journal
https://read.qxmd.com/read/38513263/one-stone-three-birds-silver-sulfadiazine-modulates-the-stability-and-dynamics-of-hydrogels-for-infected-wound-healing
#21
JOURNAL ARTICLE
Ye Huang, Haifei Kang, Yue Wang, Kun Liu, Wenying Wei, Honglian Dai
Dynamic covalent bond hydrogels have demonstrated significant application potential in biomedical fields for their dynamic reversibility. However, the contradiction between the stability and dynamics of the hydrogel restricts its application. Here, utilizing silver sulfadiazine (AgSD) as a catalyst, we constructed hyaluronic acid-based hydrogels through imine bond crosslinking and incorporated disulfide bonds within the same crosslinking chain. It was found that AgSD can accelerate the formation of imine crosslinking bonds to improve the stability of hydrogels, thereby shortening the gelation time by approximately 36...
March 21, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38513154/bv2-membrane-coated-pegylated-liposomes-delivered-hfgf21-to-cortical-and-hippocampal-microglia-for-alzheimer-s-disease-therapy
#22
JOURNAL ARTICLE
Heng-Cai Wang, Wei Yang, Ling Xu, Yong-Hui Han, Yi Lin, Cui-Tao Lu, Kwonseop Kim, Ying-Zheng Zhao, Xi-Chong Yu
Microglia-mediated inflammation is involved in the pathogenesis of Alzheimer's disease (AD), whereas hFGF21 has demonstrated the ability to regulate microglia activation in Parkinson's disease, indicating a potential therapeutic role in AD. However, challenges such as aggregation, rapid inactivation, and the blood-brain barrier hinder its effectiveness in treating AD. This study develops targeted delivery of hFGF21 to activated microglia using BV2 membrane-coated PEGylated liposomes (hFGF21@BCM-LIP), preserving the bioactivity of hFGF21...
March 21, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38511587/high-scale-3d-bioprinting-platform-for-the-automated-production-of-vascularized-organs-on-a-chip
#23
JOURNAL ARTICLE
Anna Fritschen, Nils Lindner, Sebastian Scholpp, Philipp Richthof, Jonas Dietz, Philipp Linke, Zeno Guttenberg, Andreas Blaeser
3D bioprinting possesses the potential to revolutionize contemporary methodologies for fabricating tissue models employed in pharmaceutical research and experimental investigations. This is enhanced by combining bioprinting with advanced Organs-on-a-Chip (OOCs), which includes a complex arrangement of multiple cell types representing organ-specific cells, connective tissue and vasculature. However, both OOCs and bioprinting so far demand a high degree of manual intervention, thereby impeding efficiency and inhibiting scalability to meet technological requirements...
March 21, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38509761/ultrasound-activated-piezoelectric-nanoparticles-trigger-microglia-activity-against-glioblastoma-cells
#24
JOURNAL ARTICLE
Margherita Montorsi, Carlotta Pucci, Daniele De Pasquale, Attilio Marino, Maria Cristina Ceccarelli, Martina Mazzuferi, Martina Bartolucci, Andrea Petretto, Mirko Prato, Doriana Debellis, Giorgio De Simoni, Giammarino Pugliese, Massimiliano Labardi, Gianni Ciofani
Glioblastoma multiforme (GBM) is the most aggressive brain cancer, characterized by a rapid and drug-resistant progression. GBM "builds" around its primary core a genetically heterogeneous tumor-microenvironment (TME), recruiting surrounding healthy brain cells by releasing various intercellular signals. Glioma-associated microglia (GAM) represent the largest population of collaborating cells, which, in the TME, usually exhibit the anti-inflammatory M2 phenotype, thus promoting an immunosuppressing environment that helps tumor growth...
March 20, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38508583/the-role-of-reactive-oxygen-species-in-alzheimer-s-disease-from-mechanism-to-biomaterials-therapy
#25
REVIEW
Zhuohang Yu, Feng Luo
Alzheimer's disease (AD) is a chronic, insidious, and progressive neuro-degenerative disease that remains a clinical challenge for society. The fully approved drug lecanemab exhibits the prospect of therapy against the pathological processes, while debatable adverse events conflict with the drug concentration required for the anticipated therapeutic effects. Reactive oxygen species (ROS) are involved in the pathological progression of AD, as has been demonstrated in much research regarding oxidative stress (OS)...
March 20, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38508224/one-pot-synthesis-of-luminescent-and-photothermal-carbon-boron-nitride-quantum-dots-exhibiting-cell-damage-protective-effects
#26
JOURNAL ARTICLE
Grazia M L Consoli, Ludovica Maugeri, Nicolò Musso, Antonino Gulino, Luisa D'Urso, Paolo Bonacci, Gianpiero Buscarino, Giuseppe Forte, Salvatore Petralia
Zero-dimensional boron nitride quantum dots (BNQDs) are arousing interest for their versatile optical, chemical, and biochemical properties. Introducing carbon contents in BNQDs nanostructures is a great challenge to modulate their physic-chemical properties and applications. Among the carbon moieties, phenolic groups have attracted attention for their biochemical properties and phenol-containing nanomaterials are showing great promise for biomedical applications. Herein, the first example of direct synthesis of water dispersible BNQDs exposing phenolic and carboxylic groups is presented...
March 20, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38508211/engineered-hsa-mir-455-3p-abundant-extracellular-vesicles-derived-from-three-dimensional-cultured-adipose-mesenchymal-stem-cells-for-tissue-engineering-hyaline-cartilage-regeneration
#27
JOURNAL ARTICLE
Jian-Guo Chen, En-Chong Zhang, Ying-Ying Wan, Tian-Yu Huang, Yu-Chen Wang, Hai-Yue Jiang
Efforts are made to enhance the inherent potential of extracellular vesicles (EVs) by utilizing three-dimensional (3D) culture platforms and engineered strategies for functional cargo-loading. We successfully isolate three distinct types of adipose mesenchymal stem cells-derived EVs (ADSCs-EVs) utilizing 3D culture platforms consisting of porous gelatin methacryloyl (PG), PG combined with sericin methacryloyl (PG/SerMA), or PG combined with chondroitin sulfate methacryloyl (PG/ChSMA). These correspond to PG-EVs, PG/SerMA-EVs, and PG/ChSMA-EVs, respectively...
March 20, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38507713/effects-of-a-bioengineered-allogeneic-cellularized-construct-bacc-on-primary-human-macrophage-phenotype
#28
JOURNAL ARTICLE
Lindsay A Steele, Beatriz Hernaez Estrada, Kara L Spiller
The mechanisms behind the pro-healing effects of multicellular, bioengineered allogeneic cellularized constructs (BACC) are not known. Macrophages are key regulators of every phase of the wound healing process and are the primary cells that mediate the response to biomaterials. We hypothesized that cells within the BACC modulate macrophage behavior, which may contribute to the mechanism by which BACC promotes healing. To probe the influence of cells within the BACC compared to effects of the underlying collagen substrate, primary human macrophages were cultured in direct or indirect contact with BACC or with the same collagen substrate used in the BACC manufacturing...
March 20, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38507709/glucose-oxidase-energized-osmium-with-dual-active-centers-and-triple-enzyme-activities-for-infected-diabetic-wound-management
#29
JOURNAL ARTICLE
Shaobin He, Mengting Lin, Qionghua Zheng, Bo Liang, Xinjie He, Yin Zhang, Qiuxia Xu, Haohua Deng, Kelong Fan, Wei Chen
Diabetic wounds are susceptible to bacterial infections, largely linked to high blood glucose levels (hyperglycemia). To treat such wounds, enzymes like glucose oxidase (GOx) can be combined with nanozymes (nanomaterials mimic enzymes) to use glucose effectively for purposes. However, there is still room for improvement in these systems, particularly in terms of process simplification, enzyme activity regulation, and treatment effects. Herein, our approach utilizes GOx to directly facilitate the biomineralized growth of osmium (Os) nanozyme (GOx-OsNCs), leading to dual-active centers and remarkable triple enzyme activities...
March 20, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38507269/localized-surface-plasmon-resonance-enhanced-photocatalytic-antibacterial-of-in-situ-sprayed-0d-2d-heterojunction-composite-hydrogel-for-treating-diabetic-wound
#30
JOURNAL ARTICLE
Zhengao Wang, Wei Li, Youzhun Fan, Cairong Xiao, Zhifeng Shi, Yunbing Chang, Guoyan Liang, Chengli Liu, Zurong Zhu, Peng Yu, Xuebin Yang, Zhiguo Song, Chengyun Ning
Chronic diabetic wounds pose significant challenges due to uncontrolled bacterial infections, prolonged inflammation, and impaired angiogenesis. The rapid advancement of photo-responsive antibacterial therapy showed promise in addressing these complex issues, particularly utilizing 2D heterojunction materials, which offer unique properties. Herein, we designed an in situ sprayed Bi/BiOCl 0D/2D heterojunction composite fibrin gel with the characteristics of rapid formation and effective near-infrared activation for the treatment of non-healing diabetes-infected wounds...
March 20, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38502895/compartmentalization-into-outer-and-inner-shells-of-hollow-nanospheres-for-antibiosis-based-on-chemistry-and-physical-damages
#31
JOURNAL ARTICLE
Chengju Sheng, Yanjun Ding, Mingming Guo
There is a substantially ascending demand for nonantibiotic strategies to overcome the resistance of bacterial infections. Here, we report the discovery of a distinctive antibacterial structure. The novel structure of nanoparticle strategy is proposed for appreciable bacteria killing by the smart design of the delayed addition of crosslinkers into the reaction mixture. [2-(methacryloyloxy)ethyl]trimethylammonium chloride solution (MTCl), a water-soluble ionic liquid (IL), it has narrow-size material distribution, good whiteness and high weather resistance...
March 19, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38502033/a-novel-cacu-metal-organic-framework-based-multimodal-treatment-platform-for-enhanced-synergistic-therapy-of-hepatocellular-carcinoma
#32
JOURNAL ARTICLE
Weijun Chen, Meiyang Yang, Huili Wang, Junling Song, Congjin Mei, Lipeng Qiu, Jinghua Chen
Metal ions have attracted a lot of interest in antitumor therapy due to their unique mechanism of action. However, multiple death mechanisms associated with metal ions to synergistic antitumor have few studies mainly due to the serious challenges in designing and building metal-associated multimodal treatment platform. Hence, a series of glutathione-activatable CaCu-based metal-organic-frameworks loaded with doxorubicin and ovalbumin were successfully designed and synthesized with an "all in one" strategy, which was modified by galactosamine-linked hyaluronic acid to prepare multimodal treatment platform (SCC/DOX@OVA-HG) for targeted delivery and synergistic antitumor therapy...
March 19, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38501563/dual-self-assembly-of-puerarin-and-silk-fibroin-into-supramolecular-nanofibrillar-hydrogel-for-infected-wound-treatment
#33
JOURNAL ARTICLE
Dan Yang, Wei Zhao, Shengyu Zhang, Yu Liu, Jingmei Teng, Yuxi Ma, Rongjian Huang, Hua Wei, Hailan Chen, Jiantao Zhang, Jing Chen
The treatment of infected wounds remains a challenging biomedical problem because of the complex microenvironment at the wound bed. Some natural bioactive small-molecule hydrogelators with unique rigid structures can self-assemble into supramolecular hydrogels, serving as supporting dressings and therapeutic agents for wound healing. However, they are still suffered from low structural stability and bio-functionality. Herein, we proposed a supramolecular hydrogel antibacterial dressing with a dual nanofibrillar network structure...
March 19, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38501303/red-nir-i-fluorescence-carbon-dots-based-on-rhein-with-active-oxygen-scavenging-and-colitis-targeting-for-uc-therapeutics
#34
JOURNAL ARTICLE
Jiashan Xia, Jiayu Wang, Fengyuan Liu, Zhiqiong Chen, Changmei Chen, Xiangshu Cheng, Yu Chao, Yue Wang, Tao Deng
Ulcerative colitis (UC) is a lifelong inflammatory disease characterized by uncontrolled inflammatory response and intestinal epithelial barrier damage that continuously promote disease progression. Rhein, as an active monomer in traditional Chinese medicine, has dual biological effects of controlling inflammatory responses and promoting intestinal mucosal repair. However, their clinical application is limited by their hydrophobicity and poor bioavailability. L-arginine, as a complement to NO, has synergistic and attenuating effects...
March 19, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38499190/biomimetic-platelet-cloaked-nanoparticles-for-the-delivery-of-anti-inflammatory-curcumin-in-the-treatment-of-atherosclerosis
#35
JOURNAL ARTICLE
Flavia Fontana, Giuseppina Molinaro, Sofia Moroni, Giulia Pallozzi, Mónica P A Ferreira, Rubén Pareja Tello, Khalil Elbadri, Giulia Torrieri, Alexandra Correia, Marianna Kemell, Luca Casettari, Christian Celia, Hélder A Santos
Atherosclerosis still represents a major driver of cardiovascular diseases worldwide. Together with accumulation of lipids in the plaque, inflammation has been recognized as one of the key players in the formation and development of atherosclerotic plaque. Systemic anti-inflammatory treatments have been successful in reducing the disease burden, but are correlated with severe side effects, underlining the need for targeted formulations. In this work, curcumin is chosen as the anti-inflammatory payload model and further loaded in lignin-based nanoparticles (NPs)...
March 18, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38497832/tantalum-particles-promote-m2-macrophage-polarization-and-regulate-local-bone-metabolism-via-macrophage-derived-exosomes-influencing-the-fates-of-bmscs
#36
JOURNAL ARTICLE
Junjun Yang, Xiaoyuan Gong, Tao Li, Zengzilu Xia, Rui He, Xiongbo Song, Xin Wang, Jiangyi Wu, Jiajia Chen, Fangzheng Wang, Ran Xiong, Yangjing Lin, Guangxing Chen, Liu Yang, Kaiyong Cai
In this study, we explored the regulatory role and mechanisms of tantalum (Ta) particles in the bone tissue microenvironment. Ta particle deposition occurs in both clinical samples and animal tissues following porous Ta implantation. Unlike titanium (Ti) particles promoting M1 macrophage (Mϕ) polarization, Ta particles regulating calcium signaling pathways and promoting M2 Mϕ polarization. Ta-induced M2 Mϕ enhance bone marrow-derived mesenchymal stem cells (BMSCs) proliferation, migration, and osteogenic differentiation through exosomes (Exo) by upregulating miR-378a-3p/miR-221-5p and downregulating miR-155-5p/miR-212-5p...
March 18, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38491859/the-combination-of-membrane-disruption-and-ftsz-targeting-by-a-chemotherapeutic-hydrogel-synergistically-combats-pathogens-infections
#37
JOURNAL ARTICLE
Xianyuan Wei, Jintong Guo, Xiaorui Geng, Bin Xue, Shaohui Huang, Zhen Yuan
The emergence of multidrug-resistant (MDR) bacteria poses a significant challenge to global health. Due to a shortage of antibiotics, alternative therapeutic strategies are urgently needed. Unfortunately, colistin, the last-resort antibiotic, has unavoidable nephrotoxicity and hepatotoxicity, and its single killing mechanism is prone to drug resistance. To address this challenge, we propose a promising combinatorial approach that includes colistin, a membrane-disrupting antimicrobial agent, and chelerythrine (CHE), a FtsZ protein inhibitor...
March 16, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38490740/robust-gradient-hydrogel-loaded-nanofiber-fleshy-artificial-skin-via-a-coupled-microfluidic-electrospinning-reactive-coating-strategy
#38
JOURNAL ARTICLE
Qing Li, Rong Chen, Tingting Cui, Yuting Bai, Jie Hu, Jiafei Yu, Gefei Wang, Su Chen
Skin regeneration has attracted tremendous interest due to the important role of skin for human protection and beauty. Thus, methods allowing artificial skin to be carried out in a controllable fashion are potentially important for wound healing, which involves an intersection of materials, medicine, biology and other disciplines. Herein, aiming at a new general methodology for fleshy materials, we designed and fabricated a new hydrogel-loaded hydrophobic-hydrophilic nanofiber fleshy artificial skin. The gradient hydrogel-loaded nanofiber artificial skin integrates both advantages of nanofiber and hydrogel, exhibiting fleshy feature (comparability to real skin in terms of appearance, texture and function), excellent air permeability, compatibility, good mechanical and antibacterial property...
March 15, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38490686/hierarchically-biomimetic-scaffolds-with-anisotropic-micropores-and-nanotopological-patterns-to-promote-bone-regeneration-via-geometric-modulation
#39
JOURNAL ARTICLE
Xin Wei, Jiaxin Chen, Hui-Yuan Shen, Kai Jiang, Haohao Ren, Yao Liu, En Luo, Jin Zhang, Jia-Zhuang Xu, Zhong-Ming Li
Structural engineering is an appealing means to modulate osteogenesis without the intervention of exogenous cells or therapeutic agents. In this work, we developed a novel three-dimensional (3D) scaffold with anisotropic micropores and nanotopographical patterns. Scaffolds with oriented pores were fabricated via the selective extraction of water-soluble polyethylene oxide (PEO) from its poly(ε-caprolactone) (PCL) co-continuous mixture and uniaxial stretching. The plate apatite-like lamellae were subsequently hatched on the pore walls through surface-induced epitaxial crystallization...
March 15, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38490171/the-h-2-o-2-self-sufficient-3d-printed-%C3%AE-tcp-scaffolds-with-synergistic-anti-tumor-effect-and-reinforced-osseointegration
#40
JOURNAL ARTICLE
Qing Wang, Jingyan Qiu, Hang Zhang, Xuan Wang, Yanzheng Chen, Xiang Li, Jinsong Pan
Tumor recurrence and massive bone defects are two critical challenges for postoperative treatment of oral and maxillofacial tumor, posing serious threats to the health of patients. Herein, in order to eliminate residual tumor cells and promote osteogenesis simultaneously, the hydrogen peroxide (H2 O2 ) self-sufficient TCP-PDA-CaO2 -CeO2 (TPCC) scaffolds are designed by preparing CaO2 or/and CeO2 nanoparticles (NPs)/chitosan solution and modifying the NPs into polydopamine (PDA)-modified 3D printed TCP scaffolds by rotary coating method...
March 15, 2024: Advanced Healthcare Materials
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