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RSC Advances

Richard P Harrison, Veeren M Chauhan, David Onion, Jonathan W Aylott, Virginie Sottile
Silica-coated superparamagnetic iron nanoparticles (SiMAGs) are an exciting biomedical technology capable of targeted delivery of cell-based therapeutics and disease diagnosis. However, in order to realise their full clinical potential, their intracellular fate must be determined. The analytical techniques of super-resolution fluorescence microscopy, particle counting flow cytometry and pH-sensitive nanosensors were applied to elucidate mechanisms of intracellular SiMAG processing in human mesenchymal stem cell (hMSCs)...
January 24, 2019: RSC Advances
Maya Miller, Edit Y Tshuva
A tetrakis(phenolato) Ti(iv) complex was synthesized in racemic and optically pure form, exhibiting high hydrolytic stability, and similar cytotoxicity for all stereochemical forms on HT-29 and A2780 cancer cells. Higher activity of the racemate on drug-resistant A2780cp and A2780adr lines implies a beneficial activity of both enantiomers rendering enantiomeric resolution unnecessary.
November 27, 2018: RSC Advances
Marc Zimmermann, Dmitry Grigoriev, Nikolay Puretskiy, Alexander Böker
This publication demonstrates the abilities of a precise and straightforward microcontact printing approach for the preparation of patchy silica particles. In a broad particle size range, it is possible to finely tune the number and parameters of three-dimensional patches like diameter and thickness using only polyethyleneimine ink, poly(dimethoxysilane) as stamp material and a suitable release solvent.
November 27, 2018: RSC Advances
Fatima Zia, Michaela Kendall, Steve P Watson, Paula M Mendes
Nanoparticles are key components underlying recent technological advances in various industrial and medical fields, and thus understanding their mode of interaction with biological systems is essential. However, while several nanoparticle systems have been shown to interact with blood platelets, many questions remain concerning the mechanisms of platelet activation and the role that the physicochemical properties of nanoparticles play in inducing platelet aggregation. Here, using negatively charged polystyrene nanoparticles with sizes of 25, 50, 119, 151, 201 nm and negatively charged platinum nanoparticles with sizes of 7 and 73 nm, we show that it is not the size of the nanoparticles but rather the nanoparticle surface area that is critical in mediating the effects on platelet activation...
November 12, 2018: RSC Advances
Shaojiang Chen, John Popovich, Wenwen Zhang, Collin Ganser, Shelley E Haydel, Dong-Kyun Seo
Antimicrobial zeolites ion-exchanged with inexpensive transition metal ions (such as zinc, copper, and iron) are critically important for a broader adoption of the materials for public health applications. Due to the high surface area and small particle sizes, nanozeolites are particularly promising in enhancing the efficacy of the zeolite-based antimicrobial materials. By using highly-crystalline nanostructured zeolites (FAU) with textural mesoporosity, we report a comprehensive study on the materials characteristics of zinc-, copper-, and iron-ion exchanged nanozeolites, the ion release properties, and antibacterial efficacy against methicillin-resistant Staphylococcus aureus (MRSA), as well as a comparison of the properties to those obtained for the corresponding microsized zeolites...
November 12, 2018: RSC Advances
Zhenzhen Xie, Mandapati V Ramakrishnam Raju, Andrew C Stewart, Michael H Nantz, Xiao-An Fu
Chemiresistor-based gas sensors for detection of target volatile organic compounds (VOCs) in air face common challenges of poor sensitivity and selectivity as well as suffering from interference by other constituent gases and/or humidity. This work demonstrates that functionalizing gold nanoparticles (AuNPs) with a designed thiol monolayer improves sensitivity and selectivity of the derived AuNPs gas sensor. We report the synthesis and application of a thiol ligand fitted with both a urea motif and a tert -butyl end group for functionalizing AuNPs...
October 21, 2018: RSC Advances
A Mohankumar, G Shanmugam, D Kalaiselvi, C Levenson, S Nivitha, G Thiruppathi, P Sundararaj
East Indian Sandalwood Oil (EISO) has diverse beneficial effects and has been used for thousands of years in traditional folk-medicine for treatment of different human ailments. However, there has been no in-depth scientific investigation to decipher the neuroprotective and geroprotective mechanism of EISO and its principle components, α- and β-santalol. Hence the current study was undertaken to assess the protective effects of EISO, and α- and β-santalol against neurotoxic (6-OHDA/6-hydroxydopamine) and proteotoxic (α-synuclein) stresses in a Caenorhabditis elegans model...
October 3, 2018: RSC Advances
Anjana Radhakrishnan, Christopher M Furze, Mohd Syed Ahangar, Elizabeth Fullam
One of the major obstacles to obtaining a complete structural and functional understanding of proteins encoded by the Mycobacterium tuberculosis ( Mtb ) pathogen is due to significant difficulties in producing recombinant mycobacterial proteins. Recent advances that have utilised the closely related Mycobacterium smegmatis species as a native host have been effective. Here we have developed a method for the rapid screening of both protein production and purification strategies of mycobacterial proteins in whole M...
September 27, 2018: RSC Advances
Bieke Onghena, Eleonora Papagni, Ernesto Rezende Souza, Dipanjan Banerjee, Koen Binnemans, Tom Vander Hoogerstraete
A speciation study was carried out for lanthanide complexes formed in the organic phase after solvent extraction with quaternary ammonium and phosphonium nitrate extractants. These extractants are liquid at room temperature and were applied in their undiluted form. A comparison was made between the quaternary compound trihexyl(tetradecyl)phosphonium nitrate, the nitrate form of the commercial extractant Cyphos IL 101, and Aliquat 336 nitrate, the nitrate form of the commercial trialkylmethylammonium chloride extractant Aliquat 336 (alkyl = mixture of C8 and C10 chains)...
September 17, 2018: RSC Advances
Ilia Villate-Beitia, Norman F Truong, Idoia Gallego, Jon Zárate, Gustavo Puras, José Luis Pedraz, Tatiana Segura
The lack of ideal non-viral gene carriers has motivated the combination of delivery systems and tissue-engineered scaffolds, which may offer relevant advantages such as enhanced stability and reduced toxicity. In this work, we evaluated a new combination between niosome non-viral vectors and hyaluronic acid (HA) hydrogel scaffolds, both widely studied due to their biocompatibility as well as their ability to incorporate a wide variety of molecules. We evaluated three different niosome formulations (niosomes 1 , 2 and 3 ) varying in composition of cationic lipid, helper lipid and non-ionic tensioactives...
September 17, 2018: RSC Advances
Matthew Tridgett, Charles Moore-Kelly, Jean-Louis H A Duprey, Lorea Orueta Iturbe, Chi W Tsang, Haydn A Little, Sandeep K Sandhu, Matthew R Hicks, Timothy R Dafforn, Alison Rodger
It is a challenge within the field of biomimetics to recreate the properties of light-harvesting antennae found in plants and photosynthetic bacteria. Attempts to recreate these biological structures typically rely on the alignment of fluorescent moieties via attachment to an inert linear scaffold, e.g. DNA, RNA or amyloid fibrils, to enable Förster resonance energy transfer (FRET) between attached chromophores. While there has been some success in this approach, refinement of the alignment of the chromophores is often limited, which may limit the efficiency of energy transfer achieved...
August 23, 2018: RSC Advances
Francesca Leonardi, Adrián Tamayo, Stefano Casalini, Marta Mas-Torrent
Understanding the physics behind the operational mechanism of Electrolyte-Gated Organic Field-Effect Transistors (EGOFETs) is of paramount importance for the correct interpretation of the device response. Here, we report the systematic functionalization of the gate electrode of an EGOFET with self-assembled monolayers with a variety of dipolar moments showing that both the chemical nature and the monolayer density influence the electrical characteristics of the device.
August 1, 2018: RSC Advances
Michael Chin, Cecilia Cisneros, Stephanie M Araiza, Kevin M Vargas, Kristi M Ishihara, Fangyuan Tian
Adsorption and photodegradation of rhodamine B by ZIF-8 nanocrystals were studied using spectroscopic techniques coupled with density functional theory (DFT) cluster calculations. A fast adsorption rate was observed in the dark, but upon exposure to visible light or UV irradiation the adsorption rate noticeably increased. Although several studies previously reported this phenomenon involving bulk ZIF-8 powder, this is the first mechanistic study to our knowledge that demonstrates adsorption and degradation of rhodamine B by nanosized ZIF-8 under various light conditions...
July 29, 2018: RSC Advances
Peng Zhu, Carl Atkinson, Suraj Dixit, Qi Cheng, Danh Tran, Kunal Patel, Yu-Lin Jiang, Scott Esckilsen, Kayla Miller, Grace Bazzle, Patterson Allen, Alfred Moore, Ann-Marie Broome, Satish N Nadig
Hypothermic preservation is the standard of care for storing organs prior to transplantation. Endothelial and epithelial injury associated with hypothermic storage causes downstream graft injury and, as such, the choice of an ideal donor organ preservation solution remains controversial. Cold storage solutions, by design, minimize cellular necrosis and optimize cellular osmotic potential, but do little to assuage immunological cell activation or immune cell priming post transplantation. Thus, here we explore the efficacy of our previously described novel Targeted Rapamycin Micelles (TRaM) as an additive to standard-of-care University of Wisconsin preservation solution as a means to alter the immunological microenvironment post transplantation using in vivo models of tracheal and aortic allograft transplantation...
July 23, 2018: RSC Advances
Michael Muzika, Natali H Muskat, Shani Sarid, Oshrit Ben-David, Ryan A Mehl, Eyal Arbely
Genetic code expansion technology enables the site-specific incorporation of dozens of non-canonical amino acids (NCAAs) into proteins expressed in live cells. The NCAAs can introduce various chemical functionalities into proteins, ranging from natural post-translational modifications, to spectroscopic probes and chemical handles for bioorthogonal reactions. These chemical groups provide powerful tools for structural, biochemical, and biophysical studies, which may require significant quantities of recombinantly expressed proteins...
July 17, 2018: RSC Advances
Bekele Hailegnaw, Getachew Adam, Herwig Heilbrunner, Dogukan H Apaydin, Christoph Ulbricht, Niyazi Serdar Sariciftci, Markus C Scharber
In this article, we present the improvement in device performance and stability as well as reduction in hysteresis of inverted mixed-cation-mixed-halide perovskite solar cells (PSCs) using a low temperature, solution processed titanium oxide (TiO x ) interlayer between [6,6]-phenyl-C61 butyric acid methyl ester (PCBM) and an Al electrode. Upon applying a TiO x interlayer, device resistance was reduced compared to that of the control devices, which results in improved rectification of the characteristic current density-voltage ( J - V ) curve and improved overall performance of the device...
July 10, 2018: RSC Advances
Lech Sznitko, Luigi Romano, Dominika Wawrzynczyk, Konrad Cyprych, Jaroslaw Mysliwiec, Dario Pisignano
We present stacked organic lasing heterostructures made by different species of light-emitting electrospun fibers, each able to provide optical gain in a specific spectral region. A hierarchical architecture is obtained by conformable layers of fibers with disordered two-dimensional organization and three-dimensional compositional heterogeneity. Lasing polymer fibers are superimposed in layers, showing asymmetric optical behavior from the two sides of the organic heterostructure, and tailored and bichromatic stimulated emission depending on the excitation direction...
July 3, 2018: RSC Advances
Joydeb Mandal, R S Varunprasaath, Wenqing Yan, Mohammad Divandari, Nicholas D Spencer, Matthias Dübner
An investigation of the polymerisation of 2-hydroxyethyl methacrylate (HEMA) by means of surface-initiated atom transfer radical polymerisation (SI-ATRP) has been carried out in situ using a quartz crystal microbalance, with multiple reinitiations under continuous flow of the reaction mixture. The SI-ATRP kinetics of HEMA were studied continuously by means of changes in the frequency, varying conditions including temperature and solvent composition, as well as monomer and catalyst concentrations, showing the influence of key reaction parameters on SI-ATRP kinetics...
June 3, 2018: RSC Advances
Kokkarachedu Varaprasad, Dariela Nunez, Murali Mohan Yallapu, Tippabattini Jayaramudu, Elizabeth Elgueta, Patricio Oyarzun
Herein, two kinds of nano-hydroxyapatite were synthesized from Clam and Magellan shell by wet chemical precipitation method. Mainly, carboxymethyl cellulose/acrylamide/nano-hydroxyapatite composite hydrogels were developed via a free-radical polymerization process and investigated as a sorbent for Acid Blue 113 (AB) from aqueous AB solution. The swelled and kinetic behaviours of hydrogels were investigated using a gravimetric method. The swelling properties of the CMC-AM-hydrogels were influenced by the calcium electrolytes (Ca2+ ) content in nano-hydroxyapatites...
May 16, 2018: RSC Advances
Edyta Niezabitowska, Jessica Smith, Mark R Prestly, Riaz Akhtar, Felix W von Aulock, Yan Lavallée, Hanene Ali-Boucetta, Tom O McDonald
The geometries and surface properties of nanocarriers greatly influence the interaction between nanomaterials and living cells. In this work we combine multiwalled carbon nanotubes (CNTs) with poly-ε-caprolactone (PCL) to produce non-spherical nanocomposites with high aspect ratios by using a facile emulsion solvent evaporation method. Particles were characterised by dynamic light scattering (DLS), scanning electron microscopy (SEM), atomic force microscopy (AFM) and asymmetric flow field flow fractionation (AF4)...
May 7, 2018: RSC Advances
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