362 cumulative years of treatment), included 188 patients diagnosed with FH (mean age 42...
March 15, 2024: Andrology
Pernille Jul Clemmensen, Nis Brix, Jörg Schullehner, Gunnar Toft, Sandra Søgaard Tøttenborg, Karin Sørig Hougaard, Anne Ahrendt Bjerregaard, Thorhallur Ingi Halldorsson, Sjurdur Frodi Olsen, Birgitte Hansen, Leslie Thomas Stayner, Torben Sigsgaard, Henrik Kolstad, Jens Peter Ellekilde Bonde, Cecilia Høst Ramlau-Hansen
BACKGROUND: Prenatal exposures to xenobiotics during the masculinization programming window are suggested to impact male fecundity later in life. Frequently used nitrosatable drugs, such as penicillins and beta2-agonists, contain amines or amides that may form teratogenic compounds in reaction with nitrite. OBJECTIVES: We explored whether maternal nitrosatable drug use during gestation was associated with biomarkers of male fecundity in adulthood; moreover, the potential modifiable effect of nitrate and vitamin intake was investigated...
March 15, 2024: Andrology
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